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Article: Combined Femoral Osteotomy and Contralateral Hip Arthroplasty to Correct Limb Alignment and Arthritis in a Scoliosis and Polio Patient: A Case Report.

Balaji, Ayush / Toga, Akira / Sanghai, Aman / Chishti, Hammad / Turner, Luke / Katoh, Shojiro

2023 Volume 15, Issue 5, Page(s) e39010

Abstract: We describe the first case of a 62-year-old female symptomatic patient with multiple comorbidities presenting with coronal limb malalignment due to scoliosis and osteoarthritis who underwent a combined total hip arthroplasty and biplane opening wedge ... ...

Abstract	We describe the first case of a 62-year-old female symptomatic patient with multiple comorbidities presenting with coronal limb malalignment due to scoliosis and osteoarthritis who underwent a combined total hip arthroplasty and biplane opening wedge osteotomy of the distal femur in one procedure. It is essential to realize that in patients who present with multiple comorbidities, combining different established procedures should be considered as a therapeutic option. We detail the operative procedure, preoperative considerations, and postoperative rehabilitation. By reviewing the literature on operative techniques, we highlight how our findings can be applied to similar cases with multiple comorbidities. Our report underscores the importance of considering combined procedures as a viable therapeutic option for patients with complex medical histories.
Language	English
Publishing date	2023-05-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.39010
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Article ; Online: Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition: Comprehensive Analysis Using Immunohistochemistry, Proteomics, and a Literature Review.

Ichimata, Shojiro / Hata, Yukiko / Yoshinaga, Tsuneaki / Katoh, Nagaaki / Kametani, Fuyuki / Yazaki, Masahide / Sekijima, Yoshiki / Nishida, Naoki

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: This study aimed to elucidate the similarities and differences between amyloid-forming corpora amylacea (CA) in the prostate and lung, examine the nature of CAs in cystic tumors of the atrioventricular node (CTAVN), and clarify the distinctions between ... ...

Abstract	This study aimed to elucidate the similarities and differences between amyloid-forming corpora amylacea (CA) in the prostate and lung, examine the nature of CAs in cystic tumors of the atrioventricular node (CTAVN), and clarify the distinctions between amyloid-forming CA and spheroid-type amyloid deposition. We conducted proteomics analyses using liquid chromatography-tandem mass spectrometry with laser microdissection and immunohistochemistry to validate the characteristics of CAs in the lung and prostate. Our findings revealed that the CAs in these organs primarily consisted of common proteins (β2-microglobulin and lysozyme) and locally produced proteins. Moreover, we observed a discrepancy between the histopathological and proteomic analysis results in CTAVN-associated CAs. In addition, while the histopathological appearance of the amyloid-forming CAs and spheroid-type amyloid deposits were nearly identical, the latter deposition lacked β2-microglobulin and lysozyme and exhibited evident destruction of the surrounding tissue. A literature review further supported these findings. These results suggest that amyloid-forming CAs in the lung and prostate are formed through a shared mechanism, serving as waste containers (wasteosomes) and/or storage for excess proteins (functional amyloids). In contrast, we hypothesize that while amyloid-forming CA and spheroid-type amyloid deposits are formed, in part, through common mechanisms, the latter are pathological.
MeSH term(s)	Male ; Humans ; Muramidase ; Immunohistochemistry ; Plaque, Amyloid ; Proteomics ; Amyloidogenic Proteins
Chemical Substances	Muramidase (EC 3.2.1.17) ; Amyloidogenic Proteins
Language	English
Publishing date	2024-04-04
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25074040
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Article: Examining the Efficacy of Drain Tip Cultures in Predicting Postoperative Surgical Site Infections in Hip Arthroplasty: A 15-Year Retrospective Study.

Toga, Akira / Balaji, Ayush / Hemmi, Osamu / Ishii, Ken / Tokunaga, Shigeyuki / Katoh, Shojiro / Izumida, Ryoichi

Cureus

2023 Volume 15, Issue 10, Page(s) e46395

Abstract: Background Postoperative surgical site infections (SSIs) are a significant complication of surgical procedures, leading to increased morbidity, prolonged hospital stays, and substantial healthcare costs; however, the use of drain tip cultures to diagnose ...

