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  1. Article ; Online: Methods for Quantitative Efferocytosis Assays.

    Taefehshokr, Nima / Heit, Bryan

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2692, Page(s) 41–59

    Abstract: Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to mediate the uptake, engulfment, and degradation of apoptotic cells. Herein, we describe microscopy-based methods for ... ...

    Abstract Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to mediate the uptake, engulfment, and degradation of apoptotic cells. Herein, we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of signaling molecule recruitment during efferocytosis using genetically encoded probes and immunofluorescent labeling. While these methods are illustrated using macrophages, they are applicable to any efferocytic cell type.
    MeSH term(s) Apoptosis ; Phagocytosis ; Macrophages/metabolism ; Phagocytes ; Signal Transduction
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3338-0_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suppression of academics and school training in Iran during the "Woman, Life, Freedom" revolution.

    Shojaei, Shahla / Taefehshokr, Nima / Ghavami, Saeid

    Biochemistry and cell biology = Biochimie et biologie cellulaire

    2023  Volume 101, Issue 6, Page(s) 496–500

    Abstract: For the past 6 months, there has been an ongoing revolution in Iran after the brutal death of Zhina (Mahsa) Amini in morality police custody. Iranian universities' professors and students have been on the frontline of this revolution and have been fired ... ...

    Abstract For the past 6 months, there has been an ongoing revolution in Iran after the brutal death of Zhina (Mahsa) Amini in morality police custody. Iranian universities' professors and students have been on the frontline of this revolution and have been fired or sentenced. On the other hand, Iranian high schools and primary schools have been under suspected toxic gas attack. In the current article, the latest status of oppression of the university students and professors and toxic gas attack on primary and high schools in Iran has been evaluated.
    MeSH term(s) Female ; Humans ; Iran ; Schools ; Universities
    Language English
    Publishing date 2023-05-19
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 54104-7
    ISSN 1208-6002 ; 0829-8211
    ISSN (online) 1208-6002
    ISSN 0829-8211
    DOI 10.1139/bcb-2023-0100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Covid-19: Perspectives on Innate Immune Evasion.

    Taefehshokr, Nima / Taefehshokr, Sina / Hemmat, Nima / Heit, Bryan

    Frontiers in immunology

    2020  Volume 11, Page(s) 580641

    Abstract: The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that ... ...

    Abstract The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that target multiple aspects of innate immunity, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) able to induce a cytokine storm, impair interferon responses, and suppress antigen presentation on both MHC class I and class II. Understanding the immune responses to SARS-CoV-2 and its immunoevasion approaches will improve our understanding of pathogenesis, virus clearance, and contribute toward vaccine and immunotherepeutic design and evaluation. This review discusses the known host innate immune response and immune evasion mechanisms driving SARS-CoV-2 infection and pathophysiology.
    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Humans ; Immune Evasion/immunology ; Immunity, Innate/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/pathology
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.580641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Covid-19

    Nima Taefehshokr / Sina Taefehshokr / Nima Hemmat / Bryan Heit

    Frontiers in Immunology, Vol

    Perspectives on Innate Immune Evasion

    2020  Volume 11

    Abstract: The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that ... ...

    Abstract The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that target multiple aspects of innate immunity, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) able to induce a cytokine storm, impair interferon responses, and suppress antigen presentation on both MHC class I and class II. Understanding the immune responses to SARS-CoV-2 and its immunoevasion approaches will improve our understanding of pathogenesis, virus clearance, and contribute toward vaccine and immunotherepeutic design and evaluation. This review discusses the known host innate immune response and immune evasion mechanisms driving SARS-CoV-2 infection and pathophysiology.
    Keywords SARS-CoV-2 ; macropahge ; innnate immune ; MHC trafficking ; cytokine - immunological terms ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Subject code 570
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Covid-19

    Taefehshokr, Nima / Taefehshokr, Sina / Hemmat, Nima / Heit, Bryan

    Frontiers in Immunology

    Perspectives on Innate Immune Evasion

    2020  Volume 11

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.580641
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online: Data_Sheet_1_Covid-19

    Nima Taefehshokr / Sina Taefehshokr / Nima Hemmat / Bryan Heit

    Perspectives on Innate Immune Evasion.PDF

    2020  

    Abstract: The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that ... ...

    Abstract The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that target multiple aspects of innate immunity, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) able to induce a cytokine storm, impair interferon responses, and suppress antigen presentation on both MHC class I and class II. Understanding the immune responses to SARS-CoV-2 and its immunoevasion approaches will improve our understanding of pathogenesis, virus clearance, and contribute toward vaccine and immunotherepeutic design and evaluation. This review discusses the known host innate immune response and immune evasion mechanisms driving SARS-CoV-2 infection and pathophysiology.
    Keywords Immunology ; Applied Immunology (incl. Antibody Engineering ; Xenotransplantation and T-cell Therapies) ; Autoimmunity ; Cellular Immunology ; Humoural Immunology and Immunochemistry ; Immunogenetics (incl. Genetic Immunology) ; Innate Immunity ; Transplantation Immunology ; Tumour Immunology ; Immunology not elsewhere classified ; Genetic Immunology ; Animal Immunology ; Veterinary Immunology ; SARS-CoV-2 ; macropahge ; innnate immune ; MHC trafficking ; cytokine - immunological terms ; covid19
    Publishing date 2020-09-30T04:02:19Z
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2.

