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  1. Article: Integrating UPLC-Q-Orbitrap MS with serum pharmacochemistry network and experimental verification to explore the pharmacological mechanisms of

    Gao, Hejun / Yuan, Ziyi / Liang, Haoxuan / Liu, Youtan

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1261772

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1261772
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  2. Article ; Online: Nanoconfined catalytic membrane assembled by nitrogen-doped carbon encapsulating Fe-based nanoparticles for rapid removal of 2,4-dichlorophenol in wastewater by peroxymonosulfate activation.

    Ma, Taigang / Ren, Hejun / Liu, Meijun / Zhou, Rui

    Journal of hazardous materials

    2024  Volume 466, Page(s) 133523

    Abstract: Surface-dependent non-radical oxidation of carbon materials-based persulfate systems show a better application prospect in the removal of pollutants in complex wastewater. However, their potential is severely limited by the restricted liquid-to-solid ... ...

    Abstract Surface-dependent non-radical oxidation of carbon materials-based persulfate systems show a better application prospect in the removal of pollutants in complex wastewater. However, their potential is severely limited by the restricted liquid-to-solid mass transfer efficiency of conventional suspension systems. In this paper, a nitrogen-doped carbon encapsulating iron-based nanoparticles (Fe@NC) was prepared, and loaded onto a polyvinylidene fluoride (PVDF) membrane to construct a novel catalytic membrane Fe@NC/PVDF. The Fe@NC/PVDF/PMS system could achieve 99.74% of 2,4-dicholophenol (2,4-DCP) removal within a retention time of 0.867 s, the kinetic constant is 840 times higher than that of Fe@NC/PMS system, and 2-5 orders of magnitude higher than that of various reported advanced oxidation processes systems. The system exhibits strong anti-interference to various water matrices, long-time operational stability at high flux (306 L·m
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133523
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  3. Article ; Online: Protective neutralizing epitopes in SARS-CoV-2.

    Liu, Hejun / Wilson, Ian A

    Immunological reviews

    2022  Volume 310, Issue 1, Page(s) 76–92

    Abstract: The COVID-19 pandemic has caused an unprecedented health crisis and economic burden worldwide. Its etiological agent SARS-CoV-2, a new virus in the coronavirus family, has infected hundreds of millions of people worldwide. SARS-CoV-2 has evolved over the ...

    Abstract The COVID-19 pandemic has caused an unprecedented health crisis and economic burden worldwide. Its etiological agent SARS-CoV-2, a new virus in the coronavirus family, has infected hundreds of millions of people worldwide. SARS-CoV-2 has evolved over the past 2 years to increase its transmissibility as well as to evade the immunity established by previous infection and vaccination. Nevertheless, strong immune responses can be elicited by viral infection and vaccination, which have proved to be protective against the emergence of variants, particularly with respect to hospitalization or severe disease. Here, we review our current understanding of how the virus enters the host cell and how our immune system is able to defend against cell entry and infection. Neutralizing antibodies are a major component of our immune defense and have been extensively studied for SARS-CoV-2 and its variants. Structures of these neutralizing antibodies have provided valuable insights into epitopes that are protective against the original ancestral virus and the variants that have emerged. The molecular characterization of neutralizing epitopes as well as epitope conservation and resistance are important for design of next-generation vaccines and antibody therapeutics.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Epitopes ; Humans ; Pandemics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-05-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13084
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  4. Article: Coexisting achalasia and leiomyoma misdiagnosed as the submucosal tumor, successfully treated by simultaneous peroral endoscopic myotomy and submucosal tunneling endoscopic resection in the same tunnel.

    Chen, Yanyu / Gao, Shan / Liu, Deliang / Zhou, Hejun

    Revista espanola de enfermedades digestivas

    2023  

    Abstract: Peroral endoscopic myotomy (POEM) is a safe and effective method in the treatment of achalasia. Meanwhile, submucosal tunneling endoscopic resection (STER) is a common endoscopic method for the treatment of submucosal tumors (SMT) in the upper digestive ... ...

    Abstract Peroral endoscopic myotomy (POEM) is a safe and effective method in the treatment of achalasia. Meanwhile, submucosal tunneling endoscopic resection (STER) is a common endoscopic method for the treatment of submucosal tumors (SMT) in the upper digestive tract. However simultaneous POEM and STER for coexisting achalasia and esophageal SMT is rarely reported. A 40-year-old woman underwent esophagoscopy after dysphagia and vomiting for 20 years. The protruding submucosal lesion with normal overlying mucosa was found in the lower part of the esophagus, nearing cardia. Considering the persistent swallowing discomfort and vomiting symptoms, the patient underwent esophageal manometry and barium esophagram, and was finally diagnosed as achalasia with esophageal submucosal tumor. Finally, POEM and STER were performed simultaneously on the patient in the same tunnel. The patient was followed up for 4 months without recurrence or complaints. We herein report a case of achalasia with esophageal leiomyoma who underwent POEM and STER in the same tunnel to remove the mass and relieve the symptoms.
    Language English
    Publishing date 2023-06-22
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9736/2023
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 199: Show issues Location:
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  5. Article ; Online: Alterations in the gut microbiota and the efficacy of adjuvant probiotic therapy in liver cirrhosis.

