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  1. Article ; Online: Sure Start children's centres did so much more than prevent paediatric admissions.

    Simons, Gemma N

    BMJ (Clinical research ed.)

    2021  Volume 374, Page(s) n2303

    MeSH term(s) Child ; Child Health Services ; Hospitalization ; Humans
    Language English
    Publishing date 2021-09-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n2303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What medical students think about measurement of their well-being

    Gemma Simons / David S Baldwin / Raymond Effah

    BMJ Open, Vol 12, Iss

    cross-sectional survey and qualitative interviews

    2022  Volume 4

    Keywords Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A critical review of the definition of 'wellbeing' for doctors and their patients in a post Covid-19 era.

    Simons, Gemma / Baldwin, David S

    The International journal of social psychiatry

    2021  Volume 67, Issue 8, Page(s) 984–991

    Abstract: Background: There is no international consensus definition of 'wellbeing'. This has led to wellbeing being captured in many different ways.: Aims: To construct an inclusive, global operational definition of wellbeing.: Methods: The differences ... ...

    Abstract Background: There is no international consensus definition of 'wellbeing'. This has led to wellbeing being captured in many different ways.
    Aims: To construct an inclusive, global operational definition of wellbeing.
    Methods: The differences between wellbeing components and determinants and the terms used interchangeably with wellbeing, such as health, are considered from the perspective of a doctor. The philosophies underpinning wellbeing and modern wellbeing research theories are discussed in terms of their appropriateness in an inclusive definition.
    Results: An operational definition is proposed that is not limited to doctors, but universal, and inclusive: 'Wellbeing is a state of positive feelings and meeting full potential in the world. It can be measured subjectively and objectively, using a salutogenic approach'.
    Conclusions: This operational definition allows the differentiation of wellbeing from terms such as quality of life and emphasises that in the face of global challenges people should still consider wellbeing as more than the absence of pathology.
    MeSH term(s) COVID-19 ; Humans ; Physicians ; Quality of Life ; SARS-CoV-2
    Language English
    Publishing date 2021-07-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3062-4
    ISSN 1741-2854 ; 0020-7640
    ISSN (online) 1741-2854
    ISSN 0020-7640
    DOI 10.1177/00207640211032259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Covid-19: doctors must take control of their wellbeing.

    Simons, Gemma / Baldwin, David S

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m1725

    MeSH term(s) Burnout, Professional ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Occupational Health ; Pandemics ; Personal Protective Equipment ; Physicians ; Pneumonia, Viral/epidemiology ; Strikes, Employee
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: What medical students think about measurement of their well-being: cross-sectional survey and qualitative interviews.

    Simons, Gemma / Effah, Raymond / Baldwin, David S

    BMJ open

    2022  Volume 12, Issue 4, Page(s) e056749

    Abstract: Objectives: To find out how medical students think well-being should be measured.: Design: A mixed-methods study comprising a cross-sectional online survey (November 2020-March 2021) and semi-structured online interviews. Views on the frequency of ... ...

    Abstract Objectives: To find out how medical students think well-being should be measured.
    Design: A mixed-methods study comprising a cross-sectional online survey (November 2020-March 2021) and semi-structured online interviews. Views on the frequency of availability for measurement, the format, type and purpose of measurement, and with whom well-being should be discussed were measured. When an outcome was scored 7-9 on a 9-point Likert scale of agreement by ≥75% of participants it was considered critical. Inductive thematic analysis was undertaken on the interview transcripts.
    Setting: All medicine programmes at University of Southampton.
    Participants: Medical students from all years took part in the survey (n=118) and interviews (n=16).
    Results: Most participants (94%) felt able to give 5 min to measure their well-being at least once per month. Research, governance and individual feedback were all considered critically important. Only subjective assessments undertaken by the individual in real-time were rated critically important (78.1%) measurement tools. Students selected that they would discuss their well-being with other medical students (n=87) nearly as often as they selected a member of the faculty (n=104). Five interview themes further explained these findings: (1) well-being is mental well-being; (2) exercise and support from friends and family are most important; (3) isolation and the design of the medicine programme are detrimental to well-being; (4) there are advantages to surveys, and conversations; (5) personal academic tutors and medical students in later years are the best to discuss well-being with.
    Conclusions: Medical students thought that measurement of their well-being was critically important for governance showing their support for quality assurance of well-being and peer support. They wanted to be able to choose surveys, or conversations, to measure their well-being, as well as the person they discussed well-being with. Four recommendations are discussed in light of these findings.
    MeSH term(s) Cross-Sectional Studies ; Education, Medical, Undergraduate/methods ; Humans ; Students, Medical ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-056749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Covid-19

    Simons, Gemma / Baldwin, David S

    doctors must take control of their wellbeing

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-05-01 07:27:19.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Covid-19

    Simons, Gemma / Baldwin, David S

    BMJ

    doctors must take control of their wellbeing

    2020  , Page(s) m1725

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1725
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: The definition of treatment resistance in anxiety disorders: a Delphi method-based consensus guideline.

