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Article ; Online: Música para os Seus Ouvidos

Tiago Fernandes Flores / Joana Filipa Correia Costa / Joana Raquel Pereira Correia

Gazeta Médica, Vol 1, Iss

Um Caso de Alucinose Musical Idiopática

2023 Volume 1

Abstract: A alucinose musical é uma doença com fisiopatologia mal-esclarecida, na qual a hipoacusia e as patologias do humor poderão ser fatores desencadeantes. Apesar de não existir uma abordagem terapêutica consensual, a psicoeducação desempenha um papel fulcral. ...

Abstract	A alucinose musical é uma doença com fisiopatologia mal-esclarecida, na qual a hipoacusia e as patologias do humor poderão ser fatores desencadeantes. Apesar de não existir uma abordagem terapêutica consensual, a psicoeducação desempenha um papel fulcral. Apresenta-se o caso de uma mulher de 84 anos de idade com hipoacusia e perturbação depressiva reativa ao papel de cuidadora do marido. Quatro dias após introdução de medicação antidepressiva iniciou quadro de alucinose musical auditiva, onde ouvia músicas da sua infância de forma contínua, ao longo do dia. Estas queixas mantiveram-se apesar da interrupção da terapêutica antidepressiva e mostraram-se refratárias à toma de antipsicóticos. Após despiste de patologias orgânicas foi iniciada psicoeducação, com enfoque no aumento da atividade social e estímulos auditivos e otimização das patologias co-mórbidas, tendo a doente apresentado evolução favorável e resolução quase completa das queixas.
Keywords	Alucinações ; Música ; Perda Auditiva/complicações ; Perturbações Mentais/complicação ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	José de Mello Saúde
Document type	Article ; Online
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Article ; Online: Música para os Seus Ouvidos

Tiago Fernandes Flores / Joana Filipa Correia Costa / Joana Raquel Pereira Correia

Gazeta Médica, Vol 1, Iss

Um Caso de Alucinose Musical Idiopática

2023 Volume 1

Abstract	A alucinose musical é uma doença com fisiopatologia mal-esclarecida, na qual a hipoacusia e as patologias do humor poderão ser fatores desencadeantes. Apesar de não existir uma abordagem terapêutica consensual, a psicoeducação desempenha um papel fulcral. Apresenta-se o caso de uma mulher de 84 anos de idade com hipoacusia e perturbação depressiva reativa ao papel de cuidadora do marido. Quatro dias após introdução de medicação antidepressiva iniciou quadro de alucinose musical auditiva, onde ouvia músicas da sua infância de forma contínua, ao longo do dia. Estas queixas mantiveram-se apesar da interrupção da terapêutica antidepressiva e mostraram-se refratárias à toma de antipsicóticos. Após despiste de patologias orgânicas foi iniciada psicoeducação, com enfoque no aumento da atividade social e estímulos auditivos e otimização das patologias co-mórbidas, tendo a doente apresentado evolução favorável e resolução quase completa das queixas.
Keywords	Alucinações ; Música ; Perda Auditiva/complicações ; Perturbações Mentais/complicação ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	José de Mello Saúde
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Herpetic Esophagitis: A Cause of Dysphagia in a Malnourished Patient.

Sousa, Bárbara / Silva, Joana / Araújo, Elsa / Costa, Raquel / Calheiros, Andre

Cureus

2023 Volume 15, Issue 8, Page(s) e43858

Abstract: Herpetic esophagitis (HE) is an esophageal infection caused by herpes simplex virus (HSV). Although less common, it can occasionally affect immunocompetent hosts. It can manifest as odynophagia and/or dysphagia and should lead to an investigation by ... ...

Abstract	Herpetic esophagitis (HE) is an esophageal infection caused by herpes simplex virus (HSV). Although less common, it can occasionally affect immunocompetent hosts. It can manifest as odynophagia and/or dysphagia and should lead to an investigation by upper digestive endoscopy with a biopsy. The authors report a case of a 65-year-old man with a past medical history relevant for schizophrenia, oligophrenia, and malnutrition, and no other history or evidence of immunosuppression, who presented with severe dysphagia over weeks and recent episodes of food aspiration with consequent pneumonia. An upper gastrointestinal endoscopy was performed, revealing severe stenosis at the level of the gastroesophageal junction with scar tissue, not transposable with the endoscope. The biopsy led to the diagnosis of hepatic esophagitis. Despite the immunocompetent status (excepting only the risk factor malnutrition) and treatment with acyclovir, with initial clinical improvement, the patient died a few weeks after diagnosis after multiple respiratory complications such as nosocomial infection. This case highlights that herpetic esophagitis is sometimes observed in immunocompetent hosts. HE has a self-limited course, with severe complications more frequent in immunosuppressed patients. However, it is also important to suspect this condition in immunocompetent patients and look for risk factors, given the potential morbidity this disease entails. In this group of patients, the presence of predisposing factors and associated comorbidities, such as malnutrition, alcohol consumption, or use of corticosteroids, have been associated with the development of viral esophagitis (including HE). HE remains a clinical challenge, especially in patients with risk factors for immunosuppression, such as malnutrition, as in the reported case.
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43858
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Article ; Online: Increased Galactosidase Beta 1 Expression as a Senescent Key Factor in β-Cells Function Modulation at the Early Steps of Type 2 Diabetes.

