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Article ; Online: Adsorption of cationic/anionic dyes and endocrine disruptors by yeast/cyclodextrin polymer composites.

Lv, Zhikun / Wang, Zhaoyang / Wang, Huaiguang / Li, Jianbin / Li, Kai

RSC advances

2024 Volume 14, Issue 10, Page(s) 6627–6641

Abstract: Factory and natural wastewaters contain a wide range of organic pollutants. Therefore, multifunctional adsorbents must be developed that can purify wastewater. Phytic acid-cross-linked Baker's yeast cyclodextrin polymer composites (IBY-PA-CDP) were ... ...

Abstract	Factory and natural wastewaters contain a wide range of organic pollutants. Therefore, multifunctional adsorbents must be developed that can purify wastewater. Phytic acid-cross-linked Baker's yeast cyclodextrin polymer composites (IBY-PA-CDP) were prepared using a one-pot method. IBY-PA-CDP was used to adsorb methylene blue (MB), bisphenol A (BPA), and methyl orange (MO). Studies on the ionic strength and strongly acidic ion salts confirmed that IBY-PA-CDP adsorbs MO through hydrophobic interactions. This also shows that Na
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07682b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analyses of lncRNA and mRNA profiles in recurrent atrial fibrillation after catheter ablation.

Tang, Huaiguang / Lu, Kongmiao / Wang, Yan / Shi, Yue / Ma, Wansheng / Chen, Xiaomeng / Li, Bingong / Shao, Yibing

European journal of medical research

2024 Volume 29, Issue 1, Page(s) 244

Abstract: Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. Catheter ablation has become a crucial treatment for AF. However, there is a possibility of atrial fibrillation recurrence after catheter ablation. Our study sought to ...

Abstract	Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. Catheter ablation has become a crucial treatment for AF. However, there is a possibility of atrial fibrillation recurrence after catheter ablation. Our study sought to elucidate the role of lncRNA‒mRNA regulatory networks in late AF recurrence after catheter ablation. Methods: We conducted RNA sequencing to profile the transcriptomes of 5 samples from the presence of recurrence after AF ablation (P-RAF) and 5 samples from the absence of recurrence after AF ablation (A-RAF). Differentially expressed genes (DEGs) and long noncoding RNAs (DE-lncRNAs) were analyzed using the DESeq2 R package. The functional correlations of the DEGs were assessed through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. A protein‒protein interaction (PPI) network was constructed using STRING and Cytoscape. We also established a lncRNA‒mRNA regulatory network between DE-lncRNAs and DEGs using BEDTools v2.1.2 software and the Pearson correlation coefficient method. To validate the high-throughput sequencing results of the hub genes, we conducted quantitative real-time polymerase chain reaction (qRT‒PCR) experiments. Results: A total of 28,528 mRNAs and 42,333 lncRNAs were detected. A total of 96 DEGs and 203 DE-lncRNAs were identified between the two groups. GO analysis revealed that the DEGs were enriched in the biological processes (BPs) of "regulation of immune response" and "regulation of immune system process", the cellular components (CCs) of "extracellular matrix" and "cell‒cell junction", and the molecular functions (MFs) of "signaling adaptor activity" and "protein-macromolecule adaptor activity". According to the KEGG analysis, the DEGs were associated with the "PI3K-Akt signaling pathway" and "MAPK signaling pathway." Nine hub genes (MMP9, IGF2, FGFR1, HSPG2, GZMB, PEG10, GNLY, COL6A1, and KCNE3) were identified through the PPI network. lncRNA-TMEM51-AS1-201 was identified as a core regulator in the lncRNA‒mRNA regulatory network, suggesting its potential impact on the recurrence of AF after catheter ablation through the regulation of COL6A1, FGFR1, HSPG2, and IGF2. Conclusions: The recurrence of atrial fibrillation after catheter ablation may be associated with immune responses and fibrosis, with the extracellular matrix playing a crucial role. TMEM51-AS1-201 has been identified as a potential key target for AF recurrence after catheter ablation.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; Gene Regulatory Networks ; Atrial Fibrillation/genetics ; Atrial Fibrillation/surgery ; RNA, Messenger/genetics ; Phosphatidylinositol 3-Kinases ; Catheter Ablation ; MicroRNAs/genetics
Chemical Substances	RNA, Long Noncoding ; RNA, Messenger ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-024-01799-3
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Article ; Online: NN-Based Reinforcement Learning Optimal Control for Inequality-Constrained Nonlinear Discrete-Time Systems With Disturbances.

