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  1. Article ; Online: Crinecerfont in a First Clinical Application of a CRH Antagonist: Further Potential Uses Are Still an Open Chapter!

    Chrousos, George P

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 4, Page(s) e1365–e1366

    MeSH term(s) Humans ; Adolescent ; Adrenal Hyperplasia, Congenital ; Receptors, Corticotropin-Releasing Hormone ; Amines ; Thiazoles
    Chemical Substances crinecerfont ; CRF receptor type 1 (5CLY6W2H1M) ; Receptors, Corticotropin-Releasing Hormone ; Amines ; Thiazoles
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online: Molecular Mechanisms in Stress and Trauma Related Disorders

    Zannas, Anthony S. / Chrousos, George P. / Stein, Murray B.

    2020  

    Keywords Medicine ; Psychiatry ; autophagy ; circadian biology ; epigenetics ; inflammation ; major depression ; posttraumatic stress disorder ; psychosocial stress
    Size 1 electronic resource (142 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230362
    ISBN 9782889636532 ; 2889636534
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Glucocorticoid Signaling Pathway: From Bench to Bedside.

    Nicolaides, Nicolas C / Chrousos, George P

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Glucocorticoids were named by Hans Hugo Bruno Selye, the modern father of stress concepts, for their important role in glucose metabolism [ ... ]. ...

    Abstract Glucocorticoids were named by Hans Hugo Bruno Selye, the modern father of stress concepts, for their important role in glucose metabolism [...].
    MeSH term(s) Glucocorticoids/metabolism ; Signal Transduction ; Stress, Physiological
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241311030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Endocrine hypertension

    Koch, Christian A. / Chrousos, George P.

    underlying mechanisms and therapy

    (Contemporary endocrinology)

    2013  

    Author's details Christian A. Koch ; George P. Chrousos ed
    Series title Contemporary endocrinology
    Keywords Hypertension--Endocrine aspects
    Subject code 616.132
    Language English
    Size XIII, 317 S. : Ill., graph. Darst., 25 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018760834
    ISBN 978-1-607-61547-7 ; 9781607615484 ; 1-607-61547-9 ; 1607615487
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 3296 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Neural Progenitor Cells and the Hypothalamus.

    Makrygianni, Evanthia A / Chrousos, George P

    Cells

    2023  Volume 12, Issue 14

    Abstract: Neural progenitor cells (NPCs) are multipotent neural stem cells (NSCs) capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. In the postnatal/adult brain, NPCs are primarily located in the subventricular zone (SVZ) ... ...

    Abstract Neural progenitor cells (NPCs) are multipotent neural stem cells (NSCs) capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. In the postnatal/adult brain, NPCs are primarily located in the subventricular zone (SVZ) of the lateral ventricles (LVs) and subgranular zone (SGZ) of the hippocampal dentate gyrus (DG). There is evidence that NPCs are also present in the postnatal/adult hypothalamus, a highly conserved brain region involved in the regulation of core homeostatic processes, such as feeding, metabolism, reproduction, neuroendocrine integration and autonomic output. In the rodent postnatal/adult hypothalamus, NPCs mainly comprise different subtypes of tanycytes lining the wall of the 3
    MeSH term(s) Adult ; Humans ; Neural Stem Cells ; Neurons ; Hypothalamus ; Brain/physiology ; Lateral Ventricles
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12141822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The human glucocorticoid receptor.

    Nicolaides, Nicolas C / Chrousos, George P

    Vitamins and hormones

    2023  Volume 123, Page(s) 417–438

    Abstract: Glucocorticoids are members of steroid hormones that are biosynthesized in the intermediate cellular zone of the adrenal cortex (zona fasciculata) and released into the peripheral blood as final products of the hypothalamic-pituitary-adrenal (HPA) axis, ... ...

    Abstract Glucocorticoids are members of steroid hormones that are biosynthesized in the intermediate cellular zone of the adrenal cortex (zona fasciculata) and released into the peripheral blood as final products of the hypothalamic-pituitary-adrenal (HPA) axis, as well as under the control of the circadian biologic system. These molecules regulate every physiologic function of the organism as they bind to an almost ubiquitous hormone-activated transcription factor, the glucocorticoid receptor (GR), which influences the rate of transcription of a huge number of target genes amounting to up to 20% of the mammalian genome. The evolving progress of cellular, molecular and computational-structural biology and the implication of epigenetics in every-day clinical practice have enabled us a deeper and ever-increasing understanding of how target tissues respond to natural and synthetic glucocorticoids. In this chapter, we summarize the current knowledge on the structure, expression, function and signaling of the human glucocorticoid receptor in normal and pathologic conditions.
    MeSH term(s) Animals ; Humans ; Receptors, Glucocorticoid/genetics ; Glucocorticoids ; Adrenal Cortex ; Epigenesis, Genetic ; Hypothalamo-Hypophyseal System ; Mammals
    Chemical Substances Receptors, Glucocorticoid ; Glucocorticoids
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2023.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.238: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Future of Exosome Bioinformatics.

