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  1. AU=Zhang Jin-Ying
  2. AU="Cho, Yun-Ho"
  3. AU=Chatr-aryamontri Andrew
  4. AU="Thompson, Kristin"
  5. AU="Horiguchi, Kumiko"
  6. AU="Wagner, Franz F"
  7. AU="Mishra, Vandana"
  8. AU=Zucker Irving H
  9. AU=Dang Vinh T
  10. AU="Andrea Benedetti"
  11. AU="Xu, Jiyu"
  12. AU="Dawson, Holli E"
  13. AU="Dominy, Katherine M"
  14. AU="Maunik Chapala"
  15. AU="Luksic, Ivica"
  16. AU="Mastronardi, Luciano"
  17. AU="Md Farijul Islam"
  18. AU="Quansah, Gabriel W"
  19. AU="Keane, Stephen"
  20. AU="Marsela, Enklajd"
  21. AU="Tate, Amanda W"
  22. AU="Solodov, E P"
  23. AU="Cheng-Fang Yen"

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  1. Artikel ; Online: Chinese herbal Jin-Ying-Tang attenuates the inflammatory response by inhibiting the activation of TLR4/MyD88/TRAF-6/NIK pathway at the mRNA level in LPS-stimulated mouse mammary epithelial cells

    Yi Qiong / Li Xin / Li Yuan-Fang / Yang Hang / Zhang Xiao-Yi / Ma Zhe / Wang Lu

    Journal of Veterinary Research, Vol 60, Iss 1, Pp 71-

    2016  Band 80

    Abstract: Introduction: The effects of Jin-Ying-Tang (JYT) on Toll-like Receptor 4 (TLR4) signalling ...

    Abstract Introduction: The effects of Jin-Ying-Tang (JYT) on Toll-like Receptor 4 (TLR4) signalling transduction of lipopolysaccharide (LPS)-stimulated mouse mammary epithelial cells (MECs) in vitro were examined. Material and Methods: The cytotoxicity of JYT (0.06-62.50 mg/mL) on mouse MECs was determined by MTT assay. The MECs were co-cultured with LPS in the presence or absence of JYT (39.10 μg/mL, 391 μg/mL, 3910 μg/mL). The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in the culture supernatants were detected by ELISA. The mRNA expression of TLR4 and downstream TLR4 signalling molecules such as myeloid differentiation factor 88 (MyD88), tumour necrosis factor receptor associated factor 6 (TRAF-6), inhibitor κB (IκB), and nuclear factor κB inducing kinase (NIK) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Results: The results showed that the IC50 of JYT on MECs was 12.25 mg/mL and JYT could significantly decrease the concentrations of IL-6 and TNF-α in LPS-stimulated MECs (P < 0.05). The mRNA expression of TLR4, MyD88, TRAF-6, IκB, and NIK was also significantly decreased when the LPS-stimulated MECs were cocultured at appropriate concentrations of JYT (P < 0.05, P < 0.01). Conclusion: These observations indicate a potential mechanism through which JYT attenuates the systemic inflammatory response to LPS-stimulated mouse mammary epithelial cells by inhibiting the activation of TLR4/MyD88/ TRAF-6/NIK pathway at the mRNA level.
    Schlagwörter mouse ; jyt ; mammary epithelial cells ; cytokine ; mrna expression ; signalling transduction ; Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2016-03-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Chinese herbal Jin-Ying-Tang attenuates the inflammatory response by inhibiting the activation of TLR4/MyD88/TRAF-6/NIK pathway at the mRNA level in LPS-stimulated mouse mammary epithelial cells

    Yi, Qiong / Hang Yang / Lu Wang / Xiao-Yi Zhang / Xin Li / Yuan-Fang Li / Zhe Ma

    Journal of Veterinary Research. 2016 Apr. 29, v. 60, no. 1

    2016  

    Abstract: Introduction: The effects of Jin-Ying-Tang (JYT) on Toll-like Receptor 4 (TLR4) signalling ...

