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Article ; Online: Management of Reconstruction of the Columella in Open Rhinoplasty Procedure

Seçkin Aydın Savaş

Bagcilar Medical Bulletin, Vol 8, Iss 1, Pp 41-

Using b-Shaped Columellar Strut Graft

2023 Volume 46

Abstract: Objective:The columellar strut graft (CSG) can help to correct nasal tip (NT) deformities in rhinoplasty. The value of using the CSG technique as a routine procedure in rhinoplasty is still being debated. The reason for this ambivalence is the increased ... ...

Abstract	Objective:The columellar strut graft (CSG) can help to correct nasal tip (NT) deformities in rhinoplasty. The value of using the CSG technique as a routine procedure in rhinoplasty is still being debated. The reason for this ambivalence is the increased rotation effect of a CSG on the NT. In this article, “b” (small letter “B”) shaped CSG was prepared differently from the traditional CSG, and two different designs of CSGs were compared in terms of nasolabial angles.Method:A total of 99 patients who were operated on using CSG between September 2018 and March 2020 were included in this study. We analyzed preoperative and postoperative lateral views of photographs and case histories of 99 patients. Traditional shape and b-shaped CSGs were used for 33 (33.3%) and 66 (66.6%) of the total patients, respectively. The groups of traditional shaped and b-shaped CSGs were compared with statistical analysis.Results:When postoperative nasolabial angles were evaluated, it was found that 36.4% and 7.6% of the nasolabial angles were above the optimal range in the traditional strut graft group and b-shaped CSG group, respectively. Wide-nasolabialangles were observed to be more common in cases with traditional strut grafts than in cases with b-Shaped CSG. The b-shaped CSG provided gain optimal projection without extended rotation. The difference between the two groups was statistically significant (p=0.00).Conclusion:The overall conclusion derived from this research is that an optimally shaped columella can be obtained using a b-shaped CSG without overrotation of the NT.
Keywords	columella reconstruction ; columellar strut graft ; open rhinoplasty ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intracranial Penetrating Trauma Caused by Fishing Sinker.

Aydin, Seckin

World neurosurgery

2019 Volume 129, Page(s) 237–240

Abstract: Background: Intracranial penetrating traumas (IPTs) are rarely encountered in neurosurgery practice. Here, we report the case of a patient with orbital and cranial trauma caused by an unexpected object.: Case description: A 37-year-old male ... ...

Abstract	Background: Intracranial penetrating traumas (IPTs) are rarely encountered in neurosurgery practice. Here, we report the case of a patient with orbital and cranial trauma caused by an unexpected object. Case description: A 37-year-old male presenting with a right orbital penetrating injury was referred to our emergency department. Neurologic examination of the patient revealed right periorbital ecchymosis, a dilated and fixed right pupil, and right hemiparesis. Cranial computed tomography showed fractures of the right orbital medial wall and the anterior skull base, as well as bifrontal and left parietal intracerebral hemorrhage accompanied by a metallic foreign body artifact. Emergency left frontoparietal decompressive craniectomy was performed, and the foreign body, identified as a fishing sinker, was removed. No additional postoperative complications were observed, and cranioplasty was performed 6 months postoperatively. Conclusions: IPTs have high morbidity and mortality rates. Early surgical intervention is often the first treatment option. Intracranial injury caused by a fishing sinker is an extremely rare low-energy intracranial penetrating trauma, and in the literature, this is the first reported case in which the patient survived.
MeSH term(s)	Adult ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/surgery ; Head Injuries, Penetrating/pathology ; Head Injuries, Penetrating/surgery ; Humans ; Male ; Orbital Fractures/etiology ; Orbital Fractures/surgery ; Skull Fractures/etiology
Language	English
Publishing date	2019-06-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.06.051
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Article ; Online: The effect of a new topographic classification on determining the prognosis of nasal fracture and treatment modality.

Aydin Savas, Seckin / Aydin, Ismail Erkan

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2023 Volume 29, Issue 2, Page(s) 212–217

Abstract: Background: Classifications of nasal fracture are based on clinical findings or radiological findings. The classification systems of nasal fracture usually determine the type of nasal fracture. It is important that a classification gives information ... ...

