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Book ; Online: Výzkum v didaktice cizích jazyků IV

Cox, Šárka / Keplová, Kateřina / Luběnová Morales, Anna / Veškrnová, Daniela / Voldánová, Žaneta / Trnová, Michaela / Janíková, Věra / Hanušová, Světlana

2021

Keywords	Language teaching & learning material & coursework ; Foreign lanuguage didactics ; Professional Development of Teachers of English Self-assessment ; Authentic Literary Text ; Mediation ; Vocabulary Knowledge in Coursebooks ; Empirical research
Language	ces
Size	1 electronic resource (173 pages)
Publisher	Masaryk University Press
Document type	Book ; Online
Note	Czech
HBZ-ID	HT030377550
ISBN	9788028000547 ; 8028000541
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The multi-specific V

Edwards, Carolyn J / Sette, Angelica / Cox, Carl / Di Fiore, Barbara / Wyre, Chris / Sydoruk, Daniela / Yadin, David / Hayes, Philip / Stelter, Szymon / Bartlett, Phillip D / Zuazo, Miren / Garcia-Granda, Maria Jesus / Benedetti, Giovanni / Fiaska, Stratoniki / Birkett, Neil R / Teng, Yumin / Enever, Carrie / Arasanz, Hugo / Bocanegra, Ana /

Chocarro, Luisa / Fernandez, Gonzalo / Vera, Ruth / Archer, Bethan / Osuch, Isabelle / Lewandowska, Martyna / Surani, Yasmin M / Kochan, Grazyna / Escors, David / Legg, James / Pierce, Andrew J

British journal of cancer

2021 Volume 126, Issue 8, Page(s) 1168–1177

Abstract: ... developed as a fully human PD1/LAG3 co-targeting multi-specific Humabody composed of linked V: Results ...

Abstract	Background: Improving cancer immunotherapy long-term clinical benefit is a major priority. It has become apparent that multiple axes of immune suppression restrain the capacity of T cells to provide anti-tumour activity including signalling through PD1/PD-L1 and LAG3/MHC-II. Methods: CB213 has been developed as a fully human PD1/LAG3 co-targeting multi-specific Humabody composed of linked V Results: CB213 shows picomolar avidity when simultaneously engaging PD1 and LAG3. Assessing LAG3/MHC-II or PD1/PD-L1 suppression individually, CB213 preferentially counters the LAG3 axis. CB213 showed superior activity vs. αPD1 antibody to induce ex vivo NSCLC patient T cell proliferation and to suppress tumour growth in a syngeneic mouse tumour model, for which both experimental systems possess PD1 and LAG3 suppressive components. Non-human primate PK of CB213 suggests weekly clinical administration. Conclusions: CB213 is poised to enter clinical development and, through intercepting both PD1 and LAG3 resistance mechanisms, may benefit patients with tumours escaping front-line immunological control.
MeSH term(s)	Animals ; Antigens, CD/immunology ; Antigens, CD/metabolism ; B7-H1 Antigen ; Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Programmed Cell Death 1 Receptor ; T-Lymphocytes
Chemical Substances	Antigens, CD ; B7-H1 Antigen ; CD223 antigen ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2021-12-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-021-01684-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Computational Insights into As(V) Removal from Water by the UiO-66 Metal–Organic Framework

Cox, Claudia S / Cossich Galicia, Valeria / Lessio, Martina

Journal of physical chemistry. 2021 Feb. 01, v. 125, no. 5

2021

Abstract: ... As(V) species from water, but the precise adsorption mechanism is not yet well understood ... and geometries for the adsorption of As(V) species present under varying pH conditions, namely ... in which two As(V) molecules adsorb in a monodentate fashion on two neighboring Zr open metal sites resulting ...

