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Article ; Online: Experts' recommendations in laser use for the treatment of urolithiasis: a comprehensive guide by the European Section of Uro-Technology (ESUT) and Training-Research in Urological Surgery and Technology (T.R.U.S.T.)-Group.

Ortner, Gernot / Somani, Bhaskar Kumar / Güven, Selcuk / Kitzbichler, Gerhard / Traxer, Olivier / Giusti, Guido / Proietti, Silvia / Liatsikos, Evangelos / Kallidonis, Panagiotis / Krambeck, Amy / Goumas, Ioannis Kartalas / Duvdevani, Mordechai / Kamphuis, Guido M / Ferretti, Stefania / Dragos, Laurian / Ghani, Khurshid / Miernik, Arkadiusz / Juliebø-Jones, Patrick / Jung, Helene /

Tailly, Thomas / Pietropaolo, Amelia / Hamri, Saeed Bin / Papatsoris, Athanasios / Sarica, Kemal / Scoffone, Cesare Marco / Cracco, Cecilia Maria / Keller, Etienne Xavier / Durutovic, Otas / Pereira, Sergio / Herrmann, Thomas R W / Nagele, Udo / Gözen, Ali Serdar / Tokas, Theodoros

World journal of urology

2024 Volume 42, Issue 1, Page(s) 33

Abstract: Purpose: To identify laser lithotripsy settings used by experts for specific clinical scenarios and to identify preventive measures to reduce complications.: Methods: After literature research to identify relevant questions, a survey was conducted ... ...

Abstract	Purpose: To identify laser lithotripsy settings used by experts for specific clinical scenarios and to identify preventive measures to reduce complications. Methods: After literature research to identify relevant questions, a survey was conducted and sent to laser experts. Participants were asked for preferred laser settings during specific clinical lithotripsy scenarios. Different settings were compared for the reported laser types, and common settings and preventive measures were identified. Results: Twenty-six laser experts fully returned the survey. Holmium-yttrium-aluminum-garnet (Ho:YAG) was the primary laser used (88%), followed by thulium fiber laser (TFL) (42%) and pulsed thulium-yttrium-aluminum-garnet (Tm:YAG) (23%). For most scenarios, we could not identify relevant differences among laser settings. However, the laser power was significantly different for middle-ureteral (p = 0.027), pelvic (p = 0.047), and lower pole stone (p = 0.018) lithotripsy. Fragmentation or a combined fragmentation with dusting was more common for Ho:YAG and pulsed Tm:YAG lasers, whereas dusting or a combination of dusting and fragmentation was more common for TFL lasers. Experts prefer long pulse modes for Ho:YAG lasers to short pulse modes for TFL lasers. Thermal injury due to temperature development during lithotripsy is seriously considered by experts, with preventive measures applied routinely. Conclusions: Laser settings do not vary significantly between commonly used lasers for lithotripsy. Lithotripsy techniques and settings mainly depend on the generated laser pulse's and generator settings' physical characteristics. Preventive measures such as maximum power limits, intermittent laser activation, and ureteral access sheaths are commonly used by experts to decrease thermal injury-caused complications.
MeSH term(s)	Humans ; Thulium ; Urolithiasis/surgery ; Lithotripsy, Laser/methods ; Lasers, Solid-State/therapeutic use ; Technology ; Holmium ; Aluminum ; Yttrium
Chemical Substances	yttrium-aluminum-garnet ; Thulium (8RKC5ATI4P) ; Holmium (W1XX32SQN1) ; Aluminum (CPD4NFA903) ; Yttrium (58784XQC3Y)
Language	English
Publishing date	2024-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04726-z
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Article: U-47700: An Emerging Threat.

Alzghari, Saeed K / Fleming, Steven W / Rambaran, Kerry Anne / Long, James E / Burkhart, Samantha / An, Jie / Furmaga, Jakub

Cureus

2017 Volume 9, Issue 10, Page(s) e1791

Abstract: ... we present an overview of the rise of a synthetic opioid known as U-47700. We describe U-47700's history ...

Abstract	Illicit opioid use continues to be an ever-growing problem in the United States. The rise of synthetic opioids is an emerging threat that is beginning to draw attention over the past few years. Herein, we present an overview of the rise of a synthetic opioid known as U-47700. We describe U-47700's history, legal status, ease of obtainment, consequences of its use, and a proposal to increase the awareness of this synthetic opioid.
Language	English
Publishing date	2017-10-22
Publishing country	United States
Document type	Editorial
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.1791
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Article: Evaluation of Patient Reported Satisfaction and Clinical Efficacy of Insulin Glargine 300 U/mL Versus 100 U/mL in Patients With Type 1 Diabetes Using Flash Glucose Monitoring System.

