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Article ; Online: Generation of Orthotopic and Subcutaneous Patient-Derived Xenograft Models from Diverse Clinical Tissue Samples of Pediatric Extracranial Solid Tumors.

Hanssen, Kimberley M / Fletcher, Jamie I / Kamili, Alvin

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2806, Page(s) 55–74

Abstract: Realistic and renewable laboratory models that accurately reflect the distinct clinical features of childhood cancers have enormous potential to speed research progress. These models help us to understand disease biology, develop new research methods, ... ...

Abstract	Realistic and renewable laboratory models that accurately reflect the distinct clinical features of childhood cancers have enormous potential to speed research progress. These models help us to understand disease biology, develop new research methods, advance new therapies to clinical trial, and implement personalized medicine. This chapter describes methods to generate patient-derived xenograft models of neuroblastoma and rhabdomyosarcoma, two tumor types for which children with high-risk disease have abysmal survival outcomes and survivors have lifelong-debilitating effects from treatment. Further, this protocol addresses model development from diverse clinical tumor tissue samples, subcutaneous and orthotopic engraftment, and approaches to avoid model loss.
MeSH term(s)	Humans ; Animals ; Mice ; Neuroblastoma/pathology ; Neuroblastoma/genetics ; Rhabdomyosarcoma/pathology ; Xenograft Model Antitumor Assays/methods ; Child ; Disease Models, Animal ; Heterografts ; Precision Medicine/methods ; Cell Line, Tumor
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3858-3_6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Radiation Enterocolitis Featuring the Perforation of the Sigmoid Colon, Small Bowel, and Entero-Colonic Fistula: A Case Report.

Meng, Muzi / Hanssen, Diego / Singh, Ajit

Cureus

2023 Volume 15, Issue 8, Page(s) e43167

Abstract: Radiation enteritis poses a treatment challenge for patients undergoing or completing radiation therapy. A significant issue has been the patient's and surgeon's lack of awareness of the condition and the radiotherapy or associated surgical treatments. A ...

Abstract	Radiation enteritis poses a treatment challenge for patients undergoing or completing radiation therapy. A significant issue has been the patient's and surgeon's lack of awareness of the condition and the radiotherapy or associated surgical treatments. A 66-year-old female presented with acute onset of diffuse abdominal pain and peritonitis for one day, status post radiation therapy following a diagnosis of cervical cancer. A review of systems was positive for diffuse sweating, chills, and nausea. The patient was diagnosed with an entero-colonic fistula with mesenteric edema. An entero-colonic fistula due to radiation enterocolitis is a rare but important complication that can occur after radiation therapy for abdominal or pelvic malignancies. With any patient who has a history of abdominal or pelvic cancer and has received radiotherapy and shows up with acute abdomen, bowel perforation should be considered in the differential diagnosis with the possible management of acute complications.
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43167
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Article: Vasomotor changes in abdominal skin after endoscopic subcutaneous/Preaponeurotic Repair of Diastasis Recti (REPA).

Hanssen, Andres / Palmisano, Ezequiel M / Hanssen, Diego A / Hanssen, Rafael A / Daes, Jorge E

International journal of surgery case reports

2020 Volume 75, Page(s) 182–184

Abstract: Introduction: Diastasis recti is a common condition with functional and cosmetic effects that can occur in both female and male patients. However, it is more prevalent in females after pregnancies and can be associated with midline hernias. The ... ...

Abstract	Introduction: Diastasis recti is a common condition with functional and cosmetic effects that can occur in both female and male patients. However, it is more prevalent in females after pregnancies and can be associated with midline hernias. The preaponeurotic endoscopic repair (REPA) has become an emerging procedure for the surgical treatment of this condition. Cases report: We present four cases of vasomotor changes in the abdominal skin, during physical activity or heat exposure, limited to the subcutaneous dissection area after REPA. All patients reported occasional skin redness (erythema) in the subcutaneous dissection area, triggered by exposure to heat or sunlight. The skin redness subsided completely in all the patients after a few minutes in a cool environment and after cessation of physical activity. Discussion: Recently, subcutaneous preaponeurotic repair of diastasis recti has gained popularity. Changes in abdominal skin sensitivity have been reported, but to the best of our knowledge, this is the first report of what appears to be vasomotor skin changes after these procedures. Conclusion: Vasomotor changes can occur after endoscopic dissections of the abdominal skin and subcutaneous tissue. Incidence and causes remain unclear.
Language	English
Publishing date	2020-09-03
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.08.056
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Article ; Online: The gut microbiome, a hidden endocrine organ with widespread metabolic implications?