Title translation	Yeni bir topografik sınıflandırmanın burun kırığının prognozunu ve tedavi şeklini belirleme üzerindeki etkisi.
Abstract	Background: Classifications of nasal fracture are based on clinical findings or radiological findings. The classification systems of nasal fracture usually determine the type of nasal fracture. It is important that a classification gives information about treatment modality and prognosis rather than determining the type of fracture. The objective of this study was to show the effect of the new topographic classification on determining the parameters of prognosis and deciding on treatment modality of the nasal fracture. Methods: We reviewed patients with nasal fracture that was referred from emergency department between December 2018 and September 2020. The views of lateral nasal radiography, the facial view of computed tomography (CT), and/or the views of three-dimensional CT were examined to analyze 120 patients with nasal bone fractures. The length of the nasal bone from the top to the base was divided into equal three levels by two lines perpendicular to the length of the nose. The location of fracture was determined as level I, II, and III, respectively, from caudal part to cranial part of the nasal bone. The demographic features of patients, the side of the fracture, the pattern of fracture, accompanying fractures, and the treatment modality were noted. Results: The frequencies of location of nasal fractures were 44%, 28%, and 27% at level I, level II, and level III, respectively, in 120 cases. It was an expected result that the frequency of fractures was low in parts with the thick bone. Considering the rates of being bilateral or unilateral, it was found that the frequency of unilateral was higher in group of level I, where the thickness of nasal bone was thin, but it was less in group of level III (p<0.05). Non-depressed/minimal-depressed pattern of fracture in group of level I accounted for 92.6% which was the highest frequency (p<0.05). Depressed/elevated fracture patterns were more common in group of level II (p<0.05). Comminuted pattern was mostly observed in group of level III. The rate of accompanying fractures and the applied treatment modality was consistent with anatomic feature of fracture's level. Conclusion: We believe that the new topographic classification evaluates the parameters of clinical prognosis such as accompanying fracture, site of fracture and pattern of fracture, and also requirement of closed or open reduction better than other classifications.
MeSH term(s)	Humans ; Skull Fractures/diagnostic imaging ; Prognosis ; Nasal Bone/diagnostic imaging ; Nasal Bone/surgery ; Tomography, X-Ray Computed/methods ; Radiography
Language	English
Publishing date	2023-02-03
Publishing country	Turkey
Document type	Review ; Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2022.09406
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Article ; Online: Evaluation of neurogranin levels in a rat model of diffuse axonal injury.

Baskurt, Ozan / Aydin, Seckin / Avci, Idris / Ozay Nayir, Pinar / Aydin, Mehmet Volkan

Acta neurobiologiae experimentalis

2024 Volume 84, Issue 1, Page(s) 80–88

Abstract: Diffuse axonal injury (DAI), one of the most common and devastating type of traumatic brain injury, is the result of the shear force on axons due to severe rotational acceleration and deceleration. Neurogranin (NRGN) is a postsynaptic protein secreted by ...

Abstract	Diffuse axonal injury (DAI), one of the most common and devastating type of traumatic brain injury, is the result of the shear force on axons due to severe rotational acceleration and deceleration. Neurogranin (NRGN) is a postsynaptic protein secreted by excitatory neurons, and synaptic dysfunction can alter extracellular NRGN levels. In this study, we examined NRGN levels in serum and cerebrospinal fluid (CSF) after experimental DAI in terms of their diagnostic value. Experimental DAI was induced using the Marmarou technique in male Wistar albino rats. Serum and CSF NRGN levels of the sham group, one‑hour, six‑hour, 24‑hour, and 72‑hour post‑DAI groups were measured by ELISA method. DAI was verified by staining with hematoxylin‑eosin and β‑amyloid precursor protein in the rat brain samples. While no histopathological and immunohistochemical changes were observed in the early hours of the post‑DAI groups, the staining of the β‑APP visibly increased over time, with positivity being most frequent and intense in the 72‑hour group. It was found that serum NRGN levels were significantly lower in the 6‑hour group than in the sham group. The serum NRGN levels in the 24‑hour group were significantly higher than those in the sham group. This study showed a dichotomy of post‑DAI serum NRGN levels in consecutive time periods. NRGN levels in CSF were higher in the one‑hour group than in the sham group and returned to baseline by 72 hours, although not significantly. Our study provides an impression of serum and CSF NRGN levels in a rat DAI model in consecutive time periods. Further studies are needed to understand the diagnostic value of NRGN.
MeSH term(s)	Rats ; Male ; Animals ; Neurogranin/metabolism ; Rats, Wistar ; Diffuse Axonal Injury/metabolism ; Diffuse Axonal Injury/pathology ; Neurons/metabolism ; Axons/metabolism
Chemical Substances	Neurogranin (132654-77-4)
Language	English
Publishing date	2024-03-28
Publishing country	Poland
Document type	Journal Article
ZDB-ID	184409-x
ISSN	1689-0035 ; 0065-1400
ISSN (online)	1689-0035
ISSN	0065-1400
DOI	10.55782/ane-2024-2543
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Article ; Online: Olfaktör oluk meningiomunun pterional yaklaşımla çıkarılmasından sonra anosminin düzelmesi

