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  1. Article ; Online: Mushroom-shaped red blood cells (pincer cells): a brief update.

    Dienstmann, Guilherme / Barbosa Dos Santos, Vitor / Comar, Samuel Ricardo

    Hematology, transfusion and cell therapy

    2021  Volume 44, Issue 3, Page(s) 462–463

    Language English
    Publishing date 2021-07-09
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2021.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Critical blue-green inclusions in neutrophil and monocyte cytoplasm in a healthy patient affected by COVID-19.

    Dienstmann, Guilherme / Comar, Samuel Ricardo / Souza, Matheus Leite Ramos de / Ruaro, Graziela / Leite, Luiz Arthur Calheiros

    Hematology, transfusion and cell therapy

    2020  Volume 42, Issue 4, Page(s) 318–319

    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2020.06.008
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  3. Article: Barriers in precision medicine implementation among Advanced Nonsquamous Cell Lung Cancer-patients: A Real-World Evidence Scenario.

    Duarte, Flavia A / Ferreira, Carlos Gil / Dienstmann, Rodrigo / Ferrari, Bruno L / Costa E Silva, Matheus / Nazareth A Junior, Pedro / Guilherme de O Salles, Paulo / Henrique C Diniz, Paulo

    Journal of market access & health policy

    2022  Volume 10, Issue 1, Page(s) 2077905

    Abstract: Background: Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited.: Objective: To investigate the time spent in nsNSCLC molecular ... ...

    Abstract Background: Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited.
    Objective: To investigate the time spent in nsNSCLC molecular profile evaluation and its influence on clinical decisions.
    Methods: nsNSCLC patients who underwent molecular testing in a private referral Brazilian center between November 2015 and February 2020 were identified. The interval from nsNSCLC diagnosis to the characterization of the molecular profile was determined. Other outcomes, focusing on the biomarker tissue journey, were also assessed.
    Results: In this cohort (
    Conclusions: Our data show a long median time from advanced nsNSCLC diagnosis and the availability of the biomarker testing in medical practice, which impacted the choice of a non-personalized therapy as the first-line.
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2001-6689
    ISSN 2001-6689
    DOI 10.1080/20016689.2022.2077905
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  4. Article: Critical blue-green inclusions in neutrophil and monocyte cytoplasm in a healthy patient affected by COVID-19

    Dienstmann, Guilherme / Comar, Samuel Ricardo / Souza, Matheus Leite Ramos de / Ruaro, Graziela / Leite, Luiz Arthur Calheiros
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #670216
    Database COVID19

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  5. Article ; Online: Critical blue-green inclusions in neutrophil and monocyte cytoplasm in a healthy patient affected by COVID-19

    Dienstmann, Guilherme / Comar, Samuel Ricardo / Souza, Matheus Leite Ramos de / Ruaro, Graziela / Leite, Luiz Arthur Calheiros

    Hematology, Transfusion and Cell Therapy

    2020  Volume 42, Issue 4, Page(s) 318–319

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2531-1379
    DOI 10.1016/j.htct.2020.06.008
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Metformin for prevention of cesarean delivery and large-for-gestational-age newborns in non-diabetic obese pregnant women: a randomized clinical trial.

    Nascimento, Iramar Baptistella do / Sales, Willian Barbosa / Dienstmann, Guilherme / Souza, Matheus Leite Ramos de / Fleig, Raquel / Silva, Jean Carl

    Archives of endocrinology and metabolism

    2020  Volume 64, Issue 3, Page(s) 290–297

    Abstract: Objective: To evaluate the use of metformin for preventing cesarean deliveries and large-for-gestational-age (LGA) newborn (NB) outcomes in non-diabetic obese pregnant women.: Subjects and methods: This is a randomized clinical trial with obese ... ...

    Abstract Objective: To evaluate the use of metformin for preventing cesarean deliveries and large-for-gestational-age (LGA) newborn (NB) outcomes in non-diabetic obese pregnant women.
    Subjects and methods: This is a randomized clinical trial with obese pregnant women, divided into 2 groups: metformin group and control group, with followed-up prenatal routine. The gestational age of participants was less than or equal to 20 weeks and were monitored throughout entire prenatal period. For outcomes of delivery and LGA newborns, absolute risk reduction (ARR) and the number needed to treat (NNT) were calculated with a 95% confidence interval (CI).
    Results: 357 pregnant women were evaluated. From the metformin group (n = 171), 68 (39.8%) subjects underwent cesarean delivery, and 117 (62.9%) subjects from the control group (n = 186) had intercurrence (p < 0.01). As for the mothers' general characteristics, there was significance for marital status (p < 0.01). Maternal-fetal results presented reduced preeclampsia (p < 0,01). Primary prophylactic results presented an ARR of 23.1 times (95% CI: 13.0-33.4) with NNT of 4 (95% CI: 3.0-7.7) and no significant values for LGA NB (p > 0.01). Secondary prophylactic outcomes presented decreased odds ratio for preeclampsia (OR = 0.17, 95% CI: 0.10-0.41).
    Conclusion: The use of metformin reduced cesarean section rates, resulted in a small number of patients to be treated, but it did not reduce LGA NB. Administering a lower dosage of metformin from the early stages to the end of treatment may yield significant results with fewer side effects. Arch Endocrinol Metab. 2020;64(3):290-7.
    MeSH term(s) Adult ; Case-Control Studies ; Cesarean Section/statistics & numerical data ; Female ; Humans ; Hypoglycemic Agents/administration & dosage ; Metformin/administration & dosage ; Obesity/drug therapy ; Pregnancy ; Pregnancy Complications/drug therapy ; Socioeconomic Factors
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2020-07-30
    Publishing country Brazil
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient.

