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Article ; Online: Covid-19 and the N95 respirator shortage: Closing the gap.

Nogee, Daniel / Tomassoni, Anthony J

Infection control and hospital epidemiology

2020 Volume 41, Issue 8, Page(s) 958

Abstract: Due to extreme shortages of personal protective equipment caused by the COVID-19 pandemic, many healthcare workers will be forced to recycle protective masks intended for disposal after a single use. We propose investigating the use of ultraviolet ... ...

Abstract	Due to extreme shortages of personal protective equipment caused by the COVID-19 pandemic, many healthcare workers will be forced to recycle protective masks intended for disposal after a single use. We propose investigating the use of ultraviolet germicidal irradiation to sterilize masks of SARS-CoV-2 for safer reuse.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.124
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Article: Covid-19 and the N95 respirator shortage: Closing the gap

Nogee, Daniel / Tomassoni, Anthony J

Infect Control Hosp Epidemiol

Abstract	Due to extreme shortages of personal protective equipment caused by the COVID-19 pandemic, many healthcare workers will be forced to recycle protective masks intended for disposal after a single use. We propose investigating the use of ultraviolet germicidal irradiation to sterilize masks of SARS-CoV-2 for safer reuse.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #214019
Database	COVID19

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Article ; Online: Covid-19 and the N95 respirator shortage

Nogee, Daniel / Tomassoni, Anthony J.

Infection Control & Hospital Epidemiology

Closing the gap

2020 Volume 41, Issue 8, Page(s) 958–958

Abstract: Abstract Due to extreme shortages of personal protective equipment caused by the COVID-19 pandemic, many healthcare workers will be forced to recycle protective masks intended for disposal after a single use. We propose investigating the use of ... ...

Abstract	Abstract Due to extreme shortages of personal protective equipment caused by the COVID-19 pandemic, many healthcare workers will be forced to recycle protective masks intended for disposal after a single use. We propose investigating the use of ultraviolet germicidal irradiation to sterilize masks of SARS-CoV-2 for safer reuse.
Keywords	Microbiology (medical) ; Epidemiology ; Infectious Diseases ; covid19
Language	English
Publisher	Cambridge University Press (CUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.124
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Upper Extremity Crotalid Envenomation: A Review of Incidence and Recent Trends in Management of Snakebites.

Razavi, S Amir / Stewart, Christopher M / Nogee, Daniel P / Geller, Robert J / Seiler, John G

The Journal of hand surgery

2022 Volume 48, Issue 12, Page(s) 1277.e1–1277.e6

Abstract: Purpose: The goal of this study was to evaluate the recent trends in the management of upper extremity Crotalid envenomation in the state of Georgia, United States.: Methods: A retrospective review of the Georgia Poison Center database looking at the ...

Abstract	Purpose: The goal of this study was to evaluate the recent trends in the management of upper extremity Crotalid envenomation in the state of Georgia, United States. Methods: A retrospective review of the Georgia Poison Center database looking at the reported snakebites to the upper extremity between 2015 and 2020 was performed. Patient demographics, timing and location of injury, severity of envenomation, treatment, including use of antivenin and surgical intervention, and reported complications related to the use of antivenin was extracted. Results: A retrospective review of snakebites between 2015 and 2020 showed 2408 snakebite cases with a mean patient age of 37.4 years. Males incurred 62.8% of all bites. The highest incidence was in summer 52.5%, and between the hours of 5 PM to midnight 57.2%. Overall, 1010 (41.9%) of all bites were categorized as venomous snakebites (55.6% copperhead, 20% rattlesnake, 2.4% cottonmouth, and 22% miscellaneous [including 3 Elapid envenomations] or unidentified. The total number of venomous bites to the upper extremity was 575 (56.9%) and 567 patients received antivenin. Envenomation severity was mild in 29%, moderate in 45%, severe in 10%, and undetermined in 16% of cases. Crotalidae polyvalent immune Fab (Ovine) was the main antivenin used, with overall mean initial therapy dose of 6.2 vials and 59% of patients receiving maintenance therapy. Three patients (0.5%) had a severe anaphylactic reaction to antivenin requiring cessation of therapy. Seven patients had acute compartment syndrome of the upper extremity requiring fasciotomy (3 copperhead, 2 rattlesnake, and 2 unidentified). There was no reported mortality during this period. Conclusions: Hand surgeons should be familiar with the management of upper extremity Crotalid envenomation. Antivenin remains the main treatment for symptomatic patients. Crotalid snakebites rarely require operative intervention. Type of study/level of evidence: Prognostic IV.
MeSH term(s)	Male ; Humans ; Animals ; Sheep ; United States/epidemiology ; Adult ; Snake Bites/epidemiology ; Snake Bites/therapy ; Antivenins/therapeutic use ; Incidence ; Upper Extremity ; Agkistrodon
Chemical Substances	Antivenins
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	605716-0
ISSN	1531-6564 ; 0363-5023
ISSN (online)	1531-6564
ISSN	0363-5023
DOI	10.1016/j.jhsa.2022.04.016
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Article ; Online: Monitoring trends in lacrimator exposures using the National Poison Data System: 2000-2021.

