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  1. Book ; Online: Intra- and Inter-individual Variability of Executive Functions: Determinant and Modulating Factors in Healthy and Pathological Conditions

    MacPherson, Sarah E. / MacPherson, Sarah E. / Gillebert, Celine R. / Robinson, Gail A. / Vallesi, Antonino

    2019  

    Keywords Science: general issues ; Psychology ; executive abilities/function ; cognitive aging ; Intelligence ; Expertise ; bilingualism ; development ; inter-individual & intra-individual differences ; Cognitive Reserve
    Size 1 electronic resource (473 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231367
    ISBN 9782889458370 ; 2889458377
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A review of the evidence base for utilizing Child-Pugh criteria for guiding dosing of anticancer drugs in patients with cancer and liver impairment.

    Palmieri, C / Macpherson, I R

    ESMO open

    2021  Volume 6, Issue 3, Page(s) 100162

    Abstract: As the liver is vital for the metabolism of many anticancer drugs, determining the correct starting doses in cancer patients with liver impairment is key to safe prescription and prevention of unnecessary adverse effects. Clinicians typically use liver ... ...

    Abstract As the liver is vital for the metabolism of many anticancer drugs, determining the correct starting doses in cancer patients with liver impairment is key to safe prescription and prevention of unnecessary adverse effects. Clinicians typically use liver function tests when evaluating patients; however, prescribing information and summaries of product characteristics often suggest dosing of anticancer drugs in patients with liver impairment based on the Child-Pugh criteria, even though the criteria were not developed for this purpose. In this review, we assessed all the oncological small molecule and cytotoxic drugs approved by the United States Food and Drug Administration (FDA) over a 5-year period from 2014 to 2018. The various entry criteria related to these drugs-with respect to hepatic function-in key pivotal studies were compared with their approved dosing recommendations found in prescribing information and summaries of product characteristics. We found that 46% of drugs have dosing recommendations based on Child-Pugh criteria alone, despite the fact that only 8% of these drugs were tested within studies that used the Child-Pugh criteria as entry criteria. Moreover, we note that the data used to make recommendations based on Child-Pugh criteria are typically from small studies that may lack an appropriate patient population. We propose that these findings, along with details surrounding the development of the Child-Pugh criteria, call into question the validity and appropriateness of using Child-Pugh criteria for dosing recommendations of anticancer drugs.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Humans ; Liver Diseases ; Liver Function Tests ; Neoplasms/complications ; Neoplasms/drug therapy ; United States
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-06-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1016/j.esmoop.2021.100162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Rezension von: Kirkby, R. J. R., Urbanisation in China]

    MacPherson, Kerrie L / Kirkby, R. J. R

    The Asian journal of public administration 9 ,1, S. 102-105

    1987  

    Author's details [rezensiert von]: Kerrie L. MacPherson
    Keywords 40;49
    Language English
    Publishing place Hong Kong
    Document type Article
    ZDB-ID 901667-3 ; 2198927-8
    ISSN 2327-6673 ; 0259-8272 ; 2327-6665
    ISSN (online) 2327-6673
    ISSN 0259-8272 ; 2327-6665
    Database ECONomics Information System

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  4. Article: Golfers are physically more active and have greater health associated quality of life than non-golfers following lower limb arthroplasty.

    Clement, N D / Robinson, P G / Murray, I R / Murray, A D / MacDonald, D / Gaston, P / Moran, M / Macpherson, G J

    Journal of orthopaedics

    2024  Volume 54, Page(s) 158–162

    Abstract: Background: The health benefits of physical activity are well recognised. This study assessed whether golfers were more physically active after lower limb arthroplasty when compared to those that did not play golf (primary outcome). In addition pre and ... ...

    Abstract Background: The health benefits of physical activity are well recognised. This study assessed whether golfers were more physically active after lower limb arthroplasty when compared to those that did not play golf (primary outcome). In addition pre and postoperative changes in health-associated quality of life (HAQoL) and joint specific outcomes between golfers and none golfers were assessed (secondary outcomes).
    Methods: There were 304 patients [THA (n = 155) or TKA (n = 149)] prospectively registered during a 4-month period undergoing lower limb arthroplasty. The mean age was 70.0 (range 37-92, standard deviation 10.2) years and included 188 (61%) females and 120 (39%) males. They completed pre and postoperative questionnaires assessing recreational activity, physical activity, HAQoL (EuroQol [EQ]), joint specific health (Oxford scores), and satisfaction.
    Results: Golfers (n = 33, 10.9%) were more likely to achieve longer than 3 hours of moderate activity during a week (48.5% vs 38.0%, odds ratio (OR) 3.4, p = 0.045) and achieved their recommended activity level (96.8% vs 77.7%, OR 8.6, p = 0.015) compared to non-golfers following arthroplasty. Postoperative EQ5D (p = 0.034) and EQVAS (p = 0.019) were significantly greater in golfers. The joint specific Oxford hip score was greater in golfers compared to non-golfers (mean difference 5.6, p = 0.022), however no difference was observed in the Oxford knee score following TKA (p = 0.495).
    Conclusion: Golfers were more likely to achieve their weekly recommended level of physical activity and had a greater HAQoL relative to those that did not play golf following lower limb arthroplasty. More specifically after THA golfers also had a greater postoperative joint specific outcome, but no such advantage was observed in those following TKA.
    Evidence level: Level II, diagnostic study.
    Language English
    Publishing date 2024-03-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2024.03.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Idiopathic Pericarditis.