Barış ÖZÖNER / Seçkin AYDIN

Cukurova Medical Journal, Vol 45, Iss 1, Pp 370-

2020 Volume 374

Abstract: Anosmi, olfaktör oluk meningiomlarının (OGM) erken belirtilerinden biridir. Ek olarak, anosminin, saptanması durumunda, operasyon sonrasında düzelmesi beklenmemektedir. Olgumuzda 42 yaşında kadın hasta, bilateral anosmi ve görme bozukluğu ile ... ...

Abstract	Anosmi, olfaktör oluk meningiomlarının (OGM) erken belirtilerinden biridir. Ek olarak, anosminin, saptanması durumunda, operasyon sonrasında düzelmesi beklenmemektedir. Olgumuzda 42 yaşında kadın hasta, bilateral anosmi ve görme bozukluğu ile başvurmaktaydı. Radyolojik incelemelerde belirgin peritümoral ödem ile birlikte büyük bir OGM saptandı. Tümör, pterional yaklaşımla, sol olfaktör sinirinin korunmasıyla, total rezeke edildi. Postoperatif erken dönemde görme bozukluğu düzeldi. Ayrıca, 6 aylık takipte sol burundan koku duyusu alınması sağlandı. Buna göre, anosminin OGM cerrahisi sonrasında kalıcı olacağı yaygın kabul gören bir durum olsada, olfaktör sinirlerin korunması ile nadir vakalarda koku alma duyusu geri kazanılabilir.
Keywords	anosmi ; olfaktör sinir ; olfaktör oluk menengiomu ; pterional yaklaşım ; olfactory nerve ; olfactory groove meningioma ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Cukurova University
Document type	Article ; Online
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Article: Skull Base Collision Tumors: Giant Non-functioning Pituitary Adenoma and Olfactory Groove Meningioma.

Aydin, Mehmet V / Yangi, Kivanc / Toptas, Ezgi / Aydin, Seckin

Cureus

2023 Volume 15, Issue 9, Page(s) e44710

Abstract: A collision tumor complex is composed of at least two different tumors, benign or malignant, with at least two different histopathological features located adjacent to each other in the exact anatomical localization. Pathologies such as meningiomas, ... ...

Abstract	A collision tumor complex is composed of at least two different tumors, benign or malignant, with at least two different histopathological features located adjacent to each other in the exact anatomical localization. Pathologies such as meningiomas, pituitary adenomas, gliomas, and schwannomas may be involved in a collision tumor complex. However, co-occurrence of pituitary adenomas and meningiomas as skull base collision tumors is rare. Here, we present a 65-year-old male patient who presented with olfactory groove meningioma and non-functioning pituitary adenoma as a collision tumor. The patient was admitted with a headache and right-sided vision loss. The patient's first neurologic examination was consistent with temporal anopsia in the right eye. Subsequent contrast-enhanced cranial MRI revealed a 65x55x40 mm heterogeneously contrast-enhanced lesion in the anterior skull base extending from the sellar region to the corpus callosum. Because of the tumor size, a two-staged operation was planned. First, the tumor was partially excised via a right frontal craniotomy with a transcranial approach, and the tumor in the sellar region was left as a residue. The pathology reports after the first surgery showed pituitary adenoma and meningeal epithelial type meningioma (WHO Grade I). The residual tumor tissue was resected seven months later via an endoscopic endonasal approach, except for the part that invaded the right anterior cerebral artery. The optic nerve was decompressed. The patient was then referred to the radiation oncology clinic for radiosurgery. Collision tumors should be considered in the differential diagnosis in preoperative evaluation and surgical planning when heterogeneously contrast-enhanced areas significantly localized adjacent to each other are seen on cranial MRI. On the other hand, when the surgeon encounters sudden changes in the appearance or consistency of the tumor during the surgery, they should suspect these tumor complexes. The diagnosis of collision tumors is quite challenging but is of great importance regarding the patient's need for postoperative radiation therapy or the recurrence characteristics of tumors. However, more studies are needed on these complexes' etiology, surgical planning, and postoperative management.
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44710
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Article ; Online: Clinical and inflammatory response to antiviral treatments in dogs with parvoviral enteritis.

