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Article ; Online: Notoamide R: A Prominent Diketopiperazine Fermentation Metabolite amongst Others of

Mantle, Peter / Roberts, Andrew / Beaumont, Claire

2023 Volume 28, Issue 8

Abstract: Ochratoxin A is historically the most notable secondary metabolite ... ...

Abstract	Ochratoxin A is historically the most notable secondary metabolite of
MeSH term(s)	Animals ; Aspergillus ochraceus/metabolism ; Ochratoxins ; Fermentation ; Aspergillus/chemistry ; Magnetic Resonance Spectroscopy
Chemical Substances	Ochratoxins
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083518
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Article ; Online: RFI Mapped by Spaceborne GNSS-R Data

Clara Chew / T. Maximillian Roberts / Steve Lowe

Navigation, Vol 70, Iss

2023 Volume 4

Abstract: Radio frequency interference (RFI) in global navigation satellite system (GNSS) frequencies can endanger human life and safety by preventing the use of these signals for navigation and positioning, in addition to degrading measurements for science ... ...

Abstract	Radio frequency interference (RFI) in global navigation satellite system (GNSS) frequencies can endanger human life and safety by preventing the use of these signals for navigation and positioning, in addition to degrading measurements for science applications. Here, we use data from the Cyclone GNSS (CYGNSS) constellation to map GNSS RFI from 2017 to 2022, identify the location of several potential sources of RFI, and quantify the duration of transmission. Although our method of RFI detection can only provide a rough approximation of transmitter positions, it is possible that advanced data processing techniques could better pinpoint their locations, once guided by these observations. We find that, since the launch of CYGNSS, GNSS jammers have proliferated across the world and are often associated with the beginnings of geopolitical unrest. Our results agree well with previous studies that have also used satellite observations to map ground-based RFI transmission.
Keywords	Canals and inland navigation. Waterways ; TC601-791 ; Naval Science ; V
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Institute of Navigation
Document type	Article ; Online
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Article ; Online: Deep learning-based insights on T:R ratio behaviour during prolonged screening for S-ICD eligibility.

ElRefai, Mohamed / Abouelasaad, Mohamed / Wiles, Benedict M / Dunn, Anthony J / Coniglio, Stefano / Zemkoho, Alain B / Roberts, Paul R

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2022

Abstract: ... ICD) is the T:R ratio. The eligibility cut-off of the T:R ratio incorporates a safety margin ... measures the degree of T:R ratio fluctuations and explore its role in S-ICD screening.: Methods ... R ratio over the duration of the recordings. Multiple T:R ratio cut-off values were applied ...

Abstract	Background: A major predictor of eligibility of subcutaneous implantable cardiac defibrillators (S-ICD) is the T:R ratio. The eligibility cut-off of the T:R ratio incorporates a safety margin to accommodate for fluctuations of ECG signal amplitudes. We introduce a deep learning-based tool that accurately measures the degree of T:R ratio fluctuations and explore its role in S-ICD screening. Methods: Patients were fitted with Holters for 24 h to record their S-ICD vectors. Our tool was used to assess the T:R ratio over the duration of the recordings. Multiple T:R ratio cut-off values were applied, identifying patients at high risk of T-wave oversensing (TWO) at each of the proposed values. The purpose of our study is to identify the ratio that recognises patients at high risk of TWO while not inappropriately excluding true S-ICD candidates. Results: Thirty-seven patients (age 54.5 + / - 21.3 years, 64.8% male) were recruited. Fourteen patients had heart-failure, 7 hypertrophic cardiomyopathy, 7 had normal hearts, 6 had congenital heart disease, and 3 had prior inappropriate S-ICD shocks due to TWO. 54% of patients passed the screening at a T: R of 1:3. All patients passed the screening at a T: R of 1:1. The only subgroup to wholly pass the screening utilising all the proposed ratios are the participants with normal hearts. Conclusion: We propose adopting prolonged screening to select patients eligible for S-ICD with low probability of TWO and inappropriate shocks. The appropriate T:R ratio likely lies between 1:3 and 1:1. Further studies are required to identify the optimal screening thresholds.
Language	English
Publishing date	2022-05-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-022-01245-6
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Zs.A 5214: Show issues

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Article ; Online: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium.

Daynes, Enya / Baldwin, Molly / Greening, Neil J / Yates, Thomas / Bishop, Nicolette C / Mills, George / Roberts, Matthew / Hamrouni, Malik / Plekhanova, Tatiana / Vogiatzis, Ioannis / Echevarria, Carlos / Nathu, Rashmita / McAuley, Hamish J C / Latimer, Lorna / Glennie, Jennifer / Chambers, Francesca / Penfold, Ruth / Hume, Emily / Megaritis, Dimitrios /

Alexiou, Charikleia / Potthoff, Sebastian / Hogg, Mitchell James / Haighton, Catherine / Nichol, Bethany / Leavy, Olivia C / Richardson, Matthew / Elneima, Omer / Singapuri, Amisha / Sereno, Marco / Saunders, Ruth M / Harris, Victoria C / Nolan, Claire M / Bolton, Charlotte / Houchen-Wolloff, Linzy / Harrison, Ewen M / Lone, Nazir / Quint, Jennifer / Chalmers, James D / Ho, Ling-Pei / Horsley, Alex / Marks, Michael / Poinasamy, Krisnah / Ramen, Betty / Wain, Louise V / Brightling, Christopher / Man, William D-C / Evans, Rachael / Singh, Sally J

Trials

2023 Volume 24, Issue 1, Page(s) 61

Abstract: Introduction: Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited controlled studies on ... ...

