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  1. Article ; Online: Corrigendum to "Reproductive Health Counseling in Adolescent Women With Epilepsy: A Single-Center Study" Pediatric Neurology 131C (2022)(49-53).

    Smith, Cheyenne C / Curcio, Angela M / Grinspan, Zachary M

    Pediatric neurology

    2023  Volume 145, Page(s) 154

    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2023.03.007
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  2. Article ; Online: Reproductive Health Counseling in Adolescent Women With Epilepsy: A Single-Center Study.

    Smith, Cheyenne C / Curcio, Angela M / Grinspan, Zachary M

    Pediatric neurology

    2022  Volume 131, Page(s) 49–53

    Abstract: Background: Counseling adolescent women with epilepsy (WWE) about reproductive health (contraception, sexual activity, and menstruation) is important given the teratogenicity of many antiseizure medications and high rates of contraception failure. Only ... ...

    Abstract Background: Counseling adolescent women with epilepsy (WWE) about reproductive health (contraception, sexual activity, and menstruation) is important given the teratogenicity of many antiseizure medications and high rates of contraception failure. Only a third of adolescent WWE report discussing contraception with their epileptologists, demonstrating a significant gap in counseling.
    Methods: We assessed factors associated with reproductive health counseling by pediatric neurologists via a retrospective chart review of adolescent (aged 12-18 years) WWE seen at a pediatric neurology clinic from 2018 to 2020.
    Results: We analyzed 219 visits among 89 unique WWE. There were 23 documented discussions on contraception (11% of visits), 8 on sexual activity (4%), and 127 on menstruation (58%). When contraception was discussed, sexual activity and menstruation were more frequently discussed. Female providers were more likely to document a discussion of menstruation (OR = 3.2, 95% CI = [1.6, 6.4]). WWE who were older at the time of visit or who had their first seizure at an older age were more likely to have documented discussions of contraception and sexual activity. Neither details of treatment regimen nor epilepsy type was associated with documentation of counseling.
    Conclusions: A minority of adolescent WWE have documented reproductive health discussions, demonstrating a need for quality improvement projects to address this gap in care.
    MeSH term(s) Adolescent ; Child ; Contraception ; Counseling ; Epilepsy/therapy ; Female ; Humans ; Reproductive Health ; Retrospective Studies
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2022.04.005
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  3. Article ; Online: Corrigendum to Patterns of Recording Epileptic Spasms in an Electronic Seizure Diary Compared to Video EEG and Historical Cohorts' Pediatric Neurology 122C (2021) (27-34).

    LaGrant, Brian / Goldenholz, Daniel M / Braun, Marvin / Moss, Robert E / Grinspan, Zachary M

    Pediatric neurology

    2023  Volume 145, Page(s) 155

    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2023.03.008
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  4. Article ; Online: Natural history variations for neuronal ceroid lipofuscinosis type 2: In support of newborn screening.

    Cabassa Miskimen, Andrea / Cohen, Lilian L / Yozawitz, Elissa G / Grinspan, Zachary M

    Epilepsia

    2023  Volume 64, Issue 5, Page(s) 1403–1404

    MeSH term(s) Humans ; Infant, Newborn ; Neonatal Screening ; Neuronal Ceroid-Lipofuscinoses/diagnosis ; Neuronal Ceroid-Lipofuscinoses/genetics
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17544
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  5. Article ; Online: Automated Identification of Surgical Candidates and Estimation of Postoperative Seizure Freedom in Children - A Focused Review.

    Samanta, Debopam / Beal, Jules C / Grinspan, Zachary M

    Seminars in pediatric neurology

    2021  Volume 39, Page(s) 100914

    Abstract: Surgery is an effective but underused treatment for drug-resistant epilepsy in children. Algorithms to identify surgical candidates and estimate the likelihood of postoperative clinical improvement may be valuable to improve access to epilepsy surgery. ... ...

