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Article ; Online: Somatic, psychological and economic benefits of regular physical activity beginning in childhood.

Fitzgerald, Samuel A / Fitzgerald, Hugh T / Fitzgerald, Nicholas M / Fitzgerald, Timothy R / Fitzgerald, Dominic A

2022 Volume 58, Issue 2, Page(s) 238–242

Abstract: Physical activity is a natural part of a healthy life-style, which should be nurtured from early childhood. Regular physical activity mitigates against the global problems of overweight and obesity, hypertension, anxiety and depression. It lowers the ... ...

Abstract	Physical activity is a natural part of a healthy life-style, which should be nurtured from early childhood. Regular physical activity mitigates against the global problems of overweight and obesity, hypertension, anxiety and depression. It lowers the morbidity and mortality from cardiovascular disease and provides hope for sustainable economics to support an ageing population into their retirement. This is preventative health economics that can be achieved with integrated support from families, communities, health-care professionals and governments at all levels. At present, children lack the support of those responsible for them at a societal level to adequately protect them from the physical and emotional consequences of reduced physical activity.
MeSH term(s)	Anxiety ; Cardiovascular Diseases ; Child ; Child, Preschool ; Exercise ; Humans ; Obesity ; Overweight
Language	English
Publishing date	2022-01-06
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15879
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Article ; Online: Covid-19 and the impact on young athletes.

Fitzgerald, Hugh T / Rubin, Sam T / Fitzgerald, Dominic A / Rubin, Bruce K

Paediatric respiratory reviews

2021 Volume 39, Page(s) 9–15

Abstract: The Covid-19 pandemic has disrupted organised sport in the community as authorities cancelled, greatly modified or postponed sporting participation as part of a strategy to reduce transmission of the virus. This had a significant impact on young athletes ...

Abstract	The Covid-19 pandemic has disrupted organised sport in the community as authorities cancelled, greatly modified or postponed sporting participation as part of a strategy to reduce transmission of the virus. This had a significant impact on young athletes and their families in relation to their psycho-social, physical and career progression considerations. The disruption is likely to continue for some years, considering the constraints of lockdowns, the need to overcome dysfunctional national logistics for delivery of medical care, fund and implement an efficacious vaccine programme locally, nationally and worldwide, develop sufficient herd immunity and create an environment of confidence in the safety of returning to sports for participants, coaches, umpires, administrators and observers. This article will consider the interim challenges regarding the physical and psychosocial importance of maintaining an active sporting programme for young athletes, reflect on safety measures for modifying sporting equipment and environmental protections to allow safest participation in training and competition and provide advice on protocols for a gradual return to sport for the young athlete after infection with Covid-19.
MeSH term(s)	Adolescent ; Athletes ; COVID-19/epidemiology ; COVID-19/prevention & control ; Child ; Communicable Disease Control ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-05-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147664-0
ISSN	1526-0550 ; 1526-0542
ISSN (online)	1526-0550
ISSN	1526-0542
DOI	10.1016/j.prrv.2021.04.005
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Article ; Online: Additive genetic variation in Pinus radiata bark chemistry and the chemical traits associated with variation in mammalian bark stripping.

Nantongo, Judith S / Potts, Brad M / Davies, Noel W / Fitzgerald, Hugh / Rodemann, Thomas / O'Reilly-Wapstra, Julianne M

Heredity

2021 Volume 127, Issue 6, Page(s) 498–509

Abstract: Secondary metabolites are suggested as a major mechanism explaining genetic variation in herbivory levels in Pinus radiata. The potential to incorporate these chemical traits into breeding/deployment programmes partly depends on the presence of additive ... ...