Abstract	Background Postoperative surgical site infections (SSIs) are a significant complication of surgical procedures, leading to increased morbidity, prolonged hospital stays, and substantial healthcare costs; however, the use of drain tip cultures to diagnose SSIs in patients is controversial. The objective of this study was to evaluate the efficacy of drain tip cultures for the prediction of postoperative SSIs in patients recovering from hip arthroplasty. Methodology The data were collected from 1204 patients who underwent hip arthroplasty procedures over 15 years, and statistical analysis was performed to evaluate the diagnostic value of drain tip culture in determining surgical site infection. We also used these data to evaluate whether preexisting conditions such as hypertension or diabetes affected the probability of a patient getting an SSI. Results Drain tip cultures were positive in 12 of 1,112 cases of primary hip arthroplasty, but only one of these 12 patients was ultimately diagnosed with an SSI (sensitivity, 12.5%; specificity, 99.0%; p = 0.0834). Results from postoperative drain tip cultures performed in patients undergoing revision arthroplasty included two false positives and three false negatives; interestingly, no true positives were detected in any of the revision arthroplasty cases we evaluated (sensitivity, 0％; specificity, 97.8％; p = 0.9355). Conclusion Our results indicate that drain tip cultures have no statistically significant predictive value for the diagnosis of postoperative SSIs and thus should not be used as a primary diagnostic or predictive tool for SSIs. We recommend exploring other diagnostic tools for the postoperative diagnosis of SSIs. Standardized guidelines should therefore be established to improve the predictive value of the different methods.
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46395
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Article ; Online: Endoscopic ultrasound imaging with high flow mode for endonasal transsphenoidal pituitary surgery.

Ishikawa, Mami / Ota, Yasushi / Naritaka, Heiji / Katoh, Shojiro

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2021 Volume 89, Page(s) 329–335

Abstract: Intraoperative ultrasound during transsphenoidal surgery (TSS) for pituitary tumors has been reported. In reports of endonasal ultrasound (US), Doppler US vessel images were informative and effective in endoscopic TSS. We performed endoscopic US imaging ... ...

Abstract	Intraoperative ultrasound during transsphenoidal surgery (TSS) for pituitary tumors has been reported. In reports of endonasal ultrasound (US), Doppler US vessel images were informative and effective in endoscopic TSS. We performed endoscopic US imaging with high flow mode, which is a novel technology, to visualize small vessels during endonasal endoscopic TSS. Six patients (five with pituitary adenomas and one with Rathoke's cleft cyst) underwent endoscopic US-assisted TSS. A small endoscopic US probe (Olympus, BF-UC260FW; diameter, 6.9 mm) was inserted transsphenoidally to the sellar floor and into the sella turcica, and endoscopic US monitoring was performed. By rotating the endoscopic US probe, the internal carotid artery, anterior cerebral artery, middle cerebral artery, various small vessels, optic nerve, and residual tumor were clearly visualized on the endoscopic US images. Real-time animated vessel images around the tumor could be generated when needed during TSS. The tumors were removed without leakage of cerebrospinal fluid in the six patients, and their visual acuity was restored. Endoscopic US with high flow mode can visualize not only main cerebral arteries but also intracranial small vessels on B-mode US images. Pituitary tumors were clearly recognized and removed safely and precisely by monitoring the cerebral artery and its small branches as landmarks.
MeSH term(s)	Adenoma/diagnostic imaging ; Adenoma/surgery ; Adult ; Cerebrospinal Fluid Leak/epidemiology ; Humans ; Male ; Middle Aged ; Natural Orifice Endoscopic Surgery/adverse effects ; Natural Orifice Endoscopic Surgery/methods ; Nose/surgery ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Postoperative Complications/epidemiology ; Sella Turcica/drug effects ; Sella Turcica/surgery ; Ultrasonography/methods
Language	English
Publishing date	2021-05-21
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2021.05.024
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Article ; Online: Novel histopathological deposition patterns of EGF-containing fibulin-like extracellular matrix protein 1 amyloidosis: an autopsy case exhibiting a possible association between AEFEMP1 amyloidosis and elastic fibres.

