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  1. Article ; Online: Robert's uterus (asymmetric septate uterus): a rare congenital Müllerian duct anomaly.

    Dunphy, Louise / Taylor, Sian / Whitby, Elspeth H / Agarwal, Umber / Alfirević, Žarko

    BMJ case reports

    2022  Volume 15, Issue 5

    Abstract: Müllerian anomalies such as Robert's uterus, which was first described by the French gynaecologist ... population. Robert's uterus is a rare phenomenon with a relative dearth of reported cases. Affected ... a Robert's uterus with a viable pregnancy in the upper left horn. She developed a ruptured horn ...

    Abstract Müllerian anomalies such as Robert's uterus, which was first described by the French gynaecologist Dr Helene Robert in 1969, are rare clinical entities and have been reported in <3% of the female population. Robert's uterus is a rare phenomenon with a relative dearth of reported cases. Affected individuals may present with pelvic pain and dysmenorrhoea that intensifies near menses or acutely, with severe abdominal pain to the emergency department. They are also associated with adverse pregnancy outcomes, abnormal fetal presentation, preterm labour, recurrent pregnancy loss and infertility. Although ultrasound has a role in its initial assessment, MRI is the best modality to further delineate its anatomy. It is typically managed via laparotomy and total horn resection, endometrectomy of the blind cavity or abdominal metroplasty. The authors present the case of a 40-year-old woman at 19+3 weeks gestation with acute onset of left-sided abdominal pain. A transvaginal ultrasound and MRI of the pelvis confirmed a Robert's uterus with a viable pregnancy in the upper left horn. She developed a ruptured horn with significant haemoperitoneum. An emergency laparotomy was performed and a non-viable fetus was evident. Only a few cases of pregnancy in the blind hemicavity have been reported so far. This case also highlights the importance of considering this diagnosis in young females presenting with dysmenorrhoea and normal menstrual flow. It is imperative to render a prompt diagnosis, as minimally invasive procedures may be more effective if detected before the formation of adnexal endometriomas.
    MeSH term(s) Abdominal Pain ; Adult ; Dysmenorrhea/etiology ; Female ; Humans ; Infant, Newborn ; Mullerian Ducts/abnormalities ; Mullerian Ducts/surgery ; Pelvis ; Pregnancy ; Uterus/abnormalities ; Uterus/diagnostic imaging ; Uterus/surgery
    Language English
    Publishing date 2022-05-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-244237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Postoperative prophylaxis in Crohn's disease after intestinal resection: a retrospective analysis.

    O'Connor, Anthony / Hamlin, Peter J / Taylor, Jennifer / Selinger, Christian / Scott, Nigel / Ford, Alexander C

    Frontline gastroenterology

    2016  Volume 8, Issue 3, Page(s) 203–209

    Abstract: Introduction: Up to 80% of patients with Crohn's disease (CD) may require surgery at some point ...

    Abstract Introduction: Up to 80% of patients with Crohn's disease (CD) may require surgery at some point in their lives, and it is estimated that as many as 40% may require several surgeries. It has been suggested that prophylactic medication decreases the rate of clinical and endoscopic recurrence following intestinal resection. This study aims to describe real-world clinical outcomes observed from a pragmatic, individualised strategy in postoperative CD.
    Methods: All patients undergoing intestinal resection for CD between 2009 and 2013 were identified. The endpoint of the study, treatment success, was defined as glucocorticosteroid-free, resection-free survival, at the last point of follow-up, without requiring an escalation or change of therapy during this time. Clinical information was extracted from chart reviews, endoscopy and radiology reports, and from prescribing databases. Patients were followed from the date of surgery, and the last point of follow-up was 31 January 2015.
    Results: 149 patients were analysed. Median duration of follow-up was 32 months (range 1-69 months). 101 patients received postoperative prophylactic therapy, and 48 did not. In 77 (51.7%) patients, thiopurines were used as first-line therapy, with treatment success occurring in 32 (41.6%) with a median follow-up of 25 months. 11 patients (7.4%) received anti-tumour necrosis factor (TNF)-α monotherapy, with treatment success occurring in 5 patients (45.5%) with a median follow-up of 35 months. 13 (8.7%) patients received first-line combination therapy, with 11 (84.6%) patients achieving treatment success with a median follow-up of 21 months.
    Conclusions: In our study, combination therapy with anti-TNF-α and immunomodulator therapy was well tolerated, efficacious (efficacy appeared durable for patients with postoperative CD) and superior to monotherapy with either thiopurines or anti-TNF-α drugs. Several limitations notwithstanding, our data suggest that there may be merit in the use of combination therapy in carefully selected postoperative patients whose care has been individualised via a multidisciplinary team meeting format. Prospective, controlled studies are therefore required to further assess the efficacy and safety of combination therapy for postoperative prophylaxis in CD.
    Language English
    Publishing date 2016-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2016-100749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multicentric Castleman's disease in a Ghanaian adult.