Abstract	Secondary metabolites are suggested as a major mechanism explaining genetic variation in herbivory levels in Pinus radiata. The potential to incorporate these chemical traits into breeding/deployment programmes partly depends on the presence of additive genetic variation for the relevant chemical traits. In this study, near-infrared spectroscopy was used to quantify the constitutive and induced levels of 54 compounds in the bark of trees from 74 P. radiata full-sib families. The trees sampled for chemistry were protected from browsing and induced levels were obtained by subjecting half of the trees to artificial bark stripping. The treatment effect on bark chemistry was assessed along with narrow-sense heritability, the significance of non-additive genetic effects and the additive genetic correlations of compounds with bark stripping by mammalian herbivores that was observed in unprotected replicates of the field trial. The results indicated: (i) significant additive genetic variation, with low-moderate narrow-sense heritability estimates for most compounds; (ii) while significant induced effects were detected for some chemicals, no significant genetic variation in inducibility was detected; and (iii) sugars, fatty acids and a diterpenoid positively genetically correlated while a sesquiterpenoid negatively genetically correlated with bark stripping by the mammalian herbivore, the Bennett's wallaby (Macropus rufogriseus). At the onset of browsing, a trade-off with height was detected for selecting higher amounts of this sesquiterpenoid. However, overall, results showed potential to incorporate chemical traits into breeding/deployment programmes. The quantitative genetic analyses of the near infrared predicted chemical traits produced associations with mammalian bark stripping that mostly conform with those obtained using standard wet chemistry.
MeSH term(s)	Animals ; Genetic Variation ; Herbivory ; Humans ; Pinus/genetics ; Plant Bark ; Plant Breeding
Language	English
Publishing date	2021-10-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2423-5
ISSN	1365-2540 ; 0018-067X
ISSN (online)	1365-2540
ISSN	0018-067X
DOI	10.1038/s41437-021-00476-z
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Article ; Online: Improving the Management and Treatment of Diabetic Foot Infection: Challenges and Research Opportunities.

Turzańska, Kaja / Adesanya, Oluwafolajimi / Rajagopal, Ashwene / Pryce, Mary T / Fitzgerald Hughes, Deirdre

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Diabetic foot infection (DFI) management requires complex multidisciplinary care pathways with off-loading, debridement and targeted antibiotic treatment central to positive clinical outcomes. Local administration of topical treatments and advanced wound ...

Abstract	Diabetic foot infection (DFI) management requires complex multidisciplinary care pathways with off-loading, debridement and targeted antibiotic treatment central to positive clinical outcomes. Local administration of topical treatments and advanced wound dressings are often used for more superficial infections, and in combination with systemic antibiotics for more advanced infections. In practice, the choice of such topical approaches, whether alone or as adjuncts, is rarely evidence-based, and there does not appear to be a single market leader. There are several reasons for this, including a lack of clear evidence-based guidelines on their efficacy and a paucity of robust clinical trials. Nonetheless, with a growing number of people living with diabetes, preventing the progression of chronic foot infections to amputation is critical. Topical agents may increasingly play a role, especially as they have potential to limit the use of systemic antibiotics in an environment of increasing antibiotic resistance. While a number of advanced dressings are currently marketed for DFI, here we review the literature describing promising future-focused approaches for topical treatment of DFI that may overcome some of the current hurdles. Specifically, we focus on antibiotic-impregnated biomaterials, novel antimicrobial peptides and photodynamic therapy.
MeSH term(s)	Humans ; Diabetic Foot/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Communicable Diseases/drug therapy ; Bandages ; Diabetes Mellitus/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043913
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Article ; Online: Comment on "A Comprehensive Analysis of Groundwater Quality in The Barnett Shale Region".

McHugh, Thomas / Molofsky, Lisa / Fitzgerald, Lauren / Connor, John

Environmental science & technology

2016 Volume 50, Issue 1, Page(s) 496–497

MeSH term(s)	Geologic Sediments/chemistry ; Groundwater/chemistry ; Water Quality
Language	English
Publishing date	2016-01-05
Publishing country	United States
Document type	Comment ; Letter
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.5b05067
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Article ; Online: Improving Health Equity in Rheumatology Through Workforce Diversification and Support for Health Equity Research and Education.

Vassileva, Maria T / Suresh, Vandana / Chan, Andrew C / Akinsete, Alisha Valdez / Blanco, Irene / Blazer, Ashira / Criscione-Schreiber, Lisa / Dowell, Sharon / Feldman, Candace H / FitzGerald, John / Gilbert, Mileka / Hughes, Grant / Husni, M Elaine / Kerr, Gail / Kwan, Olivia / Mantilla, Bryanna / Nilson, Susanne / Rivadeneira, Alfredo Carlos / Rodríguez, Martha /

Smith, Benjamin J / Soulsby, William Daniel / Wong, Stephen Chee-Yung / Yazdany, Jinoos / Ross, Will

Arthritis & rheumatology (Hoboken, N.J.)

2024

Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42804
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Article ; Online: The Fire and Tree Mortality Database, for empirical modeling of individual tree mortality after fire.

