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  1. Book: David M. Lawrence, M.D. in first person

    Lawrence, David / Walker, Larry / Garber, Kim M

    an oral history

    (Hospital administration oral history collection)

    2013  

    Institution American Hospital Association,
    Center for Hospital and Healthcare Administration History,
    Health Research and Educational Trust,
    Author's details interviewed by Larry Walker on February 25, 2013 ; edited by Kim M. Garber ; sponsored by American Hospital Association, Center for Hospital and Healthcare Administration History and Health Research & Educational Trust
    Series title Hospital administration oral history collection
    MeSH term(s) Hospital Administrators ; History, 20th Century ; Hospital Administration/history
    Keywords United States
    Language English
    Size 37 pages :, portrait ;, 29 cm.
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article ; Online: n-Butyl-α-D-fructofuranoside Isolated from Ulmus davidiana Enhances Nrf2 Activity Through Activation of JNK.

    Choi, Hee-Jin / Choi, Hee-Jung / Park, Mi-Joo / Chung, Tae-Wook / Joo, Myungsoo / Kim, Cheorl-Ho / Chang, Hyun-Wook / Son, Jong-Keun / Ha, Ki-Tae

    Current pharmaceutical biotechnology

    2016  Volume 17, Issue 13, Page(s) 1181–1188

    Abstract: ... its constituent compounds, including catechin-3-O-α-L-rhamnopyranoside, α-nigerose, n-butyl α-D ... Background: The root bark of Ulmus davidiana Nakai (Ulmaceae), a traditional Korean ... effect of U. davidiana and identified a novel Nrf2 activator from its constituent compounds.: Methods ...

    Abstract Background: The root bark of Ulmus davidiana Nakai (Ulmaceae), a traditional Korean medicinal plant, is used for treating inflammatory diseases.
    Objective: We investigated the Nrf2-activating effect of U. davidiana and identified a novel Nrf2 activator from its constituent compounds.
    Methods: Cytotoxicity was measured by MTT assay, and the Nrf2 activity was examined by luciferasereporter assay and western blot analysis. The expression of Nrf2-dependent antioxidant genes was estimated by RT-PCR. The signal pathway related to Nrf2 activation was analyzed by treating specific signaling inhibitors. Anti-inflammatory effects were determined using an NO assay and western blot analysis.
    Results: Ulmus davidiana and its constituent compounds, including catechin-3-O-α-L-rhamnopyranoside, α-nigerose, n-butyl α-D-fructofuranoside (NBF), and procyanidin B3, enhanced the transcriptional activity of Nrf2. Of these compounds, only NBF possessed a distinctive structure and exhibited ROS-independent Nrf2 activation. In addition, NBF significantly increased the nuclear translocation of Nrf2 and the expression of Nrf2-dependent detoxifying enzymes, including HO-1 and NQO-1, in dose-dependent manner. The Nrf2 activation induced by NBF was mediated by the phosphorylation of JNK. Consequently, pretreatment with NBF inhibited the LPS-induced expression of pro-inflammatory genes.
    Conclusion: To the best of our knowledge, this is the first study to report on the Nrf2-activating effect of U. davidiana and NBF. Given the importance of Nrf2 as a negative regulator in various inflammatory diseases, NBF could be considered as a novel candidate for the prevention and treatment of inflammatory diseases.
    MeSH term(s) Animals ; Enzyme Activation/drug effects ; Fructose/analogs & derivatives ; Fructose/isolation & purification ; Fructose/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; NF-E2-Related Factor 2/metabolism ; Phosphorylation ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Ulmus/chemistry
    Chemical Substances NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Fructose (30237-26-4) ; butyl fructofuranoside (80971-60-4) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2016-09-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201017666160920161238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6212: Show issues Location:
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  3. Book: Clinical Handbook of Psychotropic Drugs

    Procyshyn, Ric M. / Bezchlibnyk-Butler, Kalyna Z. / Kim, David D.

    2023  

    Keywords Pharmacy ; Psychopharmacology ; Psychotropic drugs
    Language English
    Size 484 p.
    Edition 25
    Publisher Hogrefe Publishing
    Document type Book
    Note PDA Manuell_21
    Format 242 x 275 x 32
    ISBN 9780889376328 ; 0889376328
    Database PDA

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  4. Article ; Online: The role of simulation modelling in public health policy evaluation.

    Kim, David D

    The Lancet. Public health

    2024  Volume 9, Issue 3, Page(s) e150–e151

    MeSH term(s) Humans ; Computer Simulation ; Health Policy ; Public Policy
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(24)00027-6
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  5. Article ; Online: Accounting for Nonhealth and Future Costs in Cost-Effectiveness Analysis: Distributional Impacts of a US Cancer Prevention Strategy.

    Kim, David D

    PharmacoEconomics

    2023  Volume 41, Issue 9, Page(s) 1151–1164

    Abstract: Objective: To provide up-to-date and comprehensive US data tables to estimate future net resource use, including nonlabor market production, and examine distributional impacts of including nonhealth and future costs in cost-effectiveness results.: ... ...

