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Article: XRCT images reveal climate control on wound recovery after intense flood in Mediterranean riparian trees

Ballesteros-Cánovas, Juan Antonio / Madrigal-González, Jaime / Albert, Carolina Guardiola / González, Carina / Stoffel, Markus

Trees. 2022 Oct., v. 36, no. 5

2022

Abstract: KEY MESSAGE: In the Mediterranean region, the recovery of riparian trees after wounds can be jeopardized under drier climate condition and cooccurrence of extreme flood events. Climate change could impair riparian vegetation dynamics through more intense ...

Abstract	KEY MESSAGE: In the Mediterranean region, the recovery of riparian trees after wounds can be jeopardized under drier climate condition and cooccurrence of extreme flood events. Climate change could impair riparian vegetation dynamics through more intense and frequent climatic extreme events such as flash flooding. However, it is still poorly known how climate warming can also impair vegetation recovery through control on cellular traits after such extreme events. Here, we analyze how Mediterranean riparian tree species (namely Alnus glutinosa, Fraxinus angustifolia, and Salix atrocinerea) recover after wounds caused by intense floods using 239 X-ray computed tomography (XRCT) images taken on 30 trees. The XRCT imagery allowed to characterize wounds-related macroscopic parameters in different sections along the stems in three dimensions. Then, we quantified the annual wound closure rates by dating dendrochronologically each wound and measuring the annual overgrowth on the wounded area. Finally, we used linear mixed models to investigate how wound closure rates are affected by climate conditions. Our results show that wound closure varies between species. A. glutinosa and F. angustifolia presented higher wound recovery rates than S. atrocinerea. However, the statistical analyses suggest that F. angustifolia and S. atrocinerea tend to recover much less(more) during drier(wetter) years than A. glutinosa. Our results suggest that A. glutinosa could be more stressed under climate change in the Mediterranean region, where the cooccurrence of drier conditions with extreme flood events may increase.
Keywords	Alnus glutinosa ; Fraxinus angustifolia ; Salix atrocinerea ; X-radiation ; climate change ; climatic factors ; riparian vegetation ; tomography ; trees ; Mediterranean region
Language	English
Dates of publication	2022-10
Size	p. 1529-1538.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	90595-1
ISSN	1432-2285 ; 0931-1890
ISSN (online)	1432-2285
ISSN	0931-1890
DOI	10.1007/s00468-022-02310-3
Database	NAL-Catalogue (AGRICOLA)

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Article: Remission of type 2 diabetes: A critical appraisal.

Ricci, Michele / Mancebo-Sevilla, Juan José / Cobos Palacios, Lidia / Sanz-Cánovas, Jaime / López-Sampalo, Almudena / Hernández-Negrin, Halbert / Pérez-Velasco, Miguel Angel / Pérez-Belmonte, Luis M / Bernal-López, Maria Rosa / Gómez-Huelgas, Ricardo

Frontiers in endocrinology

2023 Volume 14, Page(s) 1125961

MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/therapy ; Hypoglycemic Agents ; Insulin
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1125961
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Article ; Online: Adverse outcomes in patients with heart failure admitted for COVID‑19 in association with the use of renin-angiotensin‑aldosterone system inhibitors.

Pérez-Belmonte, Luis M / Sanz-Cánovas, Jaime / Salinas, Alejandro / Garcia-Klepzig, Jose Luis / Méndez-Bailón, Manuel / Gómez-Huelgas, Ricardo

Polish archives of internal medicine

2021 Volume 132, Issue 1

MeSH term(s)	Angiotensin Receptor Antagonists/adverse effects ; COVID-19 ; Heart Failure/drug therapy ; Humans ; Renin-Angiotensin System ; SARS-CoV-2
Chemical Substances	Angiotensin Receptor Antagonists
Language	English
Publishing date	2021-10-22
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16126
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Article: COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia.

López-Sampalo, Almudena / Cobos-Palacios, Lidia / Vilches-Pérez, Alberto / Sanz-Cánovas, Jaime / Vargas-Candela, Antonio / Mancebo-Sevilla, Juan José / Hernández-Negrín, Halbert / Gómez-Huelgas, Ricardo / Bernal-López, María Rosa

Biomedicines

2023 Volume 11, Issue 3

Abstract: 1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle ... ...

Abstract	(1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3) the relationship between muscle strength with symptomatic and functional evolution in older patients affected by/recovered from COVID-19; (2) Methods: A prospective, longitudinal study of patients aged ≥65 years who had suffered from COVID-19 infection between 1 March and 31 May 2020, as confirmed by PCR or subsequent seroconversion. Persistent symptoms, as well as anthropometric, clinical, and analytical characteristics, were analyzed at 3 and 12 months after infection. The degree of sarcopenia was determined by dynamometry and with SARC-F; (3) Results: 106 participants, aged 76.8 ± 7 years, were included. At 3 months postinfection, a high percentage of sarcopenic patients was found, especially among women and in those with hospitalization. At 12 months postinfection, this percentage had decreased, coinciding with a functional and symptomatic recovery, and the normalization of inflammatory parameters, especially interleukin-6 (4.7 ± 11.6 pg/mL vs. 1.5 ± 2.4 pg/mL,
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030733
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Article ; Online: Corticosteroid therapy in patients with heart failure hospitalized for COVID-19: a multicenter retrospective study.

