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  1. Book: The latest in optical coherence tomography

    Costello, Fiona

    (Journal of neuro-ophthalmology ; 34,3, Suppl. 1)

    2014  

    Author's details featuring articles by Fiona Costello
    Series title Journal of neuro-ophthalmology ; 34,3, Suppl. 1
    Collection
    Language English
    Size S28 S. : Ill., graph. Darst.
    Publisher Wolters Kluwer Health Lippincott Williams & Wilkins
    Publishing place Hagerstown, MD
    Publishing country United States
    Document type Book
    HBZ-ID HT018459559
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1670 -34,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Publisher Correction to: Advantages and Pitfalls of the Use of Optical Coherence Tomography for Papilledema.

    Costello, Fiona / Hamann, Steffen

    Current neurology and neuroscience reports

    2024  Volume 24, Issue 3, Page(s) 65

    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-024-01334-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Neuromyelitis Optica Spectrum Disorders.

    Costello, Fiona

    Continuum (Minneapolis, Minn.)

    2022  Volume 28, Issue 4, Page(s) 1131–1170

    Abstract: Purpose of review: This article reviews the cardinal clinical features, distinct immunopathology, current diagnostic criteria, relapse-related risk factors, emerging biomarkers, and evolving treatment strategies pertaining to neuromyelitis optica ... ...

    Abstract Purpose of review: This article reviews the cardinal clinical features, distinct immunopathology, current diagnostic criteria, relapse-related risk factors, emerging biomarkers, and evolving treatment strategies pertaining to neuromyelitis optica spectrum disorders (NMOSD).
    Recent findings: The discovery of the pathogenic aquaporin-4 (AQP4)-IgG autoantibody and characterization of NMOSD as an autoimmune astrocytopathy have spearheaded the identification of key immunologic therapeutic targets in this disease, including but not limited to the complement system, the interleukin 6 (IL-6) receptor, and B cells. Accordingly, four recent randomized controlled trials have demonstrated the efficacy of three new NMOSD therapies, namely eculizumab, satralizumab, and inebilizumab.
    Summary: Currently, NMOSD poses both diagnostic and treatment challenges. It is debated whether individuals who are seropositive for myelin oligodendrocyte glycoprotein (MOG)-IgG belong within the neuromyelitis optica spectrum. This discussion is fueled by disparities in treatment responses between patients who are AQP4-IgG seropositive and seronegative, suggesting different immunopathologic mechanisms may govern these conditions. As our understanding regarding the immune pathophysiology of NMOSD expands, emerging biomarkers, including serum neurofilament light chain and glial fibrillary acidic protein (GFAP), may facilitate earlier relapse detection and inform long-term treatment decisions. Future research focal points should include strategies to optimize relapse management, restorative treatments that augment neurologic recovery, and practical solutions that promote equitable access to approved therapies for all patients with NMOSD.
    MeSH term(s) Aquaporin 4 ; Autoantibodies ; Biomarkers ; Humans ; Immunoglobulin G ; Myelin-Oligodendrocyte Glycoprotein ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/therapy ; Recurrence
    Chemical Substances Aquaporin 4 ; Autoantibodies ; Biomarkers ; Immunoglobulin G ; Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000001168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Erythropoietin and optic neuritis in the TONE study.

    Costello, Fiona

    The Lancet. Neurology

    2021  Volume 20, Issue 12, Page(s) 970–971

    MeSH term(s) Erythropoietin ; Humans ; Optic Neuritis
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(21)00378-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5955: Show issues Location:
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  5. Article ; Online: Advantages and Pitfalls of the Use of Optical Coherence Tomography for Papilledema.

    Costello, Fiona / Hamann, Steffen

    Current neurology and neuroscience reports

    2024  Volume 24, Issue 3, Page(s) 55–64

    Abstract: Purpose of review: Papilledema refers to optic disc swelling caused by raised intracranial pressure. This syndrome arises from numerous potential causes, which may pose varying degrees of threat to patients. Manifestations of papilledema range from mild ...

