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  1. Article ; Online: The pandemic of the vulnerable.

    Neerland, Bjørn Erik

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2020  Volume 140, Issue 11

    Title translation De sårbares pandemi.
    MeSH term(s) Humans ; Influenza, Human/epidemiology ; Pandemics ; Vulnerable Populations
    Language Norwegian
    Publishing date 2020-08-14
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cognitive decline and dementia: does delirium matter?

    Selbæk, Geir / Neerland, Bjørn Erik

    The Lancet. Healthy longevity

    2022  Volume 3, Issue 4, Page(s) e217–e218

    MeSH term(s) Cognitive Dysfunction ; Delirium ; Dementia/psychology ; Humans
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(22)00056-3
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  3. Article: Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis.

    Golubovic, Jelena / Neerland, Bjørn Erik / Aune, Dagfinn / Baker, Felicity A

    Brain sciences

    2022  Volume 12, Issue 5

    Abstract: Delirium is a neuropsychiatric syndrome represented by an acute disturbance in attention, awareness and cognition, highly prevalent in older, and critically ill patients, and associated with poor outcomes. This review synthesized existing evidence on the ...

    Abstract Delirium is a neuropsychiatric syndrome represented by an acute disturbance in attention, awareness and cognition, highly prevalent in older, and critically ill patients, and associated with poor outcomes. This review synthesized existing evidence on the effectiveness of music interventions on delirium in adults, and music interventions (MIs), psychometric assessments and outcome measures used. We searched MEDLINE, PsychINFO, SCOPUS, Clinical Trials and CENTRAL for quantitative designs comparing any MIs to standard care or another intervention. From 1150 studies 12 met the inclusion criteria, and 6 were included in the meta-analysis. Narrative synthesis showed that most studies focused on prevention, few assessed delirium severity, with the majority of studies reporting beneficial effects. The summary relative risk for incident delirium comparing music vs. no music in postsurgical and critically ill older patients was 0.52 (95% confidential interval (CI): 0.20−1.35, I2 = 79.1%, heterogeneity <0.0001) for the random effects model and 0.47 (95% CI: 0.34−0.66) using the fixed effects model. Music listening interventions were more commonly applied than music therapy delivered by credentialed music therapists, and delirium assessments methods were heterogeneous, including both standardized tools and systematic observations. Better designed studies are needed addressing effectiveness of MIs in specific patient subgroups, exploring the correlations between intervention-types/dosages and delirium symptoms.
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12050568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [No title information]

    Neerland, Bjørn Erik / Watne, Leiv Otto / Krogseth, Maria

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2020  Volume 140

    Title translation Delirium hos pasienter med covid-19.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Delirium/complications ; Humans ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language Norwegian
    Publishing date 2020-04-03
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records.

    Titlestad, Irit / Haugarvoll, Kristoffer / Solvang, Stein-Erik H / Norekvål, Tone Merete / Skogseth, Ragnhild E / Andreassen, Ole A / Årsland, Dag / Neerland, Bjørn Erik / Nordrehaug, Jan Erik / Tell, Grethe S / Giil, Lasse M

    Age and ageing

    2024  Volume 53, Issue 2

    Abstract: Background: In-hospital delirium is associated with adverse outcomes and is underdiagnosed, limiting research and clinical follow-up.: Objective: To compare the incidence of in-hospital delirium determined by chart-based review of electronic medical ... ...

    Abstract Background: In-hospital delirium is associated with adverse outcomes and is underdiagnosed, limiting research and clinical follow-up.
    Objective: To compare the incidence of in-hospital delirium determined by chart-based review of electronic medical records (D-CBR) with delirium discharge diagnoses (D-DD). Furthermore, to identify differences in symptoms, treatments and delirium triggers between D-CBR and D-DD.
    Method: The community-based cohort included 2,115 participants in the Hordaland Health Study born between 1925 and 1927. Between 2018 and 2022, we retrospectively reviewed hospital electronic medical records from baseline (1997-99) until death prior to 2023. D-DD and D-CBR were validated using The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for delirium.
    Results: Of the 2,115 participants, 638 had in-hospital delirium. The incidence rate (IR) of D-CBR was 29.8 [95% confidence interval 28, 32] per 1,000 person-years, whereas the IR by D-DD was 3.4 [2.8, 4.2]. The IR ratio was 9.14 (P < 0.001). Patients who received pharmacological treatment for delirium (n = 121, odds ratio (OR) 3.4, [2.1, 5.4], P < 0.001), who were affected by acute memory impairment (n = 149, OR 2.8, [1.8, 4.5], P < 0.001), or change in perception (n = 137, OR 2.9, [1.8, 4.6] P < 0.001) had higher odds for D-DD. In contrast, post-operative cases (OR 0.2, [0.1, 0.4], P < 0.001) had lower odds for D-DD.
    Conclusion: Underdiagnosis of in-hospital delirium was a major issue in our study, especially in less severe delirium cases. Our findings emphasise the need for integrating systematic delirium diagnostics and documentation into hospital admission and discharge routines.
    MeSH term(s) Humans ; Delirium/diagnosis ; Delirium/epidemiology ; Delirium/therapy ; Retrospective Studies ; Risk Factors ; Hospitals ; Medical Records
    Language English
    Publishing date 2024-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afae006
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    Zs.MO 448: Show issues

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  6. Article ; Online: Pharmacological Management of Delirium.

    Neerland, Bjørn Erik / Neufeld, Karin J / Slooter, Arjen J C

    JAMA psychiatry

    2019  Volume 76, Issue 9, Page(s) 983

    MeSH term(s) Delirium/drug therapy ; Humans ; Network Meta-Analysis
    Language English
    Publishing date 2019-07-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2019.1513
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  7. Article ; Online: Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses.