Hanssen, Nordin M J / Nieuwdorp, Max

Best practice & research. Clinical endocrinology & metabolism

2021 Volume 35, Issue 3, Page(s) 101543

Language	English
Publishing date	2021-05-05
Publishing country	Netherlands
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2052339-7
ISSN	1878-1594 ; 1532-1908 ; 1521-690X
ISSN (online)	1878-1594 ; 1532-1908
ISSN	1521-690X
DOI	10.1016/j.beem.2021.101543
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Article ; Online: Breastfeeding in women with systemic lupus erythematosus: results from a Norwegian quality register.

Bjerkaas Hanssen, Maylinn / Malm Gulati, Agnete / Koksvik, Hege / Wallenius, Marianne

International breastfeeding journal

2023 Volume 18, Issue 1, Page(s) 37

Abstract: Background: Knowledge on breastfeeding among women with systemic lupus erythematosus (SLE) is sparse. We wanted to identify the frequency of breastfeeding in SLE, and to compare breastfeeding women with SLE to non-breastfeeding women to examine possible ...

Abstract	Background: Knowledge on breastfeeding among women with systemic lupus erythematosus (SLE) is sparse. We wanted to identify the frequency of breastfeeding in SLE, and to compare breastfeeding women with SLE to non-breastfeeding women to examine possible differences in disease characteristics and self-reported health data between the groups. Methods: Prospective data on women with SLE from RevNatus, a consent-based Norwegian nationwide quality register was used for this study. Data were collected during January 2016 to September 2021. We used data registered at inclusion when planning pregnancy or in 1 Results: A total of 114 pregnancies in 101 SLE women were included in the analysis. A majority of the women (78%) breastfed six weeks postpartum. Six and 12 months after delivery, breastfeeding rates were 54% and 30% respectively. Six weeks postpartum, non-breastfeeding women showed higher prevalence of emergency caesarean delivery (p = 0.038), preeclampsia (p = 0.056) and lower educational level (p = 0.046) compared to breastfeeding women. 12 months after delivery, we observed a higher frequency of multiparity among breastfeeding women (p = 0.017) compared to non-breastfeeding. Overall, we found low disease activity in both groups at all registrations in the follow-up, and disease activity did not differ between the groups. More than 70% of both breastfeeding and non-breastfeeding women used hydroxychloroquine (HCQ). Conclusions: Breastfeeding rate in women with SLE was high six weeks postpartum. Multiparous women breastfed longer than primiparas. Disease activity, use of HCQ, and self-reported health data were comparable between the groups. Our data indicate that health professionals should encourage women with SLE to breastfeed.
MeSH term(s)	Pregnancy ; Humans ; Female ; Pregnancy Outcome/epidemiology ; Breast Feeding ; Prospective Studies ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/drug therapy ; Hydroxychloroquine/therapeutic use
Chemical Substances	Hydroxychloroquine (4QWG6N8QKH)
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2227239-2
ISSN	1746-4358 ; 1746-4358
ISSN (online)	1746-4358
ISSN	1746-4358
DOI	10.1186/s13006-023-00576-y
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Article ; Online: Statistically assessing vertical change on a sandy beach from permanent laser scanning time series

Mieke Kuschnerus / Roderik Lindenbergh / Sander Vos / Ramon Hanssen

ISPRS Open Journal of Photogrammetry and Remote Sensing, Vol 11, Iss , Pp 100055- (2024)

2024

Abstract: ... with the help of multiple hypothesis testing. In our example case, slopes of 0.032 m/day and sudden changes of 0 ... 031 m can be identified with statistical power of 80% and with 95% significance in 24-h time series ...

