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  1. Article: Cronkhite-Canada syndrome.

    Samoha, Smadar / Arber, Nadir

    Digestion

    2005  Volume 71, Issue 4, Page(s) 199–200

    MeSH term(s) Diagnosis, Differential ; Humans ; Intestinal Polyposis/diagnosis ; Taste Disorders/diagnosis ; Zinc/deficiency
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2005
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000086134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side.

    Samoha, Smadar / Arber, Nadir

    Oncology

    2005  Volume 69 Suppl 1, Page(s) 33–37

    Abstract: Cancer is predicted to become the leading cause of death--surpassing heart disease--by the end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 new cases and 500,000 deaths expected worldwide per year. There is much ... ...

    Abstract Cancer is predicted to become the leading cause of death--surpassing heart disease--by the end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 new cases and 500,000 deaths expected worldwide per year. There is much evidence to suggest a link between the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevention of colorectal cancer (CRC). The consumption of NSAIDs is not problem free, and the number of deaths due to NSAIDs equals the number of deaths from AIDS or leukemia. Therefore, although chemoprevention of CRC is possible, drugs that have more acceptable side effect profiles than the currently available NSAIDs are required. Since up to 50% of polyps and 85% of colonic tumors in humans overexpress cyclooxygenase (COX-2), COX-2 inhibitors are an ideal drug candidate for CRC prevention or treatment.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Clinical Trials as Topic ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/prevention & control ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/therapeutic use ; Humans ; Membrane Proteins ; Mice ; Prostaglandin-Endoperoxide Synthases/physiology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors ; Membrane Proteins ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1)
    Language English
    Publishing date 2005
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 250101-6
    ISSN 1423-0232 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000086630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cronkhite-Canada Syndrome

    Samoha, Smadar / Arber, Nadir

    Digestion

    2005  Volume 71, Issue 4, Page(s) 199–200

    Institution Integrated Cancer Prevention Center, Tel Aviv Medical Center and Tel Aviv University, Tel Aviv, Israel
    Language English
    Publishing date 2005-08-19
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Editorial
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000086134
    Database Karger publisher's database

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  4. Article: Cyclooxygenase-2 Inhibition Prevents Colorectal Cancer: From the Bench to the Bed Side

    Samoha, Smadar / Arber, Nadir

    Oncology

    2005  Volume 69, Issue 1, Page(s) 33–37

    Abstract: Cancer is predicted to become the leading cause of death – surpassing heart disease – by the end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 new cases and 500,000 deaths expected worldwide per year. There is much ...

    Institution Integrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel
    Abstract Cancer is predicted to become the leading cause of death – surpassing heart disease – by the end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 new cases and 500,000 deaths expected worldwide per year. There is much evidence to suggest a link between the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevention of colorectal cancer (CRC). The consumption of NSAIDs is not problem free, and the number of deaths due to NSAIDs equals the number of deaths from AIDS or leukemia. Therefore, although chemoprevention of CRC is possible, drugs that have more acceptable side effect profiles than the currently available NSAIDs are required. Since up to 50% of polyps and 85% of colonic tumors in humans overexpress cyclooxygenase (COX-2), COX-2 inhibitors are an ideal drug candidate for CRC prevention or treatment
    Keywords Adenomas ; Colorectal cancer ; Chemoprevention ; Cyclooxygenase ; Polyps
    Language English
    Publishing date 2005-10-04
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Paper
    ZDB-ID 250101-6
    ISBN 978-3-8055-8003-8 ; 978-3-318-01268-2 ; 3-8055-8003-7 ; 3-318-01268-8
    ISSN 1423-0232 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000086630
    Database Karger publisher's database

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