    Neerland, Bjørn Erik / Wyller, Torgeir Bruun / Wyller, Vegard Bruun Bratholm

    BMC geriatrics

    2019  Volume 19, Issue 1, Page(s) 23

    Abstract: Background: Alterations in autonomic nervous system (ANS) activity might be involved in the pathophysiology of delirium. The aim was to explore autonomic cardiovascular control in older patients with and without delirium.: Methods: Fourteen patients ( ...

    Abstract Background: Alterations in autonomic nervous system (ANS) activity might be involved in the pathophysiology of delirium. The aim was to explore autonomic cardiovascular control in older patients with and without delirium.
    Methods: Fourteen patients (five with delirium) acutely admitted to the geriatric ward with an infection were enrolled in the study. Patients with atrial fibrillation, a pacemaker, or on treatment with beta-blockers, calcium channel blockers or acetylcholinesterase inhibitors were not eligible. Continuous, non-invasive hemodynamic variables were measured during supine rest (5 min) and head-up tilt (HUT) to 15 degrees (10 min). Heart rate (HR), blood pressure (BP) and stroke volume (SV) were recorded beat-to-beat. Cardiac output (CO), total peripheral resistance (TPR), end-diastolic volume (EDV) and heart rate variability (HRV) values were calculated.
    Results: Median age was 86 years. HR, BP, SV, CO, TPR and EDV were similar across the two groups at rest, but there was a trend towards a greater increase in systolic BP and HR during HUT in the delirium group. At rest, all HRV indices were higher in the delirium group, but the differences were not statistically significant. During HUT, the delirium group had higher power spectral density (PSD) (representing total variability) (p = 0.06) and a lower low frequency (LF)/high frequency (HF)-ratio (an index of sympathovagal balance) than the control group (p = 0.06). Also, delirious patients had a significantly greater reduction in standard deviation of RR-intervals (SDNN) (representing total variability) from baseline than controls (p = 0.01) during HUT.
    Conclusions: This explorative pilot study on autonomic cardiovascular control in delirium suggests that there may be differences in HRV that should be further investigated in larger samples.
    MeSH term(s) Aged ; Aged, 80 and over ; Autonomic Nervous System/physiology ; Blood Pressure/physiology ; Communicable Diseases/epidemiology ; Communicable Diseases/physiopathology ; Delirium/epidemiology ; Delirium/physiopathology ; Female ; Heart Rate/physiology ; Humans ; Male ; Norway/epidemiology ; Pilot Projects ; Standing Position ; Tilt-Table Test/methods
    Language English
    Publishing date 2019-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-019-1035-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Delirium in patients with hip fracture is associated with increased heart rate variability.

    Ernst, Gernot / Watne, Leiv Otto / Rostrup, Morten / Neerland, Bjørn Erik

    Aging clinical and experimental research

    2020  Volume 32, Issue 11, Page(s) 2311–2318

    Abstract: Background: Heart rate variability (HRV) is a method to assess the autonomic nervous system and reflects possibly central brain states. HRV has previously not been examined in patients with hip fracture and delirium.: Aims: To explore HRV parameters ... ...

    Abstract Background: Heart rate variability (HRV) is a method to assess the autonomic nervous system and reflects possibly central brain states. HRV has previously not been examined in patients with hip fracture and delirium.
    Aims: To explore HRV parameters in hip fracture patients with and without delirium.
    Methods: Patients admitted to Oslo University Hospital with hip fracture and sinus rhythm in electrocardiogram (ECG) were included. Delirium was diagnosed using the confusion assessment method. HRV was assessed preoperatively after a relaxing period of five minutes, by measuring an ECG signal over 5 min. Parameters in time domain (the standard deviation of the QRS distances-SDNN) and frequency domain (total power (TP), low frequency (LF), high frequency (HF) and LF/HF ratio) were calculated.
    Results: Seventy-five patients were included in the study, and 21 of them had subsyndromal delirium and were excluded from the analysis. Fifty-four patients with a mean age of 83.5 years (SD 8.6, 78% females) were included. Twenty-six patients (48%) had preoperative delirium, 11 (20%) developed delirium postoperatively, whereas 17 (31%) never developed delirium. SDNN, TP and HF values were significantly higher in patients with delirium compared to patients without delirium, and LF and LF/HF were lower. Patients developing postoperative delirium had decreased LF and increased HF before symptom onset.
    Discussion: Increased SDNN, TP and HF and decreased LF values might reflect an abnormal stress response in delirium.
    Conclusion: HRV measurements in patients with hip fractures provide additional information beyond heart rate and might be used to identify relevant pathophysiological factors in delirium.
    MeSH term(s) Aged, 80 and over ; Arrhythmias, Cardiac ; Autonomic Nervous System ; Delirium/diagnosis ; Female ; Heart Rate ; Hip Fractures/complications ; Humans ; Male
    Language English
    Publishing date 2020-01-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-019-01447-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hvordan beskrive delirium?

    Neerland, Bjørn Erik / Krogseth, Maria / Wyller, Torgeir Bruun

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2018  Volume 138, Issue 5

    Title translation How to describe delirium?.
    MeSH term(s) Arousal/classification ; Attention/classification ; Awareness/classification ; Consciousness/classification ; Delirium/classification ; Delirium/complications ; Humans ; Norway ; Terminology as Topic ; Translations
    Language Norwegian
    Publishing date 2018-03-05
    Publishing country Norway
    Document type Letter
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.18.0087
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