Al Hayek, Ayman Abdullah / Alwin Robert, Asirvatham / Al Saeed, Abdulghani H / Al Dawish, Mohamed Abdulaziz

Clinical medicine insights. Endocrinology and diabetes

2022 Volume 15, Page(s) 11795514221098415

Abstract: ... of concentrated insulin glargine 300 U/mL (Gla-300) among patients with type 1 diabetes (T1D) using a flash ... with T1D (aged 14-40 years), who were treated with Glargine 100 U/mL (Gla-100) and switched to Gla-300 ...

Abstract	Background and aims: To analyze patient-reported satisfaction and clinical effectiveness of concentrated insulin glargine 300 U/mL (Gla-300) among patients with type 1 diabetes (T1D) using a flash glucose monitoring (FGM) system. Methods: This comparative study was conducted among 86 patients with T1D (aged 14-40 years), who were treated with Glargine 100 U/mL (Gla-100) and switched to Gla-300 at day 1 (baseline). The following data were collected from each patient: demographic information, clinical parameters, and glycemic control markers. All patients completed the Diabetes Treatment Satisfaction Questionnaire (Arabic version), first at baseline and then after 12 weeks. A comparison was done for all the data recorded at baseline (on Gla-100) and after 12 weeks (on Gla-300) and subjected to analysis. Results: Compared to patients treated with Gla-100, significant improvements were observed in the Gla-300 group, in terms of the ambulatory glucose profile (AGP) markers, such as percentage of time spent within the target range of the glucose levels (70-180 mg/dL) ( Conclusion: Compared to the patients on Gla-100, patients treated with Gla-300 exhibited significant improvements in the AGP markers and degree of treatment satisfaction.
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628990-8
ISSN	1179-5514
ISSN	1179-5514
DOI	10.1177/11795514221098415
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Article ; Online: Evolution and Functions of Plant U-Box Proteins: From Protein Quality Control to Signaling.

Trenner, Jana / Monaghan, Jacqueline / Saeed, Bushra / Quint, Marcel / Shabek, Nitzan / Trujillo, Marco

Annual review of plant biology

2022 Volume 73, Page(s) 93–121

Abstract: ... U-box-containing E3 ligases have massively expanded in the plant kingdom and have diversified ... into plant U-box proteins (PUBs). PUBs likely originated from two or three ancestral forms, fusing ... on their evolution and structural adaptations of key U-box residues, as well as their various roles in plant cells. ...

Abstract	Posttranslational modifications add complexity and diversity to cellular proteomes. One of the most prevalent modifications across eukaryotes is ubiquitination, which is orchestrated by E3 ubiquitin ligases. U-box-containing E3 ligases have massively expanded in the plant kingdom and have diversified into plant U-box proteins (PUBs). PUBs likely originated from two or three ancestral forms, fusing with diverse functional subdomains that resulted in neofunctionalization. Their emergence and diversification may reflect adaptations to stress during plant evolution, reflecting changes in the needs of plant proteomes to maintain cellular homeostasis. Through their close association with protein kinases, they are physically linked to cell signaling hubs and activate feedback loops by dynamically pairing with E2-ubiquitin-conjugating enzymes to generate distinct ubiquitin polymers that themselves act as signals. Here, we complement current knowledgewith comparative genomics to gain a deeper understanding of PUB function, focusing on their evolution and structural adaptations of key U-box residues, as well as their various roles in plant cells.
MeSH term(s)	Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants/metabolism ; Proteome ; Signal Transduction ; Ubiquitin ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Plant Proteins ; Proteome ; Ubiquitin ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2098209-4
ISSN	1545-2123 ; 1543-5008
ISSN (online)	1545-2123
ISSN	1543-5008
DOI	10.1146/annurev-arplant-102720-012310
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Article ; Online: Association between Endometriosis and the Risk of Ovarian, Endometrial, Cervical, and Breast Cancer: A Population-Based Study from the U.S. National Inpatient Sample 2016-2019.

Al-Badawi, Ismail Abdulrahman / Abu-Zaid, Ahmed / Alomar, Osama / Alsabban, Mohannad / Alsehaimi, Saud Owaimer / Alqarni, Saad M S / Alabdrabalamir, Safa Nasser / Baradwan, Saeed / Al Baalharith, Maha / AlOdaini, Amal A / Saleh, Saleh A K / Adly, Heba M / Bukhari, Ibtihal Abdulaziz / Salem, Hany

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 1, Page(s) 472–481

Abstract: Objective: We investigated the potential relationship between endometriosis and risk of ovarian, endometrial, cervical, and breast cancers using the National Inpatient Sample (NIS) database.: Methods: We utilized the International Classification of ... ...