Abstract	In the view of climate change, understanding and managing effects on coastal areas and adjacent cities is essential. Permanent Laser Scanning (PLS) is a successful technique to not only observe notably sandy coasts incidentally or once every year, but (nearly) continuously over extended periods of time. The collected point cloud observations form a 4D point cloud data set representing the evolution of the coast provide the opportunity to assess change processes at high level of detail. For an exemplary location in Noordwijk, The Netherlands, three years of hourly point clouds were acquired on a 1 km long section of a typical Dutch urban sandy beach. Often, the so-called level of detection is used to assess point cloud differences from two epochs. To explicitly incorporate the temporal dimension of the height estimates from the point cloud data set, we revisit statistical testing theory. We apply multiple hypothesis testing on elevation time series in order to identify different coastal processes, like aeolian sand transport or bulldozer works. We then estimate the minimal detectable bias for different alternative hypotheses, to quantify the minimal elevation change that can be estimated from the PLS observations over a certain period of time. Additionally, we analyse potential error sources and influences on the elevation estimations and provide orders of magnitudes and possible ways to deal with them. Finally we conclude that elevation time series from a long term PLS data set are a suitable input to identify aeolian sand transport with the help of multiple hypothesis testing. In our example case, slopes of 0.032 m/day and sudden changes of 0.031 m can be identified with statistical power of 80% and with 95% significance in 24-h time series on the upper beach. In the intertidal area the presented method allows to classify daily elevation time series over one month according to the dominating model (sudden change or linear trend) in either eroding or accreting behaviour.
Keywords	0000 ; 1111 ; Geography (General) ; G1-922 ; Surveying ; TA501-625
Subject code	550
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fecal microbiota transplantation and fiber supplementation, better together?

Hanssen, Nordin M J / Nieuwdorp, Max

Cell reports. Medicine

2021 Volume 2, Issue 9, Page(s) 100403

Abstract: Fecal microbiota transplantation (FMT) is emerging as a tool to study the microbiome and as a potential treatment for several non-infectious diseases. Recently, Mocanu et al. showed that supplementing low fermentable fiber after FMT may improve insulin ... ...

Abstract	Fecal microbiota transplantation (FMT) is emerging as a tool to study the microbiome and as a potential treatment for several non-infectious diseases. Recently, Mocanu et al. showed that supplementing low fermentable fiber after FMT may improve insulin sensitivity in severely obese individuals.
Language	English
Publishing date	2021-09-23
Publishing country	United States
Document type	Research Support, Non-U.S. Gov't ; Journal Article ; Comment
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2021.100403
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Article ; Online: Interactie tussen het microbioom en het immuunsysteem.

Hanssen, Nordin M J / Nieuwdorp, Max

Nederlands tijdschrift voor geneeskunde

2021 Volume 164

Abstract: The gut microbiome has received considerable attention in the general media and scientific literature, and a pattern between loss of diversity of the microbiome and several chronic illnesses is emerging. In fact, an increasingly solid body of literature ... ...

Title translation	Interaction between the microbiome and the immune system.
Abstract	The gut microbiome has received considerable attention in the general media and scientific literature, and a pattern between loss of diversity of the microbiome and several chronic illnesses is emerging. In fact, an increasingly solid body of literature reveals how the microbiome modulates our health, risk of several conditions and even our behaviour. Research focussing on the interactions between the microbiome and the function of the immune system in particular has yielded important new insights that have deepened the understanding of the development of several diseases. The microbiome plays a key role in the dysregulated host response that defines sepsis, inflammation in cardio-metabolic diseases and loss of self-tolerance in auto-immune disorders. These distinct conditions are all three characterized by dysbiosis, altered gut-permeability and an altered balance between the innate and adaptive immune system. This axis may be targetable and several clinical studies are evaluating whether interventions targeting the gut microbiome may improve outcomes in these diseases.
MeSH term(s)	Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Immune System ; Inflammation ; Microbiota
Language	Dutch
Publishing date	2021-05-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Strategies to improve implementation of collaborative care for functional disorders and persistent somatic symptoms: A qualitative study using a Research World Café design.

