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  1. Article: Domestic violence reporting during the COVID-19 pandemic: evidence from Latin America.

    Perez-Vincent, Santiago M / Carreras, Enrique

    Review of economics of the household

    2022  Volume 20, Issue 3, Page(s) 799–830

    Abstract: This article examines changes in the frequency and characteristics of domestic violence reports following the onset of the COVID-19 pandemic and the imposition of mobility restrictions in six Latin American countries. We find significantly different ... ...

    Abstract This article examines changes in the frequency and characteristics of domestic violence reports following the onset of the COVID-19 pandemic and the imposition of mobility restrictions in six Latin American countries. We find significantly different patterns between reports of psychological and physical violence, non-cohabitant and cohabitant violence, and across alternative reporting channels (domestic violence hotlines, emergency lines, and police reports). Calls to domestic violence hotlines soared, suggesting that this channel was best suited to respond to victims' needs during the pandemic. In turn, calls to emergency lines and police complaints declined (especially in the first weeks of the pandemic), consistent with an increase in the perceived (relative) cost of using these channels. The results reveal how the pandemic altered domestic violence victims' demand for institutional help and highlight the relevance of domestic violence hotlines as an accessible and valuable service.
    Language English
    Publishing date 2022-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099806-5
    ISSN 1573-7152 ; 1569-5239
    ISSN (online) 1573-7152
    ISSN 1569-5239
    DOI 10.1007/s11150-022-09607-9
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  2. Article ; Online: Prevalence and correlates of disability in Latin America and the Caribbean: Evidence from 8 national censuses.

    Berlinski, Samuel / Duryea, Suzanne / Perez-Vincent, Santiago M

    PloS one

    2021  Volume 16, Issue 10, Page(s) e0258825

    Abstract: We estimate disability prevalence rates and gaps in social conditions in eight Latin America and the Caribbean (LAC) countries and project current and future disability prevalence rates in the region. Using data from representative samples of the ... ...

    Abstract We estimate disability prevalence rates and gaps in social conditions in eight Latin America and the Caribbean (LAC) countries and project current and future disability prevalence rates in the region. Using data from representative samples of the population in eight countries, we find that reported disability prevalence varies widely across countries, ranging between 4.5 percent in Trinidad and Tobago (2011) to 24.9 percent in Brazil (2010). Differences in surveying approaches and demographic structures likely explain a part of this variation. We find marked sociodemographic gradients for disability. We also report significant disability gaps: people living with disabilities have lower educational attendance and completion rates and lower employment rates. We use age and sex-specific disability rates from our sample of countries and information on the current and future demographic structures in LAC countries to project disability prevalence for the whole region. We project that the total number of people with disabilities in this region will increase by approximately 60 million between 2020 and 2050. Our projections suggest that countries need to systematically plan and implement inclusion policies to adequately address the growing population of people with disabilities in the years to come.
    MeSH term(s) Caribbean Region/epidemiology ; Censuses ; Disabled Persons/statistics & numerical data ; Female ; Humans ; Latin America/epidemiology ; Male ; Prevalence ; Socioeconomic Factors
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0258825
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  3. Article: Crime under lockdown: The impact of COVID-19 on citizen security in the city of Buenos Aires.

    Perez-Vincent, Santiago M / Schargrodsky, Ernesto / García Mejía, Mauricio

    Criminology & public policy

    2021  Volume 20, Issue 3, Page(s) 463–492

    Abstract: Research summary: This paper studies the impact of the COVID-19 pandemic and the subsequent lockdown on criminal activity in the City of Buenos Aires, Argentina. Following quarantine restrictions, we find a large, significant, robust, and immediate ... ...