    Abstract Introduction: The effects of Jin-Ying-Tang (JYT) on Toll-like Receptor 4 (TLR4) signalling transduction of lipopolysaccharide (LPS)-stimulated mouse mammary epithelial cells (MECs) in vitro were examined. Material and Methods: The cytotoxicity of JYT (0.06-62.50 mg/mL) on mouse MECs was determined by MTT assay. The MECs were co-cultured with LPS in the presence or absence of JYT (39.10 μg/mL, 391 μg/mL, 3910 μg/mL). The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in the culture supernatants were detected by ELISA. The mRNA expression of TLR4 and downstream TLR4 signalling molecules such as myeloid differentiation factor 88 (MyD88), tumour necrosis factor receptor associated factor 6 (TRAF-6), inhibitor κB (IκB), and nuclear factor κB inducing kinase (NIK) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Results: The results showed that the IC₅₀ of JYT on MECs was 12.25 mg/mL and JYT could significantly decrease the concentrations of IL-6 and TNF-α in LPS-stimulated MECs (P < 0.05). The mRNA expression of TLR4, MyD88, TRAF-6, IκB, and NIK was also significantly decreased when the LPS-stimulated MECs were cocultured at appropriate concentrations of JYT (P < 0.05, P < 0.01). Conclusion: These observations indicate a potential mechanism through which JYT attenuates the systemic inflammatory response to LPS-stimulated mouse mammary epithelial cells by inhibiting the activation of TLR4/MyD88/ TRAF-6/NIK pathway at the mRNA level.
    Schlagwörter coculture ; cytotoxicity ; enzyme-linked immunosorbent assay ; epithelial cells ; gene expression ; inflammation ; inhibitory concentration 50 ; interleukin-6 ; lipopolysaccharides ; mammary glands ; messenger RNA ; mice ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; Toll-like receptor 4 ; transcription factor NF-kappa B ; tumor necrosis factor-alpha
    Sprache Englisch
    Erscheinungsverlauf 2016-0429
    Umfang p. 71-80.
    Erscheinungsort De Gruyter Open
    Dokumenttyp Artikel
    ISSN 2450-8608
    DOI 10.1515/jvetres-2016-0011
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Buch: Chang yong Zhong yao du xing yan jiu jin zhan ji ying yong

    Zhang, Geng

    2013  

    Verfasserangabe zhu bian Zhang Geng, Ma Wei, Xu Hongfeng
    Mesh-Begriff(e) Drugs, Chinese Herbal/toxicity ; Plants, Medicinal/toxicity ; Drugs, Chinese Herbal/therapeutic use
    Sprache Chinesisch
    Umfang 4, 798 pages.
    Ausgabenhinweis Di 1 ban.
    Dokumenttyp Buch
    ISBN 9787535262264 ; 7535262260
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  4. Artikel ; Online: [Retracted] Downregulation of microRNA‑195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA.

    Zhao, Wen-Jing / Zhang, Hai-Fang / Su, Jin-Ying

    Molecular medicine reports

    2023  Band 27, Heft 6

    Abstract: Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 3C were strikingly similar to data appearing in different form in another article by different authors at a ...

    Abstract Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Fig. 3C were strikingly similar to data appearing in different form in another article by different authors at a diferent research institute. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to
    Sprache Englisch
    Erscheinungsdatum 2023-05-19
    Erscheinungsland Greece
    Dokumenttyp Retraction of Publication
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2023.13012
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  5. Artikel ; Online: Motor symptoms of Parkinson's disease are affected by temperature: A controlled pilot study.

    Huang, Ting / Wang, Xi-Xi / Gao, Chen-Yu / Zhao, Jin-Ying / Pan, Rong-Rong / Jin, Hui-Hui / Tian, You-Yong / Zhang, Ying-Dong

    Brain and behavior

    2024  Band 14, Heft 1, Seite(n) e3369

    Abstract: Purpose: The motor symptoms (MS) of Parkinson's disease (PD) have been affecting the quality of life in patients. In clinical practice, most patients with PD report that MS are more severe in winter than in summer, and hyperthermic baths (HTB) could ... ...

