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  1. Article ; Online: Which trial do we need? Randomized, placebo-controlled trial of antiviral treatment in patients hospitalized for influenza.

    Hosszu-Fellous, Krisztina / Vetter, Pauline / Agoritsas, Thomas / Kaiser, Laurent

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  Volume 30, Issue 5, Page(s) 567–569

    MeSH term(s) Humans ; Influenza, Human/drug therapy ; Antiviral Agents/therapeutic use ; Hospitalization ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Placebos/administration & dosage
    Chemical Substances Antiviral Agents ; Placebos
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4541: Show issues Location:
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  2. Article ; Online: Different virus, same mistakes: Why (re-) emerging viruses are one step ahead of us.

    Vetter, Pauline / Jacquérioz, Frédérique / Eckerle, Isabella

    Innovation (Cambridge (Mass.))

    2022  Volume 3, Issue 4, Page(s) 100273

    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Editorial
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2022.100273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [No title information]

    Kaiser, Laurent / Vetter, Pauline / Calmy, Alexandra / Manuel, Oriol / Calandra, Thierry

    Revue medicale suisse

    2022  Volume 18, Issue 777, Page(s) 691–692

    Title translation Bas les masques, et après ?
    Language French
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2022.18.777.691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Different virus, same mistakes

    Pauline Vetter / Frédérique Jacquérioz / Isabella Eckerle

    The Innovation, Vol 3, Iss 4, Pp 100273- (2022)

    Why (re-) emerging viruses are one step ahead of us

    2022  

    Keywords Science (General) ; Q1-390
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Spécificités de l’infection à SARS-CoV-2 chez les patients âgés.

    Parent, Thibault / Skoula, Eirini / Vetter, Pauline / Prendki, Virginie

    Revue medicale suisse

    2022  Volume 18, Issue 777, Page(s) 702–706

    Abstract: COVID-19 has strongly impacted the elderly population with a particularly high mortality rate due to several reasons: sometimes difficult and delayed diagnosis, multimorbidity, immunosenescence, frailty, which seems to be a better prognostic marker than ... ...

    Title translation Specificities of SARS-CoV-2 infection in elderly patients.
    Abstract COVID-19 has strongly impacted the elderly population with a particularly high mortality rate due to several reasons: sometimes difficult and delayed diagnosis, multimorbidity, immunosenescence, frailty, which seems to be a better prognostic marker than age. Treatment includes both therapies specifically directed against SARS CoV-2 (monoclonal antibodies, systemic corticosteroids, tocilizumab, remdesivir) and symptomatic and palliative treatments. Vaccination, especially the booster, is essential to reduce the risk of infection and severe forms. The emergence of variants is a challenge because of their impact on vaccine and treatment efficacy. Specific studies in the elderly are needed to improve their management.
    MeSH term(s) Aged ; COVID-19 ; COVID-19 Vaccines ; Frailty ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language French
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2022.18.777.702
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  6. Article: Ebola : vaccin et traitements efficaces mais épidémie persistante.

    Vetter, Pauline / Kaiser, Laurent

    Revue medicale suisse

    2020  Volume 16, Issue 690, Page(s) 739–743

    Abstract: The Ebola virus disease outbreak raging in the North-Kivu and Ituri provinces of Democratic Republic of the Congo already accounts for more than 3400 cases, from which 2200 died. Major progress have been achieved since the 2014-2016 West Africa outbreak. ...

    Title translation Ebola : an uncontrolled outbreak despite vaccines and new treatments.
    Abstract The Ebola virus disease outbreak raging in the North-Kivu and Ituri provinces of Democratic Republic of the Congo already accounts for more than 3400 cases, from which 2200 died. Major progress have been achieved since the 2014-2016 West Africa outbreak. A vaccine is now approved by the European Medicine Agency and has been administered to more than 250 000 volunteers in the field. New specific antiviral treatments are now available. Ebola virus disease shifted from a deadly disease to a preventable, curable one. However, the long-lasting conflict and repeated attacks of civilians and health workers hampers the control of the outbreak.
    MeSH term(s) Africa, Western/epidemiology ; Antiviral Agents/supply & distribution ; Antiviral Agents/therapeutic use ; Democratic Republic of the Congo/epidemiology ; Disease Outbreaks/statistics & numerical data ; Ebola Vaccines/administration & dosage ; Ebola Vaccines/supply & distribution ; Ebolavirus/drug effects ; Ebolavirus/immunology ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Humans
    Chemical Substances Antiviral Agents ; Ebola Vaccines
    Language French
    Publishing date 2020-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Identification of a measles variant displaying mutations impacting molecular diagnostics, Geneva, Switzerland, 2023.