    Wu, Zengrong / Zhou, Hejun / Liu, Deliang / Deng, Feihong

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1218552

    Abstract: Background: Liver cirrhosis is the end stage of various chronic liver diseases (CLDs). The gut microbiota can impact the liver environment and trigger chronic liver inflammation through the gut-liver axis. Alteration of the gut microbiota has become an ... ...

    Abstract Background: Liver cirrhosis is the end stage of various chronic liver diseases (CLDs). The gut microbiota can impact the liver environment and trigger chronic liver inflammation through the gut-liver axis. Alteration of the gut microbiota has become an effective strategy in the biological treatment of cirrhosis.
    Methods: Twenty-eight patients with liver cirrhosis and 16 healthy individuals were included, and fresh stool samples were collected. We analyzed changes in the gut microbiota between groups by 16S rRNA sequencing and evaluated the association between microbiota alterations and hepatic function. Additionally, 102 cirrhotic patients were retrospectively enrolled and divided into a probiotic group (n=44) and a nonprobiotic group (n=58) in addition to standard treatment for cirrhosis. Patients were monitored for hematological parameters and hepatic function during the six-month follow-up.
    Results: The gut microbiota profile of patients with cirrhosis was greatly different from that of healthy individuals, presenting with significantly reduced α diversity and decreased abundance of representative SCFA-producing bacteria including
    Conclusion: Severe microbial dysbiosis existed in patients with liver cirrhosis, especially patients who reached the decompensatory stage. SCFA-producing bacteria were significantly reduced in cirrhosis. Altered gut microbiota cause changes in functional modules, which may contribute to cirrhosis progression and are associated with clinical prognosis. Adjuvant probiotic supplementation to enhance SCFA-producing bacteria can be a prospective therapy for patients with cirrhosis.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Retrospective Studies ; RNA, Ribosomal, 16S/genetics ; Liver Cirrhosis/complications ; Liver Cirrhosis/therapy ; Liver Cirrhosis/microbiology ; Bacteria/genetics ; Probiotics/therapeutic use
    Chemical Substances RNA, Ribosomal, 16S ; chlorfenethol (L0079FA965)
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1218552
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  6. Article ; Online: Saikosaponin a promotes neutrophil extracellular trap formation and bactericidal activity.

    Zhang, Lanqiu / Hu, Zhengwei / Yang, Lei / Liu, Tianyu / Xun, Jing / Zhang, Qi / Wang, Ximo / Gao, Hejun / Jin, Zhongkui

    Natural product research

    2024  , Page(s) 1–8

    Abstract: This study aimed to investigate the effects of SSa, one of the major triterpenoid saponins extracted ... ...

    Abstract This study aimed to investigate the effects of SSa, one of the major triterpenoid saponins extracted from
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2343918
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  7. Article: Attentional bias to threat is modulated by stimulus content: an fNIRS study.

    Liu, Hejun / Zhang, Qihan / Elhai, Jon D / Montag, Christian / Yang, Haibo

    Frontiers in human neuroscience

    2024  Volume 17, Page(s) 1308457

    Abstract: People are evolutionarily predisposed to associate threat relevant stimuli with fear or aversiveness and show an attentional bias toward threat. Attentional bias modification (ABM) has been shown to reduce threat biases, while quantitative reviews ... ...

    Abstract People are evolutionarily predisposed to associate threat relevant stimuli with fear or aversiveness and show an attentional bias toward threat. Attentional bias modification (ABM) has been shown to reduce threat biases, while quantitative reviews assessing the effectiveness of bias modification yielded inconsistent results. The current study examined the relationship between the training effect of attentional bias to threat and the type of threatening stimuli. Twenty-two participants performed a modified dot-probe task while undergoing functional near-infrared spectroscopy (fNIRS) imaging. Results indicated that there was a strong pattern of attentional avoidance among individuals in an animal but not human threat condition. Furthermore, findings from fNIRS confirmed that the influence from type of threatening stimulus would be modulated by cortical activation patterns, especially in the ventrolateral prefrontal cortices (vlPFC) and angular gyrus. Overall, these results suggest that stimulus-specific may play a major role in personalization of specific psychological interventions.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2023.1308457
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  8. Article ; Online: A modeling and calibrating method of FBG sensors for wing deformation displacement measurement

    Yanhong Liu / Yan Huang / Hejun Yao / Wei Liang / Yuan Xu

    Heliyon, Vol 9, Iss 5, Pp e15932- (2023)

    2023  

    Abstract: The airborne distributed Position and Orientation System (POS) is a key piece of equipment for providing high-precision motion parameters for aerial remote sensing systems. However, wing deformation degrades the performance of distributed POS, thus, it ... ...