    Abstract Purpose: The motor symptoms (MS) of Parkinson's disease (PD) have been affecting the quality of life in patients. In clinical practice, most patients with PD report that MS are more severe in winter than in summer, and hyperthermic baths (HTB) could temporarily improve MS. The study aimed to evaluate the effects of seasonal variation and aquatic thermal environment of HTB on the MS of PD.
    Patients and methods: A cross-sectional study of 203 Chinese Han patients was performed. Univariate and multivariate analyses were performed to analyze seasonal variation in MS relative to baseline data (sex, age at onset, duration, season of birth, Hoehn and Yahr stage, family history, levodopa equivalent dose, and the effect of HTB on MS). Ten subjects participated in the HTB study, and one patient dropped out. The paired Wilcoxon rank test was used to assess the differences in the Movement Disorder Society-United Parkinson's disease Rating Scale (MDS-UPDRS) part III motor examination total scores and the modified Webster Symptoms Score between non-HTB and before HTB and between non-HTB and after HTB.
    Results: The improvement of MS after HTB was an independent risk factor for seasonal variation in MS (OR, 25.203; 95% CI, 10.951-58.006; p = .000). Patients with PD had significant improvements in the MDS-UPDRS part III motor examination total scores, especially in bradykinesia (p = .043), rigidity (p = .008), posture (p = .038), and rest tremor amplitude (p = .047).
    Conclusion: Seasonal variation in temperature and water temperature of HTB may affect MS in some patients with PD. Simple HTB could be recommended as physiotherapy for patients with PD who report temperature-sensitive MS.
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Parkinson Disease/drug therapy ; Pilot Projects ; Quality of Life ; Salicylates ; Temperature
    Chemische Substanzen 4-trifluoromethylsalicylic acid (328-90-5) ; Salicylates
    Sprache Englisch
    Erscheinungsdatum 2024-02-20
    Erscheinungsland United States
    Dokumenttyp Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.3369
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  6. Artikel ; Online: Bivalirudin vs. heparin in paediatric and adult patients on extracorporeal membrane oxygenation: A meta-analysis.

    Li, Mei-Juan / Shi, Jin-Ying / Zhang, Jin-Hua

    British journal of clinical pharmacology

    2022  Band 88, Heft 6, Seite(n) 2605–2616

    Abstract: Aims: Unfractionated heparin (UFH) has been the primary anticoagulant of choice on extracorporeal membrane oxygenation (ECMO). However, it is debatable whether bivalirudin (BIV), a direct thrombin inhibitor, may be considered a better alternative ... ...

    Abstract Aims: Unfractionated heparin (UFH) has been the primary anticoagulant of choice on extracorporeal membrane oxygenation (ECMO). However, it is debatable whether bivalirudin (BIV), a direct thrombin inhibitor, may be considered a better alternative anticoagulant option.
    Methods: We searched Embase, Pubmed, Cochrane library, Clinicaltrials.gov, CNKI and Wanfang databases up to 15 June 2021. Randomized controlled trials and observational studies were considered eligible for inclusion. Random-effects meta-analyses, including subgroup analyses, were conducted.
    Results: A total of 9 studies containing 994 patients were enrolled. All articles were retrospective cohort studies. Compared with UFH, BIV was associated with lower risks of major bleeding (risk ratio [RR]: 0.32, 95% confidence interval [CI] 0.22-0.49), ECMO in-circuit thrombosis (RR: 0.57, 95% CI 0.43-0.74), stroke (RR: 0.52, 95% CI 0.29-0.95) and in-hospital mortality (RR: 0.82, 95% CI 0.69-0.99), and higher rates of survival to ECMO decannulation (RR: 1.18, 95% CI 1.03-1.34). Pooled risk estimates did not show a significant association with clinical thrombotic events (RR: 0.69, 95% CI 0.45-1.07). Moreover, BIV was associated with a lower risk of ECMO in-circuit thrombosis and in-hospital mortality in the adult subgroup but not in the paediatric subgroup. However, leave-one-out sensitivity analyses indicated that the results of stroke, survival to ECMO decannulation and in-hospital mortality should be interpreted with caution.
    Conclusion: BIV appears to be a potential alternative to UFH in paediatric and adult patients requiring ECMO.
    Mesh-Begriff(e) Adult ; Anticoagulants/adverse effects ; Child ; Extracorporeal Membrane Oxygenation/adverse effects ; Heparin/adverse effects ; Hirudins ; Humans ; Peptide Fragments ; Recombinant Proteins/adverse effects ; Retrospective Studies ; Stroke ; Thrombosis/epidemiology ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemische Substanzen Anticoagulants ; Hirudins ; Peptide Fragments ; Recombinant Proteins ; Heparin (9005-49-6) ; bivalirudin (TN9BEX005G)
    Sprache Englisch
    Erscheinungsdatum 2022-02-14
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15251
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study.

    Cheng, Meng-Die / Zheng, Ying-Ying / Zhang, Xing-Yan / Ruzeguli, Tuersun / Sureya, Yisimayili / Didaer, Yisha / Ailiman, Mahemuti / Zhang, Jin-Ying

    Journal of inflammation research

    2024  Band 17, Seite(n) 1845–1855

    Abstract: Background: The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score. Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF).: Methods: A ... ...