    Abstract Purpose of review: Papilledema refers to optic disc swelling caused by raised intracranial pressure. This syndrome arises from numerous potential causes, which may pose varying degrees of threat to patients. Manifestations of papilledema range from mild to severe, and early diagnosis is important to prevent vision loss and other deleterious outcomes. The purpose of this review is to highlight the role of optical coherence tomography (OCT) in the diagnosis and management of syndromes of raised intracranial pressure associated with papilledema.
    Recent findings: Ophthalmoscopy is an unreliable skill for many clinicians. Optical coherence tomography is a non-invasive ocular imaging technique which may fill a current care gap, by facilitating detection of papilledema for those who cannot perform a detailed fundus examination. Optical coherence tomography may help confirm the presence of papilledema, by detecting subclinical peripapillary retinal nerve fiber layer (pRNFL) thickening that might otherwise be missed with ophthalmoscopy. Enhanced depth imaging (EDI) and swept source OCT techniques may identify optic disc drusen as cause of pseudo-papilledema. Macular ganglion cell inner plexiform layer (mGCIPL) values may provide early signs of neuroaxonal injury in patients with papilledema and inform management for patients with syndromes of raised intracranial pressure. There are well-established advantages and disadvantages of OCT that need to be fully understood to best utilize this method for the detection of papilledema. Overall, OCT may complement other existing tools by facilitating detection of papilledema and tracking response to therapies.  Moving forward, OCT findings may be included in deep learning models to diagnose papilledema.
    MeSH term(s) Humans ; Papilledema/diagnostic imaging ; Optic Disk/diagnostic imaging ; Tomography, Optical Coherence/methods ; Retinal Ganglion Cells ; Nerve Fibers ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/diagnostic imaging
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-023-01327-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Neuro-ophthalmic manifestations of autoimmune disorders: diagnostic pearls & pitfalls.

    Poonja, Sabrina / Costello, Fiona

    Current opinion in ophthalmology

    2023  Volume 34, Issue 6, Page(s) 500–513

    Abstract: Purpose of review: The purpose of this review is to highlight a clinical-anatomical approach to localizing neuro-ophthalmic manifestations of associated autoimmune disorders.: Recent findings: Our understanding of autoimmune conditions has changed ... ...

    Abstract Purpose of review: The purpose of this review is to highlight a clinical-anatomical approach to localizing neuro-ophthalmic manifestations of associated autoimmune disorders.
    Recent findings: Our understanding of autoimmune conditions has changed considerably over recent years, particularly with the emergence of novel autoantibodies. Cardinal neuro-ophthalmic signs and symptoms of antibody-mediated autoimmune disorders have been well characterized; knowledge thereof may be the first step towards an accurate diagnosis.
    Summary: A thorough history, further refined by a comprehensive examination are cornerstones to disease localization in clinical medicine. Taken together, these essential steps both guide investigations and facilitate early recognition of autoimmune disorders. From a neuro-ophthalmic perspective, it is important to understand heralding signs and symptoms of autoimmune syndromes, avoid cognitive errors, and remain mindful of common diagnostic pitfalls to optimize care.
    Video abstract: http://links.lww.com/COOP/A61.
    MeSH term(s) Humans ; Autoimmune Diseases/diagnosis ; Autoantibodies ; Syndrome
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Review ; Video-Audio Media ; Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000001001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Patterns and utility of myelin oligodendrocyte glycoprotein (MOG) antibody testing in cerebrospinal fluid.

    Burton, Jodie M / Youn, Saerom / Al-Ani, Abdullah / Costello, Fiona

    Journal of neurology

    2024  

    Abstract: Background: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an idiopathic central nervous system (CNS) demyelinating disease gaining recognition with wider availability of cell-based assay (CBA) testing and recently ... ...

    Abstract Background: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an idiopathic central nervous system (CNS) demyelinating disease gaining recognition with wider availability of cell-based assay (CBA) testing and recently published diagnostic criteria. However, uncertainty remains regarding the interpretation of antibody titers, particularly cerebrospinal fluid (CSF) MOG antibody titers.
    Methods: All MOG IgG CBA results performed by the provincial MitogenDx laboratory in Alberta from July 2017 to July 2023 were retrieved. Chart review was performed in patients with both serum and CSF testing and ≥ 1 positive MOG antibody result. Demographics, antibody titers, clinical and imaging features, treatment, and diagnosis were analyzed based on serum/CSF status.
    Results: Among 4494 MOG CBA assays, there were 413 CSF samples in 402 patients, and 268 patients had at least one associated serum sample. Mean time between CSF and serum testing was 20.9 days (range 0-870 days), most with testing within 30 days. Five of the 268 patients had serum positive/CSF positive MOG antibodies, 4 with acute disseminated encephalomyelitis and 1 with longitudinally extensive transverse myelitis. Twenty-three patients had serum positive/CSF negative MOG and 13/23 with optic neuritis. CSF MOG antibody positive patients were younger, and more likely to remain MOG seropositive versus CSF negative patients. No seronegative patient had MOG antibodies in CSF.
    Conclusions: In province-wide testing, CSF MOG antibodies were rare, only in MOG seropositive patients and none with optic neuritis. Our study does not support a clear role for CSF MOG antibody testing in the majority of patients, although further study is required.
    Language English
    Publishing date 2024-02-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12213-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.40: Show issues Location:
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  8. Article ; Online: Contemporary management challenges in seropositive NMOSD.

