LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 382

Search options

  1. Article: Chaotic breathing in post-COVID-19 breathlessness: a key feature of dysfunctional breathing can be characterised objectively by approximate entropy.

    Samaranayake, Chinthaka B / Warren, Christopher / Rhamie, Serena / Haji, Gulam / Wort, S John / Price, Laura C / McCabe, Colm / Hull, James H

    ERJ open research

    2023  Volume 9, Issue 4

    Abstract: Post-COVID-19 breathing pattern disorder can be characterised by application of nonlinear statistical modelling of exercise ventilatory ... ...

    Abstract Post-COVID-19 breathing pattern disorder can be characterised by application of nonlinear statistical modelling of exercise ventilatory data
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00117-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Pulmonary hypertension in ARDS: inflammation matters!

    Price, Laura C / Wort, S John

    Thorax

    2017  Volume 72, Issue 5, Page(s) 396–397

    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2016-209199
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Pulmonary vasodilator treatment in pulmonary hypertension due to left heart or lung disease: time for a high-definition picture?

    Piccari, Lucilla / Bernardo, Roberto J / Rodríguez-Chiaradía, Diego / Vitulo, Patrizio / Wort, S John / Sahay, Sandeep

    Pulmonary circulation

    2021  Volume 11, Issue 2, Page(s) 20458940211018074

    Language English
    Publishing date 2021-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1177/20458940211018074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Earlier diagnosis and international registries may improve outcomes in pulmonary tumour thrombotic microangiopathy.

    Price, Laura C / Wort, S John

    The European respiratory journal

    2016  Volume 47, Issue 2, Page(s) 690–691

    MeSH term(s) Female ; Humans ; Hypertension, Pulmonary/diagnosis ; Lung Neoplasms/diagnosis ; Male ; Thrombotic Microangiopathies/diagnosis
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01736-2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Sendaway capillary NT-proBNP in pulmonary hypertension.

    Stubbs, Harrison D / Cannon, John / Knightbridge, Emily / Durrington, Charlotte / Roddis, Chloe / Gin-Sing, Wendy / Massey, Fiona / Knight, Daniel S / Virsinskaite, Ruta / Lordan, James L / Sear, Eleanor / Apple-Pinguel, Joy / Morris, Eleanor / Johnson, Martin K / Wort, Stephen J

    BMJ open respiratory research

    2024  Volume 11, Issue 1

    Abstract: Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker of cardiac ventricular wall stress that is incorporated into pulmonary hypertension (PH) risk stratification models. Sendaway sampling may enable patients to perform NT- ... ...

    Abstract Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker of cardiac ventricular wall stress that is incorporated into pulmonary hypertension (PH) risk stratification models. Sendaway sampling may enable patients to perform NT-proBNP tests remotely. This UK-wide study aimed to assess the agreement of sendaway NT-proBNP with standard venous NT-proBNP and to assess the effect of delayed processing.
    Methods: Reference venous NT-proBNP was collected from PH patients. Samples for capillary and venous sendaway tests were collected contemporaneously, mailed to a reference laboratory and processed at 3 and 7 days using a Roche Cobas e411 device. Differences in paired measurements were analysed with Passing-Bablok regression, percentage difference plots and the % difference in risk strata.
    Results: 113 patients were included in the study. 13% of day 3 capillary samples were insufficient. Day 3 capillary samples were not equivalent to reference samples (Passing Bablok analysis slope of 0.91 (95% CI 0.88 to 0.93) and intercept of 6.0 (95% CI 0.2 to 15.9)). The relative median difference was -7% and there were acceptable limits of agreement. Day 3 capillary NT-proBNP accurately risk stratified patients in 93.5% of cases. By comparison, day 3 venous results accurately risk stratified patients in 90.1% of cases and were equivalent by Passing-Bablok regression. Delayed sampling of sendaway tests led to an unacceptable level of agreement and systematically underestimated NT-proBNP.
    Conclusions: Sendaway NT-proBNP sampling may provide an objective measure of right ventricular strain for virtual PH clinics. Results must be interpreted with caution in cases of delayed sampling.
    MeSH term(s) Humans ; Natriuretic Peptide, Brain ; Hypertension, Pulmonary/diagnosis ; Peptide Fragments ; Biomarkers
    Chemical Substances pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments ; Biomarkers
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-002124
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Use of pulmonary arterial hypertension therapies in patient swith sarcoidosis-associated pulmonary hypertension.