    Dei-Adomakoh, Y A / Segbefia, C / Ekem, I / Taylor, A

    Ghana medical journal

    2013  Volume 47, Issue 2, Page(s) 92–95

    Abstract: Castleman's disease is a rare cause of lymphoid hyperplasia that may result in localized symptoms ... Castleman's disease with combination chemotherapy. ...

    Abstract Castleman's disease is a rare cause of lymphoid hyperplasia that may result in localized symptoms or an aggressive, multisystem disorder that can mimic other diseases like lymphoma or tuberculosis. We describe a case of a 55-year-old Ghanaian male who was successfully diagnosed and managed for multicentric Castleman's disease with combination chemotherapy.
    MeSH term(s) Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy ; Castleman Disease/diagnosis ; Castleman Disease/drug therapy ; Castleman Disease/pathology ; Cyclophosphamide/administration & dosage ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prednisolone/administration & dosage ; Rituximab ; Vincristine/administration & dosage
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Cyclophosphamide (8N3DW7272P) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2013-08-21
    Publishing country Ghana
    Document type Case Reports ; Journal Article
    ZDB-ID 2259233-7
    ISSN 2616-163X ; 0016-9560
    ISSN (online) 2616-163X
    ISSN 0016-9560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Crohn's disease; a review.

    TAYLOR, E E T

    Postgraduate medical journal

    2007  Volume 25, Issue 284, Page(s) 245–254

    MeSH term(s) Crohn Disease ; Disease ; Humans ; Intestinal Diseases ; Intestines
    Language English
    Publishing date 2007-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/pgmj.25.284.245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Fatigue in Parkinson's disease: a review.

    Friedman, Joseph H / Brown, Richard G / Comella, Cynthia / Garber, Carol E / Krupp, Lauren B / Lou, Jau-Shin / Marsh, Laura / Nail, Lillian / Shulman, Lisa / Taylor, C Barr

    Movement disorders : official journal of the Movement Disorder Society

    2007  Volume 22, Issue 3, Page(s) 297–308

    Abstract: Fatigue is a common problem in Parkinson's disease (PD), often the most troubling of all symptoms ...

    Abstract Fatigue is a common problem in Parkinson's disease (PD), often the most troubling of all symptoms. It is poorly understood, generally under-recognized, and has no known treatment. This article reviews what is known about the symptom, putting it into the context of fatigue in other disorders, and outlines a program for developing better understanding and therapy.
    MeSH term(s) Animals ; Fatigue/epidemiology ; Fatigue/etiology ; Humans ; Parkinson Disease/complications ; Parkinson Disease/epidemiology
    Language English
    Publishing date 2007-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.21240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Does a patient's Mallampati score predict outcome after maxillomandibular advancement for obstructive sleep apnoea?

    Islam, Shofiq / Selbong, Uthaya / Taylor, Christopher J / Ormiston, Ian W

    The British journal of oral & maxillofacial surgery

    2015  Volume 53, Issue 1, Page(s) 23–27

    Abstract: The Mallampati airway classification has been used to estimate the success of uvulopalatopharyngoplasty in patients with obstructive sleep apnoea (OSA) but its predictive value in maxillomandibular advancement has not been proved. We aimed to explore the ...

