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Article ; Online: Middle East Respiratory Syndrome coronavirus vaccine development: updating clinical studies using platform technologies.

Choi, Jung-Ah / Kim, Jae-Ouk

2022 Volume 60, Issue 3, Page(s) 238–246

Abstract: Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility ... ...

Abstract	Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility outbreaks have continued to occur since its first identification in 2012. The World Health Organization has declared MERS-CoV a priority pathogen for worldwide research and vaccine development due to its epidemic potential and the insufficient countermeasures available. The Coalition for Epidemic Preparedness Innovations is supporting vaccine development against emerging diseases, including MERS-CoV, based on platform technologies using DNA, mRNA, viral vector, and protein subunit vaccines. In this paper, we review the usefulness and structure of a spike glycoprotein as a MERS-CoV vaccine candidate molecule, and provide an update on the status of MERS-CoV vaccine development. Vaccine candidates based on both DNA and viral vectors coding MERS-CoV spike gene have completed early phase clinical trials. A harmonized approach is required to assess the immunogenicity of various candidate vaccine platforms. Platform technologies accelerated COVID-19 vaccine development and can also be applied to developing vaccines against other emerging viral diseases.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; COVID-19 Vaccines ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Viral Vaccines/genetics
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-01-28
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-022-1547-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Predicting Maximum Oxygen Uptake from Non-Exercise and Submaximal Exercise Tests in Paraplegic Men with Spinal Cord Injury.

Lee, Bum-Suk / Bae, Jae-Hyuk / Choi, Yu-Jin / Lee, Jung-Ah

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 5

Abstract: This study aimed to develop prediction equations for maximum oxygen uptake ( ... ...

Abstract	This study aimed to develop prediction equations for maximum oxygen uptake (VO
Language	English
Publishing date	2023-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11050763
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Article ; Online: High-Resolution Finger MRI: What Should You Look for in Trauma of the Fingers?

Lee, Kyoung Yeon / Rim, Jiwon / Choi, Jung-Ah / Khil, Eun Kyung

Journal of the Korean Society of Radiology

2023 Volume 84, Issue 5, Page(s) 1031–1046

Abstract: The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high ... ...

Abstract	The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high resolution of 3T MRI with dedicated surface coils allows for optimal assessment of the intricate soft tissue structures of the fingers. There have been several reports on detailed MRI features of the basic anatomy and common pathological findings of the finger and hand. Understanding the normal anatomy and familiarization with common traumatic lesions of the ligaments, tendons, and pulleys of the fingers on high-resolution MRI will allow radiologists to perform accurate preoperative evaluations of traumatic hand lesions. The purpose of this study is to review the normal hand anatomy and common traumatic lesions of the finger on high-resolution MRI and correlate them with surgical findings.
Language	English
Publishing date	2023-09-25
Publishing country	Korea (South)
Document type	Journal Article ; Review
ISSN	2951-0805
ISSN (online)	2951-0805
DOI	10.3348/jksr.2022.0123
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Article: Middle East Respiratory Syndrome coronavirus vaccine development: updating clinical studies using platform technologies

Choi, Jung-ah / Kim, Jae-Ouk

journal of microbiology. 2022 Mar., v. 60, no. 3

2022

Abstract	Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility outbreaks have continued to occur since its first identification in 2012. The World Health Organization has declared MERS-CoV a priority pathogen for worldwide research and vaccine development due to its epidemic potential and the insufficient countermeasures available. The Coalition for Epidemic Preparedness Innovations is supporting vaccine development against emerging diseases, including MERS-CoV, based on platform technologies using DNA, mRNA, viral vector, and protein subunit vaccines. In this paper, we review the usefulness and structure of a spike glycoprotein as a MERS-CoV vaccine candidate molecule, and provide an update on the status of MERS-CoV vaccine development. Vaccine candidates based on both DNA and viral vectors coding MERS-CoV spike gene have completed early phase clinical trials. A harmonized approach is required to assess the immunogenicity of various candidate vaccine platforms. Platform technologies accelerated COVID-19 vaccine development and can also be applied to developing vaccines against other emerging viral diseases.
Keywords	COVID-19 infection ; DNA ; Middle East respiratory syndrome coronavirus ; World Health Organization ; genes ; glycoproteins ; health services ; immunogenicity ; mortality ; pathogens ; protein subunits ; respiratory tract diseases ; vaccine development ; viruses
Language	English
Dates of publication	2022-03
Size	p. 238-246.
Publishing place	The Microbiological Society of Korea
Document type	Article
Note	Review
ZDB-ID	2012399-1
ISSN	1225-8873
ISSN	1225-8873
DOI	10.1007/s12275-022-1547-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The new HLA-DQA1*03:50Q allele discovered by next-generation sequencing in a Korean family.