    Abstract Research summary: This paper studies the impact of the COVID-19 pandemic and the subsequent lockdown on criminal activity in the City of Buenos Aires, Argentina. Following quarantine restrictions, we find a large, significant, robust, and immediate decline in property crime reported to official agencies, police arrests, and crime reported in victimization surveys. We observe no significant change in homicides, and a significant increase in arrests for "resistance to authorities". The decrease in criminal activity was greater in business and transportation areas, but still large in commercial and residential areas (including informal settlements). After the sharp and immediate fall, crime recovered but, by the end of 2020, it had not reached its initial levels. The arrest data additionally shows a reduction in the distance from the detainee's address to the crime location, and a fall in the number of detainees from outside the City of Buenos Aires. Crime became more local as mobility was restricted.
    Policy implications: We find no evidence that the reduction in the number of detainees from outside the City of Buenos Aires led to a displacement of crimeto suburban areas. This result aligns with the hypothesis that focalized place-based interventions have the potential to reduce overall crime rates. Moreover, the increase in arrests for "resistance to authorities" at the checkpoints set up during the lockdown shows that the enforcement of mobility restrictions can cause frictions between citizens and police, negatively affecting police's legitimacy. We also find that the increased government presence for the provision of health and social services in informal settlements during the pandemic led, as a positive externality, to an additional decrease in crime.
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2094251-5
    ISSN 1745-9133 ; 1538-6473
    ISSN (online) 1745-9133
    ISSN 1538-6473
    DOI 10.1111/1745-9133.12555
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  4. Article ; Online: Prevalence and correlates of disability in Latin America and the Caribbean

    Samuel Berlinski / Suzanne Duryea / Santiago M. Perez-Vincent

    PLoS ONE, Vol 16, Iss

    Evidence from 8 national censuses

    2021  Volume 10

    Abstract: We estimate disability prevalence rates and gaps in social conditions in eight Latin America and the Caribbean (LAC) countries and project current and future disability prevalence rates in the region. Using data from representative samples of the ... ...

    Abstract We estimate disability prevalence rates and gaps in social conditions in eight Latin America and the Caribbean (LAC) countries and project current and future disability prevalence rates in the region. Using data from representative samples of the population in eight countries, we find that reported disability prevalence varies widely across countries, ranging between 4.5 percent in Trinidad and Tobago (2011) to 24.9 percent in Brazil (2010). Differences in surveying approaches and demographic structures likely explain a part of this variation. We find marked sociodemographic gradients for disability. We also report significant disability gaps: people living with disabilities have lower educational attendance and completion rates and lower employment rates. We use age and sex-specific disability rates from our sample of countries and information on the current and future demographic structures in LAC countries to project disability prevalence for the whole region. We project that the total number of people with disabilities in this region will increase by approximately 60 million between 2020 and 2050. Our projections suggest that countries need to systematically plan and implement inclusion policies to adequately address the growing population of people with disabilities in the years to come.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  5. Article ; Online: Prevalence and correlates of disability in Latin America and the Caribbean

    Samuel Berlinski / Suzanne Duryea / Santiago M Perez-Vincent

    PLoS ONE, Vol 16, Iss 10, p e

    Evidence from 8 national censuses.

    2021  Volume 0258825

    Abstract: We estimate disability prevalence rates and gaps in social conditions in eight Latin America and the Caribbean (LAC) countries and project current and future disability prevalence rates in the region. Using data from representative samples of the ... ...

    Abstract We estimate disability prevalence rates and gaps in social conditions in eight Latin America and the Caribbean (LAC) countries and project current and future disability prevalence rates in the region. Using data from representative samples of the population in eight countries, we find that reported disability prevalence varies widely across countries, ranging between 4.5 percent in Trinidad and Tobago (2011) to 24.9 percent in Brazil (2010). Differences in surveying approaches and demographic structures likely explain a part of this variation. We find marked sociodemographic gradients for disability. We also report significant disability gaps: people living with disabilities have lower educational attendance and completion rates and lower employment rates. We use age and sex-specific disability rates from our sample of countries and information on the current and future demographic structures in LAC countries to project disability prevalence for the whole region. We project that the total number of people with disabilities in this region will increase by approximately 60 million between 2020 and 2050. Our projections suggest that countries need to systematically plan and implement inclusion policies to adequately address the growing population of people with disabilities in the years to come.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  6. Article ; Online: Fulminant myocarditis proven by early biopsy and outcomes.

