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  1. Article ; Online: Immiscible hydrous Fe-Ca-P melt and the origin of iron oxide-apatite ore deposits.

    Hou, Tong / Charlier, Bernard / Holtz, François / Veksler, Ilya / Zhang, Zhaochong / Thomas, Rainer / Namur, Olivier

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 1415

    Abstract: ... separation of an iron-rich melt has been invoked, but Fe-Ca-P-rich and Si-poor melts similar in composition ...

    Abstract The origin of iron oxide-apatite deposits is controversial. Silicate liquid immiscibility and separation of an iron-rich melt has been invoked, but Fe-Ca-P-rich and Si-poor melts similar in composition to the ore have never been observed in natural or synthetic magmatic systems. Here we report experiments on intermediate magmas that develop liquid immiscibility at 100 MPa, 1000-1040 °C, and oxygen fugacity conditions (fO
    Language English
    Publishing date 2018-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-03761-4
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  2. Article: Teaching medicine after Covid-19: the place of museums in the biomedical university curriculum.

    Charlier, P

    Ethics, medicine, and public health

    2023  , Page(s) 100920

    Language English
    Publishing date 2023-06-09
    Publishing country France
    Document type Editorial
    ISSN 2352-5525
    ISSN 2352-5525
    DOI 10.1016/j.jemep.2023.100920
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  3. Article ; Online: Death and end of life in France after COVID-19.

    Charlier, Philippe

    Lancet (London, England)

    2023  Volume 402, Issue 10419, Page(s) 2290

    MeSH term(s) Humans ; COVID-19 ; France/epidemiology ; Terminal Care ; Death
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02557-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immiscible hydrous Fe–Ca–P melt and the origin of iron oxide-apatite ore deposits

    Hou, T. / Charlier, B. / Holtz, F. / Veksler, I. / Zhang, Z. / Thomas, R. / Namur, O.

    Nature Communications

    2018  

    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Immiscible hydrous Fe–Ca–P melt and the origin of iron oxide-apatite ore deposits

    Tong Hou / Bernard Charlier / François Holtz / Ilya Veksler / Zhaochong Zhang / Rainer Thomas / Olivier Namur

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: ... field thus allowing the Fe–Ca–P melt to separate easily from host silicic magma and produce iron oxide ...

    Abstract The origin of iron oxide-apatite deposits remains enigmatic and controversial. Here, the authors perform experiments on intermediate magmas and show that increasing aH2O and fO2 enlarges the two-liquid field thus allowing the Fe–Ca–P melt to separate easily from host silicic magma and produce iron oxide-apatite ores.
    Keywords Science ; Q
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Immiscible hydrous Fe–Ca–P melt and the origin of iron oxide-apatite ore deposits

    Tong Hou / Bernard Charlier / François Holtz / Ilya Veksler / Zhaochong Zhang / Rainer Thomas / Olivier Namur

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: ... field thus allowing the Fe–Ca–P melt to separate easily from host silicic magma and produce iron oxide ...

    Abstract The origin of iron oxide-apatite deposits remains enigmatic and controversial. Here, the authors perform experiments on intermediate magmas and show that increasing aH2O and fO2 enlarges the two-liquid field thus allowing the Fe–Ca–P melt to separate easily from host silicic magma and produce iron oxide-apatite ores.
    Keywords Science ; Q
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: The consequences of Covid-19 in terms of public health for the year 2022: New challenges.

    Charlier, P

    Ethics, medicine, and public health

    2022  Volume 21, Page(s) 100757

    Language English
    Publishing date 2022-01-10
    Publishing country France
    Document type Editorial
    ISSN 2352-5525
    ISSN 2352-5525
    DOI 10.1016/j.jemep.2022.100757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recombinant P-selectin glycoprotein ligand-immunoglobulin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction. The P-Selectin Antagonist Limiting Myonecrosis (PSALM) trial.

    Mertens, Paul / Maes, Alex / Nuyts, Johan / Belmans, Ann / Desmet, Walter / Esplugas, Enric / Charlier, Filip / Figueras, Jaime / Sambuceti, Gianmario / Schwaiger, Markus / Mortelmans, Luc / Van de Werf, Frans

    American heart journal

    2006  Volume 152, Issue 1, Page(s) 125.e1–8

    Abstract: ... selectins, initiate those inflammatory changes at the endothelial wall surface. Recombinant P-selectin ... glycoprotein ligand-immunoglobulin (rPSGL-Ig), a P-selectin antagonist, was shown to have beneficial effects ... in the placebo group vs 3.8% in the 75-mg dose and 4.3% in the 150-mg rPSGL-Ig treatment group; P = not ...