Choi, Sooin / Bang, Hae In / Chae, Soobin / Young, Im Hwa / Kim, Jung-Ah

HLA

2023 Volume 102, Issue 6, Page(s) 770–772

Abstract: DQA1*03:50Q differs from DQA1*03:02:01:01 by a three-nucleotide insertion at gDNA position 3968 in exon 2. ...

Abstract	DQA103:50Q differs from DQA103:02:01:01 by a three-nucleotide insertion at gDNA position 3968 in exon 2.
MeSH term(s)	Humans ; Alleles ; Sequence Analysis, DNA ; HLA-DQ alpha-Chains/genetics ; High-Throughput Nucleotide Sequencing ; Republic of Korea
Chemical Substances	HLA-DQA1 antigen ; HLA-DQ alpha-Chains
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15210
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Article ; Online: High-Resolution Finger MRI

Kyoung Yeon Lee / Jiwon Rim / Jung-Ah Choi / Eun Kyung Khil

Journal of the Korean Society of Radiology, Vol 84, Iss 5, Pp 1031-

What Should You Look for in Trauma of the Fingers?

2023 Volume 1046

Abstract	The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high resolution of 3T MRI with dedicated surface coils allows for optimal assessment of the intricate soft tissue structures of the fingers. There have been several reports on detailed MRI features of the basic anatomy and common pathological findings of the finger and hand. Understanding the normal anatomy and familiarization with common traumatic lesions of the ligaments, tendons, and pulleys of the fingers on high-resolution MRI will allow radiologists to perform accurate preoperative evaluations of traumatic hand lesions. The purpose of this study is to review the normal hand anatomy and common traumatic lesions of the finger on high-resolution MRI and correlate them with surgical findings.
Keywords	fingers ; anatomy ; finger injuries ; diagnostic imaging ; magnetic resonance imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	The Korean Society of Radiology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predicting Maximum Oxygen Uptake from Non-Exercise and Submaximal Exercise Tests in Paraplegic Men with Spinal Cord Injury

Bum-Suk Lee / Jae-Hyuk Bae / Yu-Jin Choi / Jung-Ah Lee

Healthcare, Vol 11, Iss 763, p

2023 Volume 763

Abstract: This study aimed to develop prediction equations for maximum oxygen uptake (VO 2 max) based on non-exercise (anthropometric) and submaximal exercise (anthropometric and physiological) variables in paraplegic men with a spinal cord injury. All ... ...

Abstract	This study aimed to develop prediction equations for maximum oxygen uptake (VO 2 max) based on non-exercise (anthropometric) and submaximal exercise (anthropometric and physiological) variables in paraplegic men with a spinal cord injury. All participants were tested on an arm ergometer using a maximal graded exercise test. Anthropometric variables such as age, height, weight, body fat, body mass index, body fat percentage, and arm muscle mass and physiological variables such as VO 2 , VCO 2 , and heart rate at 3 and 6 min of graded exercise tests were included in the multiple linear regression analysis. The prediction equations revealed the following. Regarding non-exercise variables, VO 2 max was correlated with age and weight (equation R = 0.771, R 2 = 0.595, SEE= 3.187). Regarding submaximal variables, VO 2 max was correlated with weight and VO 2 and VCO 2 at 6 min (equation R = 0.892, R 2 = 0.796, SEE = 2.309). In conclusion, our prediction equations can be used as a cardiopulmonary function evaluation tool to estimate VO 2 max simply and conveniently using the anthropometric and physiological characteristics of paraplegic men with spinal cord injuries.
Keywords	maximum oxygen uptake ; prediction equation ; non-exercise test ; submaximal test ; spinal cord injury ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Utility of Preoperative Shear-Wave Elastography of the Supraspinatus Muscle for Predicting Successful Rotator Cuff Repair: A Prospective Observational Study With MRI Correlation.

Jeong, Jeung Yeol / Khil, Eun Kyung / Kim, A Yeon / Lee, Seun Ah / Choi, Jung-Ah

AJR. American journal of roentgenology

2022 Volume 218, Issue 6, Page(s) 1051–1060

Abstract: BACKGROUND. ...

Abstract	BACKGROUND.
MeSH term(s)	Aged ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscular Atrophy ; Prospective Studies ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/pathology ; Rotator Cuff/surgery ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/pathology ; Rotator Cuff Injuries/surgery ; Rupture/pathology
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.21.27129
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Article ; Online: Novel MRI signs of ruptured disc in the cervical spine with intraoperative comparisons.

Khil, Eun Kyung / Choi, Il / Lee, Seun Ah / Seo, Woorim / Choi, Jung-Ah

European radiology

2022 Volume 33, Issue 2, Page(s) 1475–1485

Abstract: Objectives: To evaluate the diagnostic performance of two novel MRI signs for extruded disc (ED) and uncontained ED (ruptured disc, RD) in the cervical spine using intraoperative findings as reference.: Methods: This retrospective study included ... ...

