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  1. Article ; Online: COVID-19 and acute or chronic kidney disease: a crescent learning.

    Rodrigues, Cibele Isaac Saad / Azevedo, Rafael Bellotti / Muxfeldt, Elizabeth Silaid

    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

    2022  Volume 44, Issue 3, Page(s) 305–307

    MeSH term(s) COVID-19 ; Humans ; Kidney Glomerulus ; Renal Insufficiency, Chronic/complications
    Language Portuguese
    Publishing date 2022-07-19
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2022-E005en
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 and cancer

    Tomás de Souza Mello / Rafael Bellotti Azevedo / João Victor Gonçalves de-Hollanda / Leonardo Villa Leão Ferreira / Fabricio Montalvão

    Brazilian Journal of Oncology, Vol 17, Iss

    an extensive review

    2021  Volume 00

    Abstract: Emerging data postulates that cancer is an important risk factor for disease severity and higher in-hospital mortality amongst patients with COVID-19. From a pathophysiological perspective, COVID-19 induces an overproduction of inflammatory cytokines, ... ...

    Abstract Emerging data postulates that cancer is an important risk factor for disease severity and higher in-hospital mortality amongst patients with COVID-19. From a pathophysiological perspective, COVID-19 induces an overproduction of inflammatory cytokines, causing systemic inflammation, hypercoagulability, and multiple organ dysfunction syndrome. The exact pathophysiological mechanisms associated with severe COVID-19 disease in patients with cancer is uncertain. Moreover, the challenge of implementing social distancing in patients requiring specific anticancer treatments urged international societies to issue recommendations regarding the adoption of safety measures to reduce transmission risk and optimize anticancer treatment during the COVID-19 pandemic. We provide an extensive review of the clinical outcomes, prognosis and management of patients with cancer and COVID-19 infection.
    Keywords covid-19 ; cancer ; pathophysiology ; clinical outcome ; management ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Covid-19 and the cardiovascular system

    Azevedo, Rafael Bellotti / Botelho, Bruna Gopp / Hollanda, João Victor Gonçalves de / Ferreira, Leonardo Villa Leão / Junqueira de Andrade, Letícia Zarur / Oei, Stephanie Si Min Lilienwald / Mello, Tomás de Souza / Muxfeldt, Elizabeth Silaid

    Journal of Human Hypertension ; ISSN 0950-9240 1476-5527

    a comprehensive review

    2020  

    Keywords Internal Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1038/s41371-020-0387-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Covid-19 and the cardiovascular system: a comprehensive review.

    Azevedo, Rafael Bellotti / Botelho, Bruna Gopp / Hollanda, João Victor Gonçalves de / Ferreira, Leonardo Villa Leão / Junqueira de Andrade, Letícia Zarur / Oei, Stephanie Si Min Lilienwald / Mello, Tomás de Souza / Muxfeldt, Elizabeth Silaid

    Journal of human hypertension

    2020  Volume 35, Issue 1, Page(s) 4–11

    Abstract: Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular ... ...

    Abstract Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular system. The pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by overproduction of inflammatory cytokines (IL-6 and TNF-α) leading to systemic inflammation and multiple organ dysfunction syndrome, acutely affecting the cardiovascular system. Hypertension (56.6%) and diabetes (33.8%) are the most prevalent comorbidities among individuals with COVID-19, who require hospitalization. Furthermore, cardiac injury, defined as elevated us-troponin I, significantly relates to inflammation biomarkers (IL-6 and C-reactive protein (CRP), hyperferritinemia, and leukocytosis), portraying an important correlation between myocardial injury and inflammatory hyperactivity triggered by viral infection. Increased risk for myocardial infarction, fulminant myocarditis rapidly evolving with depressed systolic left ventricle function, arrhythmias, venous thromboembolism, and cardiomyopathies mimicking STEMI presentations are the most prevalent cardiovascular complications described in patients with COVID-19. Moreover, SARS-CoV-2 tropism and interaction with the RAAS system, through ACE2 receptor, possibly enhances inflammation response and cardiac aggression, leading to imperative concerns about the use of ACEi and ARBs in infected patients. Cardiovascular implications result in a worse prognosis in patients with COVID-19, emphasizing the importance of precocious detection and implementation of optimal therapeutic strategies.
    MeSH term(s) Animals ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/virology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/virology ; Cardiovascular System/physiopathology ; Cardiovascular System/virology ; Heart Disease Risk Factors ; Host-Pathogen Interactions ; Humans ; Prognosis ; Renin-Angiotensin System ; Risk Assessment ; SARS-CoV-2/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-020-0387-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Covid-19 and the cardiovascular system: a comprehensive review

    Azevedo, Rafael Bellotti / Botelho, Bruna Gopp / Hollanda, João Victor Gonçalves de / Ferreira, Leonardo Villa Leão / Junqueira de Andrade, Letícia Zarur / Oei, Stephanie Si Min Lilienwald / Mello, Tomás de Souza / Muxfeldt, Elizabeth Silaid

    J. hum. hypertens

    Abstract: Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular ... ...

    Abstract Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular system. The pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by overproduction of inflammatory cytokines (IL-6 and TNF-α) leading to systemic inflammation and multiple organ dysfunction syndrome, acutely affecting the cardiovascular system. Hypertension (56.6%) and diabetes (33.8%) are the most prevalent comorbidities among individuals with COVID-19, who require hospitalization. Furthermore, cardiac injury, defined as elevated us-troponin I, significantly relates to inflammation biomarkers (IL-6 and C-reactive protein (CRP), hyperferritinemia, and leukocytosis), portraying an important correlation between myocardial injury and inflammatory hyperactivity triggered by viral infection. Increased risk for myocardial infarction, fulminant myocarditis rapidly evolving with depressed systolic left ventricle function, arrhythmias, venous thromboembolism, and cardiomyopathies mimicking STEMI presentations are the most prevalent cardiovascular complications described in patients with COVID-19. Moreover, SARS-CoV-2 tropism and interaction with the RAAS system, through ACE2 receptor, possibly enhances inflammation response and cardiac aggression, leading to imperative concerns about the use of ACEi and ARBs in infected patients. Cardiovascular implications result in a worse prognosis in patients with COVID-19, emphasizing the importance of precocious detection and implementation of optimal therapeutic strategies.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #688700
    Database COVID19

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