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Book ; Online ; E-Book: Nutrition and Diet in Health

Oladiji, Adenike Temidayo / Oladele, Johnson Olaleye / Ajayi, Ebenezer I. O.

Principles and Applications

2024

Abstract: Nutrition and Diet in Health: Principles and Applications reviews and discusses the issues related to the roles of nutrition and diet in human health and diseases. ...

Author's details	edited by Adenike Temidayo Oladiji, Johnson Olaleye Oladele, and Ebenezer I. O. Ajayi
Abstract	Nutrition and Diet in Health: Principles and Applications reviews and discusses the issues related to the roles of nutrition and diet in human health and diseases.
Keywords	Diet in disease ; Diet therapy ; Nutrition
Subject code	615.854
Language	English
Size	1 online resource (289 pages)
Edition	First edition.
Publisher	CRC Press
Publishing place	Boca Raton, FL
Document type	Book ; Online ; E-Book
Note	Includes index.
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-003-85840-6 ; 1-003-36149-8 ; 9781032421711 ; 978-1-003-85840-9 ; 978-1-003-36149-7 ; 1032421711
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom-induced toxicities.

Ajisebiola, Babafemi Siji / Oladele, Johnson Olaleye / Adeyi, Akindele Oluwatosin

Toxicon : official journal of the International Society on Toxinology

2023 Volume 233, Page(s) 107242

Abstract: Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom ... ...

Abstract	Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom potency. This research aimed to identify the main active antivenom compound in the M. oleifera fraction responsible for neutralizing the toxicities induced by BAV. The compounds identified from M. oleifera fraction were docked in silico against the catalytic site of the Snake Venom Metalloproteinase (SVMP) to determine the lead inhibitor compound. The antivenom potency of the lead inhibitor compound was tested against BAV toxicities and metalloproteinase isolated from BAV using in vitro and in vivo methods, while EchiTab-Plus polyvalent antivenom served as a standard drug. The in silico prediction revealed kaempferol as the lead inhibitor compound with a docking score of -7.0 kcal/mol. Kaempferol effectively inhibited metalloproteinase activity at 0.2 mg/ml, compared to antivenom (0.4 mg/ml) and demonstrated significant antihaemorrhagic, antihaemolytic and coagulant effects against BAV activities. Furthermore, kaempferol showed a significant dose-dependent effect on altered haematological indices observed in rats challenged with LD
MeSH term(s)	Animals ; Rats ; Antivenins/pharmacology ; Antivenins/therapeutic use ; Moringa oleifera ; Kaempferols/pharmacology ; Kaempferols/therapeutic use ; Snake Venoms ; Snake Bites/drug therapy ; Metalloproteases/therapeutic use
Chemical Substances	Antivenins ; Kaempferols ; Snake Venoms ; Metalloproteases (EC 3.4.-)
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107242
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Article: Functional Bioactivities of Soluble Seed Proteins from Two Leguminous Seeds.

Adewole, Taiwo Scholes / Dudu, Boluwatife Bolanle / Oladele, Johnson Olaleye / Oyeleke, Oyedotun Moses / Kuku, Adenike

Preventive nutrition and food science

2023 Volume 28, Issue 2, Page(s) 160–169

Abstract: Storage proteins ... ...

Abstract	Storage proteins from
Language	English
Publishing date	2023-06-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2668373-8
ISSN	2287-8602 ; 2287-1098
ISSN (online)	2287-8602
ISSN	2287-1098
DOI	10.3746/pnf.2023.28.2.160
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Article ; Online: Water-soluble phenolics from

Adewale, Omowumi Oyeronke / Oyelola, Roseline Fadera / Adetuyi, Oluwatosin Adefunke / Adebisi, Oluwaseun Abraham / Adekomi, Damilare Adedayo / Oladele, Johnson Olaleye

Drug and chemical toxicology

2024 , Page(s) 1–14

Abstract: Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal ... ...

Abstract	Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal protection. Thus, this study investigates the role of pre and post-treatment of rats with water-soluble phenolics from
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2024.2329762
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Article ; Online: Kaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats.

Adeyi, Akindele Oluwatosin / Ajisebiola, Babafemi Siji / Sanni, Akanni Abubakar / Oladele, Johnson Olaleye / Mustapha, Abdur-Rahman Kolawole / Oyedara, Omotayo Opemipo / Fagbenro, Olukunle Silas

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3933

Abstract: Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative ... ...