    Price, Laura C / Kouranos, Vaileios / Baughman, Robert / Bloom, Chloe / Stewart, Iain / Shlobin, Oksana / Nathan, Steven / Dimopoulos, Konstantinos / Falconer, Jonathan / Gupta, Rohit / McCabe, Colm / Samaranayake, Chinthaka / Mason, Thomas / Mukherjee, Bhashkhar / Taube, Catherine / Sahni, Ankita / Kempny, Aleksander / Semple, Thomas / Renzoni, Elizabetta /
    Wells, Athol / Wort, S John

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

    2024  Volume 41, Issue 1, Page(s) e2024024

    Language English
    Publishing date 2024-03-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1339192-6
    ISSN 2532-179X ; 1124-0490
    ISSN (online) 2532-179X
    ISSN 1124-0490
    DOI 10.36141/svdld.v41i1.15515
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2076: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Right ventricular functional recovery assessment with stress echocardiography and cardiopulmonary exercise testing after pulmonary embolism: a pilot prospective multicentre study.

    Samaranayake, Chinthaka Bhagya / Upham, John / Tran, Khoa / Howard, Luke S / Nguyen, Sean / Lwin, Myo / Anderson, James / Wahi, Sudhir / Price, Laura C / Wort, Stephen / Li, Wei / McCabe, Colm / Keir, Gregory J

    BMJ open respiratory research

    2023  Volume 10, Issue 1

    Abstract: Background: Data on right ventricular (RV) exercise adaptation following acute intermediate and high-risk pulmonary embolism (PE) remain limited. This study aimed to evaluate the symptom burden, RV functional recovery during exercise and cardiopulmonary ...

    Abstract Background: Data on right ventricular (RV) exercise adaptation following acute intermediate and high-risk pulmonary embolism (PE) remain limited. This study aimed to evaluate the symptom burden, RV functional recovery during exercise and cardiopulmonary exercise parameters in survivors of intermediate and high-risk acute PE.
    Methods: We prospectively recruited patients following acute intermediate and high-risk PE at four sites in Australia and UK. Study assessments included stress echocardiography, cardiopulmonary exercise testing (CPET) and ventilation-perfusion (VQ) scan at 3 months follow-up.
    Results: Thirty patients were recruited and 24 (median age: 55 years, IQR: 22) completed follow-up. Reduced peak oxygen consumption (VO
    Conclusion: In our cohort, impaired RV adaptation on exercise was seen in almost one-third of patients. Combined stress echocardiography and CPET may enable more accurate phenotyping of patients with persistent symptoms following acute PE to allow timely detection of long-term complications.
    MeSH term(s) Humans ; Middle Aged ; Echocardiography, Stress ; Exercise Test ; Prospective Studies ; Quality of Life ; Pulmonary Embolism/diagnostic imaging ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-001637
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Tumoral pulmonary hypertension.

    Price, Laura C / Seckl, Michael J / Dorfmüller, Peter / Wort, S John

    European respiratory review : an official journal of the European Respiratory Society

    2019  Volume 28, Issue 151

    Abstract: Tumoral pulmonary hypertension (PH) comprises a variety of subtypes in patients with a current or previous malignancy. Tumoral PH principally includes the tumour-related pulmonary microvascular conditions pulmonary tumour microembolism and pulmonary ... ...

    Abstract Tumoral pulmonary hypertension (PH) comprises a variety of subtypes in patients with a current or previous malignancy. Tumoral PH principally includes the tumour-related pulmonary microvascular conditions pulmonary tumour microembolism and pulmonary tumour thrombotic microangiopathy. These inter-related conditions are frequently found in
    MeSH term(s) Animals ; Antineoplastic Agents/adverse effects ; Arterial Pressure ; Humans ; Hydrogen-Ion Concentration ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/physiopathology ; Molecular Targeted Therapy/adverse effects ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Neoplasms/pathology ; Neoplastic Cells, Circulating/drug effects ; Neoplastic Cells, Circulating/pathology ; Prognosis ; Pulmonary Artery/drug effects ; Pulmonary Artery/pathology ; Pulmonary Artery/physiopathology ; Risk Assessment ; Risk Factors ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-02-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0065-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3265: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Covid-19 pneumonia and pulmonary vascular disease: A UK Centre perspective.