Li, Shu / Ding, Liang / Zheng, Miao / Liu, Zixuan / Li, Xinyu / Yang, Huaiguang / Gao, Haibo / Deng, Zongquan

IEEE transactions on neural networks and learning systems

2023 Volume PP

Abstract: Based on actor-critic neural networks (NNs), an optimal controller is proposed for solving the constrained control problem of an affine nonlinear discrete-time system with disturbances. The actor NNs provide the control signals and the critic NNs work as ...

Abstract	Based on actor-critic neural networks (NNs), an optimal controller is proposed for solving the constrained control problem of an affine nonlinear discrete-time system with disturbances. The actor NNs provide the control signals and the critic NNs work as the performance indicators of the controller. By converting the original state constraints into new input constraints and state constraints, the penalty functions are introduced into the cost function, and then the constrained optimal control problem is transformed into an unconstrained one. Further, the relationship between the optimal control input and worst-case disturbance is obtained using the Game theory. With Lyapunov stability theory, the control signals are ensured to be uniformly ultimately bounded (UUB). Finally, the effectiveness of the control algorithms is tested through a numeral simulation using a third-order dynamic system.
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2023.3287881
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Article ; Online: Utilization of high-K+-cane molasses for enhanced S-Adenosylmethionine production by manipulation of a K+ transport channel in Saccharomyces cerevisiae

Guo, Yan / Wang, Huiyi / Wei, Xin / Wang, Zhiqi / Wang, Huaiguang / Chen, Jing / Li, Jianbin / Liu, Jidong

Biochemical Engineering Journal. 2023 Feb. 09, p.108846-

2023 , Page(s) 108846–

Abstract: S-Adenosylmethionine (SAM) is a valuable compound extensively used in depression treatment and biological methyl donor, which is biosynthesized from ATP and L-methionine with SAM synthase (SAM-s) as a catalyst. In this research, the weak SAM-s activity ... ...

Abstract	S-Adenosylmethionine (SAM) is a valuable compound extensively used in depression treatment and biological methyl donor, which is biosynthesized from ATP and L-methionine with SAM synthase (SAM-s) as a catalyst. In this research, the weak SAM-s activity was a key factor and led to low SAM titer in Saccharomyces cerevisiae. Then, a novel K⁺ uptake channel was introduced to the SAM production pathway of Saccharomyces cerevisiae, activated by K⁺ in molasses to enhance the SAM synthase (SAM-s) activity and thereby improve the production efficiency of SAM. As a result, the intracellular K⁺ concentration and SAM-s activity were 1.23- and 1.31-fold higher than the control leading to a 24% increase to 0.93 ± 0.04g/L in SAM titer. In combination with bioprocess optimization resulted in a final yield of 2.22 ± 0.01g/L in shake flasks and 15.37 ± 0.89g/L in a 5-L bioreactor from pretreated molasses. This work provides a practical and cost-effective strategy for the large-scale biosynthesis of SAM from cane molasses.
Keywords	S-adenosylmethionine ; Saccharomyces cerevisiae ; bioprocessing ; bioreactors ; biosynthesis ; catalysts ; cost effectiveness ; molasses ; S-Adenosylmethionine synthase ; K+ transport channel ; Cane molasses
Language	English
Dates of publication	2023-0209
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2012139-8
ISSN	1369-703X
ISSN	1369-703X
DOI	10.1016/j.bej.2023.108846
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.

Li, Xuelian / Zhu, Xianjie / Li, Bingong / Xia, Baohua / Tang, Huaiguang / Hu, Jinxing / Ying, Ru

Experimental cell research

2022 Volume 419, Issue 1, Page(s) 113300

Abstract: The myocardial fibrosis in response to myocardial infarction (MI) is closely related to the dysbalance of endothelial-to-mesenchymal transition (EndMT). Although numerous reports indicate that α7 nicotinic acetylcholine receptor (α7nAChR) activates the ... ...