    Macpherson, R B

    Glasgow medical journal

    2018  Volume 21, Issue 2, Page(s) 114–116

    Language English
    Publishing date 2018-11-14
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 414084-9
    ISSN 0367-4800
    ISSN 0367-4800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Case of Enteritis Terminating in Gangrene.

    Macpherson, R N

    Glasgow medical journal

    2018  Volume 2, Issue 17, Page(s) 196–198

    Language English
    Publishing date 2018-11-14
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 414084-9
    ISSN 0367-4800
    ISSN 0367-4800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effect of Bamlanivimab as Monotherapy or in Combination with Etesevimab or Sotrovimab on Persistently High Viral Load in Patients with Mild-to-Moderate COVID-19: A Randomized, Phase 2 BLAZE-4 Trial.

    Nichols, Russell M / Macpherson, Lisa / Patel, Dipak R / Yeh, Wendy W / Peppercorn, Amanda

    Infectious diseases and therapy

    2024  Volume 13, Issue 2, Page(s) 401–411

    Abstract: Introduction: Treatment with monoclonal antibodies provides rapid, passive immunity and may stop COVID-19 disease progression. The study evaluated the effect of bamlanivimab (BAM) or BAM + etesevimab (ETE)/sotrovimab compared to placebo on SARS-CoV-2 ... ...

    Abstract Introduction: Treatment with monoclonal antibodies provides rapid, passive immunity and may stop COVID-19 disease progression. The study evaluated the effect of bamlanivimab (BAM) or BAM + etesevimab (ETE)/sotrovimab compared to placebo on SARS-CoV-2 viral load in patients with COVID-19.
    Methods: The phase 2, randomized, single-dose study included patients aged between ≥ 18 and < 65 years, not hospitalized at the time of randomization, and had ≥ 1 mild or moderate COVID-19 symptoms. Study included arms 1-6 (placebo, BAM 175 mg + ETE 350 mg, BAM 700 mg + ETE 1400 mg, BAM 2800 mg + ETE 2800 mg, BAM 700 mg alone, and BAM 350 mg + ETE 700 mg, respectively), BAM 700 mg + ETE 700 mg unintentional dosing; and arms 7 and 8 (BAM 700 mg + sotrovimab 500 mg and placebo, respectively). The primary endpoint was proportion of patients with SARS-CoV-2 log viral load > 5.27 on day 7 (persistently high viral load [PHVL]) who received BAM or BAM + (ETE or sotrovimab).
    Results: A total of 725 patients, mean age 39.6 years (range 18-75 years), 50.2% male were randomized and infused with study drug in arms 1-6; and a total 202 patients, mean age 38 years (range 18-63 years), 53.5% female were randomized and infused with study drug in arms 7 and 8. A significantly lower proportion of patients in arms 2-6 and arm 7 experienced PHVL on day 7 compared to placebo. On day 7, patients in arms 2, 3, and 6 consistently experienced significantly greater reduction in viral load than placebo. Significant improvement was observed in time to viral load clearance and time to symptom improvement by day 29 in some arms compared to placebo. No new safety concerns were observed with drug combinations.
    Conclusion: The study demonstrated that a significantly lower proportion of patients with mild-to-moderate COVID-19 treated with BAM or BAM + (ETE or sotrovimab) experienced a PHVL at day 7.
    Trial registration: ClinicalTrials.gov identifier, NCT04634409.
    Language English
    Publishing date 2024-01-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-024-00918-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: "Arming half-baked people with weapons!" Information enclaving among professionals and the need for a care-centred model for antibiotic use information in Uganda, Tanzania and Malawi.

    Nayiga, Susan / MacPherson, Eleanor E / Mankhomwa, John / Nasuwa, Fortunata / Pongolani, Raymond / Kabuleta, Rita / Kesby, Mike / Dacombe, Russell / Hilton, Shona / Grace, Delia / Feasey, Nicholas / Chandler, Clare I R

    Global health action

    2024  Volume 17, Issue 1, Page(s) 2322839

    Abstract: Background: The overuse of antimicrobial medicines is a global health concern, including as a major driver of antimicrobial resistance. In many low- and middle-income countries, a substantial proportion of antibiotics are purchased over-the-counter ... ...