    Abstract Surgery is an effective but underused treatment for drug-resistant epilepsy in children. Algorithms to identify surgical candidates and estimate the likelihood of postoperative clinical improvement may be valuable to improve access to epilepsy surgery. We provide a focused review of these approaches. For adults with epilepsy, tools to identify surgical candidates and predict seizure and cognitive outcomes (Ie, Cases for Epilepsy (toolsforepilepsy.com) and Epilepsy Surgery Grading Scale) have been validated and are in use. Analogous tools for children need development. A promising approach is to apply statistical learning tools to clinical datasets, such as electroencephalogram tracings, imaging studies, and the text of clinician notes. Demonstration projects suggest these techniques have the potential to be highly accurate, and await further validation and clinical application.
    MeSH term(s) Adult ; Child ; Drug Resistant Epilepsy ; Electroencephalography ; Epilepsy ; Freedom ; Humans ; Retrospective Studies ; Seizures/diagnosis ; Seizures/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1290000-x
    ISSN 1558-0776 ; 1071-9091
    ISSN (online) 1558-0776
    ISSN 1071-9091
    DOI 10.1016/j.spen.2021.100914
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  6. Article ; Online: The burden of pediatric status epilepticus: Epidemiology, morbidity, mortality, and costs.

    Gurcharran, Kevin / Grinspan, Zachary M

    Seizure

    2018  Volume 68, Page(s) 3–8

    Abstract: Purpose: To summarize the epidemiology, morbidity, mortality, and costs of status epilepticus (SE) in the pediatric population.: Method: Review of the medical literature.: Results: The overall incidence of pediatric SE is roughly 20 per 100,000 ... ...

    Abstract Purpose: To summarize the epidemiology, morbidity, mortality, and costs of status epilepticus (SE) in the pediatric population.
    Method: Review of the medical literature.
    Results: The overall incidence of pediatric SE is roughly 20 per 100,000 children per year, with overall mortality of 3%. Underlying etiology is the biggest risk factor for SE, with symptomatic (acute > remote) etiologies associated with worse outcomes. The most common cause of SE in children is febrile SE, though this entity occurs primarily in early childhood. After a first episode, the risk of recurrence is similar to the risk after a first unprovoked seizure (25-40%). SE is expensive, regularly costing more than $10,000 per episode and often more than $100,000 for refractory cases.
    Conclusion: SE is not an uncommon neurologic emergency and depending on the associated etiology can carry significant morbidity, mortality, and cost especially if treatment is not performed in a timely manner.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Infant ; Status Epilepticus/economics ; Status Epilepticus/epidemiology ; Status Epilepticus/etiology
    Language English
    Publishing date 2018-08-29
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2018.08.021
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  7. Article ; Online: Development and Evaluation of Computable Phenotypes in Pediatric Epilepsy:3 Cases.

    Pan, Sabrina / Wu, Alan / Weiner, Mark / M Grinspan, Zachary

    Journal of child neurology

    2021  Volume 36, Issue 11, Page(s) 990–997

    Abstract: Introduction: Computable phenotypes allow identification of well-defined patient cohorts from electronic health record data. Little is known about the accuracy of diagnostic codes for important clinical concepts in pediatric epilepsy, such as (1) risk ... ...

    Abstract Introduction: Computable phenotypes allow identification of well-defined patient cohorts from electronic health record data. Little is known about the accuracy of diagnostic codes for important clinical concepts in pediatric epilepsy, such as (1) risk factors like neonatal hypoxic-ischemic encephalopathy; (2) clinical concepts like treatment resistance; (3) and syndromes like juvenile myoclonic epilepsy. We developed and evaluated the performance of computable phenotypes for these examples using electronic health record data at one center.
    Methods: We identified gold standard cohorts for neonatal hypoxic-ischemic encephalopathy, pediatric treatment-resistant epilepsy, and juvenile myoclonic epilepsy via existing registries and review of clinical notes. From the electronic health record, we extracted diagnostic and procedure codes for all children with a diagnosis of epilepsy and seizures. We used these codes to develop computable phenotypes and evaluated by sensitivity, positive predictive value, and the F-measure.
    Results: For neonatal hypoxic-ischemic encephalopathy, the best-performing computable phenotype (HIE
    Conclusion: The variable accuracy of our computable phenotypes (hypoxic-ischemic encephalopathy high, treatment resistance medium, and juvenile myoclonic epilepsy low) demonstrates the heterogeneity of success using administrative data to identify cohorts important for pediatric epilepsy research.
    MeSH term(s) Brain/diagnostic imaging ; Cross-Sectional Studies ; Electroencephalography/methods ; Electronic Health Records/statistics & numerical data ; Epilepsy/diagnosis ; Female ; Humans ; Infant, Newborn ; Magnetic Resonance Imaging/methods ; Male ; Phenotype ; Registries/statistics & numerical data ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/08830738211019578
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  8. Article ; Online: Priorities for Newborn Screening of Genetic Epilepsy.