    Abstract Objective: To provide up-to-date and comprehensive US data tables to estimate future net resource use, including nonlabor market production, and examine distributional impacts of including nonhealth and future costs in cost-effectiveness results.
    Methods: Using a published US cancer prevention simulation model, the paper evaluated the lifetime cost effectiveness of implementing a 10% excise tax on processed meats across age- and sex-specific population subgroups. The model examined multiple scenarios accounting for cancer-related healthcare expenditure (HCE) only, cancer-related and unrelated background HCE, adding productivity benefits (i.e., patient time, cancer-related productivity loss, and background labor and nonlabor market production), and with nonhealth consumption costs, adjusted for household economies of scale. Additional analyses include using population-average versus age-sex-specific estimates for quantifying production and consumption value, as well as comparing direct model estimation versus postcorrections with Meltzer's approximation for incorporating future resource use.
    Results: Accounting for nonhealth and future costs impacted cost-effectiveness results across population subgroups, often leading to changes in "cost-saving" determination. Including nonlabor market production had a noticeable impact on estimating future resource use and reduced the bias toward undervaluing productivity among females and older populations. The use of age-sex-specific estimates resulted in less favorable cost-effectiveness results compared with population-average estimates. Meltzer's approximation provided reasonable corrections among the middle-aged population for re-engineering cost-effectiveness ratios from a healthcare sector to a societal perspective.
    Conclusion: With updated US data tables, this paper can help researchers conduct a comprehensive value assessment to reflect net resource use (health and nonhealth resource use minus production value) from a societal perspective.
    MeSH term(s) Male ; Middle Aged ; Female ; Humans ; Cost-Benefit Analysis ; Delivery of Health Care ; Efficiency ; Neoplasms/prevention & control
    Chemical Substances HCE (4479-32-7)
    Language English
    Publishing date 2023-05-17
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1100273-6
    ISSN 1179-2027 ; 1170-7690
    ISSN (online) 1179-2027
    ISSN 1170-7690
    DOI 10.1007/s40273-023-01275-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 3579: Show issues Location:
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  6. Book ; Online: Imagining Human Rights

    Kim, David D. / Kaul, Susanne

    2015  

    Abstract: Why is it that human rights are considered inviolable norms of justice at local and global scales although the number of their violations has steadily increased in modern history? On the surface, this paradox seems to be reducible to a straightforward ... ...

    Abstract Why is it that human rights are considered inviolable norms of justice at local and global scales although the number of their violations has steadily increased in modern history? On the surface, this paradox seems to be reducible to a straightforward discrepancy between idealism and reality in humanitarian affairs, but Imagining Human Rights complicates the picture by offering interdisciplinary perspectives on the imaginary status of human rights. By that the contributors mean not merely subject to imagination, open to interpretation or far too abstract, but also formative of a social imaginary with emphatic identifications and shared values. From a variety of disciplinary perspectives, they explore critical ways of engaging in rigorous interdisciplinary conversations about the origin and language of human rights, personal dignity, redistributive justice, and international solidarity. Together, they show how and why a careful examination of the intersection between disciplinary investigations is essential for imagining human rights at large. Examples range from the legitimacy of land ownership rights and the inadequacy of human faculty to make sense of mass violence in visual representation to the stewardship of human rights promoters and the genealogy of human rights
    Keywords Literature (General) ; Philosophy (General) ; Law in general. Comparative and uniform law. Jurisprudence
    Size 1 electronic resource (viii, 227 p.)
    Publisher De Gruyter
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090303
    ISBN 9783110376616 ; 9783110387292 ; 311037661X ; 3110387298
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online: Forces of Nature

    Fedman, David / Kim, Eleana J / Park, Albert L / Kim, Eleana J

    New Perspectives on Korean Environments

    2023  

    Keywords Conservation of the environment ; Politics & government ; environmental history of Korea, Korean environmentalism, environmental politics in Korea, nature and wildlife in Korea, industrial pollution, climate change in Korea, Korean environmental humanities, natural disaster in Korea, Korean beef industry
    Language English
    Size 1 electronic resource (258 pages)
    Publisher Cornell University Press
    Publishing place Ithaca
    Document type Book ; Online
    Note English
    HBZ-ID HT030381535
    ISBN 9781501768781 ; 1501768786
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Author Reply.

    Kim, David D / Neumann, Peter J

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2023  Volume 26, Issue 10, Page(s) 1578–1579

    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2023.06.017
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    Zs.A 5904: Show issues Location:
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  9. Article ; Online: Cost-effectiveness Thresholds Used by Study Authors, 1990-2021.

    Neumann, Peter J / Kim, David D

    JAMA

    2023  Volume 329, Issue 15, Page(s) 1312–1314

    MeSH term(s) Cost-Benefit Analysis ; Cost-Effectiveness Analysis ; Developing Countries/economics ; Quality-Adjusted Life Years ; Delivery of Health Care/economics
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.1792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Atlas of peripheral nerve surgery

    Kim, Daniel H. / Hudson, Alan R. / Kline, David G.

    (Expert consult)

    2013  

    Author's details Daniel H. Kim ; Alan R. Hudson ; David G. Kline
    Series title Expert consult
    Keywords Peripheral Nerves / surgery ; Atlases
    Language English
    Size XI, 274 S. : zahlr. Ill.
    Edition 2. ed.
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017570627
    ISBN 978-1-4557-0988-5 ; 1-4557-0988-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 C 5 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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