Mamo, Nick / Tak, Lineke M / Olde Hartman, Tim C / Rosmalen, Judith G M / Hanssen, Denise J C

Journal of psychosomatic research

2024 , Page(s) 111665

Abstract: Introduction: Persistent somatic symptoms and functional disorders (PSS/FD) are often complex conditions requiring care from multiple disciplines. One way of bringing the different disciplines together is through collaborative care. Little is known ... ...

Abstract	Introduction: Persistent somatic symptoms and functional disorders (PSS/FD) are often complex conditions requiring care from multiple disciplines. One way of bringing the different disciplines together is through collaborative care. Little is known about the implementation barriers faced and relevant strategies to tackle the barriers in this field. Therefore, using expert knowledge, we aim to develop realistic strategies for dealing with implementation barriers of collaborative care in PSS/FD. Methods: The Research World Café method is a single-session, expert-based method with multiple focus-groups forming and reforming to answer a set of inter-related questions, under the guidance of moderators. Using this method, participants involved in PSS/FD care across different areas of healthcare in the Netherlands developed several realistic strategies for dealing with ten implementation barriers for collaborative care in PSS/FD that were previously identified in a Delphi study. Strategies were grouped into strategy clusters using a card-sorting task. Results: Thirty-three participants took part, representing ten different disciplines, most commonly physiotherapists, psychologists, and physicians. In total, 54 strategies, identified in response to the ten barriers, were grouped into eight strategy clusters. The strategy clusters were professional education, communication, care coordination, care pathways, joint consults, funding, patient involvement, and prevention. Conclusion: We identified a number of useful strategies for dealing with implementation barriers for collaborative care in PSS/FD. Many strategies provided ways to deal with multiple barriers at once. The effects of applying these strategies in collaborative care in PSS/FD will need testing through implementation studies, as well as in other areas needing multidisciplinary care.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2024.111665
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Article ; Online: Quality indicators for collaborative care networks in persistent somatic symptoms and functional disorders: a modified delphi study.

Mamo, Nick / Tak, Lineke M / van de Klundert, Manouk A W / Olde Hartman, Tim C / Rosmalen, Judith G M / Hanssen, Denise J C

BMC health services research

2024 Volume 24, Issue 1, Page(s) 225

Abstract: Background: Care for persistent somatic symptoms and functional disorders (PSS/FD) is often fragmented. Collaborative care networks (CCNs) may improve care quality for PSS/FD. Effectiveness likely depends on their functioning, but we lack a ... ...

Abstract	Background: Care for persistent somatic symptoms and functional disorders (PSS/FD) is often fragmented. Collaborative care networks (CCNs) may improve care quality for PSS/FD. Effectiveness likely depends on their functioning, but we lack a straightforward quality evaluation system. We therefore aimed to develop quality indicators to evaluate CCNs for PSS/FD. Method: Using an online three-round modified Delphi process, an expert panel provided, selected and ranked quality indicators for CCNs in PSS/FD. Recruited experts were diverse healthcare professionals with relevant experience in PSS/FD care in the Netherlands. Results: The expert panel consisted of 86 professionals representing 15 disciplines, most commonly physiotherapists, psychologists and medical specialists. 58% had more than 10 years experience in PSS/FD care. Round one resulted in 994 quotations, which resulted in 46 unique quality indicators. These were prioritised in round two and ranked in round three by the panel, resulting in a final top ten. The top three indicators were: "shared vision of care for PSS/FD", "pathways tailored to the individual patient", and "sufficiently-experienced caregivers for PSS/FD". Conclusions: The identified quality indicators to evaluate CCNs in the field of PSS/FD can be implemented in clinical practice and may be useful in improving services and when assessing effectiveness.
MeSH term(s)	Humans ; Quality Indicators, Health Care ; Delphi Technique ; Medically Unexplained Symptoms ; Netherlands ; Physical Therapists
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10589-w
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