    Costello, Fiona / Burton, Jodie M

    Journal of neurology

    2022  Volume 269, Issue 10, Page(s) 5674–5681

    Abstract: Neuromyelitis optica spectrum disorders (NMOSD) is an inflammatory disorder of the central nervous system that presents unique management challenges. Neurologic disability in NMOSD is directly linked to acute attacks, therefore, relapse prevention is an ... ...

    Abstract Neuromyelitis optica spectrum disorders (NMOSD) is an inflammatory disorder of the central nervous system that presents unique management challenges. Neurologic disability in NMOSD is directly linked to acute attacks, therefore, relapse prevention is an overarching goal of care. To this end, identifying effective biomarkers that predict relapse onset and severity is of critical importance. As treatment becomes more precision-based and patient-centred, clinicians will need to be familiar with managing circumstances of particular vulnerability for patients with NMOSD, including infection, pregnancy, and the post-partum phase. The discovery of the pathogenic aquaporin-4 Immunoglobulin G (AQP4 IgG) autoantibody almost 20 years ago ultimately distinguished NMOSD as an autoimmune astrocytopathy and helped spearhead recent therapeutic advancements. Targeted therapies, including eculizumab, satralizumab, and inebilizumab, approved for use in aquaporin-4 immunoglobulin G (AQP4 IgG) seropositive patients with NMOSD will likely improve outcomes, but there are formidable costs involved. Importantly, seronegative patients continue to have limited therapeutic options. Moving forward, areas of research exploration should include relapse prevention, restorative therapies, and initiatives that promote equitable access to approved therapies for all people living with NMOSD.
    MeSH term(s) Aquaporin 4 ; Autoantibodies ; Biomarkers ; Humans ; Immunoglobulin G ; Neuromyelitis Optica/drug therapy ; Neuromyelitis Optica/therapy
    Chemical Substances Aquaporin 4 ; Autoantibodies ; Biomarkers ; Immunoglobulin G
    Language English
    Publishing date 2022-07-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-11241-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Optic neuritis: current challenges in diagnosis and management.

    Benard-Seguin, Etienne / Costello, Fiona

    Current opinion in neurology

    2022  Volume 36, Issue 1, Page(s) 10–18

    Abstract: Purpose of review: The primary aim of this review is to describe the clinical course, salient imaging features, and relevant serological profiles of common optic neuritis (ON) subtypes. Key diagnostic challenges and treatment options will also be ... ...

    Abstract Purpose of review: The primary aim of this review is to describe the clinical course, salient imaging features, and relevant serological profiles of common optic neuritis (ON) subtypes. Key diagnostic challenges and treatment options will also be discussed.
    Recent findings: ON is a broad term that describes an inflammatory optic nerve injury arising from a variety of potential causes. ON can occur sporadically, however there is particular concern for co-associated central nervous system (CNS) inflammatory syndromes including multiple sclerosis (MS), neuromyelitis optic spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). The ON subtypes that often herald MS, NMOSD, and MOGAD differ with respect to serological antibody profile and neuroimaging characteristics, yet there is significant overlap in their clinical presentations. A discerning history and thorough examination are critical to rendering the correct diagnosis.
    Summary: Optic neuritis subtypes vary with respect to their long-term prognosis and accordingly, require different acute treatment strategies. Moreover, delays in identifying MOGAD, and certainly NMOSD, can be highly detrimental because affected individuals are vulnerable to permanent vision loss and neurologic disability from relapses.
    MeSH term(s) Humans ; Neuromyelitis Optica/complications ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/therapy ; Aquaporin 4 ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies ; Optic Neuritis/diagnosis ; Optic Neuritis/therapy ; Multiple Sclerosis/diagnosis ; Inflammation
    Chemical Substances Aquaporin 4 ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Invited Commentary: Form Versus Function: A State of Disunion?

    Costello, Fiona

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2017  Volume 37, Issue 1, Page(s) 15–16

    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000000473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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