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  1. Article ; Online: Access Polyarylbipyrazoles via Palladium-Catalysis and Visible-Light-Driven C(sp

    Zhang, Shen-Yuan / Li, Zhi / Hu, Li-Yan / Li, Jin-Tao / Wu, Lei

    Organic letters

    2024  Volume 26, Issue 15, Page(s) 2949–2954

    Abstract: An unprecedented palladium-catalyzed and visible-light-driven relay reaction of allenylphosphine oxide with in situ generated nitrile imines is presented for the direct synthesis of highly valuable polyarylbipyrazole skeletons. This one-pot strategy ... ...

    Abstract An unprecedented palladium-catalyzed and visible-light-driven relay reaction of allenylphosphine oxide with in situ generated nitrile imines is presented for the direct synthesis of highly valuable polyarylbipyrazole skeletons. This one-pot strategy involves double 1,3-dipolar cycloaddition and C(sp
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biocontrol and Growth Promotion Potential of

    Huang, Ning / Jin, Xin / Wen, Jin-Tao / Zhang, Yi-Fei / Yang, Xu / Wei, Guang-Yu / Wang, Yi-Kun / Qin, Min

    Polish journal of microbiology

    2024  Volume 73, Issue 1, Page(s) 29–38

    Abstract: Fungal diseases form perforated disease spots in tobacco plants, resulting in a decline in tobacco yield and quality. The present study investigated the antagonistic effect ... ...

    Abstract Fungal diseases form perforated disease spots in tobacco plants, resulting in a decline in tobacco yield and quality. The present study investigated the antagonistic effect of
    MeSH term(s) Nicotiana ; Bacillus subtilis/genetics ; Disease Resistance ; Rhizoctonia
    Language English
    Publishing date 2024-03-04
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2234080-4
    ISSN 2544-4646 ; 1733-1331
    ISSN (online) 2544-4646
    ISSN 1733-1331
    DOI 10.33073/pjm-2024-004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic Insights into Global

    Yang, Jin-Tao / Zhang, Li-Juan / Lu, Yang / Zhang, Rong-Min / Jiang, Hong-Xia

    Microbiology spectrum

    2023  Volume 11, Issue 4, Page(s) e0108923

    Abstract: In recent years, ...

    Abstract In recent years,
    MeSH term(s) Animals ; Humans ; Escherichia coli ; Phylogeny ; beta-Lactamases/genetics ; Plasmids/genetics ; Escherichia coli Infections/epidemiology ; Genomics ; Thailand ; Anti-Bacterial Agents
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01089-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Three-component synthesis of arylsulfonyl-substituted indolo[2,1-

    Zhang, Jie / Yang, Zixian / Yu, Jin-Tao / Pan, Changduo

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 15, Page(s) 3067–3071

    Abstract: An efficient arylsulfonylation/cyclization of 2-aryl- ...

    Abstract An efficient arylsulfonylation/cyclization of 2-aryl-
    MeSH term(s) Cyclization ; Indoles
    Chemical Substances Indoles
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob00409g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Metal-Free Photoinduced Hydrocyclization of Unactivated Alkenes toward Ring-Fused Quinazolin-4(3

    Yang, Zixian / Wu, Xian / Zhang, Jie / Yu, Jin-Tao / Pan, Changduo

    Organic letters

    2023  Volume 25, Issue 10, Page(s) 1683–1688

    Abstract: A visible-light-induced hydrocyclization of unactivated alkenes was developed using 3CzClIPN as the photocatalyst to generate substituted α-methyldeoxyvasicinones and α-methylmackinazolinones in moderate to good yields. An intermolecular hydrogen atom ... ...

    Abstract A visible-light-induced hydrocyclization of unactivated alkenes was developed using 3CzClIPN as the photocatalyst to generate substituted α-methyldeoxyvasicinones and α-methylmackinazolinones in moderate to good yields. An intermolecular hydrogen atom transfer with THF as the hydrogen source was involved. Mechanism studies indicated that the intramolecular addition of the
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c00329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical Analysis of Laparoscopic Common Bile Duct Primary Suture and T-Tube Drainage in the Treatment of Common Bile Duct Stones.