Abstract	Introduction: Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited controlled studies on interventions that can support those with ongoing symptoms, there has been some promise in rehabilitation interventions in improving function and symptoms either using face-to-face or digital methods, but evidence remains limited and these studies often lack a control group. Methods and analysis: This is a nested single-blind, parallel group, randomised control trial with embedded qualitative evaluation comparing rehabilitation (face-to-face or digital) to usual care and conducted within the PHOSP-COVID study. The aim of this study is to determine the effectiveness of rehabilitation interventions on exercise capacity, quality of life and symptoms such as breathlessness and fatigue. The primary outcome is the Incremental Shuttle Walking Test following the eight week intervention phase. Secondary outcomes include measures of function, strength and subjective assessment of symptoms. Blood inflammatory markers and muscle biopsies are an exploratory outcome. The interventions last eight weeks and combine symptom-titrated exercise therapy, symptom management and education delivered either in a face-to-face setting or through a digital platform ( www.yourcovidrecovery.nhs.uk ). The proposed sample size is 159 participants, and data will be intention-to-treat analyses comparing rehabilitation (face-to-face or digital) to usual care. Ethics and dissemination: Ethical approval was gained as part of the PHOSP-COVID study by Yorkshire and the Humber Leeds West Research NHS Ethics Committee, and the study was prospectively registered on the ISRCTN trial registry (ISRCTN13293865). Results will be disseminated to stakeholders, including patients and members of the public, and published in appropriate journals. Strengths and limitations of this study • This protocol utilises two interventions to support those with ongoing symptoms of COVID-19 • This is a two-centre parallel-group randomised controlled trial • The protocol has been supported by patient and public involvement groups who identified treatments of symptoms and activity limitation as a top priority.
MeSH term(s)	Adult ; Humans ; COVID-19 ; Quality of Life ; Single-Blind Method ; Dyspnea ; Fatigue/diagnosis ; Fatigue/etiology ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07093-7
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Article ; Online: Reassessing rumination: Validity of the Day Reconstruction Method for Rumination (DRM-R) to assess episodes of rumination in daily life.

Rosenfeld, Eve A / Lyman, Cassondra / Wojcik, Curtis M / Macia, Kathryn S / Roberts, John E

Psychological assessment

2023 Volume 35, Issue 12, Page(s) 1098–1107

Abstract: ... for assessing daily episodes of rumination, the Day Reconstruction Method for Rumination (DRM-R). Participants ( ...

Abstract	Rumination is a robust vulnerability to depression and potential treatment target. However, we know relatively little about rumination in daily life. This study tested the validity of a new approach for assessing daily episodes of rumination, the Day Reconstruction Method for Rumination (DRM-R). Participants (
MeSH term(s)	Humans ; Mental Disorders ; Anxiety ; Cognition ; Neuroticism
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1000939-5
ISSN	1939-134X ; 1040-3590
ISSN (online)	1939-134X
ISSN	1040-3590
DOI	10.1037/pas0001282
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Article ; Online: The Physician Legacy of Stewart R. Roberts, MD (1878-1941), "The Osler of the South".

Roberts, Charles S

The American journal of cardiology

2021 Volume 162, Page(s) 191–196

MeSH term(s)	Cardiology/education ; Cardiology/history ; Education, Medical/history ; History, 19th Century ; History, 20th Century ; Humans ; Southeastern United States
Language	English
Publishing date	2021-12-23
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2021.09.007
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Article ; Online: Correction: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium.

Alexiou, Charikleia / Potthof, Sebastian / Hogg, Mitchell James / Haighton, Catherine / Nichol, Bethany / Leavy, Olivia C / Richardson, Matthew / Elneima, Omer / Singapuri, Amisha / Sereno, Marco / Saunders, Ruth M / Harris, Victoria C / Nolan, Claire M / Bolton, Charlotte / Houchen-Wolloff, Linzy / Harrison, Ewen M / Lone, Nazir / Quint, Jennifer / Chalmers, James D / Ho, Ling-Pei / Horsley, Alex / Marks, Michael / Poinasamy, Krisnah / Ramen, Betty / Wain, Louise V / Brightling, Christopher / Man, William D-C / Evans, Rachael / Singh, Sally J

Trials

2023 Volume 24, Issue 1, Page(s) 98

Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07132-3
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Article ; Online: Achieving end-to-end success in the clinic: Pfizer's learnings on R&D productivity.

