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Article ; Online: Kgaria

Halling, R E / Fechner, N A / Holmes, G / Davoodian, N

2023 Volume 12, Page(s) 31–45

Abstract: ... ...

Abstract	Kgaria
Language	English
Publishing date	2023-07-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3007859-3
ISSN	2589-3831 ; 2589-3823
ISSN (online)	2589-3831
ISSN	2589-3823
DOI	10.3114/fuse.2023.12.02
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Masticatory Structure and Function in Children with Cerebral Palsy-A Pilot Study.

Szuflak, Karolina / Malak, Roksana / Fechner, Brittany / Sikorska, Dorota / Samborski, Włodzimierz / Mojs, Ewa / Gerreth, Karolina

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 7

Abstract: 1) Background: Muscle tension around the head and neck influences orofacial functions. The data exist concerning head posture during increased salivation; however, little is known about muscle tightness during this process. This study aims to ... ...

Abstract	(1) Background: Muscle tension around the head and neck influences orofacial functions. The data exist concerning head posture during increased salivation; however, little is known about muscle tightness during this process. This study aims to investigate whether or not any muscles are related to problems with eating, such as drooling in individuals with cerebral palsy; (2) Methods: Nineteen patients between the ages of 1 and 14 were examined prior to the physiotherapy intervention. This intervention lasted three months and consisted of: relaxing muscles via the strain-counterstrain technique, functional exercises based on the NeuroDevelopmental Treatment-Bobath method, and functional exercises for eating; (3) Results: the tone of rectus capitis posterior minor muscle on the left side (
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11071029
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Article: Do Teachers Question the Reality of Pain in Their Students? A Survey Using the Concept of Pain Inventory-Proxy (COPI-Proxy).

Fechner, Rebecca / Noel, Melanie / Verhagen, Arianne / Turbitt, Erin / Pate, Joshua W

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: ... consistency (Cronbach's alpha = 0.72) and moderate convergent validity with the COPI (r = 0.56). The results ...

Abstract	An assessment of a teacher's concept of their student's pain could be useful to guide preventative and targeted school-based pain science education. We aimed to assess a teacher's own concept of pain against their concept of their student's pain and examine the psychometric properties of the tool. Teachers of 10-12-year-old children were invited to participate in an online survey via social media. We modified the Concept of Pain Inventory (COPI) by inserting a vignette (COPI-Proxy), and we included questions to explore teacher stigma. Overall, a sample of 233 teachers participated in the survey. The COPI-Proxy scores showed that teachers can conceptualize their student's pain separately but are influenced by their own beliefs. Only 76% affirmed the pain in the vignette as real. Teachers used potentially stigmatizing language to describe pain in their survey responses. The COPI-Proxy had acceptable internal consistency (Cronbach's alpha = 0.72) and moderate convergent validity with the COPI (r = 0.56). The results show the potential benefit of the COPI-Proxy for assessing someone's concept of another's pain, particularly for teachers who are important social influencers of children.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020370
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Article ; Online: Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial.

Fechner, J / El-Boghdadly, K / Spahn, D R / Motsch, J / Struys, M M R F / Duranteau, O / Ganter, M T / Richter, T / Hollmann, M W / Rossaint, R / Bercker, S / Rex, S / Drexler, B / Schippers, F / Morley, A / Ihmsen, H / Kochs, E

Anaesthesia

2024 Volume 79, Issue 4, Page(s) 410–422

Abstract: Remimazolam, a short-acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management of patients with multiple comorbidities remains unclear. In this phase 3 randomised controlled trial, ... ...

Abstract	Remimazolam, a short-acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management of patients with multiple comorbidities remains unclear. In this phase 3 randomised controlled trial, we compared the anaesthetic efficacy and the incidence of postinduction hypotension during total intravenous anaesthesia with remimazolam vs. propofol. A total of 365 patients (ASA physical status 3 or 4) scheduled for elective surgery were assigned randomly to receive total intravenous anaesthesia with remimazolam (n = 270) or propofol (n = 95). Primary outcome was anaesthetic effect, quantified as the percentage of time with Narcotrend® Index values ≤ 60, during surgery (skin incision to last skin suture), with a non-inferiority margin of -10%. Secondary outcome was the incidence of postinduction hypotensive events. Mean (SD) percentage of time with Narcotrend Index values ≤ 60 during surgery across all patients receiving remimazolam (93% (20.7)) was non-inferior to propofol (99% (4.2)), mean difference (97.5%CI) -6.28% (-8.89-infinite); p = 0.003. Mean (SD) number of postinduction hypotension events was 62 (38.1) and 71 (41.1) for patients allocated to the remimazolam and propofol groups, respectively; p = 0.015. Noradrenaline administration events (requirement for a bolus and/or infusion) were also lower in patients allocated to remimazolam compared with propofol (14 (13.5) vs. 20 (14.6), respectively; p < 0.001). In conclusion, in patients who were ASA physical status 3 or 4, the anaesthetic effect of remimazolam was non-inferior to propofol.
MeSH term(s)	Humans ; Propofol ; Anesthetics ; Benzodiazepines ; Hypotension/chemically induced
Chemical Substances	Propofol (YI7VU623SF) ; remimazolam (7V4A8U16MB) ; Anesthetics ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2024-01-14
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.16205
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Article: An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in

Fryer, Emily / Guha, Sujay / Rogel-Hernandez, Lucero E / Logan-Garbisch, Theresa / Farah, Hodan / Rezaei, Ehsan / Mollhoff, Iris N / Nekimken, Adam L / Xu, Angela / Selin Seyahi, Lara / Fechner, Sylvia / Druckmann, Shaul / Clandinin, Thomas R / Rhee, Seung Y / Goodman, Miriam B

bioRxiv : the preprint server for biology

2024

Abstract: Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe ... ...

