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  1. Article ; Online: Re. "Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B<sub>12</sub> in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)": Authors' response.

    Tan, Chuen Wen / Ho, Liam Pock / Ng, Heng Joo

    Nutrition (Burbank, Los Angeles County, Calif.)

    2022  Volume 103-104, Page(s) 111801

    MeSH term(s) Humans ; Aged ; Vitamin B 12/therapeutic use ; Vitamin D ; Magnesium ; COVID-19 ; Cohort Studies ; Vitamins/therapeutic use
    Chemical Substances Vitamin B 12 (P6YC3EG204) ; Vitamin D (1406-16-2) ; Magnesium (I38ZP9992A) ; Vitamins
    Language English
    Publishing date 2022-07-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2022.111801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2290: Show issues Location:
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  2. Article: The clinical application of venous ultrasound in diagnosis and follow-up of lower extremity deep vein thrombosis (DVT): a case-based discussion.

    Akram, Farooq / Fan, Bingwen Eugene / Tan, Chuen Wen / Teoh, Wey Chyi / Prandoni, Paolo / Yap, Eng Soo

    Thrombosis journal

    2023  Volume 21, Issue 1, Page(s) 110

    Abstract: Current clinical practice guidelines lack explicit guidance on the indications and appropriate timing of venous ultrasound (US) in lower extremity deep vein thrombosis (DVT) follow-up. Moreover, abnormal findings reported on venous US in DVT follow-up or ...

    Abstract Current clinical practice guidelines lack explicit guidance on the indications and appropriate timing of venous ultrasound (US) in lower extremity deep vein thrombosis (DVT) follow-up. Moreover, abnormal findings reported on venous US in DVT follow-up or suspected recurrent DVT may be difficult for clinicians to interpret, which carries risk of harm from inappropriate use of anti- coagulation and increased healthcare resource utilization. Due to the above factors, over-use of ultrasound in diagnosis and follow-up of lower extremity DVT has been reported in western health systems. We have undertaken a case-based discussion and a scoping review of existing guidelines on the use of venousUS following prior diagnosis of DVT, to guide appropriate interpretation of commonly reported US abnormalities and provide our suggestions in the light of best available evidence on appropriate timing to perform follow-up US in management of lower extremity DVT.
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-023-00550-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Platelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin

    David M. Ross / Hai Po Helena Liang / Zeenet Iqra / Shane Whittaker / Chuen Wen Tan / Brian J. Dale / Vivien M. Chen

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN). The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood. Platelet mitochondria play a role in platelet activation, ... ...

    Abstract Abstract Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN). The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood. Platelet mitochondria play a role in platelet activation, but their number and function have not been extensively explored in MPN to date. We observed an increased number of mitochondria in platelets from MPN patients compared with healthy donors. MPN patients had an increased proportion of dysfunctional platelet mitochondria. The fraction of platelets with depolarized mitochondria at rest was increased in essential thrombocythemia (ET) patients and the mitochondria were hypersensitive to depolarization following thrombin agonist stimulation. Live microscopy showed a stochastic process in which a higher proportion of individual ET platelets underwent mitochondrial depolarization and after a shorter agonist exposure compared to healthy donors. Depolarization was immediately followed by ballooning of the platelet membrane, which is a feature of procoagulant platelets. We also noted that the mitochondria of MPN patients were on average located nearer the platelet surface and we observed extrusion of mitochondria from the platelet surface as microparticles. These data implicate platelet mitochondria in a number of prothrombotic phenomena. Further studies are warranted to assess whether these findings correlate with clinical thrombotic events.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Platelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin.

    Ross, David M / Liang, Hai Po Helena / Iqra, Zeenet / Whittaker, Shane / Tan, Chuen Wen / Dale, Brian J / Chen, Vivien M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9172

    Abstract: Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN). The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood. Platelet mitochondria play a role in platelet activation, but their ... ...