    Domschke, Katharina / Seuling, Patrik D / Schiele, Miriam A / Bandelow, Borwin / Batelaan, Neeltje M / Bokma, Wicher A / Branchi, Igor / Broich, Karl / Burkauskas, Julius / Davies, Simon J C / Dell'Osso, Bernardo / Fagan, Harry / Fineberg, Naomi A / Furukawa, Toshi A / Hofmann, Stefan G / Hood, Sean / Huneke, Nathan T M / Latas, Milan / Lidbetter, Nicky /
    Masdrakis, Vasilios / McAllister-Williams, R Hamish / Nardi, Antonio E / Pallanti, Stefano / Penninx, Brenda W J H / Perna, Giampaolo / Pilling, Steve / Pini, Stefano / Reif, Andreas / Seedat, Soraya / Simons, Gemma / Srivastava, Shrikant / Steibliene, Vesta / Stein, Dan J / Stein, Murray B / van Ameringen, Michael / van Balkom, Anton J L M / van der Wee, Nic / Zwanzger, Peter / Baldwin, David S

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2024  Volume 23, Issue 1, Page(s) 113–123

    Abstract: Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition of treatment- ... ...

    Abstract Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition of treatment-resistant anxiety disorders (TR-AD) informing such trials is currently lacking. We used a Delphi method-based consensus approach to provide internationally agreed, consistent and clinically useful operational criteria for TR-AD in adults. Following a summary of the current state of knowledge based on international guidelines and an available systematic review, a survey of free-text responses to a 29-item questionnaire on relevant aspects of TR-AD, and an online consensus meeting, a panel of 36 multidisciplinary international experts and stakeholders voted anonymously on written statements in three survey rounds. Consensus was defined as ≥75% of the panel agreeing with a statement. The panel agreed on a set of 14 recommendations for the definition of TR-AD, providing detailed operational criteria for resistance to pharmacological and/or psychotherapeutic treatment, as well as a potential staging model. The panel also evaluated further aspects regarding epidemiological subgroups, comorbidities and biographical factors, the terminology of TR-AD vs. "difficult-to-treat" anxiety disorders, preferences and attitudes of persons with these disorders, and future research directions. This Delphi method-based consensus on operational criteria for TR-AD is expected to serve as a systematic, consistent and practical clinical guideline to aid in designing future mechanistic studies and facilitate clinical trials for regulatory purposes. This effort could ultimately lead to the development of more effective evidence-based stepped-care treatment algorithms for patients with anxiety disorders.
    Language English
    Publishing date 2024-01-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.21177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genetic Screening for

    Solanich, Xavier / Vargas-Parra, Gardenia / van der Made, Caspar I / Simons, Annet / Schuurs-Hoeijmakers, Janneke / Antolí, Arnau / Del Valle, Jesús / Rocamora-Blanch, Gemma / Setién, Fernando / Esteller, Manel / van Reijmersdal, Simon V / Riera-Mestre, Antoni / Sabater-Riera, Joan / Capellá, Gabriel / van de Veerdonk, Frank L / van der Hoven, Ben / Corbella, Xavier / Hoischen, Alexander / Lázaro, Conxi

    Frontiers in immunology

    2021  Volume 12, Page(s) 719115

    Abstract: Introduction: Loss-of-function : Methods: We prospectively studied males between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen to treat COVID-19. The coding region of : Results: TLR7: ... ...

    Abstract Introduction: Loss-of-function
    Methods: We prospectively studied males between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen to treat COVID-19. The coding region of
    Results: TLR7
    Conclusions: This study supports a rationale for the genetic screening for
    MeSH term(s) Adult ; Amino Acid Substitution ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/pathology ; Genetic Testing ; Humans ; Male ; Middle Aged ; Mutation, Missense ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/immunology
    Chemical Substances TLR7 protein, human ; Toll-Like Receptor 7
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.719115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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