    Taefehshokr, Nima / Taefehshokr, Sina / Heit, Bryan

    Pathogens (Basel, Switzerland)

    2020  Volume 9, Issue 12

    Abstract: The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December 2019 in China, and has led to thousands of mortalities globally each day. While ... ...

    Abstract The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December 2019 in China, and has led to thousands of mortalities globally each day. While the innate immune response serves as the first line of defense, viral clearance requires activation of adaptive immunity, which employs B and T cells to provide sanitizing immunity. SARS-CoV-2 has a potent arsenal of mechanisms used to counter this adaptive immune response through processes, such as T cells depletion and T cell exhaustion. These phenomena are most often observed in severe SARS-CoV-2 patients, pointing towards a link between T cell function and disease severity. Moreover, neutralizing antibody titers and memory B cell responses may be short lived in many SARS-CoV-2 patients, potentially exposing these patients to re-infection. In this review, we discuss our current understanding of B and T cells immune responses and activity in SARS-CoV-2 pathogenesis.
    Language English
    Publishing date 2020-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9121027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Promising approaches in cancer immunotherapy.

    Taefehshokr, Nima / Baradaran, Behzad / Baghbanzadeh, Amir / Taefehshokr, Sina

    Immunobiology

    2019  Volume 225, Issue 2, Page(s) 151875

    Abstract: Immunotherapy is a promising field, which enhances and harnesses the powers of the host immune system against cancer and in recent years, has become a major application of the fundamental research of cancer immunology. Cancer immunotherapy is often more ... ...

    Abstract Immunotherapy is a promising field, which enhances and harnesses the powers of the host immune system against cancer and in recent years, has become a major application of the fundamental research of cancer immunology. Cancer immunotherapy is often more targeted than non-specific therapy approaches, including radiotherapy or chemotherapy, as the immune system can be trained to remember cancer cells, highlighting a durable approach that can be maintained after the treatment completion. Immunotherapy functions by directing the immune system to attack the tumour cells via targeting tumour antigens, also enhancing the existing anti-tumour immune responses. Current strategies include non-specific immunotherapy, cancer vaccines, oncolytic virus therapy, monoclonal antibodies, immune checkpoints and T cell therapy. The combination of effective approaches can increase the immunotherapy efficacy, leading to durable anti-tumour immune responses. This review will discuss the immunotherapy approaches, particularly immune checkpoints and T cell therapy, which are the most common clinical applications in cancer immunotherapy.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Humans ; Immunity/immunology ; Immunotherapy/methods ; Neoplasms/immunology ; Neoplasms/therapy
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2019-11-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2019.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.32: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Covid-19: Perspectives on Innate Immune Evasion

    Taefehshokr, Nima / Taefehshokr, Sina / Hemmat, Nima / Heit, Bryan

    Front Immunol

    Abstract: The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that ... ...

    Abstract The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that target multiple aspects of innate immunity, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) able to induce a cytokine storm, impair interferon responses, and suppress antigen presentation on both MHC class I and class II. Understanding the immune responses to SARS-CoV-2 and its immunoevasion approaches will improve our understanding of pathogenesis, virus clearance, and contribute toward vaccine and immunotherepeutic design and evaluation. This review discusses the known host innate immune response and immune evasion mechanisms driving SARS-CoV-2 infection and pathophysiology.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #886167
    Database COVID19

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  10. Article: Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2

    Taefehshokr, Nima / Taefehshokr, Sina / Heit, Bryan

    Pathogens. 2020 Dec. 08, v. 9, no. 12

    2020  

    Abstract: The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December 2019 in China, and has led to thousands of mortalities globally each day. While ... ...

    Abstract The current coronavirus disease 2019 (COVID-19) pandemic, a disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was first identified in December 2019 in China, and has led to thousands of mortalities globally each day. While the innate immune response serves as the first line of defense, viral clearance requires activation of adaptive immunity, which employs B and T cells to provide sanitizing immunity. SARS-CoV-2 has a potent arsenal of mechanisms used to counter this adaptive immune response through processes, such as T cells depletion and T cell exhaustion. These phenomena are most often observed in severe SARS-CoV-2 patients, pointing towards a link between T cell function and disease severity. Moreover, neutralizing antibody titers and memory B cell responses may be short lived in many SARS-CoV-2 patients, potentially exposing these patients to re-infection. In this review, we discuss our current understanding of B and T cells immune responses and activity in SARS-CoV-2 pathogenesis.
    Keywords B-lymphocytes ; Coronavirus infections ; Orthocoronavirinae ; T-lymphocytes ; cell-mediated immunity ; disease severity ; immune response ; innate immunity ; mortality ; neutralizing antibodies ; pandemic ; pathogenesis ; pathogens ; patients ; sanitizing ; viruses ; China
    Language English
    Dates of publication 2020-1208
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9121027
    Database NAL-Catalogue (AGRICOLA)

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