    Abstract Background: The overuse of antimicrobial medicines is a global health concern, including as a major driver of antimicrobial resistance. In many low- and middle-income countries, a substantial proportion of antibiotics are purchased over-the-counter without a prescription. But while antibiotics are widely available, information on when and how to use them is not.
    Objective: We aimed to understand the acceptability among experts and professionals of sharing information on antibiotic use with end users - patients, carers and farmers - in Uganda, Tanzania and Malawi.
    Methods: Building on extended periods of fieldwork amongst end-users and antibiotic providers in the three countries, we conducted two workshops in each, with a total of 44 medical and veterinary professionals, policy makers and drug regulators, in December 2021. We carried out extensive documentary and literature reviews to characterise antibiotic information systems in each setting.
    Results: Participants reported that the general public had been provided information on medicine use in all three countries by national drug authorities, health care providers and in package inserts. Participants expressed concern over the danger of sharing detailed information on antibiotic use, particularly that end-users are not equipped to determine appropriate use of medicines. Sharing of general instructions to encourage professionally-prescribed practices was preferred.
    Conclusions: Without good access to prescribers, the tension between enclaving and sharing of knowledge presents an equity issue. Transitioning to a client care-centred model that begins with the needs of the patient, carer or farmer will require sharing unbiased antibiotic information at the point of care.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Malawi ; Tanzania ; Uganda ; Administrative Personnel
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540569-X
    ISSN 1654-9880 ; 1654-9880
    ISSN (online) 1654-9880
    ISSN 1654-9880
    DOI 10.1080/16549716.2024.2322839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Referral practices of recent graduate and experienced physiotherapists working in Australian primary care for people with musculoskeletal conditions.

    Macpherson, S / Rebbeck, T R / Coates, S / Evans, K

    Musculoskeletal science & practice

    2023  Volume 64, Page(s) 102745

    Abstract: Background: People with musculoskeletal conditions often seek care from physiotherapists. Some, particularly those at risk of poor outcomes, may benefit from referral to physiotherapists with expertise in managing musculoskeletal conditions and/or ... ...

    Abstract Background: People with musculoskeletal conditions often seek care from physiotherapists. Some, particularly those at risk of poor outcomes, may benefit from referral to physiotherapists with expertise in managing musculoskeletal conditions and/or multidisciplinary care. Understanding referral practices of physiotherapists, and how experience influences those practices, may assist in implementing optimal care pathways in primary care.
    Aims: Explore (i) current referral practices of recent graduate and experienced physiotherapists who manage musculoskeletal conditions; (ii) opinions about referral to specialist physiotherapists for people at risk of poor outcomes.
    Methods: This qualitative study consisted of 23 semi-structured interviews with recent graduate (n = 9) and experienced physiotherapists (n = 14) working in primary care. Perspectives of participants' current referral practices (to whom, when and why they are referred) and referral to specialist physiotherapists were sought. Interviews were recorded and transcribed verbatim prior to analysis.
    Results: Referral practices for both groups were influenced by specific diagnoses, complexity of presentations, confidence, self-awareness, the clinical environment and system-related factors. Experienced physiotherapists were more confident and specific in their referrals and had established trusted networks compared with new graduates. Early referral to specialist physiotherapists was more likely when therapists were co-located. Barriers to early referral were lack of awareness, health system factors and impact on the patient (e.g., financial, time, continuity of care).
    Conclusion: Understanding factors influencing referral decisions may improve both intra- and interprofessional care for people with musculoskeletal conditions. Referral of people at risk of poor outcomes to specialist physiotherapists may be improved by greater intraprofessional awareness and clarity of roles.
    MeSH term(s) Humans ; Referral and Consultation ; Physical Therapists ; Musculoskeletal Diseases/therapy ; Australia ; Qualitative Research ; Primary Health Care
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2888772-4
    ISSN 2468-7812
    ISSN (online) 2468-7812
    DOI 10.1016/j.msksp.2023.102745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Henry's clinical diagnosis and management by laboratory methods

    MacPherson, Richard A. / Pincus, Matthew R. / Henry, John Bernard

    2016  

    Title variant Clinical diagnosis and management by laboratory methods
    Author's details Richard A. McPherson ; Matthew R. Pincus
    Keywords Diagnosis, Laboratory
    Subject code 616.0756
    Language English
    Dates of publication Elsevier
    Size XVII, 1565 S. : zahlr. Ill., graph. Darst., 29 cm
    Edition 23. ed.
    Publishing place St. Louis, Mo
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT018998561
    ISBN 978-0-323-29568-0 ; 0-323-29568-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 1385 available for loan (reading room) Lesesaal EG
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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