Abstract	Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative potential of kaempferol on NnV-induced male reproductive toxicity. Fifty male wistar rats were sorted randomly into five groups (n = 10) for this study. Group 1 were noted as the control, while rats in groups 2 to 5 were injected with LD
MeSH term(s)	Rats ; Male ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Kaempferols/pharmacology ; Kaempferols/metabolism ; Sperm Motility ; Semen/metabolism ; Testis/metabolism ; Epididymis/metabolism ; Spermatozoa/metabolism ; Rats, Wistar ; Testosterone/metabolism ; Oxidative Stress ; Anti-Inflammatory Agents/pharmacology ; Naja
Chemical Substances	Antioxidants ; Kaempferols ; Testosterone (3XMK78S47O) ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54523-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Covid-19 treatment: Investigation on the phytochemical constituents of

Oladele, Johnson Olaleye / Oyeleke, Oyedotun Moses / Oladele, Oluwaseun Titilope / Oladiji, Adenike Temidayo

Computational toxicology (Amsterdam, Netherlands)

2021 Volume 18, Page(s) 100161

Abstract: The upsurge in the current cases of COVID-19 poses a major threat on human health and population all over the globe. The emergence of new infectious diseases and increase in frequency of drug resistant viruses demand effective and novel therapeutic ... ...

Abstract	The upsurge in the current cases of COVID-19 poses a major threat on human health and population all over the globe. The emergence of new infectious diseases and increase in frequency of drug resistant viruses demand effective and novel therapeutic agents. In this study, we used bioinformatics approach to investigate the possible inhibitory potentials of phytochemical constituents of
Language	English
Publishing date	2021-02-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1113
ISSN	2468-1113
DOI	10.1016/j.comtox.2021.100161
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Article ; Online: Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom–induced toxicities

Ajisebiola, Babafemi Siji / Oladele, Johnson Olaleye / Adeyi, Akindele Oluwatosin

Toxicon. 2023 Aug. 08, p.107242-

2023 , Page(s) 107242–

Abstract	Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom potency. This research aimed to identify the main active antivenom compound in the M. oleifera fraction responsible for neutralizing the toxicities induced by BAV. The compounds identified from M. oleifera fraction were docked in silico against the catalytic site of the Snake Venom Metalloproteinase (SVMP) to determine the lead inhibitor compound. The antivenom potency of the lead inhibitor compound was tested against BAV toxicities and metalloproteinase isolated from BAV using in vitro and in vivo methods, while EchiTab-Plus polyvalent antivenom served as a standard drug. The in silico prediction revealed kaempferol as the lead inhibitor compound with a docking score of −7.0 kcal/mol. Kaempferol effectively inhibited metalloproteinase activity at 0.2 mg/ml, compared to antivenom (0.4 mg/ml) and demonstrated significant antihaemorrhagic, antihaemolytic and coagulant effects against BAV activities. Furthermore, kaempferol showed a significant dose-dependent effect on altered haematological indices observed in rats challenged with LD₅₀ of BAV. Envenomed rats also showed an increase in oxidative stress biomarkers and antioxidant enzyme activity in the heart and kidney. However, treatment with kaempferol significantly (P < 0.05) decreased malondialdehyde levels and SOD activity with concomitant enhancement of glutathione levels. Severe histopathological defects noticed in the organ tissues of envenomed rats were ameliorated after kaempferol treatment. Kaempferol is identified as the main active antivenom compound in M. oleifera, and this research highlights the potential of the compound as an effective alternative to snakebite treatment.
Keywords	Bitis arietans ; Moringa oleifera ; active sites ; antioxidant enzymes ; antivenoms ; biomarkers ; coagulants ; computer simulation ; dose response ; enzyme activity ; glutathione ; heart ; histopathology ; kaempferol ; kidneys ; lead ; malondialdehyde ; metalloproteinases ; oxidative stress ; prediction ; snake bites ; snake venoms ; Envenomation ; Natural inhibitor ; Metalloproteinase
Language	English
Dates of publication	2023-0808
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107242
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Efficacy of selected Nigerian tropical plants in the treatment of COVID-19: in silico and in vitro investigations

Oladele, Johnson Olaleye / Adewole, Taiwo Scholes / Ogundepo, Gbenga Emmanuel / Oyeleke, Oyedotun Moses / Kuku, Adenike

Environ Sci Pollut Res. 2022 Dec., v. 29, no. 59 p.89295-89339

2022

Abstract: The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into ... ...