Abstract	Metal–organic frameworks (MOFs) such as UiO-66 have shown great promise for the removal of toxic As(V) species from water, but the precise adsorption mechanism is not yet well understood. In this study, we use density functional theory calculations and cluster models to determine accurate energetics and geometries for the adsorption of As(V) species present under varying pH conditions, namely, arsenic acid and related oxyanions. As a result of this analysis, we identify a new adsorption mode in which two As(V) molecules adsorb in a monodentate fashion on two neighboring Zr open metal sites resulting from capping ligand displacement. This mode is preferred over other adsorption modes previously proposed in the literature at acidic and neutral pH. Multidentate adsorption modes involving adsorption of a single As(V) molecule onto both neighboring Zr sites become more competitive as the pH increases, consistent with the lower adsorption performance observed at basic pH. Additionally, we study the influence of the ligands capping the Zr sites on As(V) adsorption thermodynamics. We show that the hydroxide–water ligand pair is the capping ligand most easily displaced by adsorbing As(V) species, suggesting that defects present in the aqueous environment are the ideal site for As(V) species adsorption. Furthermore, we find that adsorption of phosphate oxyanions can thermodynamically compete with As(V) adsorption, thus potentially explaining the observed decreased As(V) adsorption performance in the presence of phosphates. The molecular-level insights gained in this study are used to draw general design principles for the development of new MOFs that can be employed to remove toxic oxyanions from water.
Keywords	adsorption ; arsenic ; coordination polymers ; density functional theory ; ligands ; pH ; phosphates ; thermodynamics ; toxicity
Language	English
Dates of publication	2021-0201
Size	p. 3157-3168.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1932-7455
DOI	10.1021/acs.jpcc.0c09465
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Free Trade v. protection

Cox, Harold / Money, Leo George Chiozza / Williams, Ernest Edwin

A fiscal duel between Harold Cox and Ernest A. Williams

2017

Author's details	With an introduction by L.G. Chiozza
Language	English
Dates of publication	2017-1903
Size	1 Online-Ressource (99 Seiten)
Publisher	ZBW
Publishing place	Kiel ; Hamburg
Document type	Book ; Online
Database	ECONomics Information System

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Article ; Online: Conformational regulation of Escherichia coli DNA polymerase V by RecA and ATP.

Jaszczur, Malgorzata M / Vo, Dan D / Stanciauskas, Ramunas / Bertram, Jeffrey G / Sikand, Adhirath / Cox, Michael M / Woodgate, Roger / Mak, Chi H / Pinaud, Fabien / Goodman, Myron F

PLoS genetics

2019 Volume 15, Issue 2, Page(s) e1007956

Abstract: Mutagenic translesion DNA polymerase V (UmuD'2C) is induced as part of the DNA damage-induced SOS ... until pol V interacts with a RecA nucleoprotein filament (RecA*) and ATP to form a mutasome complex, pol V ... Mut = UmuD'2C-RecA-ATP. The location of RecA relative to UmuC determines whether pol V Mut is ...

Abstract	Mutagenic translesion DNA polymerase V (UmuD'2C) is induced as part of the DNA damage-induced SOS response in Escherichia coli, and is subjected to multiple levels of regulation. The UmuC subunit is sequestered on the cell membrane (spatial regulation) and enters the cytosol after forming a UmuD'2C complex, ~ 45 min post-SOS induction (temporal regulation). However, DNA binding and synthesis cannot occur until pol V interacts with a RecA nucleoprotein filament (RecA*) and ATP to form a mutasome complex, pol V Mut = UmuD'2C-RecA-ATP. The location of RecA relative to UmuC determines whether pol V Mut is catalytically on or off (conformational regulation). Here, we present three interrelated experiments to address the biochemical basis of conformational regulation. We first investigate dynamic deactivation during DNA synthesis and static deactivation in the absence of DNA synthesis. Single-molecule (sm) TIRF-FRET microscopy is then used to explore multiple aspects of pol V Mut dynamics. Binding of ATP/ATPγS triggers a conformational switch that reorients RecA relative to UmuC to activate pol V Mut. This process is required for polymerase-DNA binding and synthesis. Both dynamic and static deactivation processes are governed by temperature and time, in which on → off switching is "rapid" at 37°C (~ 1 to 1.5 h), "slow" at 30°C (~ 3 to 4 h) and does not require ATP hydrolysis. Pol V Mut retains RecA in activated and deactivated states, but binding to primer-template (p/t) DNA occurs only when activated. Studies are performed with two forms of the polymerase, pol V Mut-RecA wt, and the constitutively induced and hypermutagenic pol V Mut-RecA E38K/ΔC17. We discuss conformational regulation of pol V Mut, determined from biochemical analysis in vitro, in relation to the properties of pol V Mut in RecA wild-type and SOS constitutive genetic backgrounds in vivo.
MeSH term(s)	Adenosine Triphosphate/metabolism ; DNA Damage ; DNA, Bacterial/biosynthesis ; DNA-Directed DNA Polymerase/chemistry ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Enzyme Activation ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Fluorescence Resonance Energy Transfer ; Genes, Bacterial ; Kinetics ; Mutation ; Protein Conformation ; Rec A Recombinases/metabolism ; SOS Response, Genetics
Chemical Substances	DNA, Bacterial ; Escherichia coli Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; UmuC protein, E coli (98059-80-4) ; Rec A Recombinases (EC 2.7.7.-) ; DNA polymerase V, E coli (EC 2.7.7.7) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; UmuD protein, E coli (EC 2.7.7.7)
Language	English
Publishing date	2019-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1007956
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zone V Extensor Tendon Repair with a Palmaris Longus Tendon Autograft and Human Umbilical Membrane.