    Abstract Background: Inflammatory responses induced by reperfusion of previously ischemic myocardial tissue may lead to further damage of the microvascular structures. A group of cell adhesion molecules, named selectins, initiate those inflammatory changes at the endothelial wall surface. Recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig), a P-selectin antagonist, was shown to have beneficial effects in several animal models of acute myocardial ischemia. We performed a mechanistic study with positron emission tomography to test the potential benefits of rPSGL-Ig in patients with ST-segment elevation acute myocardial infarction.
    Methods: Patients with ST-elevation acute myocardial infarction presenting within the first 6 hours of onset of chest pain were enrolled. All patients received alteplase. Patients were randomly assigned in a 1:1:1 ratio to 3 treatment groups: placebo; 75 mg rPSGL-Ig; 150 mg rPSGL-Ig, given intravenously. Coronary angiography was performed 90 minutes after the start of thrombolytic therapy for TIMI flow grading. Myocardial blood flow (MBF) was measured with 13NH3 at rest and after adenosine administration on day 5. Myocardial blood flow at rest was measured again at day 30, followed by measurement of 18FDG uptake. In addition, a multigated acquisition, gated equilibrium blood pool study was performed at day 30. Continuous 12-lead electrocardiogram recording was performed during the first 24 hours.
    Results: The trial was prematurely stopped by the sponsor for lack of efficacy in an accompanying larger trial after enrolling 88 patients in the current study. Median MBF in the infarct-related territory (expressed as percentage of the normalized blood flow) at day 5 was similar in the 3 treatment groups (9.1% in the placebo group vs 3.8% in the 75-mg dose and 4.3% in the 150-mg rPSGL-Ig treatment group; P = not significant). No significant differences in MBF reserve, myocardial metabolism, ST-segment resolution, left ventricular ejection fraction, or TIMI flow grade were found among the 3 groups.
    Conclusions: In this prematurely stopped mechanistic study, there was no evidence of a benefit of rPSGL-Ig given as an adjunct to thrombolysis on epicardial vessel patency, myocardial tissue reperfusion, or recovery of function.
    MeSH term(s) Adolescent ; Adult ; Aged ; Coronary Angiography ; Coronary Vessels/physiology ; Drug Therapy, Combination ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Male ; Membrane Glycoproteins/administration & dosage ; Membrane Glycoproteins/therapeutic use ; Middle Aged ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/drug therapy ; Myocardial Infarction/physiopathology ; Positron-Emission Tomography ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/therapeutic use ; Regional Blood Flow ; Stroke Volume ; Thrombolytic Therapy ; Tissue Plasminogen Activator/therapeutic use ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Fibrinolytic Agents ; Membrane Glycoproteins ; P-selectin ligand protein ; Recombinant Proteins ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2006-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2006.04.020
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  9. Article ; Online: Determinants of serum concentrations of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls among French women in the CECILE study.

    Bachelet, Delphine / Truong, Thérèse / Verner, Marc-André / Arveux, Patrick / Kerbrat, Pierre / Charlier, Corinne / Guihenneuc-Jouyaux, Chantal / Guénel, Pascal

    Environmental research

    2011  Volume 111, Issue 6, Page(s) 861–870

    Abstract: ... place of residence.: Objectives: To assess the current serum concentrations of 1,1-dichloro-2,2-bis(p ... chlorophenyl)ethylene (p,p'-DDE), the main DDT breakdown product, and of PCBs in women from two French ... We measured serum p,p'-DDE and PCB levels in 1055 general population women who were recruited in 2005-2007 ...

    Abstract Background: Dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCBs) are persistent organochlorine compounds bioaccumulating in human tissues. Body burden of organochlorines may be influenced by individual characteristics such as age, weight variations, breastfeeding, dietary habits and place of residence.
    Objectives: To assess the current serum concentrations of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), the main DDT breakdown product, and of PCBs in women from two French administrative areas (Ille-et-Vilaine and Côte d'Or). To identify determinants of the current serum levels among individual characteristics related to intake, metabolism, and excretion of organochlorines.
    Methods: We measured serum p,p'-DDE and PCB levels in 1055 general population women who were recruited in 2005-2007 to serve as controls in a case-control study on breast cancer. Associations between organochlorine levels and age, current body mass index (BMI), BMI change during the last 10 years, dietary habits, breastfeeding history, residence area and education were assessed in multivariate analyses.
    Results: Median concentrations of p,p'-DDE and total PCBs were 85 and 240ng/g lipid, respectively. Based on multivariate analyses, the main predictors of high p,p'-DDE levels included age and frequent consumption of saltwater fish in women below 50 years, and high BMI in older women. Total PCB levels increased markedly with age. Among older women, other important predictors of high PCB levels included frequent consumption of saltwater fish and low BMI. Our results are also suggestive of an inverse association between PCB levels and BMI gain during the last ten years. Women in Côte d'Or had significantly higher PCB levels than women in Ille-et-Vilaine.
    Conclusion: The patterns of associations between determinants and serum organochlorine concentrations suggest that human PCB contamination is still ongoing in France. The most important predictors of serum p,p'-DDE and PCB concentrations among French women include age, body mass index, dietary habits, and place of residence.
    MeSH term(s) Adult ; Age Factors ; Aged ; Animals ; Body Mass Index ; Dichlorodiphenyl Dichloroethylene/analogs & derivatives ; Dichlorodiphenyl Dichloroethylene/blood ; Environmental Pollutants/blood ; Female ; Fishes ; France/epidemiology ; Humans ; Middle Aged ; Polychlorinated Biphenyls/blood ; Seafood
    Chemical Substances Environmental Pollutants ; Dichlorodiphenyl Dichloroethylene (4M7FS82U08) ; Polychlorinated Biphenyls (DFC2HB4I0K)
    Language English
    Publishing date 2011-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2011.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Forensic identification by Chateaubriand?

    Charlier, P / Jacquot Barreau, S

    British dental journal

    2024  Volume 236, Issue 1, Page(s) 11–12

    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-024-6725-0
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