    Huang, Florent / Ammirati, Enrico / Ponnaiah, Maharajah / Montero, Santiago / Raimbault, Victor / Abrams, Darryl / Lebreton, Guillaume / Pellegrino, Vincent / Ihle, Joshua / Bottiroli, Maurizio / Persichini, Romain / Barrionuevo-Sánchez, Marisa Isabel / Ariza-Solé, Albert / Ng, Pauline Yeung / Sin, Simon Wai Ching / Ayer, Raj / Buscher, Hergen / Belaid, Slimane / Delmas, Clément /
    Ferreira, Rita / Roncon-Albuquerque, Roberto / Lόpez-Sobrino, Teresa / Bunge, Jeroen J H / Fisser, Christoph / Franchineau, Guillaume / McCanny, Jamie / Ohshimo, Shinichiro / Sionis, Alessandro / Hernández-Pérez, Francisco José / Barge-Caballero, Eduardo / Balik, Martin / Muglia, Henrique / Park, Sunghoon / Donker, Dirk W / Porral, Beatriz / Aïssaoui, Nadia / Mekontso Dessap, Armand / Burgos, Virginia / Lesouhaitier, Mathieu / Fried, Justin / Jung, Jae-Seung / Rosillo, Sandra / Scherrer, Vincent / Nseir, Saad / Winszewski, Hadrien / Jorge-Pérez, Pablo / Kimmoun, Antoine / Diaz, Rodrigo / Combes, Alain / Schmidt, Matthieu

    European heart journal

    2023  Volume 44, Issue 48, Page(s) 5110–5124

    Abstract: Background and aims: While endomyocardial biopsy (EMB) is recommended in adult patients with fulminant myocarditis, the clinical impact of its timing is still unclear.: Methods: Data were collected from 419 adult patients with clinically suspected ... ...

    Abstract Background and aims: While endomyocardial biopsy (EMB) is recommended in adult patients with fulminant myocarditis, the clinical impact of its timing is still unclear.
    Methods: Data were collected from 419 adult patients with clinically suspected fulminant myocarditis admitted to intensive care units across 36 tertiary centres in 15 countries worldwide. The diagnosis of myocarditis was histologically proven in 210 (50%) patients, either by EMB (n = 183, 44%) or by autopsy/explanted heart examination (n = 27, 6%), and clinically suspected cardiac magnetic resonance imaging confirmed in 96 (23%) patients. The primary outcome of survival free of heart transplantation (HTx) or left ventricular assist device (LVAD) at 1 year was specifically compared between patients with early EMB (within 2 days after intensive care unit admission, n = 103) and delayed EMB (n = 80). A propensity score-weighted analysis was done to control for confounders.
    Results: Median age on admission was 40 (29-52) years, and 322 (77%) patients received temporary mechanical circulatory support. A total of 273 (65%) patients survived without HTx/LVAD. The primary outcome was significantly different between patients with early and delayed EMB (70% vs. 49%, P = .004). After propensity score weighting, the early EMB group still significantly differed from the delayed EMB group in terms of survival free of HTx/LVAD (63% vs. 40%, P = .021). Moreover, early EMB was independently associated with a lower rate of death or HTx/LVAD at 1 year (odds ratio of 0.44; 95% confidence interval: 0.22-0.86; P = .016).
    Conclusions: Endomyocardial biopsy should be broadly and promptly used in patients admitted to the intensive care unit for clinically suspected fulminant myocarditis.
    MeSH term(s) Adult ; Humans ; Myocarditis/complications ; Biopsy/methods ; Heart Transplantation ; Cardiac Catheterization ; Magnetic Resonance Imaging ; Retrospective Studies ; Myocardium/pathology
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad707
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    Zs.A 1563: Show issues Location:
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  7. Article ; Online: Partial recessive IFN-γR1 deficiency: genetic, immunological and clinical features of 14 patients from 11 kindreds.