Esquivel, Esteban / Cox, Cameron / Purcell, Amanda / MacKay, Brendan

Case reports in orthopedics

2020 Volume 2020, Page(s) 2759281

Abstract: ... with these injuries. This is particularly true of Zone V extensor tendon injuries, as their mechanism is commonly ... a highly infectious human bite. We present the case of a human fight bite resulting in a Zone V extensor ...

Abstract	Extensor tendon repairs, although common, can be difficult injuries to treat. Their treatment is tailored to the zone of the hand that is affected since varying biomechanical forces are applied to the tendon at each zone. Prompt treatment is necessary to prevent potential complications associated with these injuries. This is particularly true of Zone V extensor tendon injuries, as their mechanism is commonly a highly infectious human bite. We present the case of a human fight bite resulting in a Zone V extensor tendon injury. The delayed presentation of this case resulted in an untreated infection that caused an abscess with associated extensor tendon necrosis and rupture. Given the large gap length between the ends of the tendons, tendon repair was performed using a palmaris longus autograft. Even when these are done in a controlled setting, adhesions are common. The compromised wound bed caused irritation, erosion, and subsequent rupture of the extensor tendon of the hand. In an effort to avoid common complications such as adhesion, the repair was then wrapped with human umbilical membrane (AVIVE® Soft Tissue Membrane, AxoGen Inc., Alachua, FL) to separate adjacent tissue and reduce inflammation. Even without access to formal physical therapy, our patient had excellent functional outcomes at his final follow-up visit. The patient was able to make a loose composite fist, had no extensor lag at the MCP joints, and had extensor lag of 15 degrees at the PIP joints of digits 4-5.
Language	English
Publishing date	2020-01-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684648-2
ISSN	2090-6757 ; 2090-6749
ISSN (online)	2090-6757
ISSN	2090-6749
DOI	10.1155/2020/2759281
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Article ; Online: The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis.

Sikand, Adhirath / Jaszczur, Malgorzata / Bloom, Linda B / Woodgate, Roger / Cox, Michael M / Goodman, Myron F

Cells

2021 Volume 10, Issue 5

Abstract: In the mid 1970s, Miroslav Radman and Evelyn Witkin proposed ... ...

Abstract	In the mid 1970s, Miroslav Radman and Evelyn Witkin proposed that
MeSH term(s)	DNA/analysis ; DNA/genetics ; DNA/metabolism ; DNA Damage ; DNA Primers ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Mutagenesis ; Mutation ; Plasmids/metabolism ; Ultraviolet Rays
Chemical Substances	DNA Primers ; Escherichia coli Proteins ; DNA (9007-49-2) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
Language	English
Publishing date	2021-05-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10051083
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Article ; Online: Type V Dural Arteriovenous Fistula Supplied by the Artery of Wollschlaeger and Wollschlaeger Causing Cervical Myelopathy and Quadriparesis.