Ulas, Nergis / Ozkanlar, Yunusemre / Ozkanlar, Seckin / Timurkan, Mehmet Ozkan / Aydin, Hakan

Journal of veterinary science

2024 Volume 25, Issue 1, Page(s) e11

Abstract: Background: Canine parvoviral enteritis (CPE) is a fatal disease worldwide. The treatment of CPE is based mainly on supportive and symptomatic treatment. Antiviral addition to the treatment may result in a higher survival.: Objectives: This study ... ...

Abstract	Background: Canine parvoviral enteritis (CPE) is a fatal disease worldwide. The treatment of CPE is based mainly on supportive and symptomatic treatment. Antiviral addition to the treatment may result in a higher survival. Objectives: This study evaluated the effects of antiviral treatments with a standardized treatment (ST) on the clinical and inflammatory response of dogs with naturally occurring CPE. Methods: Twenty-eight dogs with CPE caused by canine parvovirus type 2 were divided randomly into treatment groups. The ST group received fluid, antibiotic, antiemetic, and deworming treatments. The antiviral treatment groups received the same ST with an additional antiviral drug, recombinant feline interferon omega (rFeIFN-ω), oseltamivir (OSEL) or famciclovir (FAM). Results: Compared to the healthy control, the tumor necrosis factor-α, interleukin-1β, interferon (IFN)-α, IFN-γ, haptoglobin, and C-reactive protein values were high ( Conclusions: Antiviral drugs may be valuable in treating CPE to improve the clinical signs and survival. In addition, the decrease in NLR in favor of LYM may be an indicator of the early prognosis before the improvement of leukocytes, cytokines, and acute phase proteins in CPE.
MeSH term(s)	Animals ; Dogs ; Cats ; Parvoviridae Infections/drug therapy ; Parvoviridae Infections/veterinary ; Parvovirus, Canine ; Oseltamivir/therapeutic use ; Antiviral Agents/therapeutic use ; Enteritis/drug therapy ; Enteritis/veterinary ; Dog Diseases ; Cat Diseases/drug therapy
Chemical Substances	Oseltamivir (20O93L6F9H) ; Antiviral Agents
Language	English
Publishing date	2024-02-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2125308-0
ISSN	1976-555X ; 1976-555X
ISSN (online)	1976-555X
ISSN	1976-555X
DOI	10.4142/jvs.23139
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Article ; Online: Microsurgical anatomy of the anterior commissure through the anterior interhemispheric transcallosal approach to the third ventricle

Necmettin Tanriöver / Ayşegül Esen Aydın / Seçkin Aydın

Journal of Surgery and Medicine, Vol 4, Iss 10, Pp 853-

An anatomical and morphological study

2020 Volume 856

Abstract: Aim: The third ventricle is a funnel-shaped cavity located deep in the brain and difficult to access with surgical approach. The anterior commissure is an anatomical structure located on the anterior wall of the third ventricle. This study aimed to ... ...

Abstract	Aim: The third ventricle is a funnel-shaped cavity located deep in the brain and difficult to access with surgical approach. The anterior commissure is an anatomical structure located on the anterior wall of the third ventricle. This study aimed to demonstrate the use of the anterior interhemispheric transcallosal approaches to access the third ventricle, evaluate the microsurgical anatomy of the anterior commissure and investigate the morphological features of this region. Methods: Eleven cadaveric brain specimens were dissected using microsurgical tools. Different anterior interhemispheric routes to the third ventricle were demonstrated, and stepwise dissections were performed to expose the limbs of the anterior commissure. Morphological measurements of the anterior commissure and the third ventricle were carried out. Results: The anterior limb of the anterior commissure extends towards the anterior perforating substance, olfactory bulb, anterior olfactory nucleus and the orbitofrontal cortex. The posterior limb extends from the basal part of the caudate nucleus, passes below the substantia innominata and courses through the basal part of the putamen. It constitutes the major component of the anterior commissure and is composed of temporal and occipital fibers. The mean length of the anterior commissure body was 16.2 ± 4.2 (range 9.7–24.2) mm, while the mean width was 4.3 ± 0.7 (range 2.8–5.1) mm. Conclusion: A better understanding of the microsurgical anatomy and morphometric features of the third ventricle and anterior commissure increases the success of surgical interventions and prevents possible complications in this region.
Keywords	third ventricle ; anterior interhemispheric transcallosal approach ; anterior commissure ; microsurgical anatomy ; üçüncü ventrikül ; anterior interhemisferik transkallozal yaklaşım ; anterior komissür ; mikrocerrahi anatomi ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
Subject code	590
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Journal of Surgery and Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Complex Structure of the Anterior White Commissure of the Human Brain: Fiber Dissection and Tractography Study.