Abstract	Objective: We investigated the potential relationship between endometriosis and risk of ovarian, endometrial, cervical, and breast cancers using the National Inpatient Sample (NIS) database. Methods: We utilized the International Classification of Diseases (ICD-10) system to identify relevant codes from the NIS database (2016-2019). Univariate and multivariate regression analyses (adjusted for age, race, hospital region, hospital teaching status, income Zip score, smoking, alcohol use, and hormonal replacement therapy) were conducted to evaluate the association between endometriosis and gynecologic cancers and summarized as odds ratios (ORs) with 95% confidence intervals (CIs). Results: In the examined dataset, there were 1164 and 225,323 gynecologic cancer patients with and without endometriosis, respectively. Univariate analysis showed endometriosis was significantly associated with a higher risk of ovarian (OR = 3.42, 95% CI: 3.05-3.84, Conclusions: Patients with endometriosis exhibited unique gynecologic cancer risk profiles, with higher risks for ovarian and endometrial cancers, and no significant risk for cervical cancer. The observed connection between endometriosis and a reduced risk of breast cancer remains a perplexing phenomenon, which cannot be put into context to date.
MeSH term(s)	Female ; Humans ; Breast Neoplasms ; Endometriosis ; Inpatients ; Research Design ; Uterine Cervical Neoplasms ; Ovarian Neoplasms
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31010032
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Article ; Online: Experts' recommendations in laser use for the treatment of upper tract urothelial carcinoma: a comprehensive guide by the European Section of Uro-Technology (ESUT) and Training Research in Urological Surgery and Technology (T.R.U.S.T.) group.

Ortner, Gernot / Somani, Bhaskar Kumar / Güven, Selcuk / Kitzbichler, Gerhard / Traxer, Olivier / Giusti, Guido / Proietti, Silvia / Liatsikos, Evangelos / Kallidonis, Panagiotis / Ulvik, Øyvind / Goumas, Ioannis Kartalas / Duvdevani, Mordechai / Baard, Joyce / Kamphuis, Guido M / Ferretti, Stefania / Dragos, Laurian / Villa, Luca / Miernik, Arkadiusz / Tailly, Thomas /

Pietropaolo, Amelia / Hamri, Saeed Bin / Papatsoris, Athanasios / Gözen, Ali Serdar / Herrmann, Thomas R W / Nagele, Udo / Tokas, Theodoros

World journal of urology

2023 Volume 41, Issue 11, Page(s) 3367–3376

Abstract: Purpose: To highlight and compare experts' laser settings during endoscopic laser treatment of upper tract urothelial carcinoma (UTUC), to identify measures to reduce complications, and to propose guidance for endourologists.: Methods: Following a ... ...

Abstract	Purpose: To highlight and compare experts' laser settings during endoscopic laser treatment of upper tract urothelial carcinoma (UTUC), to identify measures to reduce complications, and to propose guidance for endourologists. Methods: Following a focused literature search to identify relevant questions, a survey was sent to laser experts. We asked participants for typical settings during specific scenarios (ureteroscopy (URS), retrograde intrarenal surgery (RIRS), and percutaneous treatment). These settings were compared among the reported laser types to find common settings and limits. Additionally, we identified preventive measures commonly applied during surgery. Results: Twenty experts completed the survey, needing a mean time of 12.7 min. Overall, most common laser type was Holmium-Yttrium-Aluminum-Garnet (Ho:YAG) (70%, 14/20) followed by Thulium fiber laser (TFL) (45%, 9/20), pulsed Thulium-Yttrium-Aluminum-Garnet (Tm:YAG) (3/20, 15%), and continuous wave (cw)Tm:YAG (1/20, 5%). Pulse energy for the treatment of distal ureteral tumors was significantly different with median settings of 0.9 J, 1 J and 0.45 J for Ho:YAG, TFL and pulsed Tm:YAG, respectively (p = 0.048). During URS and RIRS, pulse shapes were significantly different, with Ho:YAG being used in long pulse and TFL in short pulse mode (all p < 0.05). We did not find further disparities. Conclusion: Ho:YAG is used by most experts, while TFL is the most promising alternative. Laser settings largely do not vary significantly. However, further research with novel lasers is necessary to define the optimal approach. With the recent introduction of small caliber and more flexible scopes, minimal-invasive UTUC treatment is further undergoing an extension of applicability in appropriately selected patients.
MeSH term(s)	Humans ; Lithotripsy, Laser ; Carcinoma, Transitional Cell/surgery ; Lasers, Solid-State/therapeutic use ; Thulium ; Urinary Bladder Neoplasms ; Holmium
Chemical Substances	yttrium-aluminum-garnet ; Thulium (8RKC5ATI4P) ; Holmium (W1XX32SQN1)
Language	English
Publishing date	2023-10-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04632-4
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Article ; Online: An efficient built-up land expansion model using a modified U-Net