    Abstract Background: The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score. Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF).
    Methods: A total of 3741 patients were analyzed in this study. The sTIPS was calculated based on the white blood cell count (WBC) and the mean platelet volume to platelet count (MPV/PC) ratio at admission. The mean follow-up time was 22.75 months. Multivariable Cox regression analyses were used to investigate the associations between the sTIPS and all-cause mortality (ACM).
    Results: In the whole study population, multivariate Cox regression analysis showed that patients in both the sTIPS 2 and sTIPS 1 groups had significantly increased risk of ACM as compared with patients in the sTIPS 0 group (hazard ratio [HR]=1.706, 95% confidence interval [CI]: 1.405-2.072, P<0.001 and HR = 1.431, 95% CI 1.270-1.612, P<0.001). The same significant trend was observed in heart failure with preserved ejection fraction (HFpEF) patients (sTIPS1 vs sTIPS0: HR = 1.366, 95% CI 1.100-1.697, P = 0.005; sTIPS2 vs sTIPS0: HR = 1.995, 95% CI 1.460-2.725, P<0.001). However, only sTIPS 1 group had a significantly increased the risk of ACM compared to the sTIPS 0 group among patients with HFmrEF (sTIPS1 vs sTIPS0: HR = 1.648, 95% CI 1.238-2.194, P = 0.001) and HFrEF (sTIPS1 vs sTIPS0: HR = 1.322, 95% CI 1.021-1.712, P = 0.035).
    Conclusion: sTIPS is useful in predicting risk for long-term mortality in patients with HF.
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S452544
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  8. Artikel ; Online: Spontaneous umbilical artery thrombosis diagnosed in the third-trimester: A case report.

    Jin, Ying / Zhang, Shimao

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2024  Band 165, Heft 3, Seite(n) 1287–1289

    Mesh-Begriff(e) Humans ; Pregnancy ; Female ; Adult ; Thrombosis/diagnostic imaging ; Thrombosis/diagnosis ; Pregnancy Trimester, Third ; Umbilical Arteries/diagnostic imaging ; Ultrasonography, Prenatal ; Pregnancy Complications, Cardiovascular/diagnosis
    Sprache Englisch
    Erscheinungsdatum 2024-01-16
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15381
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    Zs.MO 183: Hefte anzeigen

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  9. Artikel ; Online: A Novel Conserved Linear Neutralizing Epitope on the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.

    Hua, Rong-Hong / Zhang, Shu-Jian / Niu, Bei / Ge, Jin-Ying / Lan, Ting / Bu, Zhi-Gao

    Microbiology spectrum

    2023  Band 11, Heft 4, Seite(n) e0119023

    Abstract: The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made it challenging to develop broad-spectrum prophylactic vaccines and therapeutic antibodies. Here, we have identified a broad-spectrum ... ...

    Abstract The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made it challenging to develop broad-spectrum prophylactic vaccines and therapeutic antibodies. Here, we have identified a broad-spectrum neutralizing antibody and its highly conserved epitope in the receptor-binding domain (RBD) of the spike protein (S) S1 subunit of SARS-CoV-2. First, nine monoclonal antibodies (MAbs) against the RBD or S1 were generated; of these, one RBD-specific MAb, 22.9-1, was selected for its broad RBD-binding abilities and neutralizing activities against SARS-CoV-2 variants. An epitope of 22.9-1 was fine-mapped with overlapping and truncated peptide fusion proteins. The core sequence of the epitope,
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Epitopes/genetics ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; SARS-CoV-2 ; COVID-19 ; Antibodies, Neutralizing
    Chemische Substanzen Epitopes ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; Antibodies, Neutralizing
    Sprache Englisch
    Erscheinungsdatum 2023-06-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01190-23
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  10. Artikel: Changes in the etiology of liver cirrhosis and the corresponding management strategies.

    Dai, Jin-Jin / Liu, Yue-Ying / Zhang, Zhen-Hua

    World journal of hepatology

    2024  Band 16, Heft 2, Seite(n) 146–151

    Abstract: We read with interest the article by Xing Wang, which was published in the recent issue of ... ...

    Abstract We read with interest the article by Xing Wang, which was published in the recent issue of the
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v16.i2.146
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