Kvint, Svetlana / Ramchand, Preethi / Cox, Mougnyan / Sedora-Roman, Neda I / Bagley, Linda / O'Rourke, Donald M / Hurst, Robert W / Choudhri, Omar A

World neurosurgery

2020 Volume 137, Page(s) 55–61

Abstract: ... myelopathy caused by venous congestion from a type V dural AVF supplied by the artery of Wollschlaeger and ...

Abstract	Background: The artery of Wollschlaeger and Wollschlaeger is a tentorial branch of the superior cerebellar artery that is usually not visualized on conventional cerebral angiography, unless it is pathologically enlarged. It can be recruited as part of the blood supply to tentorial dural arteriovenous fistulas (AVFs), although this occurs infrequently. Case description: Here we report the clinico-radiologic evaluation and treatment of a 48-year-old man referred to our institution for hitherto workup negative progressive, relapsing quadriparesis. This represents the first reported case of cervical myelopathy caused by venous congestion from a type V dural AVF supplied by the artery of Wollschlaeger and Wollschlaeger. Conclusions: The anatomic discrepancy between the symptomatic spinal cord lesion and the etiologic intracranial fistula frequently results in delayed care in cases of myelopathy due to intracranial dural AVFs. Familiarity with these disorders and of their pathophysiologic mechanisms is important to avoid unnecessary diagnostic delays.
MeSH term(s)	Central Nervous System Vascular Malformations/complications ; Central Nervous System Vascular Malformations/surgery ; Cerebral Arteries/surgery ; Cerebral Revascularization/methods ; Cervical Vertebrae ; Humans ; Hyperemia/etiology ; Hyperemia/surgery ; Magnetic Resonance Angiography ; Male ; Middle Aged ; Quadriplegia/etiology ; Quadriplegia/surgery ; Spinal Cord Diseases/etiology ; Spinal Cord Diseases/surgery
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.01.122
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Book ; Online: Drama, Poetry and Music in Late-Renaissance Italy

Cox, Virginia / Sampson, Lisa

The life and works of Leonora Bernardi

2023

Keywords	Literature & literary studies ; European history ; Poetry;drama;music;Renaissance;Italy;Italian studies;translation
Language	English
Size	1 electronic resource (554 pages)
Publisher	UCL Press
Publishing place	London
Document type	Book ; Online
Note	English
HBZ-ID	HT030374535
ISBN	9781800084339 ; 1800084331
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Super-Resolution of PROBA-V Images Using Convolutional Neural Networks

Märtens, Marcus / Izzo, Dario / Krzic, Andrej / Cox, Daniël

2019

Abstract: ESA's PROBA-V Earth observation satellite enables us to monitor our planet at a large scale ... an extensive dataset of both, high and low resolution images taken by PROBA-V instruments during monthly ...

Abstract	ESA's PROBA-V Earth observation satellite enables us to monitor our planet at a large scale, studying the interaction between vegetation and climate and provides guidance for important decisions on our common global future. However, the interval at which high resolution images are recorded spans over several days, in contrast to the availability of lower resolution images which is often daily. We collect an extensive dataset of both, high and low resolution images taken by PROBA-V instruments during monthly periods to investigate Multi Image Super-resolution, a technique to merge several low resolution images to one image of higher quality. We propose a convolutional neural network that is able to cope with changes in illumination, cloud coverage and landscape features which are challenges introduced by the fact that the different images are taken over successive satellite passages over the same region. Given a bicubic upscaling of low resolution images taken under optimal conditions, we find the Peak Signal to Noise Ratio of the reconstructed image of the network to be higher for a large majority of different scenes. This shows that applied machine learning has the potential to enhance large amounts of previously collected earth observation data during multiple satellite passes. Comment: To appear in Special Issue on Applications of Artificial Intelligence in Aerospace Engineering in the Journal "Astrodynamics"
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
Subject code	006
Publishing date	2019-07-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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