    Pérez-Rodríguez, Francisco-Javier / Cherpillod, Pascal / Thomasson, Valentine / Vetter, Pauline / Schibler, Manuel

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2023  Volume 29, Issue 5

    Abstract: Real-time PCR is one of the most widely used techniques to diagnose measles cases. Here we report measles virus variants with three genetic mutations in the reverse primer annealing site of a widely used PCR. The mutations result in a slight loss of the ... ...

    Abstract Real-time PCR is one of the most widely used techniques to diagnose measles cases. Here we report measles virus variants with three genetic mutations in the reverse primer annealing site of a widely used PCR. The mutations result in a slight loss of the PCR sensitivity. Variants bearing the three mutations presently circulate in different countries since at least the end of 2021. Our findings highlight the usefulness of molecular surveillance in monitoring if oligonucleotides in diagnostic tests remain adequate.
    MeSH term(s) Humans ; Switzerland ; Pathology, Molecular ; RNA, Viral/genetics ; Measles/diagnosis ; Measles/epidemiology ; Measles virus/genetics ; Mutation ; Sensitivity and Specificity ; Reverse Transcriptase Polymerase Chain Reaction
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-10-27
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2024.29.5.2400034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5066: Show issues Location:
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  8. Article: Traitement du SARS-CoV-2 en pédiatrie : quelles évidences et quelle utilité ?

    Fougère, Yves / Rohr, Marie / Vetter, Pauline / Wagner, Noémie

    Revue medicale suisse

    2021  Volume 17, Issue 726, Page(s) 344–348

    Abstract: Although SARS-CoV-2 infects individuals of all ages, children show less severe symptoms. Nevertheless, the very rare COVID-19 severe cases in paediatrics require our full attention. Much research has been conducted and is still ongoing on effective ... ...

    Title translation Treatment of SARS-CoV-2 in paediatrics : what is the evidence to date?
    Abstract Although SARS-CoV-2 infects individuals of all ages, children show less severe symptoms. Nevertheless, the very rare COVID-19 severe cases in paediatrics require our full attention. Much research has been conducted and is still ongoing on effective treatments. On the antiviral front, no molecule has been proven effective yet and the results of several studies on the benefit of monoclonal antibodies and convalescent plasma are pending. On the side of immunomodulators, the benefit of steroids has been demonstrated for patients severely ill. Other molecules are being investigated. However, all these studies focused on adults and paediatric data are warranted.
    MeSH term(s) Adult ; COVID-19/therapy ; Child ; Coronavirus Infections ; Humans ; Immunization, Passive ; Pediatrics ; SARS-CoV-2
    Language French
    Publishing date 2021-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
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  9. Article ; Online: Prevalence of Post-Coronavirus Disease Condition 12 Weeks After Omicron Infection Compared With Negative Controls and Association With Vaccination Status.

    Nehme, Mayssam / Vetter, Pauline / Chappuis, François / Kaiser, Laurent / Guessous, Idris

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 9, Page(s) 1567–1575

    Abstract: Background: Post-coronovirus disease (COVID) symptoms can persist several months after severe acute respiratory syndrome coronavirus 2 infection. Little is known, however, about the prevalence of post-COVID condition following infections from Omicron ... ...

    Abstract Background: Post-coronovirus disease (COVID) symptoms can persist several months after severe acute respiratory syndrome coronavirus 2 infection. Little is known, however, about the prevalence of post-COVID condition following infections from Omicron variants and how this varies according to vaccination status. This study evaluates the prevalence of symptoms and functional impairment 12 weeks after an infection by Omicron variants (BA.1 and BA.2) compared with negative controls tested during the same period.
    Methods: Outpatient individuals who tested positive or negative for COVID-19 infection between December 2021 and February 2022 at the Geneva University Hospitals were followed 12 weeks after their test date.
    Results: Overall, 11.7% of Omicron cases had symptoms 12 weeks after the infection compared with 10.4% of individuals who tested negative during the same period (P < .001), and symptoms were much less common in vaccinated versus nonvaccinated individuals with Omicron infection (9.7% vs 18.1%; P < .001). There were no significant differences in functional impairment at 12 weeks between Omicron cases and negative controls, even after adjusting for multiple potential confounders.
    Conclusions: The differential prevalence of post-COVID symptoms and functional impairment attributed to Omicron BA.1 and BA.2 infection is low when compared with negative controls. Vaccination is associated with lower prevalence of post-COVID symptoms.
    MeSH term(s) Humans ; Prevalence ; COVID-19/epidemiology ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  10. Article ; Online: Covid-19: a puzzle with many missing pieces.

    Vetter, Pauline / Eckerle, Isabella / Kaiser, Laurent

    BMJ (Clinical research ed.)

    2020  Volume 368, Page(s) m627

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections ; Humans ; Pneumonia, Viral ; Retrospective Studies ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-02-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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