    John Wort, S / Arachchillage, D J / McCabe, C / Price, L C

    Respiratory medicine and research

    2020  Volume 78, Page(s) 100781

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Critical Care/methods ; Critical Care/standards ; Extracorporeal Membrane Oxygenation/methods ; Extracorporeal Membrane Oxygenation/standards ; Humans ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/therapy ; Hypertension, Pulmonary/virology ; Lung Diseases/epidemiology ; Lung Diseases/therapy ; Lung Diseases/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/therapy ; Pulmonary Embolism/virology ; Pulmonary Veno-Occlusive Disease/epidemiology ; Pulmonary Veno-Occlusive Disease/etiology ; Pulmonary Veno-Occlusive Disease/therapy ; SARS-CoV-2/physiology ; United Kingdom/epidemiology ; Vascular Diseases/epidemiology ; Vascular Diseases/therapy ; Vascular Diseases/virology
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country France
    Document type Editorial
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2020.100781
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1.

    Mumby, Sharon / Perros, Frederic / Grynblat, Julien / Manaud, Gregoire / Papi, Alberto / Casolari, Paolo / Caramori, Gaetano / Humbert, Marc / John Wort, S / Adcock, Ian M

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 193

    Abstract: Background: Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal (BET) proteins are required for ...

    Abstract Background: Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal (BET) proteins are required for the expression of a subset of NF-κB-induced inflammatory genes which can be inhibited by the BET mimic JQ1+. We hypothesised that JQ+ would supress TNFα-driven inflammatory responses in human pulmonary vascular cells from PAH patients.
    Methods: Immunohistochemical staining of human peripheral lung tissue (N = 14 PAH and N = 12 non-PAH) was performed for the BET proteins BRD2 and 4. Human pulmonary microvascular endothelial cells (HPMEC) and pulmonary artery smooth muscle cells (HPASMC) from PAH patients (N = 4) and non-PAH controls (N = 4) were stimulated with TNFα in presence or absence of JQ1+ or its inactive isomer JQ1-. IL-6 and -8 mRNA was measured by RT-qPCR and protein levels by ELISA. Chromatin immunoprecipitation analysis was performed using EZ-ChIP™ and NF-κB p65 activation determined using a TransAm kit. MTT assay was used to measure cell viability.
    Results: Nuclear staining of BRD2 and BRD4 was significantly (p < 0.0001) increased in the lung vascular endothelial and smooth muscle cells from PAH patients compared to controls with normal lung function. TNFα-driven IL-6 release from both HPMECs and HPASMCs was greater in PAH cells than control cells. Levels of CXCL8/IL-8 protein release was higher in PAH HPASMCs than in control cells with similar release observed in HPMECs. TNFα-induced recruitment of activated NF-κB p65 to the IL-6 and CXCL8/IL-8 promoters were similar in both cell types and between subject groups. JQ1+ suppressed TNFα-induced IL-6 and CXCL8/IL-8 release and mRNA expression to a comparable extent in control and PAH HPMECs and HPASMCs. JQ1 had a greater efficacy on IL-6 release in HPMEC and on CXCL8/IL-8 release in HPASMC.
    Conclusion: BET inhibition decreases TNFα driven inflammation in primary pulmonary vascular cells. The anti-inflammatory actions of JQ1 suggests distinct cell-specific regulatory control of these genes. BET proteins could be a target for future therapies for PAH.
    MeSH term(s) Humans ; Pulmonary Arterial Hypertension ; Tumor Necrosis Factor-alpha ; Interleukin-8 ; Endothelial Cells ; Interleukin-6 ; NF-kappa B ; Nuclear Proteins/genetics ; Transcription Factors/genetics ; Familial Primary Pulmonary Hypertension ; Cell Cycle Proteins
    Chemical Substances Tumor Necrosis Factor-alpha ; Interleukin-8 ; (+)-JQ1 compound ; Interleukin-6 ; NF-kappa B ; Nuclear Proteins ; Transcription Factors ; BRD4 protein, human ; Cell Cycle Proteins
    Language English
    Publishing date 2023-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02499-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top