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  1. Article ; Online: Author Correction: A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site.

    Szylar, Gabriella / Wysoczanski, Riccardo / Marshall, Helina / Marks, Daniel J B / José, Ricardo / Ehrenstein, Michael R / Brown, Jeremy S

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5676

    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10026-0
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  2. Article ; Online: Management of the capsule in trapeziometacarpal joint implant arthroplasty: resection versus repair.

    Reischenböck, Vanessa / Marks, Miriam / Imhof, Jenny / Schindele, Stephan / Herren, Daniel B

    The Journal of hand surgery, European volume

    2024  , Page(s) 17531934241227788

    Abstract: We compared the effects of capsule resection versus capsule suturing in patients treated with a dual-mobility trapeziometacarpal joint prosthesis. We included 131 patients with capsular resection and 57 patients with repair. The mean scores for pain and ... ...

    Abstract We compared the effects of capsule resection versus capsule suturing in patients treated with a dual-mobility trapeziometacarpal joint prosthesis. We included 131 patients with capsular resection and 57 patients with repair. The mean scores for pain and the brief Michigan Hand Outcomes Questionnaire were similar between the groups preoperatively and at 6 weeks and 1 year postoperatively. Mean key pinch strength was also similar in both groups before surgery and at 1 year, but higher in the capsular resection than in the suture group at 6 weeks. The incidence of complications reported throughout the 1-year postoperative period was not significantly different between the groups. One implant in the capsular resection group was revised for reasons most likely unrelated to capsule management. We conclude that the capsule can be safely resected during trapeziometacarpal joint implant arthroplasty.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/17531934241227788
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  3. Article ; Online: A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site.

    Szylar, Gabriella / Wysoczanski, Riccardo / Marshall, Helina / Marks, Daniel J B / José, Ricardo / Ehrenstein, Michael R / Brown, Jeremy S

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3990

    Abstract: To investigate local tissue responses to infection we have developed a human model of killed Streptococcus pneumoniae challenge by intradermal injection into the forearm. S. pneumoniae intradermal challenge caused an initial local influx of granulocytes ... ...

    Abstract To investigate local tissue responses to infection we have developed a human model of killed Streptococcus pneumoniae challenge by intradermal injection into the forearm. S. pneumoniae intradermal challenge caused an initial local influx of granulocytes and increases in TNF, IL6 and CXCL8. However, by 48 h lymphocytes were the dominant cell population, mainly consisting of CD4 and CD8 T cells. Increases in local levels of IL17 and IL22 and the high proportion of CD4 cells that were CCR6
    MeSH term(s) CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Humans ; Streptococcus pneumoniae ; T-Lymphocytes, Regulatory ; Th17 Cells
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07914-w
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  4. Article ; Online: Author Correction

    Gabriella Szylar / Riccardo Wysoczanski / Helina Marshall / Daniel J. B. Marks / Ricardo José / Michael R. Ehrenstein / Jeremy S. Brown

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site

    2022  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Carcinoembryonic antigen-expressing oncolytic measles virus derivative in recurrent glioblastoma: a phase 1 trial.

    Galanis, Evanthia / Dooley, Katharine E / Keith Anderson, S / Kurokawa, Cheyne B / Carrero, Xiomara W / Uhm, Joon H / Federspiel, Mark J / Leontovich, Alexey A / Aderca, Ileana / Viker, Kimberly B / Hammack, Julie E / Marks, Randolph S / Robinson, Steven I / Johnson, Derek R / Kaufmann, Timothy J / Buckner, Jan C / Lachance, Daniel H / Burns, Terry C / Giannini, Caterina /
    Raghunathan, Aditya / Iankov, Ianko D / Parney, Ian F

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 493

    Abstract: ... in the resection cavity after tumor resection on day 5 (Group B). A total of 22 patients received study treatment ... 9 in Group A and 13 in Group B. Primary endpoint was safety and toxicity: treatment was well ...

    Abstract Measles virus (MV) vaccine strains have shown significant preclinical antitumor activity against glioblastoma (GBM), the most lethal glioma histology. In this first in human trial (NCT00390299), a carcinoembryonic antigen-expressing oncolytic measles virus derivative (MV-CEA), was administered in recurrent GBM patients either at the resection cavity (Group A), or, intratumorally on day 1, followed by a second dose administered in the resection cavity after tumor resection on day 5 (Group B). A total of 22 patients received study treatment, 9 in Group A and 13 in Group B. Primary endpoint was safety and toxicity: treatment was well tolerated with no dose-limiting toxicity being observed up to the maximum feasible dose (2×10
    MeSH term(s) Humans ; Oncolytic Viruses ; Measles virus/genetics ; Glioblastoma ; Carcinoembryonic Antigen/genetics ; Oncolytic Virotherapy ; Neoplasm Recurrence, Local/therapy ; Measles Vaccine ; Tumor Microenvironment
    Chemical Substances Carcinoembryonic Antigen ; Measles Vaccine
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43076-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intraoperative Load Tolerance of the Thumb Carpometacarpal Joint After Resection-Suspension-Interposition Arthroplasty.