    Abstract The airborne distributed Position and Orientation System (POS) is a key piece of equipment for providing high-precision motion parameters for aerial remote sensing systems. However, wing deformation degrades the performance of distributed POS, thus, it is urgent to obtain high-precision deformation information to assist distributed POS. In this study, a modeling and calibrating method of fiber Bragg grating (FBG) sensors for wing deformation displacement measurement is proposed. First, based on the cantilever beam theory and piecewise superposition, a modeling and calibrating method for wing deformation displacement measurement is established. The wing is then placed under different deformation conditions, and the changes in the wing deformation displacement and corresponding wavelength variations of the pasted FBG sensors are obtained using theodolite coordinate measurement system and FBG demodulator, respectively. Subsequently, linear least square fitting is deployed to develop the relationship model between the wavelength variations of the FBG sensors and wing deformation displacement. Finally, the wing deformation displacement at the measuring point in the temporal and spatial dimensions is obtained by fitting and interpolation. An experiment is conducted, and the results show that the accuracy of the proposed method can reach 0.721 mm with a wing length of 3 m, which can be used in the motion compensation of an airborne distributed POS.
    Keywords Wing deformation measurement ; Fiber bragg grating sensor ; Airborne distributed position and orientation system ; Fitting and interpolation ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 620
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  9. Article: A modeling and calibrating method of FBG sensors for wing deformation displacement measurement.

    Liu, Yanhong / Huang, Yan / Yao, Hejun / Liang, Wei / Xu, Yuan

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e15932

    Abstract: The airborne distributed Position and Orientation System (POS) is a key piece of equipment for providing high-precision motion parameters for aerial remote sensing systems. However, wing deformation degrades the performance of distributed POS, thus, it ... ...

    Abstract The airborne distributed Position and Orientation System (POS) is a key piece of equipment for providing high-precision motion parameters for aerial remote sensing systems. However, wing deformation degrades the performance of distributed POS, thus, it is urgent to obtain high-precision deformation information to assist distributed POS. In this study, a modeling and calibrating method of fiber Bragg grating (FBG) sensors for wing deformation displacement measurement is proposed. First, based on the cantilever beam theory and piecewise superposition, a modeling and calibrating method for wing deformation displacement measurement is established. The wing is then placed under different deformation conditions, and the changes in the wing deformation displacement and corresponding wavelength variations of the pasted FBG sensors are obtained using theodolite coordinate measurement system and FBG demodulator, respectively. Subsequently, linear least square fitting is deployed to develop the relationship model between the wavelength variations of the FBG sensors and wing deformation displacement. Finally, the wing deformation displacement at the measuring point in the temporal and spatial dimensions is obtained by fitting and interpolation. An experiment is conducted, and the results show that the accuracy of the proposed method can reach 0.721 mm with a wing length of 3 m, which can be used in the motion compensation of an airborne distributed POS.
    Language English
    Publishing date 2023-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15932
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  10. Article ; Online: Peroxidase like Zn doped Prussian blue facilitates salinity tolerance in winter wheat through seed dressing.

    Xu, Wenlong / Feng, Yingchen / Ding, Zixuan / Liu, Hejun / Wu, Hongsheng / Ye, Enyi / Orooji, Yasin / Xiao, Qingbo / Zhang, Zhiyang

    International journal of biological macromolecules

    2024  Volume 267, Issue Pt 2, Page(s) 131477

    Abstract: Salt stress severely limits the growth and yield of wheat in saline-alkali soil. While nanozymes have shown promise in mitigating abiotic stress by scavenging reactive oxygen species (ROS) in plants, their application in alleviating salt stress for wheat ...

    Abstract Salt stress severely limits the growth and yield of wheat in saline-alkali soil. While nanozymes have shown promise in mitigating abiotic stress by scavenging reactive oxygen species (ROS) in plants, their application in alleviating salt stress for wheat is still limited. This study synthesized a highly active nanozyme catalyst known as ZnPB (Zn-modified Prussian blue) to improve the yield and quality of wheat in saline soil. According to the Michaelis-Menten equation, ZnPB demonstrates exceptional peroxidase-like enzymatic activity, thereby mitigating oxidative damage caused by salt stress. Additionally, studies have shown that the ZnPB nanozyme is capable of regulating intracellular Na
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131477
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