    Sologuren, Ithaisa / Boisson-Dupuis, Stéphanie / Pestano, Jose / Vincent, Quentin Benoit / Fernández-Pérez, Leandro / Chapgier, Ariane / Cárdenes, María / Feinberg, Jacqueline / García-Laorden, M Isabel / Picard, Capucine / Santiago, Esther / Kong, Xiaofei / Jannière, Lucile / Colino, Elena / Herrera-Ramos, Estefanía / Francés, Adela / Navarrete, Carmen / Blanche, Stéphane / Faria, Emilia /
    Remiszewski, Pawel / Cordeiro, Ana / Freeman, Alexandra / Holland, Steven / Abarca, Katia / Valerón-Lemaur, Mónica / Gonçalo-Marques, José / Silveira, Luisa / García-Castellano, José Manuel / Caminero, José / Pérez-Arellano, José Luis / Bustamante, Jacinta / Abel, Laurent / Casanova, Jean-Laurent / Rodríguez-Gallego, Carlos

    Human molecular genetics

    2011  Volume 20, Issue 8, Page(s) 1509–1523

    Abstract: We report a series of 14 patients from 11 kindreds with recessive partial (RP)-interferon (IFN)-γR1 deficiency. The I87T mutation was found in nine homozygous patients from Chile, Portugal and Poland, and the V63G mutation was found in five homozygous ... ...

    Abstract We report a series of 14 patients from 11 kindreds with recessive partial (RP)-interferon (IFN)-γR1 deficiency. The I87T mutation was found in nine homozygous patients from Chile, Portugal and Poland, and the V63G mutation was found in five homozygous patients from the Canary Islands. Founder effects accounted for the recurrence of both mutations. The most recent common ancestors of the patients with the I87T and V63G mutations probably lived 1600 (875-2950) and 500 (200-1275) years ago, respectively. The two alleles confer phenotypes that are similar but differ in terms of IFN-γR1 levels and residual response to IFN-γ. The patients suffered from bacillus Calmette-Guérin-osis (n= 6), environmental mycobacteriosis (n= 6) or tuberculosis (n= 1). One patient did not suffer from mycobacterial infections but had disseminated salmonellosis, which was also present in two other patients. Age at onset of the first environmental mycobacterial disease differed widely between patients, with a mean value of 11.25 ± 9.13 years. Thirteen patients survived until the age of 14.82 ± 11.2 years, and one patient died at the age of 7 years, 9 days after the diagnosis of long-term Mycobacterium avium infection and the initiation of antimycobacterial treatment. Up to 10 patients are currently free of infection with no prophylaxis. The clinical heterogeneity of the 14 patients was not clearly related to either IFNGR1 genotype or the resulting cellular phenotype. RP-IFN-γR1 deficiency is, thus, more common than initially thought and should be considered in both children and adults with mild or severe mycobacterial diseases.
    MeSH term(s) Adolescent ; Adult ; Amino Acid Sequence ; Child ; Child, Preschool ; Female ; Founder Effect ; Genes, Recessive ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Interferon-gamma/metabolism ; Male ; Molecular Sequence Data ; Monocytes/metabolism ; Mutation, Missense ; Mycobacterium Infections/genetics ; Mycobacterium Infections/immunology ; Mycobacterium Infections/microbiology ; Mycobacterium avium ; Mycobacterium bovis ; Osteomyelitis/genetics ; Osteomyelitis/microbiology ; Pedigree ; Phenotype ; Phosphorylation ; Pneumonia, Bacterial/genetics ; Protein Transport ; Receptors, Interferon/deficiency ; Receptors, Interferon/genetics ; Receptors, Interferon/immunology ; STAT1 Transcription Factor/metabolism ; Salmonella ; Salmonella Infections/genetics ; Tuberculosis/genetics ; Tuberculosis/microbiology ; Tuberculosis/mortality ; Young Adult ; Interferon gamma Receptor
    Chemical Substances Receptors, Interferon ; STAT1 Transcription Factor ; STAT1 protein, human ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2011-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddr029
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  8. Article ; Online: Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial)