    Behm, Pascal / Marks, Miriam / Ferguson, Stephen J / Brodbeck, Michael / Herren, Daniel B

    Journal of hand surgery global online

    2021  Volume 4, Issue 1, Page(s) 40–44

    Abstract: Purpose: The objective was to measure the intraoperative load tolerance of the thumb carpometacarpal (CMC) joint after trapeziectomy, tendon suspension, and interposition.: Methods: In this single-center prospective study, preoperative pinch grip, ... ...

    Abstract Purpose: The objective was to measure the intraoperative load tolerance of the thumb carpometacarpal (CMC) joint after trapeziectomy, tendon suspension, and interposition.
    Methods: In this single-center prospective study, preoperative pinch grip, thumb mobility, and hypermobility of the thumb CMC joint were determined by 2 hand surgeons. Patients completed the brief Michigan Hand Outcomes Questionnaire. During surgery and upon removal of the trapezium, the surgeon subjectively rated the degree of thumb CMC load tolerance as "stable," "medium stable," or "unstable." A measurement system with an integrated force sensor was used to measure intraoperative thumb CMC load tolerance. The thumb ray was displaced manually by 10 mm toward the scaphoid, and the counteracting force was measured over the entire displacement. The objective load tolerance was determined as the maximal measured force after trapezium resection, tendon suspension, and interposition. Analysis of variance was used to test for the differences in load tolerance between the surgical steps. Spearman's coefficient was used to find correlations between load tolerance and clinical or patient-reported variables.
    Results: Twenty-nine patients with a mean age of 70 years (SD, 8.1 years) were available for analysis. The measured intraoperative load tolerance after trapeziectomy was 15.5 N (SD, 5.4 N) and significantly increased to 18.7 N (SD, 5.5 N) after suspension. Load tolerance only slightly increased after tendon interposition, increasing the force to 20.3 N (SD, 6.7 N). Neither the surgeon's subjective stability rating nor the clinical or patient-reported variables correlated with the measured load tolerance after trapeziectomy.
    Conclusions: Our results show that tendon suspension leads to the highest increase in thumb CMC load tolerance during resection-suspension-interposition arthroplasty.
    Clinical relevance: Tendon suspension appears to be the most important step in stabilizing the metacarpal base after trapeziectomy, whereas tendon interposition does not seem to have a relevant additional effect regarding load tolerance, at least immediately after surgery.
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 2589-5141
    ISSN (online) 2589-5141
    DOI 10.1016/j.jhsg.2021.10.005
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  7. Article ; Online: A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site

    Gabriella Szylar / Riccardo Wysoczanski / Helina Marshall / Daniel J. B. Marks / Ricardo José / Michael E. Ehrenstein / Jeremy S. Brown

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: Abstract To investigate local tissue responses to infection we have developed a human model of killed Streptococcus pneumoniae challenge by intradermal injection into the forearm. S. pneumoniae intradermal challenge caused an initial local influx of ... ...

    Abstract Abstract To investigate local tissue responses to infection we have developed a human model of killed Streptococcus pneumoniae challenge by intradermal injection into the forearm. S. pneumoniae intradermal challenge caused an initial local influx of granulocytes and increases in TNF, IL6 and CXCL8. However, by 48 h lymphocytes were the dominant cell population, mainly consisting of CD4 and CD8 T cells. Increases in local levels of IL17 and IL22 and the high proportion of CD4 cells that were CCR6+ suggested a significant Th17 response. Furthermore, at 48 h the CD4 population contained a surprisingly high proportion of likely memory Treg cells (CCR6 positive and CD45RA negative CD4+CD25highCD127low cells) at 39%. These results demonstrate that the intradermal challenge model can provide novel insights into the human response to S. pneumoniae and that Tregs form a substantial contribution of the normal human lymphocyte response to infection with this important pathogen.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Fifteen Years of Spinal Fusion Outcomes in Children With Cerebral Palsy: Are We Getting Better?

    Badin, Daniel / Shah, Suken A / Narayanan, Unni G / Cahill, Patrick J / Marrache, Majd / Samdani, Amer F / Yaszay, Burt / Hunsberger, Joann B / Marks, Michelle C / Sponseller, Paul D

    Spine

    2023  Volume 49, Issue 4, Page(s) 247–254

    Abstract: Study design: Retrospective multicenter study.: Objective: We reviewed 15-year trends in operative factors, radiographic and quality of life outcomes, and complication rates in children with cerebral palsy (CP)-related scoliosis who underwent spinal ... ...