Pérez-Belmonte, Luis M / Sanz-Cánovas, Jaime / Salinas, Alejandro / Fornie, Iñigo Sagastagoitia / Méndez-Bailón, Manuel / Gómez-Huelgas, Ricardo

Internal and emergency medicine

2021 Volume 16, Issue 8, Page(s) 2301–2305

MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Aged ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/mortality ; Critical Care/methods ; Female ; Heart Failure/complications ; Heart Failure/drug therapy ; Heart Failure/mortality ; Hospital Mortality ; Humans ; Hydroxychloroquine/therapeutic use ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Adrenal Cortex Hormones ; Hydroxychloroquine (4QWG6N8QKH)
Language	English
Publishing date	2021-10-12
Publishing country	Italy
Document type	Letter ; Multicenter Study
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-021-02843-4
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Article: Statins and Peripheral Arterial Disease: A Narrative Review.

Jansen-Chaparro, Sergio / López-Carmona, María D / Cobos-Palacios, Lidia / Sanz-Cánovas, Jaime / Bernal-López, M Rosa / Gómez-Huelgas, Ricardo

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 777016

Abstract: Peripheral arterial disease (PAD) is a highly prevalent atherosclerotic condition. In patients with PAD, the presence of intermittent claudication leads to a deterioration in quality of life. In addition, even in asymptomatic cases, patients with PAD are ...

Abstract	Peripheral arterial disease (PAD) is a highly prevalent atherosclerotic condition. In patients with PAD, the presence of intermittent claudication leads to a deterioration in quality of life. In addition, even in asymptomatic cases, patients with PAD are at high risk of cardiac or cerebrovascular events. Treatment of PAD is based on lifestyle modifications; regular exercise; smoking cessation; and control of cardiovascular risk factors, including hypercholesterolemia. A growing number of studies have shown that statins reduce cardiovascular risk and improve symptoms associated with PAD. Current guidelines recommend the use of statins in all patients with PAD in order to decrease cardiovascular events and mortality. However, the prescribing of statins in patients with PAD is lower than in those with coronary heart disease. This review provides relevant information from the literature that supports the use of statins in patients with PAD and shows their potential benefit in decreasing lower limb complications as well as cardiovascular morbidity and mortality.
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.777016
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Article ; Online: Functional neurological disorders after COVID-19 and SARS-CoV-2 vaccines: a national multicentre observational study.

Alonso-Canovas, Araceli / Kurtis, Monica M / Gomez-Mayordomo, Victor / Macías-García, Daniel / Gutiérrez Viedma, Álvaro / Mondragón Rezola, Elisabet / Pagonabarraga, Javier / Aranzabal Orgaz, Lidia / Masjuan, Jaime / Martinez-Castrillo, Juan Carlos / Pareés, Isabel

Journal of neurology, neurosurgery, and psychiatry

2023 Volume 94, Issue 9, Page(s) 776–777

MeSH term(s)	Humans ; Conversion Disorder ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Letter
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2022-330885
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Article ; Online: Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors for cardiovascular and renal protection: A treatment approach far beyond their glucose-lowering effect.

Gómez-Huelgas, Ricardo / Sanz-Cánovas, Jaime / Cobos-Palacios, Lidia / López-Sampalo, Almudena / Pérez-Belmonte, Luis M

European journal of internal medicine

2021 Volume 96, Page(s) 26–33

Abstract: Findings from cardiovascular outcome trials on certain newer glucose-lowering drugs have shown clear cardiovascular and renal benefits. In this review, we provide an updated overview of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose ...

Abstract	Findings from cardiovascular outcome trials on certain newer glucose-lowering drugs have shown clear cardiovascular and renal benefits. In this review, we provide an updated overview of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter 2 (SGLT-2) inhibitors in terms of cardiovascular and renal protection. Both drugs have been described as diabetes/disease-modifying drugs. There is robust evidence on the benefits of GLP-1 receptor agonists in renal disease and atherosclerotic cardiovascular disease-especially in stroke-which are mainly explained by their antiproteinuric effect. However, this class of drugs has only shown neutral effects on heart failure and further studies are necessary in order to assess their role in this disease. SGLT-2 inhibitors have shown strong benefits in heart failure hospitalizations and renal outcomes, mainly through limiting glomerular filtration rate deterioration, regardless of the presence of diabetes. Nonetheless, their effect on the prevention of major adverse atherosclerotic cardiovascular events and cardiovascular mortality seems to be limited to patients with type 2 diabetes and established cardiovascular disease. Evidence on the cardiovascular and renal benefits of GLP-1 receptor agonists and SGLT-2 inhibitors have significantly modified management plans and treatment choices for patients with type 2 diabetes. There is now a focus on a multifactorial approach that goes beyond the glucose-lowering effect of these drugs, which are the preferred choice in routine clinical practice. According to the current evidence, a patient-focused approach that includes both individualized glycemic control and cardiorenal prevention using GLP-1 receptor agonists and SGLT-2 inhibitors with proven cardiovascular and renal benefits is believed to be the best strategy for achieving the treatment goals of patients with type 2 diabetes. Despite the strong cardiovascular and renal benefits of these drugs, further research is required in order to clarify questions that remain unanswered.
MeSH term(s)	Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hypoglycemic Agents/therapeutic use ; Kidney/drug effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2021-11-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2021.11.008
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Article ; Online: Corticodependent and recurrent inflammatory pseudo tumor. Analysis of cases and review.

