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Article ; Online: Synthesis and Characterization of Cobalt-Doped Ferrites for Biomedical Applications.

Kiani, Muhammad Naeem / Butt, Muhammad Shoaib / Gul, Iftikhar Hussain / Saleem, Mohsin / Irfan, Muhammad / Baluch, Abrar H / Akram, Muhammad Aftab / Raza, Mohsin Ali

ACS omega

2023 Volume 8, Issue 4, Page(s) 3755–3761

Abstract: Novel materials for biomedical applications are in critical need of time. In the present work, the antibacterial properties of ... ...

Abstract	Novel materials for biomedical applications are in critical need of time. In the present work, the antibacterial properties of Co
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c05226
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Enhanced Agile V-Model: Conformance to regulatory bodies and experiences from model's adoption to medical device development.

Khan, Aliya A / Akram, Muhammad U / Butt, Wasi H / Sirshar, Mehreen

Heliyon

2024 Volume 10, Issue 6, Page(s) e26928

Abstract: Context: Medical devices fall under the broad topic encompass everything from basic hardware to integrated software systems. The integration of software into hardware devices is not simple due to requirements of regional regulatory bodies. Therefore, ... ...

Abstract	Context: Medical devices fall under the broad topic encompass everything from basic hardware to integrated software systems. The integration of software into hardware devices is not simple due to requirements of regional regulatory bodies. Therefore, medical businesses need to oversee not only the creation of devices but also the observance of guidelines and standards established by regulatory bodies. While plan-driven methodologies prevented software from evolving or changing, agile methodologies have inherent characteristics of insufficient planning and documentation. Objectives: The objective of our research is to propose a suitable process model for medical device development, keeping in mind the regulatory requirements. Methods: First, based on the detailed analysis of literature and McHughs proposed model, we suggested the Enhanced Agile V-Model (EAV), which combines plan-driven and agile approaches. Second, we mapped the proposed model to the MDEVSPICE framework to confirm that it adhered to the rules outlined in the standard IEC62304. Finally, the proposed model is evaluated through implication to case study of wave therapeutic medical device. Results: The support of both agile and waterfall approach in EAV model helps in accommodating new requirements in the medical devices and the proposed systems engineering approach helps in hardware and software integration. The mapping of the EAV model to the MDEVSPICE shows complete compliance. Moreover, the implication of the proposed model has been clearly shown statistically and successfully implemented in our case study. Further, device usability and efficiency metrics showed confidence of P < 0.05 and for device safety and efficiency, we conducted an experiment which shows significant improvement in selected parameters. Conclusion: The proposed model shows conformance to regulatory standards, and successfully implemented in development of wave therapeutic device. However, its applicability to more compact and straightforward medical products is unknown and can be determined by using this model to analyze the performance of other medical products.
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26928
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Article: A Case of Disseminated Herpes Zoster With Polyneuropathy Following the Third Dose of the Pfizer-BioNTech Vaccine.

Riazuddin, Muhammad / Jefri, Mona H / Butt, Muhammad I / Alsalamah, Hathami I / Ali Sheikh, Aamir Nadeem M

Cureus

2023 Volume 15, Issue 1, Page(s) e33962

Abstract: SARS-CoV-2 pandemic resulted in the fast development of new vaccines, which helped contain the pandemic, but some adverse events started to rise. Recently, post-administration of mRNA-based vaccines, varicella-zoster virus (VZV) reactivation was reported. ...

Abstract	SARS-CoV-2 pandemic resulted in the fast development of new vaccines, which helped contain the pandemic, but some adverse events started to rise. Recently, post-administration of mRNA-based vaccines, varicella-zoster virus (VZV) reactivation was reported. We report a case of disseminated herpes zoster with polyneuropathy and cerebrospinal fluid (CSF) findings following the Pfizer-BioNTechvaccine. Our observation aims to increase clinicians' awareness of a possible relationship between herpes zoster reactivation and SARS-CoV-2 vaccines.
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.33962
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Article ; Online: Outbreak of acute hepatitis of unknown etiology in children: The critical role of healthcare professionals in neutralizing misleading narratives during the COVID-19 pandemic.