    Abstract The Mallampati airway classification has been used to estimate the success of uvulopalatopharyngoplasty in patients with obstructive sleep apnoea (OSA) but its predictive value in maxillomandibular advancement has not been proved. We aimed to explore the association between preoperative Mallampati scores and surgical outcome after bimaxillary advancement for OSA. We retrospectively analysed data on 50 patients who had maxillofacial operations for OSA at our hospital and stratified them into two groups based on Mallampati scores: high (class III/IV) and low (class I/II). We compared pre- and postoperative apnoea/hypopnoea indices (AHIs), Epworth sleepiness scores, and lowest recorded oxygen saturation in both groups. The postoperative values for all three outcome measures were not significantly different when patients were stratified according to the Mallampati classification (mean (SD) AHI was 41(19) before and 7 (6) after operation in the low group, and 42 (15) before and 9 (7) after in the high group). Success rates (AHI less than 15 postoperatively) were similar in both low and high score groups (p>0.05). Maxillomandibular advancement alleviates obstruction at multiple levels and our study has shown comparable surgical outcomes in both groups. The Mallampati score can be used to optimise patient selection for surgeons considering single-level procedures for OSA. Our study suggests that the Mallampati classification is less useful for the prediction of surgical outcome after maxillomandibular advancement surgery.
    MeSH term(s) Adult ; Airway Obstruction/classification ; Airway Obstruction/surgery ; Female ; Follow-Up Studies ; Forecasting ; Genioplasty/methods ; Humans ; Intubation, Intratracheal/classification ; Male ; Mandibular Advancement/methods ; Maxilla/surgery ; Middle Aged ; Osteotomy, Sagittal Split Ramus/methods ; Oxygen/blood ; Palate/pathology ; Palate, Hard/pathology ; Palate, Soft/pathology ; Retrospective Studies ; Sleep Apnea, Obstructive/surgery ; Sleep Stages/physiology ; Tongue/pathology ; Treatment Outcome
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2015-01
    Publishing country Scotland
    Document type Comparative Study ; Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2014.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Unravelling a ‘miner’s myth’ that environmental contamination in mining towns is naturally occurring

    Kristensen, Louise Jane / Mark Patrick Taylor

    Environmental geochemistry and health. 2016 Aug., v. 38, no. 4

    2016  

    Abstract: ... the nature and timing of lead contamination. We use multiple lines of evidence to unravel a ‘miner’s ... An example of this situation is from Broken Hill, New South Wales, home to one of the world’s largest leadâ ... particularly to children. Resource companies, government agencies and employees often construct ‘mythsâ ...

    Abstract Australia has a long history of metal mining and smelting. Extraction and processing have resulted in elevated levels of toxic metals surrounding mining operations, which have adverse health effects, particularly to children. Resource companies, government agencies and employees often construct ‘myths’ to down play potential exposure risks and responsibility arising from operating emissions. Typical statements include: contaminants are naturally occurring, the wind blows emissions away from residential areas, contaminants are not bioavailable, or the problem is a legacy issue and not related to current operations. Evidence from mining and smelting towns shows that such ‘myths’ are exactly that. In mining towns, the default and primary defence against contamination is that elevated metals in adjacent urban environments are from the erosion and weathering of the ore bodies over millennia—hence ‘naturally occurring’. Not only is this a difficult argument to unravel from an evidence-based perspective, but also it causes confusion and delays remediation work, hindering efforts to reduce harmful exposures to children. An example of this situation is from Broken Hill, New South Wales, home to one of the world’s largest lead–zinc–silver ore body, which has been mined continuously for over 130 years. Environmental metal concentration and lead isotopic data from soil samples collected from across Broken Hill are used to establish the nature and timing of lead contamination. We use multiple lines of evidence to unravel a ‘miner’s myth’ by evaluating current soil metal concentrations and lead isotopic compositions, geological data, historical environmental assessments and old photographic evidence to assess the impacts from early smelting along with mining to the surface soils in the city.
    Keywords adverse effects ; business enterprises ; children ; emissions ; environmental assessment ; government agencies ; human resources ; lead ; pollution ; remediation ; residential areas ; risk ; soil ; surface mining ; towns ; toxicity ; urban areas ; weathering ; wind ; New South Wales
    Language English
    Dates of publication 2016-08
    Size p. 1015-1027.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-016-9804-6
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Analgesia e sedação da S(+) cetamina e da S(+) cetamina-morfina, associadas à ropivacaína, por via peridural, no pós-operatório de intervenção cirúrgica de abdômen superior Analgesia y sedación de la S(+) cetamina y de la S(+) cetamina-morfina, asociadas a la ropivacaína, por vía peridural, en el postoperatorio de intervención quirúrgica de abdomen superior Epidural S(+) ketamine and S(+) ketamine-morphine associated with ropivacaine in the postoperative analgesia and sedation of upper abdominal surgery