Abstract	Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe behavior. To survive, nematodes must have evolved the sensory capacity to distinguish plant-made small molecules (SMs) that are harmful and must be avoided from those that are beneficial and should be sought. This ability to classify chemical cues as a function of their value is fundamental to olfaction, and represents a capacity shared by many animals, including humans. Here, we present an efficient platform based on multi-well plates, liquid handling instrumentation, inexpensive optical scanners, and bespoke software that can efficiently determine the valence (attraction or repulsion) of single SMs in the model nematode,
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.02.542933
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Article: Is it all about knowledge? A survey of attitudes toward ADHD among German pediatricians.

Fechner, Marie E / Mazheika, Yuliya / Fehr, Folkert / Jung, Ronny / Borusiak, Peter

Zeitschrift fur Gesundheitswissenschaften = Journal of public health

2022 , Page(s) 1–9

Abstract: ... The vast majority (85.5%) of 581 respondents have a positive attitude toward ADHD, i.e., ADHD exists and ...

Abstract	Aim: Sometimes treatment is not necessarily according to guidelines, which is partly due to attitudes rather than lack of knowledge. In Germany, regional differences concerning prevalence rates of ADHD exist without valid explanation. We contribute with our data to the question of attitudes toward ADHD among pediatricians in Germany. Method: A specially designed questionnaire based on the Knowledge of Attention Deficit Disorders Scale and previous surveys was sent to pediatricians. In addition to descriptive statistics, we performed factor analysis and multiple linear regression analysis. Results: The vast majority (85.5%) of 581 respondents have a positive attitude toward ADHD, i.e., ADHD exists and should be treated appropriately. Physicians with positive attitudes were older and more often had a neuropediatric specialization. Conclusion: Most of the pediatricians surveyed in Germany assess ADHD and treatment in line with medical guidelines and treat as part of multimodal therapy. Supplementary information: The online version contains supplementary material available at 10.1007/s10389-022-01758-4.
Language	English
Publishing date	2022-09-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1149070-6
ISSN	2198-1833 ; 0943-1853
ISSN	2198-1833 ; 0943-1853
DOI	10.1007/s10389-022-01758-4
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Article: Interdisciplinary Surgical Therapy of Extremity Soft-Tissue Sarcomas: A Personalized Resection and Reconstruction Algorithm.

Osterloh, Justus / Ludolph, Ingo / Grützmann, Robert / Meyer, Alexander / Lang, Werner / Horch, Raymund E / Fechner, Katja / Arkudas, Andreas

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Soft-tissue sarcomas (STS) are rare, but potentially life-threatening malignancies. STS can occur anywhere in the human body with the limbs being the most common site. Referral to a specialized sarcoma center is crucial to guarantee prompt and ... ...

Abstract	Soft-tissue sarcomas (STS) are rare, but potentially life-threatening malignancies. STS can occur anywhere in the human body with the limbs being the most common site. Referral to a specialized sarcoma center is crucial to guarantee prompt and appropriate treatment. STS treatment strategies should be discussed in an interdisciplinary tumor board to involve expertise from all available resources, including an experienced reconstructive surgeon for an optimal outcome. In many cases, extensive resection is needed to achieve R0 resection, resulting in large defects after surgery. Hence, an evaluation of whether plastic reconstruction might be required is mandatory to avoid complications due to insufficient primary wound closure. In this retrospective observational study, we present data of patients with extremity STS treated at the Sarcoma Center, University Hospital Erlangen, in 2021. We found that complications were more frequent in patients who received secondary flap reconstruction after insufficient primary wound closure compared to patients who received primary flap reconstruction. Additionally, we propose an algorithm for an interdisciplinary surgical therapy of soft-tissue sarcomas regarding resection and reconstruction and present two problematic cases to emphasize the complexity of surgical sarcoma therapy.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020262
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Article: Application of the Neonatal Behavioral Assessment Scale to Evaluate the Neurobehavior of Preterm Neonates.

Malak, Roksana / Fechner, Brittany / Sikorska, Dorota / Rosołek, Marta / Mojs, Ewa / Samborski, Włodzimierz / Baum, Ewa

Brain sciences

2021 Volume 11, Issue 10

Abstract: Background: The neonatal behavioral assessment scale (NBAS) was primarily developed to aid in the assessment of full-term neonates. The aim of this study was to detect if the NBAS was also valuable in the assessment of preterm neonates.: Materials and ...