    Lu, Jiang / Zhang, Xiao / Zeng, Chao / Gu, Jin-Tao / Cai, Huihua

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 33, Issue 7, Page(s) 622–625

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Choledocholithiasis/surgery ; Choledocholithiasis/complications ; Retrospective Studies ; Common Bile Duct/surgery ; Gallstones/surgery ; Gallstones/complications ; Drainage/adverse effects ; Postoperative Complications/etiology ; Length of Stay ; Laparoscopy/adverse effects ; Sutures/adverse effects
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2022.0485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3246: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Role of synaptotagmin 13 (SYT13) in promoting breast cancer and signaling pathways.

    Zhang, Yi-Dan / Zhong, Rui / Liu, Jin-Quan / Sun, Zhen-Xuan / Wang, Teng / Liu, Jin-Tao

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 25, Issue 6, Page(s) 1629–1640

    Abstract: Purpose: Breast cancer is one of the leading causes of tumor death worldwide in female, and the five-year overall survival of breast cancer patients remains poor. It is an urgent need to seek novel target for its treatment. Synaptotagmin 13 (SYT13) is a ...

    Abstract Purpose: Breast cancer is one of the leading causes of tumor death worldwide in female, and the five-year overall survival of breast cancer patients remains poor. It is an urgent need to seek novel target for its treatment. Synaptotagmin 13 (SYT13) is a synaptic vesicle transporting protein that regulates the malignant phenotypes of various cancers. However, its role in breast cancer is still unclear. The current study aimed to investigate the effects of SYT13 on the progression of breast cancer.
    Methods: Twenty-five pairs of breast cancer tissues and non-tumor tissues were obtained to assess the expression of SYT13. We manually modified the expression of SYT13 in MCF-7 and MDA-MB-231 cells. CCK-8 assay, EdU staining, and cell cycle analysis were carried out to measure the proliferated ability of cells. Annexin V/PI and TUNEL assays were used to detect the apoptotic ability of cells. Wound healing and transwell assays were employed to evaluate the migrated and invasive ability of breast cancer cells.
    Results: The results revealed that the mRNA and protein levels of SYT13 were higher in breast cancer tissues and cell lines. Knockdown of SYT13 inhibited the cell proliferation and induced cell cycle arrest in G1 phase of MCF-7 cells by downregulating cyclin D1 and CDK4, as well as upregulating p21. The migration and invasion of MCF-7 cells were repressed by the loss of SYT13 via the gain of E-cadherin and the loss of vimentin. Overexpression of SYT13 in MDA-MB-231 cells led to the opposite effects. Silencing of SYT13 induced the apoptosis ability of MCF-7 cells by the upregulation of bax and the downregulation of bcl-2. Moreover, we found that SYT13 depletion suppressed the FAK/AKT signaling pathway. PF573228 (a FAK inhibitor) and MK2206 (an AKT inhibitor) reversed the SYT13 overexpression-induced promotion of proliferation, migration, and invasion of MDA-MB-231 cells.
    Conclusion: The results indicated that SYT13 promoted the malignant phenotypes of breast cancer cells by the activation of FAK/AKT signaling pathway.
    MeSH term(s) Female ; Humans ; Apoptosis ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; MCF-7 Cells ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Synaptotagmins/genetics ; Synaptotagmins/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTK2 protein, human (EC 2.7.10.2) ; Synaptotagmins (134193-27-4) ; SYT13 protein, human
    Language English
    Publishing date 2023-01-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-022-03058-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6644: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Detection and projection of climatic comfort changes in China's mainland in a warming world

    Jin-Tao Zhang / Guo-Yu Ren / Qing-Long You

    Advances in Climate Change Research, Vol 13, Iss 4, Pp 507-

    2022  Volume 516

    Abstract: Climatic comfort, which refers to the comfort of the human body's thermal sensations, is important for the human habitat. Although considerable efforts have been provided to examine changes in climatic comfort response to global warming from a partial ... ...