Abstract	Objectives: To evaluate the diagnostic performance of two novel MRI signs for extruded disc (ED) and uncontained ED (ruptured disc, RD) in the cervical spine using intraoperative findings as reference. Methods: This retrospective study included patients who underwent cervical spine MRI and surgery for disc pathology with intraoperative confirmation of RD from September 1, 2016, to January 31, 2021. Two radiologists determined whether the disc was extruded or ruptured with and without the aid of two novel MRI signs suggesting RD (sign 1: blurred margin of the disc; sign 2: mushroom-shaped disc). The diagnostic performance was analyzed using surgical findings as reference. Intra- and interobserver agreements were measured for each MRI sign. Results: A total of 91 patients totaling 131 discs were enrolled (mean age: 56.02 ± 12.93; range: 26-88; 62 men and 29 women), of whom 62 were surgically confirmed with RD. When the diagnosis was based exclusively on existing ED definitions, ED was diagnosed with 62.9-79.0% sensitivity and 80.2% accuracy, whereas RD was diagnosed with 35.5-45.2% sensitivity and 67.9-71.0% accuracy. However, when the two novel MRI signs were used as an aid in the diagnosis, ED was diagnosed with 95.2-96.8% sensitivity and 84.0-88.5% accuracy, while RD was diagnosed with 95.2-96.8% sensitivity and 84.0-89.3% accuracy. Intra- and interobserver agreement was substantial (k = 00.77-0.86, 0.69-0.79, respectively, p < 0.001). Conclusions: The detection of two novel MRI signs on preoperative MRI can lead to a more accurate RD diagnosis. Key points: • The diagnostic sensitivity of MRI for cervical ruptured disc is very low (about 35-45 %) using the standardized definition of lumbar disc nomenclature. • Two novel MRI signs can lead to a more accurate diagnosis of the surgically confirmed ruptured disc in the cervical spine. • These two novel MRI signs showed substantial intra-and interobserver reliabilities.
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Lumbosacral Region ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Cervical Vertebrae/pathology ; Magnetic Resonance Imaging ; Neck/pathology ; Intervertebral Disc Displacement ; Intervertebral Disc/pathology
Language	English
Publishing date	2022-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-022-09124-4
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Article ; Online: Analysis of clinical factors and ultrasound features associated with COVID-19 vaccine-related axillary lymphadenopathy: A large group study.

Lim, Jihe / Khil, Eun Kyung / Lee, Seun Ah / Choi, Jung-Ah / Lee, Kyoung Yeon / Jo, Sang Won / Lee, Janghee

Clinical imaging

2023 Volume 105, Page(s) 110046

Abstract: Purpose: To investigate factors that distinguish COVID-19 vaccine-related axillary lymphadenopathy from malignancy or other etiologies.: Methods: From June 2021 to April 2022, 3859 consecutive female patients had breast and axillary ultrasound (US) ... ...

Abstract	Purpose: To investigate factors that distinguish COVID-19 vaccine-related axillary lymphadenopathy from malignancy or other etiologies. Methods: From June 2021 to April 2022, 3859 consecutive female patients had breast and axillary ultrasound (US) at our institution. After exclusions, 592 patients were included in the study. We retrospectively reviewed clinical history and US features of enlarged axillary lymph nodes. Assessed clinical factors included age, vaccination type, dose and vaccination date, and ultrasound features included cortical thickness, shape, marginal irregularity, focal cortical thickening, fatty hilum, and number and anatomic location of enlarged lymph nodes. The seven US features were used to score the severity of lymphadenopathy. Binary logistic models and independent two-sample t-tests were used for statistical analysis. Results: Among 592 patients (mean age 49.3 ± 10.3 years), 406(68.6%), 90(15.2%), 42(7.1), 4(0.7%) and 50(8.4%) patients received Pfizer, AstraZeneca, Moderna, Janssen and cross inoculation of more than one type, respectively. 185(31.3%), 376(63.5%) and 31(5.2%) patients received a first, second and third dose, respectively. The interval between vaccination and US was 30.9 ± 21.5 days. US showed axillary lymphadenopathy (LAP) in 113 patients (19.1%). Clinical factors associated with LAP were age younger than 50 years, mRNA vaccine, first dose and shorter interval(P < 0.05). US features associated with LAP were mean cortical thickness of 4.6 ± 1.63 mm, oval shape (70.8%), smooth margin (53.1%), focal cortical thickening (62.8%) and preserved fatty hilum (84.1%). Using our scoring method, the mean overall score for vaccine-related LAP was 2.45 ± 1.51 points. Conclusion: Awareness of influencing factors and sonographic features can help differentiate COVID-19 vaccine-related adenopathy from other etiologies.
MeSH term(s)	Adult ; Female ; Humans ; Middle Aged ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Lymphadenopathy/chemically induced ; Lymphadenopathy/diagnostic imaging ; Lymphatic Metastasis ; Retrospective Studies
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2023.110046
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