    Joachim Gerss / Javier Ripollés-Melchor / Emmanuel Futier / Melanie Meersch / Carola Wempe / Detlef Kindgen-Milles / Alexander Zarbock / Markus W Hollmann / Sigismond Lasocki / Thomas Rimmele / Tim Rahmel / Michael Adamzik / Hartmuth Nowak / Ingeborg Welters / Brian Johnston / Ane Abad-motos / Alfredo Abad-gurumeta / Marc Moritz Berger / Davide Ricci /
    Maurizio Cecconi / Gudrun Kunst / Christian Stoppe / Christian Putensen / Marlies Ostermann / Sascha Ott / Brijesh Patel / Gabriele Baldini / Antoine Lamblin / Karen Williams / Elena Mancini / Christian Arndt / Hinnerk Wulf / Marc Irqsusi / Wim Vandenberghe / John Kellum / Raphael Weiss / Jackie Donovan / Lui G Forni / Giacomo Monti / Céline Monard / Markus A Weigand / Thorsten Brenner / Ulrich Jaschinski / Carlos Lopez / Maxime Leger / Emmanuel Rineau / Philipp Simon / María Gómez-Rojo / Lars Bergmann / Alicia Waite / Savino Spadaro / Alexander Wolf / Andrew Spence / Simon Dubler / Alexander PJ Vlaar / Patrick Schober / Ben C Creagh-Brown / Nandor Marczin / Emilio Maseda / Christian Strauss / Stefano Romagnoli / Christian Nusshag / Ulrich Gobel / Ángel Candela-Toha / Jon Silversides / Nuttha Lumlertgul / Khaschayar Saadat-Gilani / Vincent Legros / Timo Brandenburger / Thomas Dimski / Laura Huthmann / Claude Pelletier / Manon Schleß / Peter Rosenberger / Helene Häberle / Jan Gerrit Haaker / Matthias Gründel / Lucia Cattin / Laura Villarino Villa / Juan Victor Lorente / Christine Martin / Jan Larmann / Wolfgang Bauer / Giovanni Borghi / Benjamin O’Brien / Thilo von Groote / Antoine Guillaume Schneider / Silvia De Rosa / Diego Parise / Alice Bernard / Paula Fernández-Valdes-Bango / Irene Romero Bhathal / A Suarez-de-la-Rica / Gianluca Villa / Raquel García-Álvarez / Antonio Siniscalchi / Richard Ellerkmann / Florian Espeter / Christian Porschen / Mahan Sadjadi / Michael Storck / Tobias Brix / Dana Meschede / Wida Amini / Carina Stenger / Julius Freytag / Jens Brands / Matthias Unterberg / Britta Marko / Fabian Dusse / Wolfgang A Wetsch / Sandra E Stoll / Hendrik Drinhaus / Bernd W Böttiger / Onnen Mörer / Lars-Olav Harnisch / Roswitha Lubjuhn / Daniel Heise / Christian Bode / Andrea Sauer / Konrad Peukert / Lennart Wild / Philippe Kruse / Jan Menzenbach / Valbona Mirakaj / Sabine Hermann / Stefanie Decker / Mona Jung-König / Tobias Hölle / Sarah Dehne / Jörg Reutershan / Thomas Prüfer / Stefan Pielmeier / Indra Wimmelmeier / Michaela Scholz / Andrea Paris / Isabel Christina Gallego Zapata / Holger Pohl / Nirmeen Fayed / Kai Dielmann / Evelyn Martin / Tilo Koch / Alexander Mück / Philipp Deetjen / Ngoc Bich Mehlmann / Peter M Spieth / Andreas Güldner / Axel Rand / Maximillian Ragaller / Martin Mirus / Rebecca Bockholt / Marc Herzog / Maren Kleine-Brüggeney / Ant Isabelle Cristiani / Marion Ohl / Monica Vieira Da Silva / Gilda Filipe de Castro Reblo / Matthias Hilty / Katharina Spanaus / Benedetta Mura / Eleonora Terreni / Francesco Magiotti / Lorenzo Turi / Cristiana Laici / Chiara Capozzi / Andrea Castelli / Massimiliano Greco / Antonio Messina / Gianluca Castellani / Romina Aceto / Vinicio Danzi / Alessandro Rigobello / Massimo De Cal / Monica Zanella / Gaetano Scaramuzzo / Riccardo La Rosa / Paolo Priani / Alberto Volta Carlo / Stefano Turi / Martina Baiardo Redaelli / Marilena Marmiere / Kittisak Weerapolchai / Shelley Lorah / Fabiola D’Amato / Aneta Bociek / Rosario Lim / Benjie Cendreda / Reynaldo Dela Cuesta / Eirini Kosifidou / Zoka Milan / Juliana Fernanda / Emma Clarey / Daveena Meeks / Nicholas J Lees / Marco Scaramuzzi / Orinta Kviatkovske / Adam Glass / Christine Turley / Charlotte Quinn / Syeda Haider / Adam Rossiter / Syed Nasser / Ned Gilbert-Kawai / Tatjana Besse-Hammer / Eric Hoste / Hannah Schaubroeck / Jan De Waele / Jenni Breel / Eline de Klerk / Harm-Jan de Grooth / Lothar Schwarte / Alexander Loer / Alicia Ruiz-Escobar / Diana Fernández-García / Nerea Gómez-Pérez / Pascual Crespo-Aliseda / Cristina Cerro-Zaballos / Cristina Fernández-Martín / Eduardo Martín-Montero / Alejandro Suarez de la Rica / Héctor Berges Gutiérrez / Maria del Pino Heredia Pérez / Maria de los Reyes Bellido Fernández / Liena Izquierdo López / Javier Valiente Lourtau / Ma Angeles Ferre Colomer / Ma Azucena Pajares Moncho / Maria Jesús Montero Hernández / Esther Pérez Sancho / Silvia Polo Matínez / Pedro Rivera Soria / Maider Puyada Jáuregui / Hugo Rivera Ramos / Marta Antelo Adrán / Ramón Adalia Bartolomé / Patricia Galán Menéndez / Laura Llinares Espin / Yuri Santiago Loaiza Aldean / Víctor MoralesAriza / Rosalía Navarro-Perez / Luis Santé-Serna / Pedro de la Calle-Elguezabal / Rubén Sánchez-Martín / Inés De Soto / Pau Vallhonrat Alcántara / Laura Perelló Cerdà / Gal·la Rouras Hurtado / Paula Rodriguez Nieto / John Narros Sicluna / Angel Molero Molinero / Juan Pablo Nocete / Elena Murcia Sánchez / Stanislas Abrard / Marie-Luce Parrouffe / Frank Bidar / Lucie Aupetitgendre / Ugo Schiff / Bertille Paquette / Gaëlle Sellier / Nathalie Borgnetta / Benjamin Brochet / Thierry Floch / Julien Coffinet / Marion Leclercq-Rouget

