LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 202

Search options

  1. Article: A "two-hit" (chemo)therapy to improve checkpoint inhibition in cancer.

    Falvo, Paolo / Orecchioni, Stefania / Raveane, Alessandro / Mitola, Giulia / Bertolini, Francesco

    Oncoscience

    2021  Volume 8, Page(s) 55–57

    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Journal Article
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.533
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: The Dual Role of Innate Lymphoid and Natural Killer Cells in Cancer. from Phenotype to Single-Cell Transcriptomics, Functions and Clinical Uses.

    Roma, Stefania / Carpen, Laura / Raveane, Alessandro / Bertolini, Francesco

    Cancers

    2021  Volume 13, Issue 20

    Abstract: The role of innate lymphoid cells (ILCs), including natural killer (NK) cells, is pivotal in inflammatory modulation and cancer. Natural killer cell activity and count have been demonstrated to be regulated by the expression of activating and inhibitory ... ...

    Abstract The role of innate lymphoid cells (ILCs), including natural killer (NK) cells, is pivotal in inflammatory modulation and cancer. Natural killer cell activity and count have been demonstrated to be regulated by the expression of activating and inhibitory receptors together with and as a consequence of different stimuli. The great majority of NK cell populations have an anti-tumor activity due to their cytotoxicity, and for this reason have been used for cellular therapies in cancer patients. On the other hand, the recently classified helper ILCs are fundamentally involved in inflammation and they can be either helpful or harmful in cancer development and progression. Tissue niche seems to play an important role in modulating ILC function and conversion, as observed at the transcriptional level. In the past, these cell populations have been classified by the presence of specific cellular receptor markers; more recently, due to the advent of single-cell RNA sequencing (scRNA-seq), it has been possible to also explore them at the transcriptomic level. In this article we review studies on ILC (and NK cell) classification, function and their involvement in cancer. We also summarize the potential application of NK cells in cancer therapy and give an overview of the most recent studies involving ILCs and NKs at scRNA-seq, focusing on cancer. Finally, we provide a resource for those who wish to start single-cell transcriptomic analysis on the context of these innate lymphoid cell populations.
    Language English
    Publishing date 2021-10-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13205042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Serotonin-Derived Fluorophore: A Novel Fluorescent Biomaterial for Copper Detection in Urine.

    Lettieri, Mariagrazia / Scarano, Simona / Caponi, Laura / Bertolini, Andrea / Saba, Alessandro / Palladino, Pasquale / Minunni, Maria

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: We took advantage of the fluorescent features of a serotonin-derived fluorophore to develop a simple and low-cost assay for copper in urine. The quenching-based fluorescence assay linearly responds within the concentration range of clinical interest in ... ...

    Abstract We took advantage of the fluorescent features of a serotonin-derived fluorophore to develop a simple and low-cost assay for copper in urine. The quenching-based fluorescence assay linearly responds within the concentration range of clinical interest in buffer and in artificial urine, showing very good reproducibility (CV
    MeSH term(s) Humans ; Copper/chemistry ; Serotonin ; Reproducibility of Results ; Fluorescent Dyes/chemistry ; Mass Spectrometry ; Spectrometry, Fluorescence/methods ; Limit of Detection
    Chemical Substances Copper (789U1901C5) ; Serotonin (333DO1RDJY) ; Fluorescent Dyes
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23063030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Biocatalyzed Synthesis of Flavor Esters and Polyesters: A Design of Experiments (DoE) Approach.

    Fabbri, Filippo / Bertolini, Federico A / Guebitz, Georg M / Pellis, Alessandro

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software ... ...

    Abstract In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software MODDE
    MeSH term(s) Biocatalysis ; Candida/enzymology ; Carboxylic Ester Hydrolases/chemistry ; Enzymes, Immobilized/chemistry ; Esters/chemical synthesis ; Flavoring Agents/chemical synthesis ; Fungal Genus Humicola/enzymology ; Fungal Proteins/chemistry ; Lipase/chemistry ; Polyesters/chemical synthesis ; Polymerization ; Thermobifida/enzymology
    Chemical Substances Enzymes, Immobilized ; Esters ; Flavoring Agents ; Fungal Proteins ; Polyesters ; Carboxylic Ester Hydrolases (EC 3.1.1.-) ; cutinase (EC 3.1.1.-) ; Lipase (EC 3.1.1.3) ; lipase B, Candida antarctica (EC 3.1.1.3)
    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168493
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Tas-102 for Refractory Metastatic Colorectal Cancer: A Multicenter Retrospective Cohort Study.