Abstract	The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into discovery of drug candidates for total eradication of all types of coronaviruses. In this context, this study sought to investigate the inhibitory effects of six selected tropical plants against four pathogenic proteins of Coronavirus-2. The medicinal plants used in this study were selected based on their traditional applications in herbal medicine to treat COVID-19 and related symptoms. The biological activities (antioxidant, free radical scavenging, and anti-inflammatory activities) of the extracts of the plants were assessed using different standard procedures. The phytochemicals present in the extracts were identified using GCMS and further screened via in silico molecular docking. The data from this study demonstrated that the phytochemicals of the selected tropical medicinal plants displayed substantial binding affinity to the binding pockets of the four main pathogenic proteins of Coronavirus-2 indicating them as putative inhibitors of Coronavirus-2 and as potential anti-coronavirus drug candidates. The reaction between these phytocompounds and proteins of Coronavirus-2 could alter the pathophysiology of COVID-19, thus mitigating its pathogenic reactions/activities. In conclusion, phytocompounds of these plants exhibited promising binding efficiency with target proteins of SARS-COV-2. Nevertheless, in vitro and in vivo studies are important to potentiate these findings. Other drug techniques or models are vital to elucidate their compatibility and usage as adjuvants in vaccine development against the highly contagious COVID-19 infection.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antioxidants ; computer simulation ; free radicals ; herbal medicines ; pathophysiology ; phytochemicals ; vaccine development
Language	English
Dates of publication	2022-12
Size	p. 89295-89339.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22025-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficacy of selected Nigerian tropical plants in the treatment of COVID-19: in silico and in vitro investigations.

Oladele, Johnson Olaleye / Adewole, Taiwo Scholes / Ogundepo, Gbenga Emmanuel / Oyeleke, Oyedotun Moses / Kuku, Adenike

Environmental science and pollution research international

2022 Volume 29, Issue 59, Page(s) 89295–89339

Abstract	The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into discovery of drug candidates for total eradication of all types of coronaviruses. In this context, this study sought to investigate the inhibitory effects of six selected tropical plants against four pathogenic proteins of Coronavirus-2. The medicinal plants used in this study were selected based on their traditional applications in herbal medicine to treat COVID-19 and related symptoms. The biological activities (antioxidant, free radical scavenging, and anti-inflammatory activities) of the extracts of the plants were assessed using different standard procedures. The phytochemicals present in the extracts were identified using GCMS and further screened via in silico molecular docking. The data from this study demonstrated that the phytochemicals of the selected tropical medicinal plants displayed substantial binding affinity to the binding pockets of the four main pathogenic proteins of Coronavirus-2 indicating them as putative inhibitors of Coronavirus-2 and as potential anti-coronavirus drug candidates. The reaction between these phytocompounds and proteins of Coronavirus-2 could alter the pathophysiology of COVID-19, thus mitigating its pathogenic reactions/activities. In conclusion, phytocompounds of these plants exhibited promising binding efficiency with target proteins of SARS-COV-2. Nevertheless, in vitro and in vivo studies are important to potentiate these findings. Other drug techniques or models are vital to elucidate their compatibility and usage as adjuvants in vaccine development against the highly contagious COVID-19 infection.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Molecular Docking Simulation ; Nigeria ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/chemistry
Chemical Substances	Antiviral Agents ; Phytochemicals
Language	English
Publishing date	2022-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22025-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chaya (Jatropha tanjorensis) leafs protect against sodium benzoate mediated renal dysfunction and hepatic damage in rats

Johnson Olaleye Oladele / Oluwaseun Titilope Oladele / Adedayo Oluwaseun Ademiluyi / Oyedotun Moses Oyeleke / Olaide Oladimeji Awosanya / Olu Israel Oyewole

Clinical Phytoscience, Vol 6, Iss 1, Pp 1-

2020 Volume 8

Abstract: Abstract Background Jatropha tanjorensis is a commonly consumed green leafy plant that has found usage in folk medicine. Sodium benzoate (C6H5COONa) is a widely used preservative in food/drink industries with potential cytotoxicity. Protective effect of ... ...

Abstract	Abstract Background Jatropha tanjorensis is a commonly consumed green leafy plant that has found usage in folk medicine. Sodium benzoate (C6H5COONa) is a widely used preservative in food/drink industries with potential cytotoxicity. Protective effect of some leafy plants on xenobiotic-induced toxicity have been established. Hence, this study sought to investigate the protective effect of methanolic leaf extract of Jatropha tanjorensis on sodium benzoate mediated renal and hepatic dysfunction in rats. Results Sodium benzoate treatment caused significant (P < 0.05) alteration in kidney (serum urea, uric acid, and creatinine) and liver (aspartate and alanine transaminases, acid and alkaline phosphatases) damage markers, serum albumin, globulin and total protein levels as well as cellular architecture which were significantly reversed in groups treated with the leaf extracts. Phytochemical screening of the leaf extract revealed the presence of terpenoids, saponins, cardiac glycosides, flavonoids and tannins. Conclusion Sodium benzoate-induced alterations in the renal and hepatic indices were mitigated following treatment with J. tanjorensis leaf extracts which suggests protective effect of the extract against sodium benzoate intoxication.
Keywords	Hepatocellular damage ; Renal dysfunction ; Phytochemical constituents ; Jatropha tanjorensis ; Sodium benzoate ; Medicine ; R ; Homeopathy ; RX1-681
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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