    Vlachakis, Dimitrios P / Diakou, Kalliopi Io / Chrousos, George P

    EMBnet.journal

    2023  Volume 28

    Language English
    Publishing date 2023-03-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2226-6089
    ISSN (online) 2226-6089
    DOI 10.14806/ej.28.0.1015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Stress on Health in Childhood and Adolescence.

    Nicolaides, Nicolas C / Chrousos, George P

    Hormone research in paediatrics

    2022  Volume 96, Issue 1, Page(s) 5–7

    MeSH term(s) Adolescent ; Humans ; Stress, Psychological ; Child ; Child Health ; Adolescent Health
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 2537278-6
    ISSN 1663-2826 ; 1663-2818
    ISSN (online) 1663-2826
    ISSN 1663-2818
    DOI 10.1159/000528065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 414: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Functional MRI Techniques Suggesting that the Stress System Interacts with Three Large Scale Core Brain Networks to Help Coordinate the Adaptive Response: A Systematic Review.

    Paltoglou, George / Stefanaki, Charikleia / Chrousos, George P

    Current neuropharmacology

    2023  Volume 22, Issue 5, Page(s) 976–989

    Abstract: Objective: Synthesis of functional MRI (fMRI) and functional connectivity (FC) analysis data on human stress system (SS) function, as it relates to the dynamic function of the Salience (SN), Default Mode (DMN) and Central Executive (CEN) networks.: ... ...

    Abstract Objective: Synthesis of functional MRI (fMRI) and functional connectivity (FC) analysis data on human stress system (SS) function, as it relates to the dynamic function of the Salience (SN), Default Mode (DMN) and Central Executive (CEN) networks.
    Methods: Systematic search of Medline, Scopus, Clinical Trials.gov, and Google Scholar databases of studies published prior to September 2022 resulted in 28 full-text articles included for qualitative synthesis.
    Results: Acute stress changes the states of intra-/inter- neural network FCs and activities from those of resting, low arousal state in the SN, DMN and CEN, during which intra- and inter-network FCs and activities of all three networks are low. SS activation is positively linked to the activity of the SN and negatively to that of the DMN, while, in parallel, it is associated with an initial decrease and a subsequent increase of the intra- network FC and activity of the CEN. The FC between the DMN and the CEN increases, while those between the SN and the CEN decrease, allowing time for frontal lobe strategy input and "proper" CEN activity and task decision. SN activation is linked to sensory hypersensitivity, "impaired" memory, and a switch from serial to parallel processing, while trait mindfulness is associated with FC changes promoting CEN activity and producing a "task-ready state".
    Conclusion: SS activation is tightly connected to that of the SN, with stress hormones likely potentiating the intra-network FC of the latter, attenuating that of the DMN, and causing a biphasic suppression- to-activation response of the CEN, all adaptive changes favoring proper decisions and survival.
    MeSH term(s) Humans ; Brain Mapping/methods ; Neural Pathways/diagnostic imaging ; Brain/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Rest/physiology
    Language English
    Publishing date 2023-08-02
    Publishing country United Arab Emirates
    Document type Systematic Review ; Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X21666230801151718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
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  10. Article: Structural and Functional Insights into CRF Peptides and Their Receptors.

    Matsoukas, Minos-Timotheos / Panagiotopoulos, Vasilis / Karageorgos, Vlasios / Chrousos, George P / Venihaki, Maria / Liapakis, George

    Biology

    2024  Volume 13, Issue 2

    Abstract: Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes. CRF and urocortins belong to the family of CRF peptides (CRF family), which ... ...

    Abstract Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes. CRF and urocortins belong to the family of CRF peptides (CRF family), which includes sauvagine, urotensin, and many synthetic peptide and non-peptide CRF analogs. Several of the CRF analogs have shown considerable therapeutic potential in the treatment of various diseases. The CRF peptide family act by interacting with two types of plasma membrane proteins, type 1 (CRF
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13020120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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