Abstract	The myocardial fibrosis in response to myocardial infarction (MI) is closely related to the dysbalance of endothelial-to-mesenchymal transition (EndMT). Although numerous reports indicate that α7 nicotinic acetylcholine receptor (α7nAChR) activates the cholinergic anti-inflammatory pathway (CAP) to regulate the magnitude of inflammatory responses, the role of α7nAChR in myocardial fibrosis, as well as the underlying mechanisms, have not been elucidated. In this study, we evaluated cardiac function, fibrosis, and EndMT signaling using a mouse model of MI and interleukin (IL)-1β-induced human cardiac microvascular endothelial cells (HCMECs). In vivo, α7nAChR deletion increased cardiac dysfunction, exacerbated the cardiac inflammatory response, and NF-κB activation, and enhanced EndMT, as shown by higher expression levels of fibroblast markers (FSP-1, α-SMA, collagen I, Snail) and decreased levels of the FGFR1, glucocorticoid receptor (GR) and endothelial marker (CD31) compared to wild-type mice. In vitro, the pharmacological activation of α7nAChR with PNU282987 significantly inhibited IL-1β-induced EndMT, as shown by a reduced transition to the fibroblast-like phenotype and the expression of fibrotic markers. Moreover, the IL-1β-mediated activation of NF-κB pathway was suppressed by PNU282987. This anti-EndMT effect of α7nAChR was associated with regulation of Snail. Furthermore, Western blot analysis further revealed that the GR antagonist RU38486 could partially counteract the effect of PNU282987 on NF-κB expression. In conclusion, our results show that α7nAChR is involved in cardiac fibrosis by inhibiting EndMT, providing a novel approach to the treatment of MI.
MeSH term(s)	Animals ; Cardiomyopathies ; Endothelial Cells ; Epithelial-Mesenchymal Transition ; Fibrosis ; Humans ; Mice ; Myocardial Infarction ; NF-kappa B ; alpha7 Nicotinic Acetylcholine Receptor
Chemical Substances	NF-kappa B ; alpha7 Nicotinic Acetylcholine Receptor
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2022.113300
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Zs.A 563: Show issues

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Article ; Online: Learning physical characteristics like animals for legged robots.

Xu, Peng / Ding, Liang / Li, Zhengyang / Yang, Huaiguang / Wang, Zhikai / Gao, Haibo / Zhou, Ruyi / Su, Yang / Deng, Zongquan / Huang, Yanlong

National science review

2023 Volume 10, Issue 5, Page(s) nwad045

Abstract: Physical characteristics of terrains, such as softness and friction, provide essential information for legged robots to avoid non-geometric obstacles, like mires and slippery stones, in the wild. The perception of such characteristics often relies on ... ...

Abstract	Physical characteristics of terrains, such as softness and friction, provide essential information for legged robots to avoid non-geometric obstacles, like mires and slippery stones, in the wild. The perception of such characteristics often relies on tactile perception and vision prediction. Although tactile perception is more accurate, it is limited to close-range use; by contrast, establishing a supervised or self-supervised contactless prediction system using computer vision requires adequate labeled data and lacks the ability to adapt to the dynamic environment. In this paper, we simulate the behavior of animals and propose an unsupervised learning framework for legged robots to learn the physical characteristics of terrains, which is the first report to manage it online, incrementally and with the ability to solve cognitive conflicts. The proposed scheme allows robots to interact with the environment and adjust their cognition in real time, therefore endowing robots with the adaptation ability. Indoor and outdoor experiments on a hexapod robot are carried out to show that the robot can extract tactile and visual features of terrains to create cognitive networks independently; an associative layer between visual and tactile features is created during the robot's exploration; with the layer, the robot can autonomously generate a physical segmentation model of terrains and solve cognitive conflicts in an ever-changing environment, facilitating its safe navigation.
Language	English
Publishing date	2023-02-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad045
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Article: The electron as a probe to measure the thickness distributions of electroactive films.

Buesen, Darren / Li, Huaiguang / Plumeré, Nicolas

Chemical science

2019 Volume 11, Issue 4, Page(s) 937–946

Abstract: Electron conducting films are ubiquitous in applications such as energy conversion, and their ability to fulfill their catalytic function can be greatly limited by inhomogeneities in their thickness or breaks within the film. Knowing the electroactive ... ...