    BMJ Open, Vol 13, Iss

    study protocol for an international, prospective, randomised controlled multicentre trial

    2023  Volume 3

    Abstract: Introduction Previous studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might ... ...

    Abstract Introduction Previous studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation.Methods and analysis The BigpAK-2 trial is an international, randomised, controlled, multicentre trial. The trial aims to enrol 1302 patients undergoing major surgery who are subsequently admitted to the intensive care or high dependency unit and are at high-risk for postoperative AKI as identified by urinary biomarkers (tissue inhibitor of metalloproteinases 2*insulin like growth factor binding protein 7 (TIMP-2)*IGFBP7)). Eligible patients will be randomised to receive either standard of care (control) or a KDIGO-based AKI care bundle (intervention). The primary endpoint is the incidence of moderate or severe AKI (stage 2 or 3) within 72 hours after surgery, according to the KDIGO 2012 criteria. Secondary endpoints include adherence to the KDIGO care bundle, occurrence and severity of any stage of AKI, change in biomarker values during 12 hours after initial measurement of (TIMP-2)*(IGFBP7), number of free days of mechanical ventilation and vasopressors, need for renal replacement therapy (RRT), duration of RRT, renal recovery, 30-day and 60-day mortality, intensive care unit length-of-stay and hospital length-of-stay and major adverse kidney events. An add-on study will investigate blood and urine samples from recruited patients for immunological functions and kidney damage.Ethics and dissemination The BigpAK-2 trial was approved by the Ethics Committee of the Medical Faculty of the University of Münster and subsequently by the corresponding Ethics Committee of the participating sites. A study amendment was approved subsequently. In the UK, the trial was adopted as an NIHR portfolio study. Results will ...
    Keywords Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
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  9. Article ; Online: Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