Khan, Yusra H / Mallhi, Tauqeer H / Alanazi, Abdullah S / Butt, Muhammad H / Khan, Amjad / Salman, Muhammad

Journal of medical virology

2022 Volume 94, Issue 9, Page(s) 4063–4064

MeSH term(s)	COVID-19/epidemiology ; Child ; Delivery of Health Care ; Disease Outbreaks ; Health Personnel ; Hepatitis ; Humans ; Pandemics
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27819
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Article ; Online: A systematic metadata harvesting workflow for analysing scientific networks.

Butt, Bilal H / Rafi, Muhammad / Sabih, Muhammad

PeerJ. Computer science

2021 Volume 7, Page(s) e421

Abstract: One of the disciplines behind the science of science is the study of scientific networks. This work focuses on scientific networks as a social network having different nodes and connections. Nodes can be represented by authors, articles or journals while ...

Abstract	One of the disciplines behind the science of science is the study of scientific networks. This work focuses on scientific networks as a social network having different nodes and connections. Nodes can be represented by authors, articles or journals while connections by citation, co-citation or co-authorship. One of the challenges in creating scientific networks is the lack of publicly available comprehensive data set. It limits the variety of analyses on the same set of nodes of different scientific networks. To supplement such analyses we have worked on publicly available citation metadata from Crossref and OpenCitatons. Using this data a workflow is developed to create scientific networks. Analysis of these networks gives insights into academic research and scholarship. Different techniques of social network analysis have been applied in the literature to study these networks. It includes centrality analysis, community detection, and clustering coefficient. We have used metadata of Scientometrics journal, as a case study, to present our workflow. We did a sample run of the proposed workflow to identify prominent authors using centrality analysis. This work is not a bibliometric study of any field rather it presents replicable Python scripts to perform network analysis. With an increase in the popularity of open access and open metadata, we hypothesise that this workflow shall provide an avenue for understanding scientific scholarship in multiple dimensions.
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
ISSN	2376-5992
ISSN (online)	2376-5992
DOI	10.7717/peerj-cs.421
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Article ; Online: Convergent synthesis, kinetics insight and allosteric computational ascriptions of thiazole-(5-aryl)oxadiazole hybrids embraced with propanamides as alkaline phosphatase inhibitors.

Butt, Abdul Rehman Sadiq / Abbasi, Muhammad Athar / Aziz-Ur-Rehman / Siddiqui, Sabahat Zahra / Muhammad, Shabbir / Raza, Hussain / Shah, Syed Adnan Ali / Shahid, Muhammad / Alsehemi, Abdullah G / Kim, Song Ja

RSC advances

2023 Volume 13, Issue 20, Page(s) 13798–13808

Abstract: ... a unique series of bi-heterocyclic hybrids, 8a-h, was synthesized in a convergent manner. The structures ...

Abstract	Considering the varied pharmacological prominence of thiazole and oxadiazole heterocyclic moieties, a unique series of bi-heterocyclic hybrids, 8a-h, was synthesized in a convergent manner. The structures of newly synthesized compounds were characterized by
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra01348k
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Article ; Online: A systematic metadata harvesting workflow for analysing scientific networks