Ichimata, Shojiro / Hata, Yukiko / Katoh, Nagaaki / Kametani, Fuyuki / Yazaki, Masahide / Sekijima, Yoshiki / Nishida, Naoki

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2022 Volume 29, Issue 2, Page(s) 139–140

MeSH term(s)	Amyloidosis/metabolism ; Autopsy ; Calcium-Binding Proteins ; Elastic Tissue/metabolism ; Epidermal Growth Factor/metabolism ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Humans
Chemical Substances	Calcium-Binding Proteins ; Extracellular Matrix Proteins ; fibulin ; Epidermal Growth Factor (62229-50-9)
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Letter
ZDB-ID	1205246-2
ISSN	1744-2818 ; 1350-6129
ISSN (online)	1744-2818
ISSN	1350-6129
DOI	10.1080/13506129.2021.2020754
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Article ; Online: Articular chondrocytes from osteoarthritic knee joints of elderly,

Katoh, Shojiro / Fujimaru, Atsuki / Senthilkumar, Rajappa / Preethy, Senthilkumar / Abraham, Samuel Jk

Regenerative therapy

2020 Volume 14, Page(s) 234–237

Abstract: Autologous ... ...

Abstract	Autologous chondrocytes
Language	English
Publishing date	2020-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2835333-X
ISSN	2352-3204 ; 2352-3204
ISSN (online)	2352-3204
ISSN	2352-3204
DOI	10.1016/j.reth.2020.03.006
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Article ; Online: Enterocolic granulomatous phlebitis associated with epidermal growth factor-containing fibulin-like extracellular matrix protein 1 deposition and focal amyloid properties: A case report.

Ichimata, Shojiro / Aikawa, Akane / Sugishita, Naonori / Katoh, Nagaaki / Kametani, Fuyuki / Tagawa, Hibiki / Handa, Yusuke / Yazaki, Masahide / Sekijima, Yoshiki / Ehara, Takashi / Nishida, Naoki / Ishizawa, Shin

Pathology international

2024 Volume 74, Issue 3, Page(s) 146–153

Abstract: A woman in her 60s with rheumatoid arthritis was admitted with fever and abdominal pain. Laparoscopic examination with the differential diagnosis of peritoneal neoplasm and infection revealed granulomatous phlebitis in the resected greater omentum. ... ...

Abstract	A woman in her 60s with rheumatoid arthritis was admitted with fever and abdominal pain. Laparoscopic examination with the differential diagnosis of peritoneal neoplasm and infection revealed granulomatous phlebitis in the resected greater omentum. Amorphous eosinophilic deposits observed in the resected tissue exhibited focal, weak positivity for Congo red but were strongly positive for thioflavin S, confirming their focal amyloid properties. Marked degeneration of elastic fibers was also evident. Electron microscopy revealed deposits around the affected elastic fibers. Immunohistochemistry revealed the deposition of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) along with T-cell-predominant lymphocytic inflammation. The definitive diagnosis was granulomatous enterocolic lymphocytic phlebitis (ELP) associated with EFEMP1 deposition exhibiting focal amyloid properties (EFEMP1/AEFEMP1), supported by proteomics analysis. This type of vasculitis is similar to amyloid-β-related angiitis of the central nervous system. Thus, we speculate that granulomatous ELP also results from an immune response that recognizes EFEMP1/AEFEMP1 deposits as foreign material and attempts to remove them. Confirmation of EFEMP1/AEFEMP1 deposition with Congo red staining is challenging, particularly in the presence of inflammation, and warrants comprehensive evaluation.
MeSH term(s)	Humans ; Female ; Epidermal Growth Factor ; Congo Red ; Phlebitis ; Inflammation ; Extracellular Matrix Proteins/metabolism ; Calcium-Binding Proteins
Chemical Substances	Epidermal Growth Factor (62229-50-9) ; fibulin ; Congo Red (3U05FHG59S) ; Extracellular Matrix Proteins ; EFEMP1 protein, human ; Calcium-Binding Proteins
Language	English
Publishing date	2024-01-19
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13405
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Article ; Online: Unicompartmental Knee Arthroplasty for Severe Osteoarthritis and Pseudarthrosis in a Patient with Neurofibromatosis.

Balaji, Ayush / Toga, Akira / Kano, Jun / Fujimaru, Atsuki / Matsumoto, Taisuke / Katoh, Shojiro

Orthopedic research and reviews

2021 Volume 13, Page(s) 63–71

Abstract: We describe the case of a 76-year-old Asian female patient who presented with severe pain and a valgus deformity of the right knee. Her past medical history included neurofibromatosis, which resulted in a severe anterior slope of the right knee, limb ... ...