    Ghoussaini, Maya / Edwards, Stacey L / Michailidou, Kyriaki / Nord, Silje / Cowper-Sal Lari, Richard / Desai, Kinjal / Kar, Siddhartha / Hillman, Kristine M / Kaufmann, Susanne / Glubb, Dylan M / Beesley, Jonathan / Dennis, Joe / Bolla, Manjeet K / Wang, Qin / Dicks, Ed / Guo, Qi / Schmidt, Marjanka K / Shah, Mitul / Luben, Robert /
    Brown, Judith / Czene, Kamila / Darabi, Hatef / Eriksson, Mikael / Klevebring, Daniel / Bojesen, Stig E / Nordestgaard, Børge G / Nielsen, Sune F / Flyger, Henrik / Lambrechts, Diether / Thienpont, Bernard / Neven, Patrick / Wildiers, Hans / Broeks, Annegien / Van't Veer, Laura J / Rutgers, Emiel J Th / Couch, Fergus J / Olson, Janet E / Hallberg, Emily / Vachon, Celine / Chang-Claude, Jenny / Rudolph, Anja / Seibold, Petra / Flesch-Janys, Dieter / Peto, Julian / Dos-Santos-Silva, Isabel / Gibson, Lorna / Nevanlinna, Heli / Muranen, Taru A / Aittomäki, Kristiina / Blomqvist, Carl / Hall, Per / Li, Jingmei / Liu, Jianjun / Humphreys, Keith / Kang, Daehee / Choi, Ji-Yeob / Park, Sue K / Noh, Dong-Young / Matsuo, Keitaro / Ito, Hidemi / Iwata, Hiroji / Yatabe, Yasushi / Guénel, Pascal / Truong, Thérèse / Menegaux, Florence / Sanchez, Marie / Burwinkel, Barbara / Marme, Frederik / Schneeweiss, Andreas / Sohn, Christof / Wu, Anna H / Tseng, Chiu-Chen / Van Den Berg, David / Stram, Daniel O / Benitez, Javier / Pilar Zamora, M / Perez, Jose Ignacio Arias / Menéndez, Primitiva / Shu, Xiao-Ou / Lu, Wei / Gao, Yu-Tang / Cai, Qiuyin / Cox, Angela / Cross, Simon S / Reed, Malcolm W R / Andrulis, Irene L / Knight, Julia A / Glendon, Gord / Tchatchou, Sandrine / Sawyer, Elinor J / Tomlinson, Ian / Kerin, Michael J / Miller, Nicola / Haiman, Christopher A / Henderson, Brian E / Schumacher, Fredrick / Le Marchand, Loic / Lindblom, Annika / Margolin, Sara / Teo, Soo Hwang / Yip, Cheng Har / Lee, Daphne S C / Wong, Tien Y / Hooning, Maartje J / Martens, John W M / Collée, J Margriet / van Deurzen, Carolien H M / Hopper, John L / Southey, Melissa C / Tsimiklis, Helen / Kapuscinski, Miroslav K / Shen, Chen-Yang / Wu, Pei-Ei / Yu, Jyh-Cherng / Chen, Shou-Tung / Alnæs, Grethe Grenaker / Borresen-Dale, Anne-Lise / Giles, Graham G / Milne, Roger L / McLean, Catriona / Muir, Kenneth / Lophatananon, Artitaya / Stewart-Brown, Sarah / Siriwanarangsan, Pornthep / Hartman, Mikael / Miao, Hui / Buhari, Shaik Ahmad Bin Syed / Teo, Yik Ying / Fasching, Peter A / Haeberle, Lothar / Ekici, Arif B / Beckmann, Matthias W / Brenner, Hermann / Dieffenbach, Aida Karina / Arndt, Volker / Stegmaier, Christa / Swerdlow, Anthony / Ashworth, Alan / Orr, Nick / Schoemaker, Minouk J / García-Closas, Montserrat / Figueroa, Jonine / Chanock, Stephen J / Lissowska, Jolanta / Simard, Jacques / Goldberg, Mark S / Labrèche, France / Dumont, Martine / Winqvist, Robert / Pylkäs, Katri / Jukkola-Vuorinen, Arja / Brauch, Hiltrud / Brüning, Thomas / Koto, Yon-Dschun / Radice, Paolo / Peterlongo, Paolo / Bonanni, Bernardo / Volorio, Sara / Dörk, Thilo / Bogdanova, Natalia V / Helbig, Sonja / Mannermaa, Arto / Kataja, Vesa / Kosma, Veli-Matti / Hartikainen, Jaana M / Devilee, Peter / Tollenaar, Robert A E M / Seynaeve, Caroline / Van Asperen, Christi J / Jakubowska, Anna / Lubinski, Jan / Jaworska-Bieniek, Katarzyna / Durda, Katarzyna / Slager, Susan / Toland, Amanda E / Ambrosone, Christine B / Yannoukakos, Drakoulis / Sangrajrang, Suleeporn / Gaborieau, Valerie / Brennan, Paul / McKay, James / Hamann, Ute / Torres, Diana / Zheng, Wei / Long, Jirong / Anton-Culver, Hoda / Neuhausen, Susan L / Luccarini, Craig / Baynes, Caroline / Ahmed, Shahana / Maranian, Mel / Healey, Catherine S / González-Neira, Anna / Pita, Guillermo / Rosario Alonso, M / Álvarez, Nuria / Herrero, Daniel / Tessier, Daniel C / Vincent, Daniel / Bacot, Francois / de Santiago, Ines / Carroll, Jason / Caldas, Carlos / Brown, Melissa A / Lupien, Mathieu / Kristensen, Vessela N / Pharoah, Paul D P / Chenevix-Trench, Georgia / French, Juliet D / Easton, Douglas F / Dunning, Alison M