Bilal H. Butt / Muhammad Rafi / Muhammad Sabih

PeerJ Computer Science, Vol 7, p e

2021 Volume 421

Abstract	One of the disciplines behind the science of science is the study of scientific networks. This work focuses on scientific networks as a social network having different nodes and connections. Nodes can be represented by authors, articles or journals while connections by citation, co-citation or co-authorship. One of the challenges in creating scientific networks is the lack of publicly available comprehensive data set. It limits the variety of analyses on the same set of nodes of different scientific networks. To supplement such analyses we have worked on publicly available citation metadata from Crossref and OpenCitatons. Using this data a workflow is developed to create scientific networks. Analysis of these networks gives insights into academic research and scholarship. Different techniques of social network analysis have been applied in the literature to study these networks. It includes centrality analysis, community detection, and clustering coefficient. We have used metadata of Scientometrics journal, as a case study, to present our workflow. We did a sample run of the proposed workflow to identify prominent authors using centrality analysis. This work is not a bibliometric study of any field rather it presents replicable Python scripts to perform network analysis. With an increase in the popularity of open access and open metadata, we hypothesise that this workflow shall provide an avenue for understanding scientific scholarship in multiple dimensions.
Keywords	Digital libraries ; Network analysis ; Centrality measures ; Citation network ; Collaboration network ; Python ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	001
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Adipose Tissue and Umbilical Cord Tissue: Potential Sources of Mesenchymal Stem Cells for Liver Fibrosis Treatment.

Ghufran, Hafiz / Azam, Maryam / Mehmood, Azra / Umair, Muhammad / Baig, Maria T / Tasneem, Saba / Butt, Hira / Riazuddin, Sheikh

Journal of clinical and experimental hepatology

2024 Volume 14, Issue 4, Page(s) 101364

Abstract: ... differentiation potential. However, AT-MSCs demonstrated a shorter doubling time (58.2 ± 7.3 vs. 82.3 ± 4.3 h ...

Abstract	Background/aims: Mesenchymal stem cells (MSCs) are potential alternatives for liver fibrosis treatment; however, their optimal sources remain uncertain. This study compares the ex-vivo expansion characteristics of MSCs obtained from adipose tissue (AT) and umbilical cord (UC) and assesses their therapeutic potential for liver fibrosis treatment. Methods: Since MSCs from early to mid-passage numbers (P2-P6) are preferable for cellular therapy, we investigated the growth kinetics of AT-MSCs and UC-MSCs up to P6 and evaluated their therapeutic effects in a rat model of liver fibrosis induced by diethylnitrosamine. Results: Results from the expansion studies demonstrated that both cell types exhibited bona fide characteristics of MSCs, including surface antigens, pluripotent gene expression, and differentiation potential. However, AT-MSCs demonstrated a shorter doubling time (58.2 ± 7.3 vs. 82.3 ± 4.3 h; Conclusion: AT-MSCs and UC-MSCs effectively reduce liver fibrosis. However, adipose cultures display an advantage by yielding a higher number of MSCs in a shorter duration, rendering them a viable choice for scenarios requiring immediate single-dose administration, often encountered in clinical settings.
Language	English
Publishing date	2024-02-12
Publishing country	India
Document type	Journal Article
ISSN	0973-6883
ISSN	0973-6883
DOI	10.1016/j.jceh.2024.101364
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Article ; Online: Comparative molecular docking analysis for analyzing the inhibitory effect of Anakinra and Ustekinumab against IL17F.

Nisar, Haseeb / Attique, Syed Awais / Javaid, Anum / Ain, Qurat Ul / Butt, Fatima / Zaid, Muhammad / Shahid, Samiah / Hassan Nasir, Muhammad / Sadaf, Saima

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 22, Page(s) 13302–13313

Abstract: ... Communicated by Ramaswamy H. Sarma. ...

Abstract	Interleukin 17 F is a member of IL-17 cytokine family with a 50% structural homology to IL-17A and plays a significant role either alone or in combination with IL-17A towards inflammation in Rheumatoid arthritis (RA). A growing number of drugs targeting IL-17 pathway are being tested against population specific disease markers. The major objective of this research was to investigate the anti-inflammatory effect of Anakinra (an IL-1 R1 inhibitor) and Ustekinumab (an IL-12 and IL-23 inhibitor) by targeting IL17F. The three dimensional structures of IL17F was taken from PDB while structures of drugs were taken from PubChem database. Docking was performed using MOE and Schrodinger ligand docking software and binding energies, including s-score using London-dG fitness function and glide score using glide internal energy function, between drug and targets were compared. Furthermore, Protein-Drug complex were subjected to 150 ns Molecular Dynamics (MD) Simulations using Schrodinger's Desmond Module. Docking and MD simulation results suggest anakinra as a more potent IL17F inhibitor and forming a more structurally stable complex.Communicated by Ramaswamy H. Sarma.
MeSH term(s)	Interleukin-17 ; Ustekinumab/pharmacology ; Molecular Docking Simulation ; Interleukin 1 Receptor Antagonist Protein/pharmacology ; Molecular Dynamics Simulation
Chemical Substances	Interleukin-17 ; Ustekinumab (FU77B4U5Z0) ; Interleukin 1 Receptor Antagonist Protein
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2173299
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Article ; Online: Use of Endpoints in Phase III Randomized Controlled Trials for Hematopoietic Stem Cell Transplantation Over the Last 15 Years: A Systematic Review.