Maduro, Ana T / Pinto, Anabela / Ferreira-Gomesb, Joana / Costa, Raquel / Soares, Raquel / Luís, Carla

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2023 Volume 131, Issue 5, Page(s) 282–289

Abstract: Background: In type 2 diabetes, insulin resistance is observed, and β-cells are incapable of responding to glycemia demands, leading to hyperglycemia. Although the nature of β-cells dysfunction in this disease is not fully understood, a link between the ...

Abstract	Background: In type 2 diabetes, insulin resistance is observed, and β-cells are incapable of responding to glycemia demands, leading to hyperglycemia. Although the nature of β-cells dysfunction in this disease is not fully understood, a link between the induction of pancreatic β-cell premature senescence and its metabolic implications has been proposed. This study aimed to understand the relationship between diabetes and pancreatic senescence, particularly at the beginning of the disease. Methods: C57Bl/6 J mice were fed two different diets, a normal diet and a high-fat diet, for 16 weeks. Pancreatic histomorphology analysis, insulin quantification, inflammation parameters, and senescence biomarkers for the experimental animals were assessed at weeks 12 and 16. Results: The results proved that diabetes onset occurred at week 16 in the High Fat Diet group, supported by glycaemia, weight and blood lipid levels. Increased β-cells size and number accompanied by increased insulin expression were observed. Also, an inflammatory status of the diabetic group was noted by increased levels of systemic IL-1β and increased pancreatic fibrosis. Finally, the expression of galactosidase-beta 1 (GLB1) was significantly increased in pancreatic β-cells. Conclusion: The study findings indicate that senescence, as revealed by an increase in GLB1 expression, is a key factor in the initial stage of diabetes.
MeSH term(s)	Animals ; Mice ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2 ; Diet, High-Fat ; Galactosidases/metabolism ; Insulin ; Insulin-Secreting Cells/metabolism ; Mice, Inbred C57BL
Chemical Substances	Blood Glucose ; Galactosidases (EC 3.2.1.-) ; Insulin
Language	English
Publishing date	2023-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-2044-8873
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Article ; Online: Association of child neurodevelopmental or behavioural problems with maternal unemployment in a population-based birth cohort.

Amaro, Joana / Costa, Raquel / Popovic, Maja / Maule, Milena Maria / Mehlum, Ingrid Sivesind / Lucas, Raquel

Social psychiatry and psychiatric epidemiology

2023 Volume 59, Issue 4, Page(s) 643–655

Abstract: Purpose: To estimate associations between suspected or diagnosed neurodevelopmental or behavioural problems in 7-year-old children and maternal unemployment at child age 7 and 10, in a Portuguese birth cohort.: Methods: We evaluated 5754 mothers and ... ...

Abstract	Purpose: To estimate associations between suspected or diagnosed neurodevelopmental or behavioural problems in 7-year-old children and maternal unemployment at child age 7 and 10, in a Portuguese birth cohort. Methods: We evaluated 5754 mothers and their children of the population-based birth cohort Generation XXI in Porto, Portugal. Data on suspected and diagnosed child neurodevelopmental and behavioural problems (exposures)-learning, attention and language problems, externalising behaviours, developmental delay, autism spectrum disorders, and other neurodevelopmental problems-were retrieved at 7 years of age by interviewing caregivers. Maternal employment status (outcome) was collected at the 7- and 10-year follow-up waves. Robust Poisson regression models were used to estimate associations. Results: After adjustment for maternal and household characteristics, women were more likely to be unemployed at child age 10 if the child had, up to age 7, any of the following suspected problems: an autism spectrum disorder (PR = 1.73; 95% CI 1.07, 2.79), developmental delay (PR = 1.58; 95% CI 1.20, 2.06), externalising behaviours (PR = 1.29; 95% CI 1.11, 1.50) or learning problems (PR = 1.26; 95% CI 1.07, 1.48). When the exposure was restricted to clinically diagnosed disorders, the magnitude of associations remained similar but estimates were less precise. Associations with unemployment were stronger at child age 10 (prospective analyses), than at child age 7 (cross-sectional). Conclusion: Having a child with learning, developmental or behavioural problems, or an autism spectrum disorder up to age 7 was associated with maternal unemployment three years later, even in a less affluent European economy where the dual-earner family structure is often necessary to make ends meet.
MeSH term(s)	Child ; Humans ; Female ; Child, Preschool ; Autism Spectrum Disorder/epidemiology ; Problem Behavior ; Prospective Studies ; Birth Cohort ; Unemployment ; Cross-Sectional Studies
Language	English
Publishing date	2023-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-023-02464-6
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Article: Primary Biliary Cholangitis Overlap With Autoimmune Hepatitis? A Case Report.