Cansler, C Alina / Hood, Sharon M / Varner, J Morgan / van Mantgem, Phillip J / Agne, Michelle C / Andrus, Robert A / Ayres, Matthew P / Ayres, Bruce D / Bakker, Jonathan D / Battaglia, Michael A / Bentz, Barbara J / Breece, Carolyn R / Brown, James K / Cluck, Daniel R / Coleman, Tom W / Corace, R Gregory / Covington, W Wallace / Cram, Douglas S / Cronan, James B /

Crouse, Joseph E / Das, Adrian J / Davis, Ryan S / Dickinson, Darci M / Fitzgerald, Stephen A / Fulé, Peter Z / Ganio, Lisa M / Grayson, Lindsay M / Halpern, Charles B / Hanula, Jim L / Harvey, Brian J / Kevin Hiers, J / Huffman, David W / Keifer, MaryBeth / Keyser, Tara L / Kobziar, Leda N / Kolb, Thomas E / Kolden, Crystal A / Kopper, Karen E / Kreitler, Jason R / Kreye, Jesse K / Latimer, Andrew M / Lerch, Andrew P / Lombardero, Maria J / McDaniel, Virginia L / McHugh, Charles W / McMillin, Joel D / Moghaddas, Jason J / O'Brien, Joseph J / Perrakis, Daniel D B / Peterson, David W / Prichard, Susan J / Progar, Robert A / Raffa, Kenneth F / Reinhardt, Elizabeth D / Restaino, Joseph C / Roccaforte, John P / Rogers, Brendan M / Ryan, Kevin C / Safford, Hugh D / Santoro, Alyson E / Shearman, Timothy M / Shumate, Alice M / Sieg, Carolyn H / Smith, Sheri L / Smith, Rebecca J / Stephenson, Nathan L / Stuever, Mary / Stevens, Jens T / Stoddard, Michael T / Thies, Walter G / Vaillant, Nicole M / Weiss, Shelby A / Westlind, Douglas J / Woolley, Travis J / Wright, Micah C

Scientific data

2020 Volume 7, Issue 1, Page(s) 194

Abstract: Wildland fires have a multitude of ecological effects in forests, woodlands, and savannas across the globe. A major focus of past research has been on tree mortality from fire, as trees provide a vast range of biological services. We assembled a database ...

Abstract	Wildland fires have a multitude of ecological effects in forests, woodlands, and savannas across the globe. A major focus of past research has been on tree mortality from fire, as trees provide a vast range of biological services. We assembled a database of individual-tree records from prescribed fires and wildfires in the United States. The Fire and Tree Mortality (FTM) database includes records from 164,293 individual trees with records of fire injury (crown scorch, bole char, etc.), tree diameter, and either mortality or top-kill up to ten years post-fire. Data span 142 species and 62 genera, from 409 fires occurring from 1981-2016. Additional variables such as insect attack are included when available. The FTM database can be used to evaluate individual fire-caused mortality models for pre-fire planning and post-fire decision support, to develop improved models, and to explore general patterns of individual fire-induced tree death. The database can also be used to identify knowledge gaps that could be addressed in future research.
MeSH term(s)	Databases as Topic ; Fires ; Forestry ; Forests ; Trees ; United States
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Dataset ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-020-0522-7
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Article ; Online: Inpatient Cross-Cover Consensus Recommendations for Medical and Surgical Residents: A Delphi Analysis.

Heidemann, Lauren A / Fitzgerald, James T / Hughes, David T / Hartley, Sarah

Journal of graduate medical education

2019 Volume 11, Issue 3, Page(s) 277–283

Abstract: Background: Residents regularly care for hospitalized patients for whom they are not the primary provider (cross-cover), often without guidance.: Objective: We identified and defined components of safe cross-cover care.: Methods: Sixty medical and ...

Abstract	Background: Residents regularly care for hospitalized patients for whom they are not the primary provider (cross-cover), often without guidance. Objective: We identified and defined components of safe cross-cover care. Methods: Sixty medical and surgical faculty physicians and chief residents from the Midwest were invited to participate in a Delphi study analyzing the appropriateness of cross-covering residents evaluating patients at bedside, deferring issues to the primary team, documenting a note, contacting the attending, and communicating with nurses. The first survey was free text, and responses were categorized. In the second survey, physicians rated categorized responses based on appropriateness using a 5-point Likert scale. Results: Forty respondents (67%) completed the first survey and 30 (50%) completed the second. Responses led to 46 categories. Twenty-eight items (60%) achieved high consensus, 8 (17%) approached consensus, and 10 (22%) did not achieve consensus, with no difference based on specialty or experience. Responses with 100% consensus included: residents should evaluate a patient at bedside whenever asked by the nurse; documentation should occur for change in level of care, death, code, or rapid response team activation; and physician-nurse communication should be respectful and closed loop. Conclusions: This regional physician panel reached consensus on 28 elements important in cross-cover care, which can be used for training and future studies.
MeSH term(s)	Communication ; Consensus ; Delphi Technique ; Humans ; Internship and Residency/methods ; Nursing Staff, Hospital ; Patient Safety ; Physician-Nurse Relations ; Physicians
Language	English
Publishing date	2019-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2578612-X
ISSN	1949-8357 ; 1949-8357
ISSN (online)	1949-8357
ISSN	1949-8357
DOI	10.4300/JGME-D-18-00707.1
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Article ; Online: Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling.

