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  1. Article ; Online: Post-traumatic hydrocephalus: unknown knowns and known unknowns.

    Kumaria, Ashwin / Tolias, Christos M

    British journal of neurosurgery

    2022  Volume 36, Issue 3, Page(s) 295–297

    MeSH term(s) Humans ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/etiology ; Hydrocephalus/surgery
    Language English
    Publishing date 2022-01-22
    Publishing country England
    Document type Editorial
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2028723
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  2. Article ; Online: Response to: "Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction".

    Kumaria, Ashwin / Tolias, Christos M

    Neuromodulation : journal of the International Neuromodulation Society

    2021  Volume 24, Issue 7, Page(s) 1289–1290

    MeSH term(s) Alzheimer Disease/therapy ; Deep Brain Stimulation ; Humans
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1500372-3
    ISSN 1525-1403 ; 1094-7159
    ISSN (online) 1525-1403
    ISSN 1094-7159
    DOI 10.1111/ner.13539
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  3. Article ; Online: Scope for Vagus Nerve Stimulation in Traumatic Brain Injury.

    Kumaria, Ashwin / Tolias, Christos M

    Neuromodulation : journal of the International Neuromodulation Society

    2020  Volume 24, Issue 6, Page(s) 1135–1136

    MeSH term(s) Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/therapy ; Humans ; Vagus Nerve ; Vagus Nerve Stimulation
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Letter
    ZDB-ID 1500372-3
    ISSN 1525-1403 ; 1094-7159
    ISSN (online) 1525-1403
    ISSN 1094-7159
    DOI 10.1111/ner.13283
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  4. Article ; Online: Vagus nerve stimulation in ischaemic stroke: further possibilities.

    Kumaria, Ashwin / Basu, Surajit / Tolias, Christos M

    British journal of neurosurgery

    2021  Volume 36, Issue 4, Page(s) 425–426

    MeSH term(s) Brain Ischemia/surgery ; Humans ; Ischemic Stroke ; Stroke/surgery ; Vagus Nerve/physiology ; Vagus Nerve Stimulation
    Language English
    Publishing date 2021-07-20
    Publishing country England
    Document type Editorial
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2021.1950633
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  5. Article ; Online: Letter by Kumaria and Tolias Regarding Article, "Vagus Nerve Stimulation Paired With Upper Limb Rehabilitation After Chronic Stroke: A Blinded Randomized Pilot Study".

    Kumaria, Ashwin / Tolias, Christos M

    Stroke

    2019  Volume 50, Issue 2, Page(s) e37

    MeSH term(s) Humans ; Pilot Projects ; Stroke ; Upper Extremity ; Vagus Nerve Stimulation
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.024182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  6. Article ; Online: Autoimmunity following traumatic brain injury: hypopituitarism and beyond.

    Kumaria, Ashwin / Robertson, Iain J A / Tolias, Christos M

    British journal of neurosurgery

    2019  Volume 35, Issue 6, Page(s) 796

    MeSH term(s) Autoimmunity ; Brain Injuries, Traumatic/complications ; Humans ; Hypopituitarism/etiology
    Language English
    Publishing date 2019-07-24
    Publishing country England
    Document type Letter
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2019.1645300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The changing landscape of cerebral revascularization surgery: A United Kingdom experience.

    Gallagher, Mathew J / Frantzias, Joseph / Kailaya-Vasan, Ahilan / Booth, Thomas C / Tolias, Christos M

    Frontiers in radiology

    2022  Volume 2, Page(s) 981501

    Abstract: Objective: We describe the chronological trends in cerebral revascularization surgery through a single-surgeon experience; and we review whether in the context of giant and fusiform cerebral aneurysms, flow-diverting stents have impacted on the use of ... ...

    Abstract Objective: We describe the chronological trends in cerebral revascularization surgery through a single-surgeon experience; and we review whether in the context of giant and fusiform cerebral aneurysms, flow-diverting stents have impacted on the use of cerebral revascularization surgery.
    Methods: We review our single institution prospectively collected database of cerebral revascularization procedures between 2006 and 2018. Comparing this to our database of flow-diverting endovascular stent procedures, we compare the treatment of fusiform and giant aneurysms. We describe patient demographics, procedural incidence, complications, and outcomes.
    Results: Between 2006 and 2018, 50 cerebral revascularization procedures were performed. The incidence of cerebral revascularization surgery is declining. In the context of giant/fusiform aneurysm treatment, the decline in cerebral revascularization is accompanied by a rise in the use of flow-diverting endovascular stents. Thirty cerebral revascularizations were performed for moyamoya disease and 11 for giant/fusiform aneurysm. Four (14%) direct bypass grafts occluded without neurological sequela. Other morbidity included hydrocephalus (2%), transient ischemic attacks (2%), and ischemic stroke (2%). There was one procedure-related mortality (2%). Flow-diverting stents were inserted for seven fusiform and seven giant aneurysms. Comparing the treatment of giant/fusiform aneurysms, there was no significant difference in morbidity and mortality between cerebral revascularization and flow-diverting endovascular stents.
    Conclusion: We conclude that with the decline in the incidence of cerebral revascularization surgery, there is a need for centralization of services to allow high standards and outcomes to be maintained.
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-8740
    ISSN (online) 2673-8740
    DOI 10.3389/fradi.2022.981501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Surgery for Malignant Acute Ischemic Stroke: A Narrative Review of the Knowns and Unknowns.