    Abstract Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN). The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood. Platelet mitochondria play a role in platelet activation, but their number and function have not been extensively explored in MPN to date. We observed an increased number of mitochondria in platelets from MPN patients compared with healthy donors. MPN patients had an increased proportion of dysfunctional platelet mitochondria. The fraction of platelets with depolarized mitochondria at rest was increased in essential thrombocythemia (ET) patients and the mitochondria were hypersensitive to depolarization following thrombin agonist stimulation. Live microscopy showed a stochastic process in which a higher proportion of individual ET platelets underwent mitochondrial depolarization and after a shorter agonist exposure compared to healthy donors. Depolarization was immediately followed by ballooning of the platelet membrane, which is a feature of procoagulant platelets. We also noted that the mitochondria of MPN patients were on average located nearer the platelet surface and we observed extrusion of mitochondria from the platelet surface as microparticles. These data implicate platelet mitochondria in a number of prothrombotic phenomena. Further studies are warranted to assess whether these findings correlate with clinical thrombotic events.
    MeSH term(s) Humans ; Blood Platelets/metabolism ; Thrombin/metabolism ; Myeloproliferative Disorders/metabolism ; Thrombocythemia, Essential/metabolism ; Thrombosis/metabolism ; Platelet Activation ; Neoplasms/metabolism ; Mitochondria
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36266-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Reflection of Metabolic Syndrome through the Window of COVID-19.

    Ho, Liam Pock / Tan, Chuen Wen / Ng, Heng Joo / Jason Chay, Wai Mun / Tan, Jing Yuan / Goh, Su Yen

    Vaccines

    2022  Volume 10, Issue 11

    Abstract: COVID-19 and metabolic syndrome, though seemingly different disorders, appear to share certain common pathogenic components, especially in the development of COVID-19-associated diabetes mellitus. The similarities include impairment in immunoendothelial, ...

    Abstract COVID-19 and metabolic syndrome, though seemingly different disorders, appear to share certain common pathogenic components, especially in the development of COVID-19-associated diabetes mellitus. The similarities include impairment in immunoendothelial, gastrointestinal, pancreatic, adipose and mitochondrial functions, with several critical micronutrients undergirding the intricate interactions among these dysfunctions. This discussion aims to highlight the parallels between COVID-19 and metabolic syndrome and to propose the possibility of SARS-CoV-2 being a prototype of an acquired etiological agent which can eventually lead to the development of classical metabolic syndrome. Based on the proposed model, the discussion will include the implication for early management of COVID-19 and metabolic syndrome.
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10111966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review.

    Lee, Lai Heng / Nagarajan, Chandramouli / Tan, Chuen Wen / Ng, Heng Joo

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 669288

    Abstract: The epidemiology of cancer associated thrombosis (CAT) in Asia is less well-studied and differs from that in the western countries. Here, we systematically examine population based and hospital-based studies reported between 1995 and 2020 to understand ... ...

    Abstract The epidemiology of cancer associated thrombosis (CAT) in Asia is less well-studied and differs from that in the western countries. Here, we systematically examine population based and hospital-based studies reported between 1995 and 2020 to understand the epidemiology of CAT in Asia. From population-based studies, the estimated incidence of VTE in cancer patients was 1.85-9.88 per 1,000 person-years. The incidence of CAT in Asia is significantly higher than non-cancer associated VTE in the general population and cancer is perhaps the most important risk factor for VTE. Hospital-based studies were heterogeneous in study designs and reveal a wide range of prevalence of VTE among cancer patients at 0.5-44.6% while the cancer prevalence rates among VTE patients ranged from 6.1 to 65.5%. The cancer sites most associated with VTE and risk factors were similar between Asian and Western studies. CAT has a major impact on the survival of patients with cancer in Asia, but thromboprophylaxis is not commonly practiced and validated risk assessment tools are lacking. This study highlights the urgent need for large multinational epidemiological studies in Asia to establish the true burden of CAT and to guide appropriate prevention strategies.
    Language English
    Publishing date 2021-05-21
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.669288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Thrombin Generation and Cancer: Contributors and Consequences.

    Reddel, Caroline J / Tan, Chuen Wen / Chen, Vivien M

    Cancers

    2019  Volume 11, Issue 1

    Abstract: The high occurrence of cancer-associated thrombosis is associated with elevated thrombin generation. Tumour cells increase the potential for thrombin generation both directly, through the expression and release of procoagulant factors, and indirectly, ... ...