Nogee, Daniel / Therriault, Colin / Yeh, Michael / Kieszak, Stephanie / Schnall, Amy / Brown, Kaitlyn / Bronstein, Alvin / Chang, Arthur / Svendsen, Erik

Clinical toxicology (Philadelphia, Pa.)

2023 Volume 61, Issue 7, Page(s) 543–550

Abstract: Context: Lacrimators are used by individuals for personal defense and by police for crowd control during periods of civil unrest. Increased public awareness about their use has raised concerns about their application and safety.: Objective: To ... ...

Abstract	Context: Lacrimators are used by individuals for personal defense and by police for crowd control during periods of civil unrest. Increased public awareness about their use has raised concerns about their application and safety. Objective: To characterize patterns of lacrimator exposures in the United States, we describe temporal trends of calls to poison centers by demographics, substances, medical outcomes, exposure sites, and scenarios. Methods: A retrospective data analysis was performed for all single-substance lacrimator exposures in the United States reported to the National Poison Data System between 2000 and 2021. Descriptive analyses were performed to examine demographic characteristics, geographic distribution, product types and medical outcomes associated with lacrimator exposures. Results: A total of 107,149 lacrimator exposure calls were identified. There was an overall decrease in calls per year, from 6,521 calls in 2000 to 2,520 in 2020, followed by an increase to 3,311 calls in 2021. A declining trend was observed independent of total poison center call volume. Oleoresin capsicum was the most commonly reported substance (81,990, 76.5%). Individuals ages 19 years and younger accounted for 62% of calls, but adults ages 20 and over were more likely to develop major clinical effects (odds ratio 3.03; 95% confidence interval 1.91-4.81; Conclusion: Lacrimator exposure calls to United States poison centers decreased from 2000 to 2021. Most calls pertain to oleoresin capsicum and individuals ages 19 and younger. Improper storage allowing children to have access to these chemicals, is a common scenario. Public safety interventions such as education about safe storage and use of lacrimators, improved product design, or regulatory changes may prevent unintentional exposures.
MeSH term(s)	Child ; Adult ; Adolescent ; Humans ; United States/epidemiology ; Poisons ; Retrospective Studies ; Poison Control Centers ; Databases, Factual ; Data Systems ; Gases
Chemical Substances	Poisons ; Gases
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2023.2227999
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Article ; Online: Notes from the Field: Acute Nonviral Hepatitis Linked to a Brand of Alkaline Bottled Water - Clark County, Nevada and California, 2020.

Ruff, Jeanne C / Zhang, Ying / Bui, David P / Therriault, Colin / Nogee, Daniel / Guthery, Stephen L / Daniel, Johnni

MMWR. Morbidity and mortality weekly report

2021 Volume 70, Issue 46, Page(s) 1617–1619

MeSH term(s)	Acute Disease ; Adult ; Alkalies/toxicity ; California/epidemiology ; Child, Preschool ; Disease Outbreaks ; Drinking Water/adverse effects ; Drinking Water/chemistry ; Female ; Hepatitis/epidemiology ; Humans ; Infant ; Male ; Nevada/epidemiology
Chemical Substances	Alkalies ; Drinking Water
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7046a6
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Article ; Online: Veratrum parviflorum

Seale, Jared T / Carpenter, Joseph E / Eisenstat, Matthew D / Kiernan, Emily A / Morgan, Brent W / Nogee, Daniel P / Pu, Xinzhu / Therriault, Colin A / Yeh, Michael / McDougal, Owen M

Clinical toxicology (Philadelphia, Pa.)