Abstract	Electron conducting films are ubiquitous in applications such as energy conversion, and their ability to fulfill their catalytic function can be greatly limited by inhomogeneities in their thickness or breaks within the film. Knowing the electroactive film thickness distribution would greatly facilitate optimization efforts, but techniques to measure this are lacking. Here, we present an electroanalytical method that provides the thickness distribution of the electrochemically accessible fraction of redox-active films in which the transfer of electrons is diffusional,
Language	English
Publishing date	2019-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/c9sc03653a
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Article ; Online: Spectroscopic Evidence for a Covalent Sigma Au–C Bond on Au Surfaces Using 13C Isotope Labeling

Huaiguang Li / Gabriel Kopiec / Frank Müller / Frauke Nyßen / Kyoko Shimizu / Marcel Ceccato / Kim Daasbjerg / Nicolas Plumeré

JACS Au, Vol 1, Iss 3, Pp 362-

2021 Volume 368

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spectroscopic Evidence for a Covalent Sigma Au-C Bond on Au Surfaces Using

Li, Huaiguang / Kopiec, Gabriel / Müller, Frank / Nyßen, Frauke / Shimizu, Kyoko / Ceccato, Marcel / Daasbjerg, Kim / Plumeré, Nicolas

JACS Au

2021 Volume 1, Issue 3, Page(s) 362–368

Abstract: The Au-C linkage has been demonstrated as a robust interface for coupling thin organic films on Au surfaces. However, the nature of the Au-C interaction remains elusive up to now. Surface-enhanced Raman spectroscopy was previously used to assign a band ... ...

Abstract	The Au-C linkage has been demonstrated as a robust interface for coupling thin organic films on Au surfaces. However, the nature of the Au-C interaction remains elusive up to now. Surface-enhanced Raman spectroscopy was previously used to assign a band at 412 cm
Language	English
Publishing date	2021-02-23
Document type	Journal Article
ISSN	2691-3704
ISSN (online)	2691-3704
DOI	10.1021/jacsau.0c00108
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Article: Gene modules and genes associated with postoperative atrial fibrillation: weighted gene co-expression network analysis and circRNA-miRNA-mRNA regulatory network analysis.

Chen, Xiaomeng / Tang, Huaiguang / Lu, Kongmiao / Niu, Zhaozhuo / Sheng, Wei / Hwang, Ho Young / Pang, Philip Y K / Phillips, Joseph D / Khoynezhad, Ali / Qu, Xiaolu / Li, Bingong / Han, Wei

Journal of thoracic disease

2023 Volume 15, Issue 9, Page(s) 4949–4960

Abstract: Background: Atrial fibrillation (AF) is the most common complication in patients undergoing cardiac surgery. However, the pathogenesis of postoperative AF (POAF) is elusive, and research related to this topic is sparse. Our study aimed to identify key ... ...

Abstract	Background: Atrial fibrillation (AF) is the most common complication in patients undergoing cardiac surgery. However, the pathogenesis of postoperative AF (POAF) is elusive, and research related to this topic is sparse. Our study aimed to identify key gene modules and genes and to conduct a circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory network analysis of POAF on the basis of bioinformatic analysis. Methods: The GSE143924 and GSE97455 data sets from the Gene Expression Omnibus (GEO) database were analyzed. Weighted gene co-expression network analysis (WGCNA) was used to identify the key gene modules and genes related to POAF. A circRNA-miRNA-mRNA regulatory network was also built according to differential expression analysis. Functional enrichment analysis was further performed according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Results: WGCNA identified 2 key gene modules and 44 key genes that were significantly related to POAF. Functional enrichment analysis of these key genes implicated the following important biological processes (BPs): endosomal transport, protein kinase B signaling, and transcription regulation. The circRNA-miRNA-mRNA regulatory network suggested that Conclusions: Our study provides foundational expression profiles following POAF based on WGCNA. The circRNA-miRNA-mRNA network offers insights into the BPs and underlying mechanisms of POAF.
Language	English
Publishing date	2023-09-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1179
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