Costa, Vitor / Moreira, Marta / Costa, Raquel / Fontes, Joana

Journal of medical cases

2021 Volume 12, Issue 4, Page(s) 131–133

Abstract: Primary biliary cholangitis (PBC) is a chronic, autoimmune cholestatic disease, characterized by inflammation of the small and medium-sized bile ducts, which can lead to cirrhosis. Two to nineteen percent of patients with PBC have been reported to have ... ...

Abstract	Primary biliary cholangitis (PBC) is a chronic, autoimmune cholestatic disease, characterized by inflammation of the small and medium-sized bile ducts, which can lead to cirrhosis. Two to nineteen percent of patients with PBC have been reported to have features that overlap with autoimmune hepatitis (AIH). We report a case of a 39-year-old man with changes in liver biochemistry, with 6 years of asymptomatic evolution, whose diagnostic investigation determined the diagnosis of PBC, however with some features of AIH.
Language	English
Publishing date	2021-02-08
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2586383-6
ISSN	1923-4163 ; 1923-4155
ISSN (online)	1923-4163
ISSN	1923-4155
DOI	10.14740/jmc3623
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Article ; Online: A case of porto-sinusoidal vascular disease

Luciana Silva / Raquel Moura / Luís Rocha / Tiago Costa / Filipe Breda / Joana Cochicho

European Journal of Case Reports in Internal Medicine (2023)

2023

Abstract: Introduction: Porto-sinusoidal vascular syndrome is characterised by specific histological changes that do not include cirrhosis, with or without portal hypertension. Patients are usually asymptomatic until development of portal hypertension ... ...

Abstract	Introduction: Porto-sinusoidal vascular syndrome is characterised by specific histological changes that do not include cirrhosis, with or without portal hypertension. Patients are usually asymptomatic until development of portal hypertension complications. Case description: A 69-year-old female with history of JAK2 positive essential thrombocythemia (ET) was referred to internal medicine consultation due to elevated liver enzymes. The patient had no previous history of liver disease. Seven months earlier, she had an ischaemic stroke and started treatment with atorvastatin. After discontinuing medication, liver enzymes returned to normal and atorvastatin-related drug-induced liver disease (DILI) was presumed. During a follow-up visit, iron deficiency anaemia was detected and an endoscopic study was performed. It revealed a gastric varix actively bleeding, which was successfully treated with cyanoacrylate. Two months later, the patient was admitted due to a new episode of variceal bleeding, and a portal hypertension complementary study was made. Discussion: Although the pathogenesis of porto-sinusoidal vascular disease (PSVD) remains poorly understood, vascular changes within the liver have been associated with several predisposing conditions, such as hypercoagulable states. Patients with ET, especially those with JAK2 mutation, are known to be at increased risk of non-cirrhotic vein thrombosis. Concerning PSVD, the association is not clear but it is believed that both PSVD and myeloproliferative neoplasms share a common denominator: a state characterised by hypercoagulability, inflammation, endothelial dysfunction and, in some cases, portal hypertension. Conclusion: Portal hypertension without cirrhosis is a rare condition, presenting diagnostic challenges and significant impact on the patient’s prognosis.
Keywords	porto-sinusoidal vascular disease ; portal hypertension ; incomplete septal fibrosis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
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Article: Changes in Coagulation Study and Risk of Developing Cholesteatoma: Is There a Link?