    Hess-Homeier, David L / Cunniff, Christopher / Grinspan, Zachary M

    Pediatric neurology

    2019  Volume 101, Page(s) 83–85

    MeSH term(s) Epilepsy/diagnosis ; Epilepsy/genetics ; Female ; Humans ; Infant, Newborn ; Male ; Neonatal Screening
    Language English
    Publishing date 2019-07-29
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2019.07.009
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  9. Article ; Online: Pediatric Mental Health Emergencies During 5 COVID-19 Waves in New York City.

    Levine, Deborah A / Oh, P Stephen / Nash, Katherine A / Simmons, Will / Grinspan, Zachary M / Abramson, Erika L / Platt, Shari L / Green, Cori

    Pediatrics

    2023  Volume 152, Issue 5

    Abstract: Objectives: To describe the proportion of pediatric mental health emergency department (MH-ED) visits across 5 COVID-19 waves in New York City (NYC) and to examine the relationship between MH-ED visits, COVID-19 prevalence, and societal restrictions.: ...

    Abstract Objectives: To describe the proportion of pediatric mental health emergency department (MH-ED) visits across 5 COVID-19 waves in New York City (NYC) and to examine the relationship between MH-ED visits, COVID-19 prevalence, and societal restrictions.
    Methods: We conducted a time-series analysis of MH-ED visits among patients ages 5 to 17 years using the INSIGHT Clinical Research Network, a database from 5 medical centers in NYC from January 1, 2016, to June 12, 2022. We estimated seasonally adjusted changes in MH-ED visit rates during the COVID-19 pandemic, compared with predicted prepandemic levels, specific to each COVID-19 wave and stratified by mental health diagnoses and sociodemographic characteristics. We estimated associations between MH-ED visit rates, COVID-19 prevalence, and societal restrictions measured by the Stringency Index.
    Results: Of 686 500 ED visits in the cohort, 27 168 (4.0%) were MH-ED visits. The proportion of MH-ED visits was higher during each COVID-19 wave compared with predicted prepandemic trends. Increased MH-ED visits were seen for eating disorders across all waves; anxiety disorders in all except wave 3; depressive disorders and suicidality/self-harm in wave 2; and substance use disorders in waves 2, 4, and 5. MH-ED visits were increased from expected among female, adolescent, Asian race, high Child Opportunity Index patients. There was no association between MH-ED visits and NYC COVID-19 prevalence or NY State Stringency Index.
    Conclusions: The proportion of pediatric MH-ED visits during the COVID-19 pandemic was higher during each wave compared with the predicted prepandemic period, with varied increases among diagnostic and sociodemographic subgroups. Enhanced pediatric mental health resources are essential to address these findings.
    MeSH term(s) Adolescent ; Humans ; Child ; Female ; Mental Health ; COVID-19/epidemiology ; Emergencies ; New York City/epidemiology ; Pandemics ; Emergency Service, Hospital
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-060553
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  10. Article ; Online: Comparative Effectiveness of Phenobarbital versus Levetiracetam for Infantile Epilepsy.

    Grinspan, Zachary M / Shellhaas, Renée A / Berg, Anne T

    Pediatric neurology

    2019  Volume 100, Page(s) 105

    MeSH term(s) Anticonvulsants/pharmacology ; Child, Preschool ; Comparative Effectiveness Research ; Epilepsy/drug therapy ; Humans ; Infant ; Levetiracetam/pharmacology ; Observational Studies as Topic ; Phenobarbital/pharmacology
    Chemical Substances Anticonvulsants ; Levetiracetam (44YRR34555) ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2019-03-01
    Publishing country United States
    Document type Letter
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2019.02.010
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