Soomro, Mehreen / Stadler, Michael / Dand, Nick / Bluett, James / Jadon, Deepak / Jalali-Najafabadi, Farideh / Duckworth, Michael / Ho, Pauline / Marzo-Ortega, Helena / Helliwell, Philip S / Ryan, Anthony W / Kane, David / Korendowych, Eleanor / Simpson, Michael A / Packham, Jonathan / McManus, Ross / Gabay, Cem / Lamacchia, Céline / Nissen, Michael J /

Brown, Matthew A / Verstappen, Suzanne M M / Van Staa, Tjeerd / Barker, Jonathan N / Smith, Catherine H / FitzGerald, Oliver / McHugh, Neil / Warren, Richard B / Bowes, John / Barton, Anne

Arthritis & rheumatology (Hoboken, N.J.)

2022 Volume 74, Issue 9, Page(s) 1535–1543

Abstract: Objectives: Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factors ... ...

Abstract	Objectives: Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factors and pathways that differentiate PsA from cutaneous-only psoriasis (PsC) and to evaluate the performance of PsA risk prediction models. Methods: Genome-wide meta-analyses were conducted separately for 5,065 patients with PsA and 21,286 healthy controls and separately for 4,340 patients with PsA and 6,431 patients with PsC. The heritability of PsA was calculated as a single-nucleotide polymorphism (SNP)-based heritability estimate (h Results: We identified a novel genome-wide significant susceptibility locus for the development of PsA on chromosome 22q11 (rs5754467; P = 1.61 × 10 Conclusion: Key biologic pathways associated with the development of PsA were identified, but the investigation of risk classification revealed modest utility in the available data sets, possibly because many of the PsC patients included in the present study were receiving treatments that are also effective in PsA. Future predictive models of PsA should be tested in PsC patients recruited from primary care.
MeSH term(s)	Arthritis, Psoriatic/complications ; Arthritis, Psoriatic/genetics ; Biological Products ; Case-Control Studies ; Genetic Predisposition to Disease/genetics ; Humans ; Psoriasis/complications ; Psoriasis/genetics ; Risk Factors
Chemical Substances	Biological Products
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42154
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Article ; Online: Student Perceptions of educational handovers.

Heidemann, Lauren A / Schiller, Jocelyn H / Allen, Brittany / Hughes, David T / Fitzgerald, James T / Morgan, Helen K

The clinical teacher

2021 Volume 18, Issue 3, Page(s) 280–284

Abstract: ... and other variables. T-tests examined differences between students who did and did not have a handover ...

Abstract	Background: Educational handovers can provide competency information about graduating medical students to residency program directors post-residency placement. Little is known about students' comfort with this novel communication. Objective: To examine graduated medical students' perceptions of educational handovers. Methods: The authors created and distributed an anonymous survey to 166 medical students at a single institution following graduation in the spring of 2018. Within this cohort, 40 students had an educational handover sent to their future program director. The survey explored comfort level with handovers (1=very uncomfortable; 5=very comfortable) and ideal content (e.g., student strengths, areas for improvement, goals, grades received after residency application). Respondents self-reported their performance in medical school and whether a handover was sent. Correlation analyses examined relationships between performance and other variables. T-tests examined differences between students who did and did not have a handover letter sent. Results: The survey response rate was 40.4% (67/166) - 47.8% of students felt comfortable with handovers, 19.4% were neutral, and 32.8% were uncomfortable. There was no correlation between self-reported medical school performance and comfort level. Respondents felt most strongly that strengths should be included, followed by goals. Those who had a handover letter sent expressed significantly higher comfort level (3.8 ± 1.0 vs. 2.6 ±1.3, p=0.003) with this communication. Conclusion: Medical students reported varying levels of comfort with educational handovers; however, those who had handovers sent had more positive perceptions. In order to improve the education continuum, it is essential to engage students in the development of this handover communication.
MeSH term(s)	Communication ; Humans ; Internship and Residency ; Perception ; Schools, Medical ; Students, Medical
Language	English
Publishing date	2021-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2151518-9
ISSN	1743-498X ; 1743-4971
ISSN (online)	1743-498X
ISSN	1743-4971
DOI	10.1111/tct.13327
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