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Article ; Online: COVID-19 epidemic curve in Brazil: a sum of multiple epidemics, whose inequality and population density in the states are correlated with growth rate and daily acceleration. An ecological study.

Pinto, Airandes de Sousa / Rodrigues, Carlos Alberto / Nascimento Sobrinho, Carlito Lopes / Cruz, Lívia Almeida da / Santos Junior, Edval Gomes Dos / Nunes, Paulo Cesar / Costa, Matheus Gomes Reis / Rocha, Manoel Otávio da Costa

Revista da Sociedade Brasileira de Medicina Tropical

2022 Volume 55, Page(s) e0118

Abstract: ... 25 to July 11, 2020. Socioeconomic data were obtained from the Instituto Brasileiro de Geografia e ...

Abstract	Background: The epidemic curve has been obtained based on the 7-day moving average of the events. Although it facilitates the visualization of discrete variables, it does not allow the calculation of the absolute variation rate. Recently, we demonstrated that the polynomial interpolation method can be used to accurately calculate the daily acceleration of cases and deaths due to COVID-19. This study aimed to measure the diversity of epidemic curves and understand the importance of socioeconomic variables in the acceleration, pek cases, and deaths due to COVID-19 in Brazilian states. Methods: Epidemiological data for COVID-19 from federative units in Brazil were obtained from the Ministry of Health's website from February 25 to July 11, 2020. Socioeconomic data were obtained from the Instituto Brasileiro de Geografia e Estatística (https://www.ibge.gov.br/). Using the polynomial interpolation methods, daily cases, deaths and acceleration were calculated. Moreover, the correlation coefficient between the epidemic curve data and socioeconomic data was determined. Results: The combination of daily data and case acceleration determined that Brazilian states were in different stages of the epidemic. Maximum case acceleration, peak of cases, maximum death acceleration, and peak of deaths were associated with the Gini index of the gross domestic product of Brazilian states and population density but did not correlate with the per capita gross domestic product of Brazilian states. Conclusions: Brazilian states showed heterogeneous data curves. Population density and socioeconomic inequality were correlated with a more rapid exponential growth in new cases and deaths.
MeSH term(s)	Acceleration ; Brazil/epidemiology ; COVID-19 ; Epidemics ; Humans ; Population Density ; SARS-CoV-2
Language	English
Publishing date	2022-02-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0118-2021
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Article ; Online: COVID-19 epidemic curve in Brazil

Airandes de Sousa Pinto / Carlos Alberto Rodrigues / Carlito Lopes Nascimento Sobrinho / Lívia Almeida da Cruz / Edval Gomes dos Santos Junior / Paulo Cesar Nunes / Matheus Gomes Reis Costa / Manoel Otávio da Costa Rocha

Revista da Sociedade Brasileira de Medicina Tropical, Vol

a sum of multiple epidemics, whose inequality and population density in the states are correlated with growth rate and daily acceleration. An ecological study

2022 Volume 55

Abstract: ... de Geografia e Estatística (https://www.ibge.gov.br/). Using the polynomial interpolation methods ...

Abstract	ABSTRACT Background: The epidemic curve has been obtained based on the 7-day moving average of the events. Although it facilitates the visualization of discrete variables, it does not allow the calculation of the absolute variation rate. Recently, we demonstrated that the polynomial interpolation method can be used to accurately calculate the daily acceleration of cases and deaths due to COVID-19. This study aimed to measure the diversity of epidemic curves and understand the importance of socioeconomic variables in the acceleration, peak cases, and deaths due to COVID-19 in Brazilian states. Methods: Epidemiological data for COVID-19 from federative units in Brazil were obtained from the Ministry of Health’s website from February 25 to July 11, 2020. Socioeconomic data were obtained from the Instituto Brasileiro de Geografia e Estatística (https://www.ibge.gov.br/). Using the polynomial interpolation methods, daily cases, deaths and acceleration were calculated. Moreover, the correlation coefficient between the epidemic curve data and socioeconomic data was determined. Results: The combination of daily data and case acceleration determined that Brazilian states were in different stages of the epidemic. Maximum case acceleration, peak of cases, maximum death acceleration, and peak of deaths were associated with the Gini index of the gross domestic product of Brazilian states and population density but did not correlate with the per capita gross domestic product of Brazilian states. Conclusions: Brazilian states showed heterogeneous data curves. Population density and socioeconomic inequality were correlated with a more rapid exponential growth in new cases and deaths.
Keywords	COVID-19 ; SARS-CoV-2 ; Polynomial interpolation ; Growth rate ; Acceleration ; Epidemic curve ; Arctic medicine. Tropical medicine ; RC955-962
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical (SBMT)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Volume-Time Curve by Three-Dimensional Echocardiography in Chagas Cardiomyopathy: Insights into the Mechanism of Hemodynamic Adaptations.