2022 Volume 60, Issue 12, Page(s) 1309–1317

Abstract: Introduction: The : Case history: Eight patients, three male and five female, presented in the spring of 2020 and 2021 with symptoms requiring emergent medical attention after ingestion of : Methods: V. parviflorum: Results: The : Discussion!# ...

Abstract	Introduction: The Case history: Eight patients, three male and five female, presented in the spring of 2020 and 2021 with symptoms requiring emergent medical attention after ingestion of Methods: V. parviflorum Results: The Discussion: Toxicity resulting from Conclusion: V. parviflorum
MeSH term(s)	Female ; Humans ; Veratrum ; Milk, Human ; Veratrum Alkaloids ; Alkaloids ; Plant Poisoning/drug therapy
Chemical Substances	Veratrum Alkaloids ; Alkaloids
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2022.2132166
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The US national registry for childhood interstitial and diffuse lung disease: Report of study design and initial enrollment cohort.

Nevel, Rebekah J / Deutsch, Gail H / Craven, Daniel / Deterding, Robin / Fishman, Martha P / Wambach, Jennifer A / Casey, Alicia / Krone, Katie / Liptzin, Deborah R / O'Connor, Michael G / Kurland, Geoffrey / Taylor, Jane B / Gower, William A / Hagood, James S / Conrad, Carol / Tam-Williams, Jade B / Fiorino, Elizabeth K / Goldfarb, Samuel / Sadreameli, Sara C /

Nogee, Lawrence M / Montgomery, Gregory / Hamvas, Aaron / Laguna, Theresa A / Bansal, Manvi / Lew, Cheryl / Santiago, Maria / Popova, Antonia / De, Aliva / Chan, Marilynn / Powers, Michael R / Josephson, Maureen B / Camburn, Devaney / Voss, Laura / Li, Yun / Young, Lisa R

Pediatric pulmonology

2023

Abstract: Introduction: Childhood interstitial and diffuse lung disease (chILD) encompasses a broad spectrum of rare disorders. The Children's Interstitial and Diffuse Lung Disease Research Network (chILDRN) established a prospective registry to advance knowledge ...

Abstract	Introduction: Childhood interstitial and diffuse lung disease (chILD) encompasses a broad spectrum of rare disorders. The Children's Interstitial and Diffuse Lung Disease Research Network (chILDRN) established a prospective registry to advance knowledge regarding etiology, phenotype, natural history, and management of these disorders. Methods: This longitudinal, observational, multicenter registry utilizes single-IRB reliance agreements, with participation from 25 chILDRN centers across the U.S. Clinical data are collected and managed using the Research Electronic Data Capture (REDCap) electronic data platform. Results: We report the study design and selected elements of the initial Registry enrollment cohort, which includes 683 subjects with a broad range of chILD diagnoses. The most common diagnosis reported was neuroendocrine cell hyperplasia of infancy, with 155 (23%) subjects. Components of underlying disease biology were identified by enrolling sites, with cohorts of interstitial fibrosis, immune dysregulation, and airway disease being most commonly reported. Prominent morbidities affecting enrolled children included home supplemental oxygen use (63%) and failure to thrive (46%). Conclusion: This Registry is the largest longitudinal chILD cohort in the United States to date, providing a powerful framework for collaborating centers committed to improving the understanding and treatment of these rare disorders.
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26568
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Article: Identifying Opioid Use Disorder in the Emergency Department: Multi-System Electronic Health Record-Based Computable Phenotype Derivation and Validation Study.

Chartash, David / Paek, Hyung / Dziura, James D / Ross, Bill K / Nogee, Daniel P / Boccio, Eric / Hines, Cory / Schott, Aaron M / Jeffery, Molly M / Patel, Mehul D / Platts-Mills, Timothy F / Ahmed, Osama / Brandt, Cynthia / Couturier, Katherine / Melnick, Edward

JMIR medical informatics

2019 Volume 7, Issue 4, Page(s) e15794

Abstract: Background: Deploying accurate computable phenotypes in pragmatic trials requires a trade-off between precise and clinically sensical variable selection. In particular, evaluating the medical encounter to assess a pattern leading to clinically ... ...