    Dienstmann, Guilherme / Avi, Karina Tolfo / Leite, Luiz Arthur Calheiros / Alano, Joaquim Squizatto / Souza, Matheus Leite Ramos de / Mulazani, Marcelo da Silva / Mendivil, Paula Cristina Gern

    Medical mycology case reports

    2019  Volume 26, Page(s) 44–46

    Abstract: The meningococcal disease manifestation associated with the presence ... ...

    Abstract The meningococcal disease manifestation associated with the presence of
    Language English
    Publishing date 2019-10-03
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2019.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Critical blue-green inclusions in neutrophil and monocyte cytoplasm in a healthy patient affected by COVID-19

    Guilherme Dienstmann / Samuel Ricardo Comar / Matheus Leite Ramos de Souza / Graziela Ruaro / Luiz Arthur Calheiros Leite

    Hematology, Transfusion and Cell Therapy, Vol 42, Iss 4, Pp 318-

    2020  Volume 319

    Keywords Diseases of the blood and blood-forming organs ; RC633-647.5 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Barriers in precision medicine implementation among Advanced Nonsquamous Cell Lung Cancer-patients

    Flavia A. Duarte / Carlos Gil Ferreira / Rodrigo Dienstmann / Bruno L. Ferrari / Matheus Costa E Silva / Pedro Nazareth A. Junior / Paulo Guilherme de O. Salles / Paulo Henrique C. Diniz

    Journal of Market Access & Health Policy, Vol 10, Iss

    A Real-World Evidence Scenario

    2022  Volume 1

    Abstract: Background Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited.Objective To investigate the time spent in nsNSCLC molecular profile ... ...

    Abstract Background Precision oncology has a prominent role in nonsquamous non-small cell lung cancer (nsNSCLC) treatment progress; however, its access in a real-world scenario might be limited.Objective To investigate the time spent in nsNSCLC molecular profile evaluation and its influence on clinical decisions.Methods nsNSCLC patients who underwent molecular testing in a private referral Brazilian center between November 2015 and February 2020 were identified. The interval from nsNSCLC diagnosis to the characterization of the molecular profile was determined. Other outcomes, focusing on the biomarker tissue journey, were also assessed.Results In this cohort (n = 78), the median time between the advanced nsNSCLC diagnosis and biomarker characterization was 40.5 days (range, 29.5–68.5). The median interval between the diagnosis and the test request was longer than the interval between the request and the results (respectively 29.0 versus 12.0 days; p < 0.001). At the treatment initiation, 51% (36/71) of the patients who received any systemic therapy did not have their driver mutations panel results available. But on these, 42% (15/36) had a targetable alteration identified later on. Among patients harboring a targetable alteration, only 46% (n = 13/28) received a tyrosine kinase inhibitor (TKI) as first-line therapy. The median time to the TKI initiation was even longer than the median time to all treatment initiation (92.0 versus 40.0 days).Conclusions Our data show a long median time from advanced nsNSCLC diagnosis and the availability of the biomarker testing in medical practice, which impacted the choice of a non-personalized therapy as the first-line.
    Keywords Precision medicine ; drug access ; non-small cell lung cancer ; Public aspects of medicine ; RA1-1270 ; Business ; HF5001-6182
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Factors Associated with the Need for Insulin as a Complementary Treatment to Metformin in Gestational Diabetes Mellitus.

    Souza, Matheus Leite Ramos de / Silva, Rodrigo Ribeiro E / Silva, Thiago Ribeiro E / Oliveira, Larissa Cano de / Dienstmann, Guilherme / Nascimento, Iramar Baptistella do / Silva, Jean Carl

    Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

    2019  Volume 41, Issue 12, Page(s) 697–702

    Abstract: Objective:  To evaluate the factors associated with the need for insulin as a complementary treatment to metformin in pregnant women with gestational diabetes mellitus (GDM).: Methods:  A case-control study was performed from April 2011 to February ... ...

    Title translation Fatores associados à necessidade de insulina como tratamento complementar à metformina na diabetes mellitus gestacional.
    Abstract Objective:  To evaluate the factors associated with the need for insulin as a complementary treatment to metformin in pregnant women with gestational diabetes mellitus (GDM).
    Methods:  A case-control study was performed from April 2011 to February 2016 with pregnant women with GDM who needed complementary treatments besides diet and physical exercise. Those treated with metformin were compared with those who, in addition to metformin, also needed the combination with insulin. Maternal characteristics and glycemic control were evaluated. Multinomial logistic regression models were developed to evaluate the influence of different therapies on neonatal outcomes.
    Results:  A total of 475 pregnant women who needed pharmacological therapy were evaluated. Of these, 366 (77.05%) were submitted to single therapy with metformin, and 109 (22.94%) needed insulin as a complementary treatment. In the analysis of the odds ratio (OR), fasting glucose (FG) < 90 mg/dL reduced the odds of needing the combination (OR: 0.438 [0.235-0.815];
    Conclusion:  Obesity resulted in an increased chance of the mother needing insulin as a complementary treatment to metformin, while FG < 90 mg/dL and primiparity were protective factors.
    MeSH term(s) Adult ; Blood Glucose/metabolism ; Case-Control Studies ; Diabetes, Gestational/blood ; Diabetes, Gestational/diet therapy ; Diabetes, Gestational/drug therapy ; Drug Therapy, Combination ; Exercise Therapy ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Metformin/therapeutic use ; Obesity, Maternal/blood ; Obesity, Maternal/complications ; Obesity, Maternal/diet therapy ; Parity ; Pregnancy
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin ; Metformin (9100L32L2N)
    Language English
    Publishing date 2019-12-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105176-8
    ISSN 1806-9339 ; 0100-7203
    ISSN (online) 1806-9339
    ISSN 0100-7203
    DOI 10.1055/s-0039-1700796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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