Pinto, Airandes de Sousa / Nunes, Maria Carmo Pereira / Rodrigues, Carlos Alberto / Oliveira, Bráulio Muzzi Ribeiro de / Medrado Neto, João da Rocha / Tan, Timothy C / Rocha, Manoel Otavio da Costa

Arquivos brasileiros de cardiologia

2022 Volume 118, Issue 6, Page(s) 1099–1105

Abstract: Background: Three-dimensional echocardiography (3D ECHO) allows the generation of a volume-time curve representative of changes in the left ventricular (LV) volume throughout the entire cardiac cycle.: Objective: This study aims to demonstrate the ... ...

Title translation	A Curva Volume-Tempo Obtida pela Ecocardiografia Tridimensional na Cardiomiopatia Chagásica: Análise do Mecanismo das Adaptações Hemodinâmicas.
Abstract	Background: Three-dimensional echocardiography (3D ECHO) allows the generation of a volume-time curve representative of changes in the left ventricular (LV) volume throughout the entire cardiac cycle. Objective: This study aims to demonstrate the hemodynamic adaptations present in Chagas cardiomyopathy (CC) by means of the volume and flow measurements obtained by the volume-time curve by 3D ECHO. Methods: Twenty patients with CC and 15 healthy subjects were prospectively enrolled in a cross-sectional design study. 3D ECHO was performed in all subjects and the volume over time curves of the LV was generated. The flow was obtained by the first derivative of the volume-time curve using the software MATLAB. Statistical significance was set at p<0.05. Results: Although CC patients had lower LV ejection fraction compared to the control group (29.8±7.5 vs. 57.7±6.1, p<0.001), stroke volume (61.5±25.2 vs. 53.8±21.0, p=0.364) and maximum ejection flow during systole (-360.3±147.5 vs. -305.6±126.0, p=0.231) were similar between the groups. Likewise, the maximum flow in the early diastolic filling phase and during atrial contraction was similar between groups. An increase in preload expressed by LV end diastolic volume (204.8±79.4 vs. 93.0±32.6), p<0.001) may maintain the flow and stroke volumes similar to the controls. Conclusion: Using a non-invasive tool, we demonstrated that an increase in LV end-diastolic volume may be the main adaptation mechanism that maintains the flow and stroke volumes in the setting of severe LV systolic dysfunction.
MeSH term(s)	Chagas Cardiomyopathy/diagnostic imaging ; Cross-Sectional Studies ; Echocardiography, Three-Dimensional/methods ; Heart Atria ; Hemodynamics ; Humans ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Function, Left
Language	Portuguese
Publishing date	2022-05-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20201308
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Article ; Online: Covid-19 growth rate analysis

Airandes de Sousa Pinto / Edval Gomes dos Santos Júnior / Carlos Alberto Rodrigues / Paulo Cesar Mendes Nunes / Livia Almeida da Cruz / Matheus Gomes Reis Costa / Manoel Otávio da Costa Rocha

Revista da Sociedade Brasileira de Medicina Tropical, Vol

application of a low-complexity tool for understanding and comparing epidemic curves

2020 Volume 53

Abstract: Abstract INTRODUCTION: The acceleration of new cases is important for the characterization and comparison of epidemic curves. The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial ... ...

Abstract	Abstract INTRODUCTION: The acceleration of new cases is important for the characterization and comparison of epidemic curves. The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial interpolation method. METHODS: Covid-19 epidemic curves from Brazil, Germany, the United States, and Russia were obtained. We calculated the instantaneous acceleration of the curve using the first derivative of the representative polynomial. RESULTS: The acceleration for all curves was obtained. CONCLUSIONS: Incorporating acceleration into an analysis of the Covid-19 time series may enable a better understanding of the epidemiological situation.
Keywords	Covid-19 ; SARS-CoV-2 ; Polynomial interpolation ; Arctic medicine. Tropical medicine ; RC955-962
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical (SBMT)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Covid-19 growth rate analysis

Pinto, Airandes de Sousa / Santos Júnior, Edval Gomes dos / Rodrigues, Carlos Alberto / Nunes, Paulo Cesar Mendes / Cruz, Livia Almeida da / Costa, Matheus Gomes Reis / Rocha, Manoel Otávio da Costa