Shahzad, Moazzam / Khalid, Muhammad Fareed / Amin, Muhammad Kashif / Ammad-Ud-Din, Mohammad / Ilyas, Usman / Mushtaq, Ali H / Butt, Atif / Anwar, Iqra / Chaudhary, Sibgha Gull / Ahmed, Nausheen / Shune, Leyla / Singh, Anurag K / Abhyankar, Sunil H / McGuirk, Joseph P / Mushtaq, Muhammad Umair

Hematology/oncology and stem cell therapy

2024 Volume 17, Issue 2, Page(s) 88–94

Abstract: This systematic review aimed to evaluate the proportion of primary and secondary endpoints in hematopoietic stem cell transplant (HSCT) phase III randomized clinical trials (RCTs) and analyze their trends in time and study sponsorship status. The Chi- ... ...

Abstract	This systematic review aimed to evaluate the proportion of primary and secondary endpoints in hematopoietic stem cell transplant (HSCT) phase III randomized clinical trials (RCTs) and analyze their trends in time and study sponsorship status. The Chi-square test and logistic regression analyses were performed using SPSS version 28. A total of 147 HSCT phase III RCTs from 2006 to 2021 reported 197 primary and 600 secondary endpoints. Overall survival (OS, 17 %), progression-free survival (PFS, 15 %), graft versus host disease (GVHD, 8 %), event-free survival (EFS, 8 %), and organ function (8 %) were the most common primary endpoints. GVHD (12.3 %, n = 74), safety/toxicity/adverse events (11.8 %, n = 71), OS (11.5 %, n = 69), PFS (9.3 %, n = 56), and relapse rate (RR; 7.5 %, n = 45) were the most common secondary endpoints during 2006-2021. After 2013, an increase was noted in the use of PFS as a primary endpoint (12 %-18 %, p = 0.196), while the use of OS as a primary endpoint declined (20 %-13 %, p = 0.170). An increase was observed in using the secondary endpoints RR (5 %-10 %, p = 0.047) and NRM (3 %-6 %, p = 0.047). EFS was used more (14 % vs. 4 %, p = 0.012) than ORR (11 % vs. 2 %, p = 0.003) as a primary endpoint in pharmaceutical-compared to non-pharmaceutical-sponsored studies. As secondary endpoints, the use of EFS (4 % vs. 1 %, p = 0.013) and ORR (4 % vs. 1 %, p = 0.028) was higher, whereas that of organ systems/functions (1.5 % vs. 5.5 %, p = 0.022) and GVHD (6.5 % vs. 15 %, p = 0.002) was lower in pharmaceutical-compared to non-pharmaceutical sponsored studies. GVHD-free relapse-free survival was reported as a primary endpoint in 2 % of studies, while only 5 % reported quality of life as a secondary endpoint. We described commonly used endpoints in HSCT phase III RCTs and patterns in their use over time by funding source and study intervention category.
MeSH term(s)	Humans ; Clinical Trials, Phase III as Topic ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Pharmaceutical Preparations ; Randomized Controlled Trials as Topic ; Transplantation, Homologous
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2024-03-30
Publishing country	Saudi Arabia
Document type	Journal Article ; Systematic Review
ZDB-ID	2651893-4
ISSN	2589-0646 ; 1658-3876
ISSN (online)	2589-0646
ISSN	1658-3876
DOI	10.56875/2589-0646.1118
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