    Abstract Study design: Retrospective multicenter study.
    Objective: We reviewed 15-year trends in operative factors, radiographic and quality of life outcomes, and complication rates in children with cerebral palsy (CP)-related scoliosis who underwent spinal fusion.
    Summary of background data: Over the past two decades, significant efforts have been made to decrease complications and improve outcomes of this population.
    Materials and methods: We retrospectively reviewed a multicenter registry of pediatric CP patients who underwent spinal fusion from 2008 to 2020. We evaluated baseline and operative, hospitalization, and complication data as well as radiographic and quality of life outcomes at a minimum 2-year follow-up.
    Results: Mean estimated blood loss and transfusion volume declined from 2.7±2.0 L in 2008 to 0.71±0.34 L in 2020 and 1.0±0.5 L in 2008 to 0.5±0.2 L in 2020, respectively, with a concomitant increase in antifibrinolytic use from 58% to 97% (all, P <0.01). Unit rod and pelvic fusion use declined from 33% in 2008 to 0% in 2020 and 96% in 2008 to 79% in 2020, respectively (both, P <0.05). Mean postoperative intubation time declined from 2.5±2.6 to 0.42±0.63 days ( P< 0.01). No changes were observed in preoperative and postoperative coronal angle and pelvic obliquity, operative time, frequency of anterior/anterior-posterior approach, and durations of hospital and intensive care unit stays. Improvements in the Caregiver Priorities and Child Health Index of Life with Disabilities postoperatively did not change significantly over the study period. Complication rates, including reoperation, superficial and deep surgical site infection, and gastrointestinal and medical complications remained stable over the study period.
    Conclusions: Over the past 15 years of CP scoliosis surgery, surgical blood loss, transfusion volumes, duration of postoperative intubation, and pelvic fusion rates have decreased. However, the degree of radiographic correction, the rates of surgical and medical complications (including infection), and health-related quality of life measures have broadly remained constant.
    MeSH term(s) Child ; Humans ; Cerebral Palsy/complications ; Multicenter Studies as Topic ; Quality of Life ; Retrospective Studies ; Scoliosis/surgery ; Spinal Fusion/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752024-4
    ISSN 1528-1159 ; 0362-2436
    ISSN (online) 1528-1159
    ISSN 0362-2436
    DOI 10.1097/BRS.0000000000004792
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    Zs.A 1305: Show issues Location:
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  9. Article ; Online: A randomised, double-blind, placebo-controlled study of the LAG-3-depleting monoclonal antibody GSK2831781 in patients with active ulcerative colitis.

    D'Haens, Geert / Peyrin-Biroulet, Laurent / Marks, Daniel J B / Lisi, Edoardo / Liefaard, Lia / Beaton, Andrew / Srinivasan, Naren / Bouma, Gerben / Prasad, Naveen / Cameron, Raymond / Kayali, Zeid / Tarzi, Ruth / Hanauer, Stephen / Sandborn, William J

    Alimentary pharmacology & therapeutics

    2023  Volume 58, Issue 3, Page(s) 283–296

    Abstract: Background: Selective depletion of T cells expressing LAG-3, an immune checkpoint receptor that is upregulated on activated T cells, has been investigated in pre-clinical models as a potential therapeutic approach in inflammatory and autoimmune diseases ...

    Abstract Background: Selective depletion of T cells expressing LAG-3, an immune checkpoint receptor that is upregulated on activated T cells, has been investigated in pre-clinical models as a potential therapeutic approach in inflammatory and autoimmune diseases where activated T cells are implicated.
    Aims: GSK2831781, a depleting monoclonal antibody that specifically binds LAG-3 proteins, may deplete activated LAG-3
    Methods: Patients with moderate to severe UC were randomised to GSK2831781 or placebo. Safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of GSK2831781 were evaluated.
    Results: One hundred four participants across all dose levels were randomised prior to an interim analysis indicating efficacy futility criteria had been met. Efficacy results focus on the double-blind induction phase of the study (GSK2831781 450 mg intravenously [IV], N = 48; placebo, N = 27). Median change from baseline (95% credible interval [CrI]) in complete Mayo score was similar between groups (GSK2831781 450 mg IV: -1.4 [-2.2, -0.7]; placebo: -1.4 [-2.4, -0.5]). Response rates for endoscopic improvement favoured placebo. Clinical remission rates were similar between groups. In the 450-mg IV group, 14 (29%) participants had an adverse event of UC versus 1 (4%) with placebo. LAG-3
    Conclusion: Despite evidence of target cell depletion in blood, GSK2831781 failed to reduce inflammation in the colonic mucosa suggesting no pharmacological effect. The study was terminated early (NCT03893565).
    MeSH term(s) Humans ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Antibodies, Monoclonal/adverse effects ; Double-Blind Method ; T-Lymphocytes ; Remission Induction ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17557
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    Zs.A 2206: Show issues Location:
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  10. Article ; Online: Re: Herren DB, Boeckstyns M, Chung KC et al. Diagnostic and treatment recommendations for recurrent or persistent symptoms after trapeziectomy: a Delphi study. J Hand Surg Eur Vol. 2024. doi: 10.1177/17531934241227386.

    De Vitis, Rocco / Taccardo, Giuseppe / Passiatore, Marco / Boekstyns, Michel / Marks, Miriam / Herren, Daniel B

    The Journal of hand surgery, European volume

    2024  , Page(s) 17531934241248567

    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/17531934241248567
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