Revista da Sociedade Brasileira de Medicina Tropical v.53 2020

application of a low-complexity tool for understanding and comparing epidemic curves

2020

Abstract	Abstract INTRODUCTION: The acceleration of new cases is important for the characterization and comparison of epidemic curves. The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial interpolation method. METHODS: Covid-19 epidemic curves from Brazil, Germany, the United States, and Russia were obtained. We calculated the instantaneous acceleration of the curve using the first derivative of the representative polynomial. RESULTS: The acceleration for all curves was obtained. CONCLUSIONS: Incorporating acceleration into an analysis of the Covid-19 time series may enable a better understanding of the epidemiological situation.
Keywords	Covid-19 ; SARS-CoV-2 ; Polynomial interpolation ; covid19
Language	English
Publishing date	2020-01-01
Publisher	Sociedade Brasileira de Medicina Tropical - SBMT
Publishing country	br
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Covid-19 growth rate analysis: application of a low-complexity tool for understanding and comparing epidemic curves.

Pinto, Airandes de Sousa / Santos Júnior, Edval Gomes Dos / Rodrigues, Carlos Alberto / Nunes, Paulo Cesar Mendes / Cruz, Livia Almeida da / Costa, Matheus Gomes Reis / Rocha, Manoel Otávio da Costa

Revista da Sociedade Brasileira de Medicina Tropical

2020 Volume 53, Page(s) e20200331

Abstract: Introduction: The acceleration of new cases is important for the characterization and comparison of epidemic curves. The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial ... ...

Abstract	Introduction: The acceleration of new cases is important for the characterization and comparison of epidemic curves. The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial interpolation method. Methods: Covid-19 epidemic curves from Brazil, Germany, the United States, and Russia were obtained. We calculated the instantaneous acceleration of the curve using the first derivative of the representative polynomial. Results: The acceleration for all curves was obtained. Conclusions: Incorporating acceleration into an analysis of the Covid-19 time series may enable a better understanding of the epidemiological situation.
MeSH term(s)	Betacoronavirus ; Brazil/epidemiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Data Analysis ; Germany/epidemiology ; Humans ; Incidence ; Normal Distribution ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Russia/epidemiology ; SARS-CoV-2 ; United States/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0331-2020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Covid-19 growth rate analysis: application of a low-complexity tool for understanding and comparing epidemic curves

Pinto, Airandes de Sousa / Santos Junior, Edval Gomes Dos / Rodrigues, Carlos Alberto / Nunes, Paulo Cesar Mendes / Cruz, Livia Almeida da / Costa, Matheus Gomes Reis / Rocha, Manoel Otavio da Costa

Revista da Sociedade Brasileira de Medicina Tropical

Abstract: INTRODUCTION: The acceleration of new cases is important for the characterization and comparison of epidemic curves The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial interpolation ... ...

Abstract	INTRODUCTION: The acceleration of new cases is important for the characterization and comparison of epidemic curves The objective of this study was to quantify the acceleration of daily confirmed cases and death curves using the polynomial interpolation method METHODS: Covid-19 epidemic curves from Brazil, Germany, the United States, and Russia were obtained We calculated the instantaneous acceleration of the curve using the first derivative of the representative polynomial RESULTS: The acceleration for all curves was obtained CONCLUSIONS: Incorporating acceleration into an analysis of the Covid-19 time series may enable a better understanding of the epidemiological situation
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #636451
Database	COVID19

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Article ; Online: Myocardial dysfunction in chagasic patients with no apparent heart disease.

Pinto, Airandes de Sousa / Oliveira, Braulio Muzzi Ribeiro de / Botoni, Fernando Antonio / Ribeiro, Antonio Luiz Pinho / Rocha, Manoel Otavio da Costa

Arquivos brasileiros de cardiologia

2008 Volume 89, Issue 6, Page(s) 385–390

Abstract: Background: The Tei index simultaneously evaluates the ventricular systolic and diastolic functions. It has a good correlation with hemodynamic data and has enabled the detection of initial ventricular function alterations of different etiologies.: ... ...