Shojaei, Hanieh / Nadi, Saeed / Shafizadeh-Moghadam, Hossein / Tayyebi, Amin / Van Genderen, J. L.

International Journal of Digital Earth. 2022 Dec. 31, v. 15, no. 1 p.148-163

2022

Abstract: This paper introduces an improved convolutional neural network based on the conventional U-Net ... the area under the total operating characteristic indicated the superiority of our modified U-Net (0.87 ... expansion accurately, independent from applying a cellular automata (CA) model. Therefore, the modified U ...

Abstract	This paper introduces an improved convolutional neural network based on the conventional U-Net for simulating built-up land expansion. The proposed method hires a pixel-wise semantic segmentation approach considering the spatial drivers affecting urbanization as data cubes. Independent variables including altitude, slope, and distance from barren, crop, greenery, roads, and urban areas for 1998, 2008, and 2018 were considered as covariates for the simulation of built-up land expansion in Tehran and Karaj regions in Iran. The proposed method was compared with the random forest (RF) algorithm as the baseline model. Evaluation using the area under the total operating characteristic indicated the superiority of our modified U-Net (0.87) over the RF (0.82) algorithm. Furthermore, evaluation using the percent correct metric indicated that our proposed model is capable of learning neighborhood effects effectively leading to simulate built-up land expansion accurately, independent from applying a cellular automata (CA) model. Therefore, the modified U-Net independent from the CA which can consider the neighborhood effects is recommended for the simulation of built-up land expansion precisely.
Keywords	algorithms ; altitude ; neural networks ; urbanization ; vegetation ; Iran ; Land use and land cover change ; built-up land expansion ; convolutional neural networks ; pixel-wise semantic segmentation ; U-Net ; total operating characteristic (TOC)
Language	English
Dates of publication	2022-1231
Size	p. 148-163.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2410527-2
ISSN	1753-8955
ISSN	1753-8955
DOI	10.1080/17538947.2021.2017035
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Article: U-47700: A Clinical Review of the Literature.

Rambaran, Kerry Anne / Fleming, Steven W / An, Jie / Burkhart, Samantha / Furmaga, Jakub / Kleinschmidt, Kurt C / Spiekerman, A Michael / Alzghari, Saeed K

The Journal of emergency medicine

2017 Volume 53, Issue 4, Page(s) 509–519

Abstract: Background: U-47700 is a synthetic opioid developed by The Upjohn Company in the 1970s, which has ... clinical trial data assessing the safety of U-47700.: Objective: To describe the signs and symptoms ... of ingestion, laboratory testing, and treatment modalities for U-47700 intoxication.: Discussion ...

Abstract	Background: U-47700 is a synthetic opioid developed by The Upjohn Company in the 1970s, which has recently appeared in the news and medical literature due to its toxicity. Currently, there are no clinical trial data assessing the safety of U-47700. Objective: To describe the signs and symptoms of ingestion, laboratory testing, and treatment modalities for U-47700 intoxication. Discussion: We searched PubMed, Embase, Web of Science, and EBSCO for articles using the term "U-47700" and "47700." The following inclusion criteria were used: had to be in English; full text; must involve humans; must be either a randomized control trial, prospective trial, retrospective analysis, case series, or case report; and must include clinical findings at presentation. We identified and extracted data from relevant articles. Ten relevant articles were included with 16 patients. Patients that died after overdose with U-47700 typically presented to the hospital with pulmonary edema. Patients who survived an overdose presented with decreased mental status and decreased respiratory rate suggestive of an opioid toxidrome. Patients also commonly had tachycardia. Immunoassays failed to identify U-47700, and the identification of U-47700 required the use of chromatographic and spectral techniques. Conclusion: We report the first clinical review of U-47700 intoxication.
MeSH term(s)	Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Benzamides/therapeutic use ; Benzamides/toxicity ; Drug Overdose/diagnosis ; Drug Overdose/drug therapy ; Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; United States
Chemical Substances	Analgesics, Opioid ; Benzamides ; Narcotic Antagonists ; U-47700 ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605559-x
ISSN	0736-4679
ISSN	0736-4679
DOI	10.1016/j.jemermed.2017.05.034
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Article ; Online: Distribution of injury in inflatable jumping amusements in the U.S. over the last 20 years.