    Abstract Climatic comfort, which refers to the comfort of the human body's thermal sensations, is important for the human habitat. Although considerable efforts have been provided to examine changes in climatic comfort response to global warming from a partial perspective, the trajectory shift in past and future climatic comfort conditions in China's mainland based on uniform indicators has not been revealed. The spatiotemporal pattern of climatic comfort over historical and future periods was investigated in this study, using China's mainland as an example. The temperature‒humidity index was adopted on the basis of homogenised meteorological station observations and high-resolution climate model simulations to analyse the trends of comfort/discomfort days from 1960 to 2017 and project changes in climatic comfort under representative concentration pathway scenarios in the late 21st century (2071–2100). Results show a substantial decrease in cold-uncomfortable days and a moderate increase in comfortable and warm-uncomfortable days from 1960 to 2017. In the late 21st century, the signals of increasing warm-uncomfortable and decreasing cold-uncomfortable days are projected to enhance significantly while the direction of changes in comfortable days exhibits a north‒south divergence. The uneven changes in warm- and cold-uncomfortable days and an overall decrease in comfortable days in the late 21st century dominate the future trends in climatic comfort in the densely populated southeast half of China. Effective measures taken for adapting to and mitigating global climate warming can considerably avoid the adverse impact of the projected change.
    Keywords Comfort ; Climate change ; Temperature‒humidity index ; Projection ; China's mainland ; Meteorology. Climatology ; QC851-999 ; Social sciences (General) ; H1-99
    Subject code 550
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Diversity of evolution in MDR monophasic S. Typhimurium among food animals and food products in Southern China from 2011 to 2018.

    Zhao, Qiu-Yun / Zhang, Lin / Yang, Jin-Tao / Wei, Hai-Jing / Zhang, Yu-Hua / Wang, Jiang-Yang / Liu, Wen-Zi / Jiang, Hong-Xia

    International journal of food microbiology

    2024  Volume 412, Page(s) 110572

    Abstract: The monophasic variant of Salmonella enterica serovar Typhimurium with the antigenic formula 1,4,[5],12:i:- is one of the most common pathogenic bacteria causing global food-borne outbreaks. However, the research on molecular characteristics and ... ...

    Abstract The monophasic variant of Salmonella enterica serovar Typhimurium with the antigenic formula 1,4,[5],12:i:- is one of the most common pathogenic bacteria causing global food-borne outbreaks. However, the research on molecular characteristics and evolution of monophasic S. typhimurium in China is still lacking. In the current study, 59 monophasic S. typhimurium strains were isolated from food animals and food products in South China between 2011 and 2018. A total of 87.5 % of monophasic S. typhimurium isolates were grouped into one independent clade with other monophasic S. typhimurium strains in China distinct from other countries by phylogenomic analysis. These isolates possess variable genotypes, including multiple ARGs on plasmid IncHI2, diverse evolutions at the fljAB locus, and virulence factors. Our results suggest that the monophasic S. typhimurium isolates currently circulating in China might be an independent epidemic subtype.
    MeSH term(s) Animals ; Salmonella Infections/microbiology ; Salmonella typhimurium/genetics ; Serogroup ; Plasmids ; Genotype ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2024.110572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Diastereodivergent and Enantioselective Synthesis of Homoallylic Alcohols via Nickel-Catalyzed Borylative Coupling of 1,3-Dienes with Aldehydes.

    Ma, Jin-Tao / Zhang, Tianze / Yao, Bo-Ying / Xiao, Li-Jun / Zhou, Qi-Lin

    Journal of the American Chemical Society

    2023  Volume 145, Issue 35, Page(s) 19195–19201

    Abstract: We present the first enantioselective nickel-catalyzed borylative coupling of 1,3-dienes with aldehydes, providing an efficient route to highly valuable homoallylic alcohols in a single step. The reaction involves the 1,4-carboboration of dienes, leading ...

    Abstract We present the first enantioselective nickel-catalyzed borylative coupling of 1,3-dienes with aldehydes, providing an efficient route to highly valuable homoallylic alcohols in a single step. The reaction involves the 1,4-carboboration of dienes, leading to the formation of C-C and C-B bonds accompanied by the construction of two continuous stereogenic centers. Enabled by a chiral spiro phosphine-oxazoline nickel complex, this transformation yields products with exceptional diastereoselectivity,
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c07697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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