    Krishnan, Kailash / Hollingworth, Milo / Nguyen, Thanh N / Kumaria, Ashwin / Kirkman, Matthew A / Basu, Surajit / Tolias, Christos / Bath, Philip M / Sprigg, Nikola

    Seminars in neurology

    2023  Volume 43, Issue 3, Page(s) 370–387

    Abstract: Malignant acute ischemic stroke (AIS) is characterized by acute neurological deterioration caused by progressive space-occupying brain edema, often occurring in the first hours to days after symptom onset. Without any treatment, the result is often fatal. ...

    Abstract Malignant acute ischemic stroke (AIS) is characterized by acute neurological deterioration caused by progressive space-occupying brain edema, often occurring in the first hours to days after symptom onset. Without any treatment, the result is often fatal. Despite advances in treatment for AIS, up to 80% of patients with a large hemispheric stroke or cerebellar stroke are at risk of poor outcome. Decompressive surgery can be life-saving in a subgroup of patients with malignant AIS, but uncertainties exist on patient selection, predictors of malignant infarction, perioperative management, and timing of intervention. Although survivors are left disabled, most agree with the original decision to undergo surgery and would make the same decision again. In this narrative review, we focus on the clinical and radiological predictors of malignant infarction in AIS and outline the technical aspects of decompressive surgery as well as duraplasty and cranioplasty. We discuss the current evidence and recommendations for surgery in AIS, highlighting gaps in knowledge, and suggest directions for future studies. KEY POINTS: · Acute ischemic stroke from occlusion of a proximal intracranial artery can progress quickly to malignant edema, which can be fatal in 80% of patients despite medical management.. · Decompression surgery is life-saving within 48 hours of stroke onset, but the benefits beyond this time and in the elderly are unknown.. · Decompressive surgery is associated with high morbidity, particularly in the elderly. The decision to operate must be made after considering the individual's preference and expectations of quality of life in the context of the clinical condition.. · Further studies are needed to refine surgical technique including value of duraplasty and understand the role monitoring intracranial pressure during and after decompressive surgery.. · More studies are needed on the pathophysiology of malignant cerebral edema, prediction models including imaging and biomarkers to identify which subgroup of patients will benefit from decompressive surgery.. · More research is needed on factors associated with morbidity and mortality after cranioplasty, safety and efficacy of implants, and comparisons between them.. · Further studies are needed to assess the long-term effects of physical disability and quality of life of survivors after surgery, particularly those with severe neurological deficits..
    MeSH term(s) Aged ; Humans ; Ischemic Stroke ; Quality of Life ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke/surgery ; Brain Edema/diagnostic imaging ; Brain Edema/etiology ; Brain Edema/surgery ; Infarction
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0043-1771208
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    Zs.A 1737: Show issues Location:
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  9. Article ; Online: Which factors influence the decision to transfer patients with traumatic brain injury to a neurosurgery unit in a major trauma network?

    Rajwani, Kapil Mohan / Lavrador, Jose Pedro / Ansaripour, Ali / Tolias, Christos M

    British journal of neurosurgery

    2020  Volume 34, Issue 3, Page(s) 271–275

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Aged ; Brain Injuries, Traumatic ; Female ; Glasgow Coma Scale ; Humans ; London ; Male ; Neurosurgery ; Patients ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2020-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2020.1742289
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  10. Article ; Online: The changing landscape of cerebral revascularization surgery

    Mathew J. Gallagher / Joseph Frantzias / Ahilan Kailaya-Vasan / Thomas C. Booth / Christos M. Tolias

    Frontiers in Radiology, Vol

    A United Kingdom experience

    2022  Volume 2

    Abstract: ObjectiveWe describe the chronological trends in cerebral revascularization surgery through a single-surgeon experience; and we review whether in the context of giant and fusiform cerebral aneurysms, flow-diverting stents have impacted on the use of ... ...

    Abstract ObjectiveWe describe the chronological trends in cerebral revascularization surgery through a single-surgeon experience; and we review whether in the context of giant and fusiform cerebral aneurysms, flow-diverting stents have impacted on the use of cerebral revascularization surgery.MethodsWe review our single institution prospectively collected database of cerebral revascularization procedures between 2006 and 2018. Comparing this to our database of flow-diverting endovascular stent procedures, we compare the treatment of fusiform and giant aneurysms. We describe patient demographics, procedural incidence, complications, and outcomes.ResultsBetween 2006 and 2018, 50 cerebral revascularization procedures were performed. The incidence of cerebral revascularization surgery is declining. In the context of giant/fusiform aneurysm treatment, the decline in cerebral revascularization is accompanied by a rise in the use of flow-diverting endovascular stents. Thirty cerebral revascularizations were performed for moyamoya disease and 11 for giant/fusiform aneurysm. Four (14%) direct bypass grafts occluded without neurological sequela. Other morbidity included hydrocephalus (2%), transient ischemic attacks (2%), and ischemic stroke (2%). There was one procedure-related mortality (2%). Flow-diverting stents were inserted for seven fusiform and seven giant aneurysms. Comparing the treatment of giant/fusiform aneurysms, there was no significant difference in morbidity and mortality between cerebral revascularization and flow-diverting endovascular stents.ConclusionWe conclude that with the decline in the incidence of cerebral revascularization surgery, there is a need for centralization of services to allow high standards and outcomes to be maintained.
    Keywords cerebral bypass surgery ; cerebral bypass ; cerebral revascularisation ; cerebral revascularization surgery ; flow diversion ; flow diverting stent ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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