    Conti, Matteo / Bolzacchini, Elena / Luchena, Giovanna / Bertu', Lorenza / Tagliabue, Paola / Aglione, Stefania / Ardizzoia, Antonio / Arnoffi, Jessica / Guida, Francesco Maria / Bertolini, Alessandro / Pastorini, Alessandro / Duro, Maria / Bettega, Donato / Roda', Giovambattista / Artale, Salvatore / Squizzato, Alessandro / Giordano, Monica

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Trifluridine/tipiracil (TAS-102) is an oral chemotherapy approved for the treatment of metastatic colorectal cancer. The efficacy and tolerability of TAS-102 were shown in phase II-III clinical trials and in several real-life studies. The elderly and ... ...

    Abstract Trifluridine/tipiracil (TAS-102) is an oral chemotherapy approved for the treatment of metastatic colorectal cancer. The efficacy and tolerability of TAS-102 were shown in phase II-III clinical trials and in several real-life studies. The elderly and other special subgroups are underrepresented in published literature. We conducted a retrospective multicenter study to assess the effectiveness and safety of TAS-102 in consecutive patients with pretreated mCRC. In particular, we estimated the effectiveness and safety of TAS-102 in elderly patients (aged ≥70, ≥75 and ≥80 years) and in special subgroups, e.g., patients with concomitant heart disease. One hundred and sixty patients were enrolled. In particular, 71 patients (44%) were 70 years of age or older, 50 (31%) were 75 years of age or older, and 23 (14%) were 80 years of age or older. 19 patients (12%) had a concomitant chronic heart disease, three (2%) patients were HIV positive, and one (<1%) patient had a
    Language English
    Publishing date 2023-07-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133465
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection.

    Ferrigno, Ilaria / Verzellesi, Laura / Ottone, Marta / Bonacini, Martina / Rossi, Alessandro / Besutti, Giulia / Bonelli, Efrem / Colla, Rossana / Facciolongo, Nicola / Teopompi, Elisabetta / Massari, Marco / Mancuso, Pamela / Ferrari, Anna Maria / Pattacini, Pierpaolo / Trojani, Valeria / Bertolini, Marco / Botti, Andrea / Zerbini, Alessandro / Giorgi Rossi, Paolo /
    Iori, Mauro / Salvarani, Carlo / Croci, Stefania

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2024  Volume 73, Issue 4, Page(s) 515–530

    Abstract: Objective and design: We aimed to identify cytokines whose concentrations are related to lung damage, radiomic features, and clinical outcomes in COVID-19 patients.: Material or subjects: Two hundred twenty-six patients with SARS-CoV-2 infection and ... ...

    Abstract Objective and design: We aimed to identify cytokines whose concentrations are related to lung damage, radiomic features, and clinical outcomes in COVID-19 patients.
    Material or subjects: Two hundred twenty-six patients with SARS-CoV-2 infection and chest computed tomography (CT) images were enrolled.
    Methods: CCL18, CHI3L1/YKL-40, GAL3, ANG2, IP-10, IL-10, TNFα, IL-6, soluble gp130, soluble IL-6R were quantified in plasma samples using Luminex assays. The Mann-Whitney U test, the Kruskal-Wallis test, correlation and regression analyses were performed. Mediation analyses were used to investigate the possible causal relationships between cytokines, lung damage, and outcomes. AVIEW lung cancer screening software, pyradiomics, and XGBoost classifier were used for radiomic feature analyses.
    Results: CCL18, CHI3L1, and ANG2 systemic levels mainly reflected the extent of lung injury. Increased levels of every cytokine, but particularly of IL-6, were associated with the three outcomes: hospitalization, mechanical ventilation, and death. Soluble IL-6R showed a slight protective effect on death. The effect of age on COVID-19 outcomes was partially mediated by cytokine levels, while CT scores considerably mediated the effect of cytokine levels on outcomes. Radiomic-feature-based models confirmed the association between lung imaging characteristics and CCL18 and CHI3L1.
    Conclusion: Data suggest a causal link between cytokines (risk factor), lung damage (mediator), and COVID-19 outcomes.
    MeSH term(s) Humans ; COVID-19 ; Interleukin-6 ; SARS-CoV-2 ; Chitinase-3-Like Protein 1 ; Early Detection of Cancer ; Radiomics ; Lung Neoplasms ; Lung/diagnostic imaging ; Cytokines ; Chemokines, CC
    Chemical Substances Interleukin-6 ; Chitinase-3-Like Protein 1 ; Cytokines ; CHI3L1 protein, human ; CCL18 protein, human ; Chemokines, CC
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-024-01852-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Covid19: Could other alternatives have been possible?