Abstract	Background: The Tei index simultaneously evaluates the ventricular systolic and diastolic functions. It has a good correlation with hemodynamic data and has enabled the detection of initial ventricular function alterations of different etiologies. Objective: To study initial biventricular function alterations in chagasic patients with no apparent heart disease, using the Tei index. Methods: Forty eight individuals were evaluated. Group 1 was comprised of 25 patients diagnosed with Chagas' disease with no apparent heart disease and normal echocardiogram; group 2 was comprised of 23 healthy individuals with negative serological tests for Chagas' disease. Results: The Tei index was significantly higher in the group of chagasic patients with no apparent heart disease when compared to that of the control group: left ventricular Tei index (0.48 +/-0.11 vs. 0.36 +/- 0.06, p < 0.001) , right ventricular Tei index (0.34 +/- 0.10 vs. 0.26 +/- 0.07, p = 0.001). The left and right ventricular Tei indexes were considered abnormal in 48% and 28% of the chagasic patients, respectively. Conclusion: Chagasic patients with no apparent heart disease present early alterations of the right and left ventricles.
MeSH term(s)	Adult ; Case-Control Studies ; Chagas Disease/diagnostic imaging ; Chagas Disease/physiopathology ; Chi-Square Distribution ; Echocardiography, Doppler/methods ; Female ; Humans ; Male ; Myocardial Contraction/physiology ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/physiopathology
Language	Portuguese
Publishing date	2008-03-03
Publishing country	Brazil
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.1590/s0066-782x2007001800006
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Article ; Online: Disfunção miocárdica em pacientes chagásicos sem cardiopatia aparente Myocardial dysfunction in chagasic patients with no apparent heart disease

Airandes de Sousa Pinto / Braulio Muzzi Ribeiro de Oliveira / Fernando Antonio Botoni / Antonio Luiz Pinho Ribeiro / Manoel Otavio da Costa Rocha

Arquivos Brasileiros de Cardiologia, Vol 89, Iss 6, Pp 385-

2007 Volume 390

Abstract: FUNDAMENTO: O índice de Tei avalia simultaneamente as funções sistólica e diastólica dos ... ventrículos. Apresenta boa correlação com dados hemodinâmicos e tem sido capaz de detectar alterações na ... função ventricular iniciais de diversas etiologias. OBJETIVO: Estudar alterações iniciais da função ...

Abstract	FUNDAMENTO: O índice de Tei avalia simultaneamente as funções sistólica e diastólica dos ventrículos. Apresenta boa correlação com dados hemodinâmicos e tem sido capaz de detectar alterações na função ventricular iniciais de diversas etiologias. OBJETIVO: Estudar alterações iniciais da função biventricular em pacientes chagásicos sem cardiopatia aparente por meio do índice de Tei. MÉTODOS: Foram avaliados 48 indivíduos. Grupo 1, constituído por 25 pacientes com diagnóstico de doença de Chagas, sem cardiopatia aparente e ecocardiograma normal; grupo 2, constituído por 23 indivíduos sadios com sorologia negativa para doença de Chagas. RESULTADOS: O índice de Tei foi significativamente mais elevado no grupo de chagásicos sem cardiopatia aparente, quando comparado aos controles. Índice de Tei do ventrículo esquerdo (0,48±0,11 x 0,36±0,06, p<0,001) , índice de Tei do ventrículo direito (0,34±0,10 x 0,26±0,07, p=0,001). O índice de Tei do ventrículo esquerdo foi considerado alterado em 48% dos chagásicos e o do ventrículo direito em 28%. CONCLUSÃO: Pacientes com doença de Chagas sem cardiopatia aparente apresentam alteração precoce dos ventrículos direito e esquerdo. BACKGROUND: The Tei index simultaneously evaluates the ventricular systolic and diastolic functions. It has a good correlation with hemodynamic data and has enabled the detection of initial ventricular function alterations of different etiologies. OBJECTIVE: To study initial biventricular function alterations in chagasic patients with no apparent heart disease, using the Tei index. METHODS: Forty eight individuals were evaluated. Group 1 was comprised of 25 patients diagnosed with Chagas´ disease with no apparent heart disease and normal echocardiogram; group 2 was comprised of 23 healthy individuals with negative serological tests for Chagas´ disease. RESULTS: The Tei index was significantly higher in the group of chagasic patients with no apparent heart disease when compared to that of the control group: left ventricular Tei index (0.48 ± 0.11 vs. 0.36 ± 0.06, p < 0.001) , right ventricular Tei index (0.34 ± 0.10 vs. 0.26 ± 0.07, p = 0.001). The left and right ventricular Tei indexes were considered abnormal in 48% and 28% of the chagasic patients, respectively. CONCLUSION: Chagasic patients with no apparent heart disease present early alterations of the right and left ventricles.
Keywords	Disfunção ventricular ; doença de Chagas ; cardiomiopatia chagásica ; Ventricular dysfunction ; Chagas´ ; disease ; cardiomyopathy ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2007-12-01T00:00:00Z
Publisher	Sociedade Brasileira de Cardiologia - SBC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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