Abstract	Background: Deploying accurate computable phenotypes in pragmatic trials requires a trade-off between precise and clinically sensical variable selection. In particular, evaluating the medical encounter to assess a pattern leading to clinically significant impairment or distress indicative of disease is a difficult modeling challenge for the emergency department. Objective: This study aimed to derive and validate an electronic health record-based computable phenotype to identify emergency department patients with opioid use disorder using physician chart review as a reference standard. Methods: A two-algorithm computable phenotype was developed and evaluated using structured clinical data across 13 emergency departments in two large health care systems. Algorithm 1 combined clinician and billing codes. Algorithm 2 used chief complaint structured data suggestive of opioid use disorder. To evaluate the algorithms in both internal and external validation phases, two emergency medicine physicians, with a third acting as adjudicator, reviewed a pragmatic sample of 231 charts: 125 internal validation (75 positive and 50 negative), 106 external validation (56 positive and 50 negative). Results: Cohen kappa, measuring agreement between reviewers, for the internal and external validation cohorts was 0.95 and 0.93, respectively. In the internal validation phase, Algorithm 1 had a positive predictive value (PPV) of 0.96 (95% CI 0.863-0.995) and a negative predictive value (NPV) of 0.98 (95% CI 0.893-0.999), and Algorithm 2 had a PPV of 0.8 (95% CI 0.593-0.932) and an NPV of 1.0 (one-sided 97.5% CI 0.863-1). In the external validation phase, the phenotype had a PPV of 0.95 (95% CI 0.851-0.989) and an NPV of 0.92 (95% CI 0.807-0.978). Conclusions: This phenotype detected emergency department patients with opioid use disorder with high predictive values and reliability. Its algorithms were transportable across health care systems and have potential value for both clinical and research purposes.
Language	English
Publishing date	2019-10-31
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2798261-0
ISSN	2291-9694
ISSN	2291-9694
DOI	10.2196/15794
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016.

Tomassoni, Anthony J / Hawk, Kathryn F / Jubanyik, Karen / Nogee, Daniel P / Durant, Thomas / Lynch, Kara L / Patel, Rushaben / Dinh, David / Ulrich, Andrew / D'Onofrio, Gail

MMWR. Morbidity and mortality weekly report

2017 Volume 66, Issue 4, Page(s) 107–111

Abstract: On the evening of June 23, 2016, a white powder advertised as cocaine was purchased off the streets from multiple sources and used by an unknown number of persons in New Haven, Connecticut. During a period of less than 8 hours, 12 patients were brought ... ...

Abstract	On the evening of June 23, 2016, a white powder advertised as cocaine was purchased off the streets from multiple sources and used by an unknown number of persons in New Haven, Connecticut. During a period of less than 8 hours, 12 patients were brought to the emergency department (ED) at Yale New Haven Hospital, experiencing signs and symptoms consistent with opioid overdose. The route of intoxication was not known, but presumed to be insufflation ("snorting") in most cases. Some patients required doses of the opioid antidote naloxone exceeding 4 mg (usual initial dose = 0.1-0.2 mg intravenously), and several patients who were alert after receiving naloxone subsequently developed respiratory failure. Nine patients were admitted to the hospital, including four to the intensive care unit (ICU); three required endotracheal intubation, and one required continuous naloxone infusion. Three patients died. The white powder was determined to be fentanyl, a drug 50 times more potent than heroin, and it included trace amounts of cocaine. The episode triggered rapid notification of public health and law enforcement agencies, interviews of patients and their family members to trace and limit further use or distribution of the fentanyl, immediate naloxone resupply and augmentation for emergency medical services (EMS) crews, public health alerts, and plans to accelerate naloxone distribution to opioid users and their friends and families. Effective communication and timely, coordinated, collaborative actions of community partners reduced the harm caused by this event and prevented potential subsequent episodes.
MeSH term(s)	Adult ; Aged ; Connecticut ; Drug Overdose/diagnosis ; Drug Overdose/therapy ; Emergency Service, Hospital ; Fatal Outcome ; Female ; Fentanyl/blood ; Fentanyl/poisoning ; Fentanyl/urine ; Humans ; Male ; Middle Aged ; Naloxone/therapeutic use
Chemical Substances	Naloxone (36B82AMQ7N) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2017-02-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mm6604a4
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