Costa, Joana Raquel / Rego, Ângela Reis / Soares, Teresa / Sousa, Cecília Almeida E / Coutinho, Miguel Bebiano

Journal of audiology & otology

2023 Volume 27, Issue 1, Page(s) 30–36

Abstract: Background and objectives: The etiopathogenesis of acquired pediatric cholesteatoma has not yet been fully clarified. Recent studies and modern technologies have led researchers to look for explanations at a molecular level. This study aims to ... ...

Abstract	Background and objectives: The etiopathogenesis of acquired pediatric cholesteatoma has not yet been fully clarified. Recent studies and modern technologies have led researchers to look for explanations at a molecular level. This study aims to understand if the origins of cholesteatoma could be related to dysfunctions in coagulation factors, thereby emphasizing its role in angiogenesis. Subjects and. Methods: This was a retrospective case-control study carried out at a tertiary hospital center between January 2010 and December 2020. The study included 92 children. The variables of the summary coagulation study (partial thromboplastin time, prothrombin time, and international normalized ratio) were compared among children with and without development of chronic otitis media with cholesteatoma. Results: The cases and controls were comparable in terms of age, type, and number of times that ventilation tubes were placed. Partial thromboplastin times tended to be higher in children who developed cholesteatoma, with a statistically significant difference between the two groups in terms of normal and abnormal partial thromboplastin times (p=0.029). Conclusions: The results of this case control study indicate that slight extension of partial thromboplastin times in the coagulation study may not meet the criteria for diagnosis of certain hematological pathologies or clinical significance, but at a molecular level may already have implications for activation of angiogenesis and other growth factors involved in the onset, growth, and expansion of acquired pediatric cholesteatoma.
Language	English
Publishing date	2023-01-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018961-5
ISSN	2384-1710 ; 2384-1621
ISSN (online)	2384-1710
ISSN	2384-1621
DOI	10.7874/jao.2022.00143
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Article ; Online: Spontaneous pneumomediastinum and pneumorrhachis in a healthy girl.

Rodrigues, Jorge / Costa, Raquel Monteiro / Magalhães, Joana / Santos, Elisabete

BMJ case reports

2021 Volume 14, Issue 2

MeSH term(s)	Female ; Humans ; Mediastinal Emphysema/diagnostic imaging ; Pneumorrhachis/diagnostic imaging ; Pneumorrhachis/etiology ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-02-26
Publishing country	England
Document type	Journal Article ; Case Reports
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-241077
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Article ; Online: A Case of Porto-Sinusoidal Vascular Disease.

Silva, Luciana / Moura, Raquel / Rocha, Luís / Costa, Tiago / Breda, Filipe / Cochicho, Joana

European journal of case reports in internal medicine

2023 Volume 10, Issue 12, Page(s) 4138

Abstract	Introduction: Porto-sinusoidal vascular syndrome is characterised by specific histological changes that do not include cirrhosis, with or without portal hypertension. Patients are usually asymptomatic until development of portal hypertension complications. Case description: A 69-year-old female with history of JAK2 positive essential thrombocythemia (ET) was referred to internal medicine consultation due to elevated liver enzymes. The patient had no previous history of liver disease. Seven months earlier, she had an ischaemic stroke and started treatment with atorvastatin. After discontinuing medication, liver enzymes returned to normal and atorvastatin-related drug-induced liver disease (DILI) was presumed.During a follow-up visit, iron deficiency anaemia was detected and an endoscopic study was performed. It revealed a gastric varix actively bleeding, which was successfully treated with cyanoacrylate.Two months later, the patient was admitted due to a new episode of variceal bleeding, and a portal hypertension complementary study was made. Discussion: Although the pathogenesis of porto-sinusoidal vascular disease (PSVD) remains poorly understood, vascular changes within the liver have been associated with several predisposing conditions, such as hypercoagulable states. Patients with ET, especially those with JAK2 mutation, are known to be at increased risk of non-cirrhotic vein thrombosis. Concerning PSVD, the association is not clear but it is believed that both PSVD and myeloproliferative neoplasms share a common denominator: a state characterised by hypercoagulability, inflammation, endothelial dysfunction and, in some cases, portal hypertension. Conclusion: Portal hypertension without cirrhosis is a rare condition, presenting diagnostic challenges and significant impact on the patient's prognosis. Learning points: The suspicion of PSVD should be raised when signs of portal hypertension are present with normal or mildly elevated liver enzymes and normal liver stiffness measurement. A liver biopsy should be performed in this situation.Although the pathogenesis of PSVD is not clearly understood, it is based on the development of vascular changes within the liver and there might be several predisposing conditions such as coagulation disorders.
Language	English
Publishing date	2023-10-30
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2023_004138
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