Fernando, Kathy / Menon, Sandeep / Jansen, Kathrin / Naik, Prakash / Nucci, Gianluca / Roberts, John / Wu, Shuang Sarah / Dolsten, Mikael

Drug discovery today

2021 Volume 27, Issue 3, Page(s) 697–704

Abstract: Over the past decade, Pfizer has focused efforts to improve its research and development (R&D ...

Abstract	Over the past decade, Pfizer has focused efforts to improve its research and development (R&D) productivity. By the end of 2020, Pfizer had achieved an industry-leading clinical success rate of 21%, a tenfold increase from 2% in 2010 and well above the industry benchmark of ∼11%. The company had also maintained the quality of innovation, because 75% of its approvals between 2016 and 2020 had at least one expedited regulatory designation (e.g., Breakthrough Therapy). Pfizer's Signs of Clinical Activity (SOCA) paradigm enabled better decision-making and, along with other drivers (biology and modality), contributed to this productivity improvement. These laid a strong foundation for the rapid and effective development of the Coronavirus 2019 (COVID-19) vaccine with BioNTech, as well as the antiviral candidate Paxlovid™, under the company's 'lightspeed' paradigm.
MeSH term(s)	Antiviral Agents/economics ; BNT162 Vaccine/economics ; COVID-19/economics ; COVID-19 Vaccines/economics ; Drug Industry/economics ; Humans ; Research/economics
Chemical Substances	Antiviral Agents ; COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2021.12.010
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Article ; Online: Histotripsy Treatment of Benign Prostatic Enlargement Using the Vortx R

Schuster, Timothy G / Wei, John T / Hendlin, Kari / Jahnke, Russell / Roberts, William W

Urology

2018 Volume 114, Page(s) 184–187

Abstract: ... ultrasound monitoring using the Vortx R: Results: Twenty-five men underwent histotripsy treatment with no ...

Abstract	Objective: To assess clinical safety (primary) and efficacy (secondary) of histotripsy for treatment of symptomatic benign prostatic enlargement in a first-in human study. Methods: Twenty-five male subjects with moderate to severe lower urinary tract symptoms, prostate size between 30 and 80 g, and no evidence of prostate cancer were enrolled at 2 sites in a prospective, single-arm study. Treatment consisted of acoustic energy delivery through the perineum with integrated real-time transrectal ultrasound monitoring using the Vortx R Results: Twenty-five men underwent histotripsy treatment with no serious intraoperative adverse events. Postoperatively, 3 cases of transient urinary retention (<3 days), 1 case of urinary retention (8 days in duration, defined as serious), a minor anal abrasion, and microscopic hematuria were considered device-related adverse events. Debulking of targeted prostate tissue was not observed with transrectal ultrasound imaging or with endoscopic visualization, and clinically meaningful improvement in uroflow or postvoid residual urine (PVR) did not occur. However, International Prostate Symptom Score improvement at 1 month was 12.5 (52.4%) ± 6.6 points (n = 25), at 3 months was 11.9 (50.8%) ± 7.6 points (n = 24), and at 6 months was 10.4 (44.0%) ± 7.6 points (n = 24) (P <.001). Conclusion: Prostate histotripsy was safe and well tolerated in this pilot human trial with improvement in lower urinary tract symptoms.
MeSH term(s)	Aged ; Hematuria/etiology ; High-Intensity Focused Ultrasound Ablation/adverse effects ; High-Intensity Focused Ultrasound Ablation/instrumentation ; High-Intensity Focused Ultrasound Ablation/methods ; Humans ; Male ; Middle Aged ; Organ Size ; Prostate/pathology ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/therapy ; Prostatism/etiology ; Severity of Illness Index ; Urinary Retention/etiology
Language	English
Publishing date	2018-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2017.12.033
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: Addressing concomitant gradient phase errors in time-interleaved chemical shift-encoded MRI fat fraction and R

Roberts, Nathan T / Hernando, Diego / Panagiotopoulos, Nikolaos / Reeder, Scott B

Magnetic resonance in medicine

2022 Volume 87, Issue 6, Page(s) 2826–2838

Abstract: ... errors in chemical shift encoded (CSE) MRI estimation of proton density fat fraction (PDFF) and R ... introduced for non-linear least squares estimation of PDFF and R: Results: The proposed fitting method ... removed PDFF and R: Conclusion: Concomitant gradient induced phase errors in multi-pass CSE-MRI ...

Abstract	Purpose: Concomitant gradients induce phase errors that increase quadratically with distance from isocenter. This work proposes a complex-based fitting method that addresses concomitant gradient phase errors in chemical shift encoded (CSE) MRI estimation of proton density fat fraction (PDFF) and R Theory and methods: A CSE-MRI spoiled gradient echo signal model, with pass-specific phase terms, is introduced for non-linear least squares estimation of PDFF and R Results: The proposed fitting method removed PDFF and R Conclusion: Concomitant gradient induced phase errors in multi-pass CSE-MRI acquisitions can result in PDFF and R
MeSH term(s)	Adipose Tissue/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Liver/metabolism ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Protons ; Reproducibility of Results
Chemical Substances	Protons
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29175
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