Vukcevich, Olivia / Schomberg, John / Wallace, Elizabeth L / Reyna, Troy / Gholizadeh, Maryam / Ferguson, Makenzie / Guner, Yigit S / Awan, Saeed

Journal of pediatric surgery

2022 Volume 57, Issue 5, Page(s) 908–914

Abstract: Purpose: To describe the distribution of injuries attributed to inflatable bounce house devices in children 2-18 years old in the United States from 2000 to 2019.: Methods: The National Electronic Injury Surveillance System (NEISS) was used to ... ...

Abstract	Purpose: To describe the distribution of injuries attributed to inflatable bounce house devices in children 2-18 years old in the United States from 2000 to 2019. Methods: The National Electronic Injury Surveillance System (NEISS) was used to identify patients <18 years of age with injuries from activities classified as amusements (NEISS Code 1293 and 3219) during the period from 2000 to 2019. Results: A weighted estimate of 159,569 injuries was obtained using NEISS statistical weights. Injury estimates and rate of estimated injury per year showed a continued linear increase from 2000-2019 (p<0.0001). Bounce house-related injuries were more common in males (53.9%) than in females (46.1%). The injuries reported most commonly were fracture (25.8%), muscle strain (25.7%), and contusion (14.5%). The factors associated with bounce house-related injury were compared between "younger" patients ≤6 years of age and "older" patients >6 years of age. In both age groups, the patient's residence was the most prevalent location of injury (≤6 yr, 95.6%; >6 yr, 97.2%), and the lower extremity was the most prevalent anatomic site of injury (≤6 yr, 34.6%, >6 yr 35.3%). Concussion was rare in both groups (≤6 yr, 1.6%; >6 yr, 2.9%); however, concussion was 86% more prevalent in those >6 years of age (p<0.0001). Conclusions: The frequency and rate of pediatric bounce house injuries has increased steadily since 2000. The most severe injuries occur disproportionately in children > 6 years old.
MeSH term(s)	Adolescent ; Age Distribution ; Brain Concussion ; Child ; Child, Preschool ; Emergency Service, Hospital ; Female ; Fractures, Bone ; Humans ; Lower Extremity ; Male ; United States/epidemiology
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2021.12.054
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Article: Brain Tumor Detection and Classification Using Fine-Tuned CNN with ResNet50 and U-Net Model: A Study on TCGA-LGG and TCIA Dataset for MRI Applications.

Asiri, Abdullah A / Shaf, Ahmad / Ali, Tariq / Aamir, Muhammad / Irfan, Muhammad / Alqahtani, Saeed / Mehdar, Khlood M / Halawani, Hanan Talal / Alghamdi, Ali H / Alshamrani, Abdullah Fahad A / Alqhtani, Samar M

Life (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: ... model based on CNN with ResNet50 and U-Net to solve this problem. This model works on the publicly ... the U-Net model is integrated for the segmentation of the tumor regions correctly. The model performance ... The results from fine-tuned ResNet50 model are IoU: 0.91, DSC: 0.95, SI: 0.95. In contrast, U-Net ...

Abstract	Nowadays, brain tumors have become a leading cause of mortality worldwide. The brain cells in the tumor grow abnormally and badly affect the surrounding brain cells. These cells could be either cancerous or non-cancerous types, and their symptoms can vary depending on their location, size, and type. Due to its complex and varying structure, detecting and classifying the brain tumor accurately at the initial stages to avoid maximum death loss is challenging. This research proposes an improved fine-tuned model based on CNN with ResNet50 and U-Net to solve this problem. This model works on the publicly available dataset known as TCGA-LGG and TCIA. The dataset consists of 120 patients. The proposed CNN and fine-tuned ResNet50 model are used to detect and classify the tumor or no-tumor images. Furthermore, the U-Net model is integrated for the segmentation of the tumor regions correctly. The model performance evaluation metrics are accuracy, intersection over union, dice similarity coefficient, and similarity index. The results from fine-tuned ResNet50 model are IoU: 0.91, DSC: 0.95, SI: 0.95. In contrast, U-Net with ResNet50 outperforms all other models and correctly classified and segmented the tumor region.
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13071449
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