Çavdar, Safiye / Aydın, Ayşegül Esen / Algın, Oktay / Aydın, Seçkin

World neurosurgery

2020 Volume 147, Page(s) e111–e117

Abstract: Objective: Commissural fibers are necessary for bilateral integration, body coordination, and complex cognitive information flow between the hemispheres. The anterior commissure (AC) has a complex architecture interconnecting areas of the frontal, ... ...

Abstract	Objective: Commissural fibers are necessary for bilateral integration, body coordination, and complex cognitive information flow between the hemispheres. The anterior commissure (AC) has a complex architecture interconnecting areas of the frontal, temporal and occipital lobes. The present study aims to demonstrate the connections and the course of the anterior (ACa) and posterior (ACp) limb of the AC using fiber dissection and diffusion tensor imaging (DTI) of the human brain. Methods: Fiber dissection was performed in a stepwise manner from lateral to medial on 6 left hemispheres. The gray matter was decorticated and the ACa-ACp was exposed. The ACa and ACp tracts were demonstrated using a high-spatial-resolution DTI with a 3T magnetic resonance unit in 13 cases. Results: Using both techniques showed that the AC has complex interconnections with large areas of the frontal (olfactory tubercles, anterior olfactory nucleus, olfactory bulb, and the orbital gyri), temporal (amygdaloidal nuclei, temporal and perirhinal cortex), and occipital (visual cortex) lobes. The ACp makes up the major component of the AC and is composed of temporal and occipital fibers. We observed that these fibers do not make a distinct bundle; the temporal fibers joined the uncinate fasciculus and the occipital fibers joined the sagittal striatum to reach their targets. Conclusions: Being aware of the course of the AC is important during transcallosal and interforniceal approaches to the third ventricle tumors and temporal lobe epilepsy surgery. The intermingling fibers of the AC can provide a better understanding of the unexplained deficit that may occur during regional surgery.
MeSH term(s)	Adolescent ; Adult ; Aged ; Anterior Commissure, Brain/diagnostic imaging ; Anterior Commissure, Brain/surgery ; Diffusion Tensor Imaging/methods ; Dissection/methods ; Female ; Humans ; Male ; Middle Aged ; White Matter/diagnostic imaging ; White Matter/surgery ; Young Adult
Language	English
Publishing date	2020-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.11.157
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Article: Secondary Parkinsonism in a Patient With a Cerebral Cavernous Hemangioma Treated With Stereotactic Radiosurgery.

Aydin, Seckin / Esen Aydin, Aysegul / Yuksel, Odhan / Tanriverdi, Taner

Cureus

2021 Volume 13, Issue 3, Page(s) e14128

Abstract: Secondary parkinsonism is defined with some symptoms similar to idiopathic Parkinson's disease, but with different etiologies. And cerebral cavernous hemangioma is one of the rare cases. A 51-year-old, male patient was consulted with tremor, rigidity and ...

Abstract	Secondary parkinsonism is defined with some symptoms similar to idiopathic Parkinson's disease, but with different etiologies. And cerebral cavernous hemangioma is one of the rare cases. A 51-year-old, male patient was consulted with tremor, rigidity and bradykinesia on the right upper extremity. The Hoehn and Yahr Parkinson's scale was Stage І. Radiological evaluations showed a deep-seated cerebral cavernous hemangioma at the left posterior insular region. The patient received stereotactic radiosurgery (CyberKnife®, Accuray Incorporated, Sunnyvale, CA, USA). Clinical and radiological improvements revealed within follow-up, respectively. Stereotactic radiosurgery may be an alternative treatment for secondary parkinsonism by reducing the risk of re-bleeding and reducing its size.
Language	English
Publishing date	2021-03-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14128
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