Sanz-Cánovas, Jaime / Lendínez-Sánchez, Gonzalo / Prieto-Sánchez, Elisa / Vicioso-Recio, Luis / Gutiérrez-Cardo, Antonio / Izurrategui-Hidalgo, Esther / Palacios-Rodríguez, Sebastián / Peláez-Angulo, José Miguel / Ropero-Luis, Guillermo / Pérez-de-Pedro, Iván / Gómez-Huelgas, Ricardo / Salgado-Ordóñez, Fernando

The American journal of the medical sciences

2023 Volume 367, Issue 2, Page(s) 135–141

Abstract: Inflammatory pseudo tumor (IP) is an infrequent process with benign evolution in most cases whose etiology and pathogenesis are unknown. It usually affects young men and children, in whom the macroscopic lesion can mimic a malignant process, which is ... ...

Abstract	Inflammatory pseudo tumor (IP) is an infrequent process with benign evolution in most cases whose etiology and pathogenesis are unknown. It usually affects young men and children, in whom the macroscopic lesion can mimic a malignant process, which is ruled out after biopsy. Therefore, the diagnosis of certainty is histological and treatment consists of corticosteroids, leaving resection for cases in which biopsy is not possible or in which it produces local complications. We present a case of an inflammatory pseudo tumor with special corticodependence that began as a long-term periodic fever and splenic focal lesion that required splenectomy for its diagnosis and that, after decreasing the corticosteroid regimen, presented recurrences at the cerebellar and systemic level requiring the association of various immunosuppressants and rituximab to achieve remission. As a result of this case, we have performed an analysis of all the pseudo tumors diagnosed in adults in the hospitals of the province of Malaga, and it has been compared with that described in the bibliography.
MeSH term(s)	Adult ; Male ; Child ; Humans ; Immunosuppressive Agents ; Neoplasms ; Splenectomy ; Adrenal Cortex Hormones ; Rituximab
Chemical Substances	Immunosuppressive Agents ; Adrenal Cortex Hormones ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2023.11.010
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Article ; Online: COVID-19 in Older Patients

Almudena López-Sampalo / Lidia Cobos-Palacios / Alberto Vilches-Pérez / Jaime Sanz-Cánovas / Antonio Vargas-Candela / Juan José Mancebo-Sevilla / Halbert Hernández-Negrín / Ricardo Gómez-Huelgas / María Rosa Bernal-López

Biomedicines, Vol 11, Iss 733, p

Assessment of Post-COVID-19 Sarcopenia

2023 Volume 733

Abstract	(1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3) the relationship between muscle strength with symptomatic and functional evolution in older patients affected by/recovered from COVID-19; (2) Methods: A prospective, longitudinal study of patients aged ≥65 years who had suffered from COVID-19 infection between 1 March and 31 May 2020, as confirmed by PCR or subsequent seroconversion. Persistent symptoms, as well as anthropometric, clinical, and analytical characteristics, were analyzed at 3 and 12 months after infection. The degree of sarcopenia was determined by dynamometry and with SARC-F; (3) Results: 106 participants, aged 76.8 ± 7 years, were included. At 3 months postinfection, a high percentage of sarcopenic patients was found, especially among women and in those with hospitalization. At 12 months postinfection, this percentage had decreased, coinciding with a functional and symptomatic recovery, and the normalization of inflammatory parameters, especially interleukin-6 (4.7 ± 11.6 pg/mL vs. 1.5 ± 2.4 pg/mL, p < 0.05). The improvement in muscle strength was accompanied by significant weight gain (71.9 ± 12.1 kg vs. 74.7 ± 12.7 kg, p < 0.001), but not by an increase in lean mass (49.6 ± 10 vs. 49.9 ± 10, p 0.29); (4) Conclusions: Older COVID-19 survivors presented a functional, clinical, and muscular recovery 12 months postinfection. Even so, it is necessary to carry out comprehensive follow-ups and assessments that include aspects of nutrition and physical activity.
Keywords	COVID-19 ; sarcopenia ; muscle strength ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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