    Taylor Brandão Schnaider / Antônio Mauro Vieira / Antônio Carlos Aguiar Brandão / Aretusa Chediak Roquim

    Revista Brasileira de Anestesiologia, Vol 57, Iss 1, Pp 8-

    2007  Volume 18

    Abstract: ... de efeitos colaterais. O objetivo foi avaliar a analgesia e a sedação pós-operatórias causadas pela S ... ropivacaína a 0,75% associada à S(+) cetamina (0,5 mg.kg-1) no Grupo Cetamina (GK); ropivacaína a 0,75 ... associada à S(+) cetamina (0,5 mg.kg-1) e à morfina (2 mg) no Grupo Cetamina-Morfina2 (GKM2); ropivacaína a ...

    Abstract JUSTIFICATIVA E OBJETIVOS: A combinação de fármacos, atuando por diferentes mecanismos de ação no corno dorsal da medula espinhal, acarreta diminuição da dor pós-operatória, com menor incidência de efeitos colaterais. O objetivo foi avaliar a analgesia e a sedação pós-operatórias causadas pela S(+) cetamina e S(+) cetamina-morfina associadas à ropivacaína, por via peridural, em colecistectomia por via subcostal. MÉTODO: Participaram do estudo 70 pacientes, de ambos os sexos, estado físico ASA I e II. Foram administradas por via peridural: ropivacaína a 0,75% associada ao cloreto de sódio a 0,9% no Grupo-controle (GC); ropivacaína a 0,75% associada à S(+) cetamina (0,5 mg.kg-1) no Grupo Cetamina (GK); ropivacaína a 0,75% associada à S(+) cetamina (0,5 mg.kg-1) e à morfina (2 mg) no Grupo Cetamina-Morfina2 (GKM2); ropivacaína a 0,75% associada à S(+) cetamina (0,5 mg.kg-1) e à morfina (3 mg) no Grupo Cetamina-Morfina3 (GKM3). A analgesia e a sedação foram observadas às duas, seis e 24 horas após o término do ato operatório. RESULTADOS: A sedação foi observada até duas horas após o término do ato operatório nos grupos GK, GKM2 e GKM3. A analgesia foi efetiva no GC até duas horas de pós-operatório, no GK nas duas e seis horas; nos GKM2 e GKM3, nas 2h, 6h e 24h. CONCLUSÕES: A S(+) cetamina e as associações S(+) cetamina-morfina promoveram sedação até duas horas após o término de ato operatório. A S(+) cetamina promoveu analgesia especialmente no momento de observação de duas horas e as associações S(+) cetamina-morfina promoveram analgesia sobretudo nos momentos de observação de 2h e 6h após o término do ato operatório. JUSTIFICATIVA Y OBJETIVOS: La combinación de fármacos, actuando por diferentes mecanismos de acción en el cuerno dorsal de la médula espinal, acarrea una disminución del dolor postoperatorio, con una menor incidencia de los efectos colaterales. El objetivo fue el de evaluar la analgesia y la sedación postoperatorias causadas por la S(+) cetamina y S(+) cetamina-morfina asociadas a la ropivacaína, por vía peridural, en colecistectomía por vía subcostal. MÉTODO: Participaron del estudio 70 pacientes, de ambos sexos, estado físico ASA I y II. Se administraron por vía peridural: ropivacaína a 0,75% asociada al cloruro de sodio a 0,9% en el Grupo Control (GC); ropivacaína a 0,75% asociada a la S(+) cetamina (0,5 mg.kg-1) en el Grupo Cetamina (GK); ropivacaína a 0,75% asociada à S(+) cetamina (0,5 mg.kg-1) y a la morfina (2 mg) en el Grupo Cetamina-Morfina2 (GKM2); ropivacaína a 0,75% asociada a la S(+) cetamina (0,5 mg.kg-1) y a la morfina (3 mg) en el Grupo Cetamina-Morfina3 (GKM3). La analgesia y la sedación fueron observadas a las 2h, 6h y 24h después del término de la operación. RESULTADOS: La sedación fue observada en 2h después de la operación en los grupos GK, GKM2 y GKM3. La analgesia quedó efectiva en el GC en 2h después del postoperatorio, en el GK en la 2h y 6h; en los GKM2 y GKM3 