    Nature communications

    2018  Volume 9, Page(s) 16193

    Abstract: This corrects the article DOI: 10.1038/ncomms5999. ...

    Abstract This corrects the article DOI: 10.1038/ncomms5999.
    Language English
    Publishing date 2018-04-10
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/ncomms16193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview.

    Vrijheid, Martine / Basagaña, Xavier / Gonzalez, Juan R / Jaddoe, Vincent W V / Jensen, Genon / Keun, Hector C / McEachan, Rosemary R C / Porcel, Joana / Siroux, Valerie / Swertz, Morris A / Thomsen, Cathrine / Aasvang, Gunn Marit / Andrušaitytė, Sandra / Angeli, Karine / Avraam, Demetris / Ballester, Ferran / Burton, Paul / Bustamante, Mariona / Casas, Maribel /
    Chatzi, Leda / Chevrier, Cécile / Cingotti, Natacha / Conti, David / Crépet, Amélie / Dadvand, Payam / Duijts, Liesbeth / van Enckevort, Esther / Esplugues, Ana / Fossati, Serena / Garlantezec, Ronan / Gómez Roig, María Dolores / Grazuleviciene, Regina / Gützkow, Kristine B / Guxens, Mònica / Haakma, Sido / Hessel, Ellen V S / Hoyles, Lesley / Hyde, Eleanor / Klanova, Jana / van Klaveren, Jacob D / Kortenkamp, Andreas / Le Brusquet, Laurent / Leenen, Ivonne / Lertxundi, Aitana / Lertxundi, Nerea / Lionis, Christos / Llop, Sabrina / Lopez-Espinosa, Maria-Jose / Lyon-Caen, Sarah / Maitre, Lea / Mason, Dan / Mathy, Sandrine / Mazarico, Edurne / Nawrot, Tim / Nieuwenhuijsen, Mark / Ortiz, Rodney / Pedersen, Marie / Perelló, Josep / Pérez-Cruz, Míriam / Philippat, Claire / Piler, Pavel / Pizzi, Costanza / Quentin, Joane / Richiardi, Lorenzo / Rodriguez, Adrian / Roumeliotaki, Theano / Sabin Capote, José Manuel / Santiago, Leonardo / Santos, Susana / Siskos, Alexandros P / Strandberg-Larsen, Katrine / Stratakis, Nikos / Sunyer, Jordi / Tenenhaus, Arthur / Vafeiadi, Marina / Wilson, Rebecca C / Wright, John / Yang, Tiffany / Slama, Remy

    Environmental epidemiology (Philadelphia, Pa.)

    2021  Volume 5, Issue 5, Page(s) e166

    Abstract: Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse ... ...

    Abstract Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2474-7882
    ISSN (online) 2474-7882
    DOI 10.1097/EE9.0000000000000166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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