Abstract	We describe the case of a 76-year-old Asian female patient who presented with severe pain and a valgus deformity of the right knee. Her past medical history included neurofibromatosis, which resulted in a severe anterior slope of the right knee, limb shortening, and congenital pseudarthrosis. She was diagnosed with severe anterolateral osteoarthritis and eburnation of the right knee that was treated surgically with a lateral unicompartmental knee arthroplasty (UKA). Bone and cartilage fragments were removed from the joint space and a UKA implant (Zimmer
Language	English
Publishing date	2021-05-14
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2520718-0
ISSN	1179-1462 ; 1179-1462
ISSN (online)	1179-1462
ISSN	1179-1462
DOI	10.2147/ORR.S304651
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Article: Enhanced miRNA-140 expression of osteoarthritis-affected human chondrocytes cultured in a polymer based three-dimensional (3D) matrix

Katoh, Shojiro / Yoshioka, Hiroshi / Senthilkumar, Rajappa / Preethy, Senthilkumar / Abraham, Samuel J.K

Life sciences. 2021 Aug. 01, v. 278

2021

Abstract: We have evaluated the potential of a three-dimensional (3D) thermoreversible gelation polymer (TGP) matrix in enhancing miRNA 140 expression (a biomarker correlating with homeostasis and cartilage regeneration) during the in vitro expansion of ... ...

Abstract	We have evaluated the potential of a three-dimensional (3D) thermoreversible gelation polymer (TGP) matrix in enhancing miRNA 140 expression (a biomarker correlating with homeostasis and cartilage regeneration) during the in vitro expansion of osteoarthritis (OA)-affected human chondrocytes.OA-chondrocytes were cultured in two-dimensional (2D) monolayer followed by culture in 3D-TGP. miRNA 140 expression levels in cell culture supernatant followed by expression in the cell lysate of both 2D and 3D-TGP cultures were analyzed.The expression of miRNA 140 in cell culture supernatant from the 3D-TGP group was 0.001 to 0.002% that in 2D culture supernatant while in the cell lysate, miRNA 140 expression in the 3D-TGP was nearly 30-fold higher than that of 2D group.The 3D-TGP matrix allows enhanced expression of miRNA 140 in OA-affected human chondrocytes in vitro which after necessary validations can be applied in clinical transplantation to significantly improve the outcome.
Keywords	biomarkers ; cartilage ; cell culture ; chondrocytes ; gelation ; homeostasis ; humans ; microRNA ; osteoarthritis ; polymers
Language	English
Dates of publication	2021-0801
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119553
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Engraftment and Proliferation of Thermoreversible-Gelation-Polymer-Encapsulated Human Corneal Limbal-Stem-Cells on Ocular Surface of a Cadaver Cornea.

Senthilkumar, Rajappa / Yoshioka, Hiroshi / Katoh, Shojiro / Iwasaki, Masaru / Surya Prakash, Vaddi / Balamurugan, Madasamy / Dedeepiya, Vidyasagar Devaprasad / Preethy, Senthilkumar / Abraham, Samuel J K

Current eye research

2023 Volume 48, Issue 6, Page(s) 564–572

Abstract: Purpose: Corneal limbal stem cell (LSC) transplantation has been reported as a potential approach to treat the damaged corneal epithelium. Scaffolds such as human amniotic membrane (hAM) are commonly employed for the : Methods: Sixteen discarded ... ...

Abstract	Purpose: Corneal limbal stem cell (LSC) transplantation has been reported as a potential approach to treat the damaged corneal epithelium. Scaffolds such as human amniotic membrane (hAM) are commonly employed for the Methods: Sixteen discarded human corneas were used to isolate the corneal epithelium which was cultured in TGP and hAM. The cell proliferation and characteristics between TGP and hAM culture methods were evaluated by microscopic observation, 3H Thymidine incorporation assay, immunoperoxidase and immunofluorescence staining. Results: The 3H Thymidine assay's results showed that TGP allowed human-donor cornea-derived LSCs to proliferate well Conclusion: TGP is found to be a multipurpose scaffold for (i)
MeSH term(s)	Humans ; Cornea ; Epithelium, Corneal/metabolism ; Cells, Cultured ; Corneal Transplantation ; Cell Proliferation ; Limbus Corneae
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2023.2180039
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