en las 2h, 6h y 24h. CONCLUSIONES: La S(+) cetamina y las asociaciones S(+) cetamina-morfina promovieron sedación hasta 2 horas después del término de la operación. La S(+) cetamina promovió analgesia especialmente 2 en horas y las asociaciones S(+) cetamina-morfina promovieron analgesia principalmente en los momentos de observación de 2h y 6h después del término de la operación. BACKGROUND AND OBJECTIVES: The association of drugs with different mechanisms of action in the dorsal horn of the spinal cord decreases postoperative pain, with a reduction in the incidence of side effects. The aim of this study was to evaluate postoperative analgesia and sedation by epidural S(+) ketamine and S(+) ketamine-morphine associated with ropivacaine in subcostal cholecystectomy. METHODS: Seventy patients of both genders, physical status ASA I and II, participated in this study. The following drugs were administered epidurally: 0.75% ropivacaine associated with 0.9% sodium chloride in the Control Group (CG); 0.75% ropivacaine associated with S(+) ketamine (0.5 mg.kg-1) in the Ketamine Group (KG); 0.75% ropivacaine associated with S(+) ketamine (0.5 mg.kg-1) and morphine (2 mg) in the Ketamine-Morphine Group2 (KMG2); 0.75% ropivacaine associated with S(+) ketamine (0.5 mg.kg-1) and morphine (3 mg) in the Ketamine-Morphine Group3 (KMG3). Analgesia and sedation were evaluated 2h, 6h, and 24h after the end of the surgery. RESULTS: Sedation was observed up to 2 hours after the end of the procedure in KG, KMG2, and KMG3. Analgesia was effective in CG up to 2 hours after the surgery, at 2h and 6h in KG, and at 2h, 6h, and 24h, in KMG2 and KMG3. CONCLUSIONS: S(+) ketamine and the associations S(+) ketamine-morphine promoted sedation up to 2h after the end of the surgical procedure. S(+) ketamine promoted analgesia especially at the moment of the 2h observation, and the associations of S(+) ketamine-morphine promoted analgesia especially at 2h and 6h after the surgery.
    Keywords ANALGESIA ; ANALGÉSICOS ; ANESTÉSICOS ; Dissociativa ; Local ; TÉCNICAS ANESTÉSICAS ; Regional ; ANALGESICS ; ANESTHETICS ; Dissociate ; ANESTHETIC TECHNIQUES ; Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2007-02-01T00:00:00Z
    Publisher Sociedade Brasileira de Anestesiologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book: Sir Bertram Windle: Bertram Coghill Alan Windle, F. R. S., F. S. A., K. S. G., M. D., M. A., LL. D., PH. D., SC. D.;

    Taylor, Monica

    a memoir

    1932  

    Author's details by Monica Taylor, S. N. D. ... With four illustrations
    Language English
    Size 3 p. l., ix-xii p., 2 l., 428 p. 2 pl., 2 port., ill.
    Publisher Longmans, Green and co
    Publishing place London, New York etc.
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book ; Online ; E-Book: Thermal physiology

    Blatteis, Clark M. / Taylor, Nigel A. S. / Mitchell, G. Duncan

    a worldwide history

    (Perspectives in Physiology)

    2022  

    Author's details edited by Clark M. Blatteis, Nigel A. S. Taylor, Duncan Mitchell
    Series title Perspectives in Physiology
    Keywords Heat/Physiological effect
    Subject code 612
    Language English
    Size 1 online resource (681 pages)
    Publisher Springer
    Publishing place New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-0716-2362-1 ; 1-0716-2360-5 ; 978-1-0716-2362-6 ; 978-1-0716-2360-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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