    Abstract The high occurrence of cancer-associated thrombosis is associated with elevated thrombin generation. Tumour cells increase the potential for thrombin generation both directly, through the expression and release of procoagulant factors, and indirectly, through signals that activate other cell types (including platelets, leukocytes and erythrocytes). Furthermore, cancer treatments can worsen these effects. Coagulation factors, including tissue factor, and inhibitors of coagulation are altered and extracellular vesicles (EVs), which can promote and support thrombin generation, are released by tumour and other cells. Some phosphatidylserine-expressing platelet subsets and platelet-derived EVs provide the surface required for the assembly of coagulation factors essential for thrombin generation in vivo. This review will explore the causes of increased thrombin production in cancer, and the availability and utility of tests and biomarkers. Increased thrombin production not only increases blood coagulation, but also promotes tumour growth and metastasis and as a consequence, thrombin and its contributors present opportunities for treatment of cancer-associated thrombosis and cancer itself.
    Language English
    Publishing date 2019-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11010100
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  8. Article ; Online: "Lockdown-thrombosis"-an unexpected problem of the COVID-19 pandemic?

    Er, Chaozer / Tan, Jing Yuan / Tan, Chuen Wen / Kaur, Hartirathpal / Cheong, May Anne / Lee, Lai Heng / Ng, Heng Joo

    Journal of thrombosis and thrombolysis

    2022  Volume 54, Issue 1, Page(s) 29–32

    Abstract: Seated immobility thromboembolism syndrome (SIT) is the association of prolonged seated immobility with increased risk of venous thromboembolism (VTE). The advent of COVID-19 resulted in implementation of lockdowns to curb its spread. This resulted in ... ...

    Abstract Seated immobility thromboembolism syndrome (SIT) is the association of prolonged seated immobility with increased risk of venous thromboembolism (VTE). The advent of COVID-19 resulted in implementation of lockdowns to curb its spread. This resulted in compulsory work from home and minimization of outdoor activities. Consequently, this would have likely led to increased prolonged sitting and reduced mobility. Few case reports and studies have observed an increase in VTE incidence during the lockdown period. We likewise performed a clinical audit of our weekly thrombosis clinic cases and revealed three cases of VTE associated with prolonged sitting during Singapore's COVID-19 lockdown. Notably, all had other minor VTE risk factors in addition to prolonged sitting. All cases had intermediate-high risk pulmonary embolism and were given extended anticoagulation. With the pandemic still ongoing, periodic lockdown and quarantine measures may continue to be imposed. While the overall VTE risk conferred by prolonged seated immobility associated with lockdown measures is likely to be small, this risk can be easily mitigated and possibly prevented by simply staying mobile.
    MeSH term(s) COVID-19/epidemiology ; Communicable Disease Control ; Humans ; Pandemics ; Pulmonary Embolism/etiology ; Pulmonary Embolism/prevention & control ; Risk Factors ; Thrombosis/complications ; Venous Thromboembolism/complications ; Venous Thromboembolism/prevention & control
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-022-02648-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4352: Show issues Location:
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  9. Article ; Online: Post-hospitalization venous thromboembolism in COVID-19 patients: Evidence against routine post-hospitalization prophylactic anticoagulation.

    Tan, Jing Yuan / Tan, Chuen Wen / Wong, Wan Hui / Cheong, May Anne / Lee, Lai Heng / Kalimuddin, Shirin / Low, Jenny Guek Hong / Ng, Heng Joo

    International journal of laboratory hematology

    2021  Volume 44, Issue 1, Page(s) e4–e7

    MeSH term(s) Adult ; Aged ; Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; COVID-19/blood ; COVID-19/complications ; Female ; Hospitalization ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Venous Thromboembolism/blood ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-06-19
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13633
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1499: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients.

    Wang, Samuel Sherng Young / Chee, Keefe / Wong, Shiun Woei / Tan, Guat Bee / Ang, Hong / Leung, Bernard PuiLam / Tan, Chuen Wen / Ramanathan, Kollengode / Dalan, Rinkoo / Cheung, Christine / Lye, David Chien / Young, Barnaby Edward / Yap, Eng Soo / Chia, Yew Woon / Fan, Bingwen Eugene

    Seminars in thrombosis and hemostasis

    2023  Volume 49, Issue 5, Page(s) 561–564

    MeSH term(s) Humans ; Blood Platelets/metabolism ; CD36 Antigens/metabolism ; COVID-19/metabolism ; P-Selectin/metabolism ; Platelet Activation
    Chemical Substances CD36 Antigens ; P-Selectin ; SELP protein, human
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0043-1762578
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
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