    Bertolini, Alessandro / Maiolani, Martina / Menatti, Elisabetta / Barbonetti, Claudio / Stiglich, Francesco / Valenti, Donato / Fregoni, Vittorio

    Journal of global antimicrobial resistance

    2020  Volume 22, Page(s) 45–46

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2020.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Gas Damping in Capacitive MEMS Transducers in the Free Molecular Flow Regime.

    Boom, Boris A / Bertolini, Alessandro / Hennes, Eric / van den Brand, Johannes F J

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 7

    Abstract: We present a novel analysis of gas damping in capacitive MEMS transducers that is based on a simple analytical model, assisted by Monte-Carlo simulations performed in Molflow+ to obtain an estimate for the geometry dependent gas diffusion time. This ... ...

    Abstract We present a novel analysis of gas damping in capacitive MEMS transducers that is based on a simple analytical model, assisted by Monte-Carlo simulations performed in Molflow+ to obtain an estimate for the geometry dependent gas diffusion time. This combination provides results with minimal computational expense and through freely available software, as well as insight into how the gas damping depends on the transducer geometry in the molecular flow regime. The results can be used to predict damping for arbitrary gas mixtures. The analysis was verified by experimental results for both air and helium atmospheres and matches these data to within 15% over a wide range of pressures.
    Language English
    Publishing date 2021-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21072566
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Drug Repurposing in Oncology, an Attractive Opportunity for Novel Combinatorial Regimens.

    Falvo, Paolo / Orecchioni, Stefania / Roma, Stefania / Raveane, Alessandro / Bertolini, Francesco

    Current medicinal chemistry

    2020  Volume 28, Issue 11, Page(s) 2114–2136

    Abstract: The costs of developing, validating and buying new drugs are dramatically increasing. On the other hand, sobering economies have difficulties in sustaining their healthcare systems, particularly in countries with an elderly population requiring ... ...

    Abstract The costs of developing, validating and buying new drugs are dramatically increasing. On the other hand, sobering economies have difficulties in sustaining their healthcare systems, particularly in countries with an elderly population requiring increasing welfare. This conundrum requires immediate action, and a possible option is to study the large, already present arsenal of drugs approved and to use them for innovative therapies. This possibility is particularly interesting in oncology, where the complexity of the cancer genome dictates in most patients a multistep therapeutic approach. In this review, we discuss a) Computational approaches; b) preclinical models; c) currently ongoing or already published clinical trials in the drug repurposing field in oncology; and d) drug repurposing to overcome resistance to previous therapies.
    MeSH term(s) Aged ; Drug Repositioning ; Humans ; Neoplasms/drug therapy
    Language English
    Publishing date 2020-10-27
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867327999200817104912
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid.

    Cuffaro, Doretta / Pinto, Diana / Silva, Ana Margarida / Bertolini, Andrea / Bertini, Simone / Saba, Alessandro / Macchia, Marco / Rodrigues, Francisca / Digiacomo, Maria

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 13

    Abstract: 1) Background: In recent years, numerous studies have highlighted the beneficial effects of extra virgin olive oil (EVOO) as an active ingredient against chronic diseases. The properties of EVOO are due to its peculiar composition, mainly to its rich ... ...

    Abstract (1) Background: In recent years, numerous studies have highlighted the beneficial effects of extra virgin olive oil (EVOO) as an active ingredient against chronic diseases. The properties of EVOO are due to its peculiar composition, mainly to its rich content of polyphenols. In fact, polyphenols may contribute to counteract oxidative stress, which often accompanies chronic diseases. In this work, the antioxidant effects of high-value polyphenol oleocanthal (OC) and its main metabolites, tyrosol (Tyr) and oleocanthalic acid (OA), respectively, have been investigated along with their impact on cell viability. (2) Methods: OC, Tyr, and OA have been evaluated regarding antiradical properties in term of scavenging capacity towards biologically relevant reactive species, including O
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Caco-2 Cells ; Polyphenols/pharmacology ; Olive Oil
    Chemical Substances Antioxidants ; oleocanthal (AC7QO6038O) ; 4-hydroxyphenylethanol (1AK4MU3SNX) ; Polyphenols ; Olive Oil
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28135150
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top