Abstract	Background: The neonatal behavioral assessment scale (NBAS) was primarily developed to aid in the assessment of full-term neonates. The aim of this study was to detect if the NBAS was also valuable in the assessment of preterm neonates. Materials and methods: We assessed 112 infants at a neonatal unit using the NBAS, 4th edition. The inclusion criteria included an oxygen saturation level between 88-95% and a heartrate of 100-205 beats per minute. Infant neurobehavior was assessed using the NBAS. Results: For full-term and preterm neonates, we observed that the NBAS enabled us to assess both groups of infants and gave relevant information pertaining to them. We found a significant correlation between the average week of gestation and response to touch, sensory input, peak of excitement, cost of attention, hand-to-mouth, and quality of alertness. Conclusions: The NBAS is a valuable scale for evaluating the neurobehavior of preterm neonates. The week of gestation at birth affects certain aspects of neurobehavior, such as response to sensory input, putting hand to mouth, peak of excitement, and cost of attention. The NBAS as an individually structured assessment may help in planning for early rehabilitation and intervention for this vulnerable population.
Language	English
Publishing date	2021-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11101285
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Article ; Online: Cognitive costs of decision-making strategies: A resource demand decomposition analysis with a cognitive architecture.

Fechner, Hanna B / Schooler, Lael J / Pachur, Thorsten

Cognition

2018 Volume 170, Page(s) 102–122

Abstract: ... Control of Thought-Rational (ACT-R). ACT-R provides the means to develop computer simulations ... it has been considered simpler than strategies like tallying. However, in both ACT-R simulations and ... an empirical study we found that under increasing cognitive demands the response times (i.e., time costs ...

Abstract	Several theories of cognition distinguish between strategies that differ in the mental effort that their use requires. But how can the effort-or cognitive costs-associated with a strategy be conceptualized and measured? We propose an approach that decomposes the effort a strategy requires into the time costs associated with the demands for using specific cognitive resources. We refer to this approach as resource demand decomposition analysis (RDDA) and instantiate it in the cognitive architecture Adaptive Control of Thought-Rational (ACT-R). ACT-R provides the means to develop computer simulations of the strategies. These simulations take into account how strategies interact with quantitative implementations of cognitive resources and incorporate the possibility of parallel processing. Using this approach, we quantified, decomposed, and compared the time costs of two prominent strategies for decision making, take-the-best and tallying. Because take-the-best often ignores information and foregoes information integration, it has been considered simpler than strategies like tallying. However, in both ACT-R simulations and an empirical study we found that under increasing cognitive demands the response times (i.e., time costs) of take-the-best sometimes exceeded those of tallying. The RDDA suggested that this pattern is driven by greater requirements for working memory updates, memory retrievals, and the coordination of mental actions when using take-the-best compared to tallying. The results illustrate that assessing the relative simplicity of strategies requires consideration of the overall cognitive system in which the strategies are embedded.
MeSH term(s)	Adult ; Cognition/physiology ; Decision Making/physiology ; Female ; Humans ; Male ; Memory, Short-Term/physiology ; Models, Psychological ; Young Adult
Language	English
Publishing date	2018
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1499940-7
ISSN	1873-7838 ; 0010-0277
ISSN (online)	1873-7838
ISSN	0010-0277
DOI	10.1016/j.cognition.2017.09.003
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Article: Impact of umbilical cord arterial pH, gestational age, and birth weight on neurodevelopmental outcomes for preterm neonates.

Malak, Roksana / Sikorska, Dorota / Rosołek, Marta / Baum, Ewa / Mojs, Ewa / Daroszewski, Przemysław / Matecka, Monika / Fechner, Brittany / Samborski, Włodzimierz

PeerJ

2021 Volume 9, Page(s) e12043

Abstract: Background: The aim of this study was to determine the impact of umbilical cord arterial pH, gestational age, and birth weight on neurodevelopmental outcomes for preterm neonates.: Methods: We examined 112 neonates. Inclusion criteria were: ... ...

Abstract	Background: The aim of this study was to determine the impact of umbilical cord arterial pH, gestational age, and birth weight on neurodevelopmental outcomes for preterm neonates. Methods: We examined 112 neonates. Inclusion criteria were: Saturations greater than 88%, and heart rates between 100-205 beats per minute. Measurements: We assessed several neurodevelopmental factors as part of the Brazelton Neonatal Behavioral Assessment Scale (NBAS), 4th edition, such as asymmetric tonic neck reflex (ATNR), motor maturity, response to sensory stimuli, habituation, and state regulation. Initial assessment parameters such as APGAR score and umbilical cord arterial pH were used to assess neonates. Results: We found a strong correlation between the presence of the sucking reflex and umbilical cord arterial pH ( Conclusions: We found that the sucking reflex may be affected in infants with low umbilical cord arterial pH values. Practitioners and parents can use the NBAS to help determine neurodevelopmental factors and outcomes in preterm infants, possibly leading to safer and more effective feeding practices and interventions.
Language	English
Publishing date	2021-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.12043
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