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  1. Article ; Online: Protective effect of breastfeeding on Kawasaki disease: A systemic review and meta-analysis.

    Yang, Wan-Jung / Lu, Wen-Hsien / Hsiao, Yu-Yang / Hsu, Tien-Wei / Chiou, Yee-Hsuan

    Pediatrics and neonatology

    2024  

    Abstract: Background: Previous research has indicated a negative correlation between exclusive breastfeeding and the incidence of Kawasaki disease (KD). However, the validation of this discovery through meta-analytical studies has been lacking. Furthermore, ... ...

    Abstract Background: Previous research has indicated a negative correlation between exclusive breastfeeding and the incidence of Kawasaki disease (KD). However, the validation of this discovery through meta-analytical studies has been lacking. Furthermore, uncertainties persist regarding whether breastfeeding reduces the risk of coronary artery lesions (CAL) or resistance to intravenous immunoglobulin (IVIG).
    Methods: A systematic exploration of the MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, and ClinicalTrials.gov databases was conducted to identify longitudinal or randomized controlled trials investigating the efficacy of breastfeeding in preventing KD. The primary focus was on the incidence of KD, with secondary emphasis placed on the incidence of CAL and IVIG resistance. Data were pooled using a frequentist-restricted maximum-likelihood random-effects model.
    Results: Of the 179 potentially eligible studies identified, five (n = 1,982,634) were included. The analysis revealed a significantly lower risk of KD (expressed as odds ratio, with 95% confidence intervals and p-values) in comparisons between exclusive breastfeeding and formula feeding (0.62, 0.43-0.91, p = 0.014), exclusive breastfeeding/partial breastfeeding and formula feeding (0.66, 0.46- 0.96, p = 0.03), and exclusive breastfeeding and partial breastfeeding/formula feeding (0.81, 0.74- 0.90, p < 0.01). However, no significant difference was observed in the risk of developing KD when comparing partial breastfeeding to formula feeding exclusively. Regarding secondary outcomes, no statistically significant difference was found in the risk of CAL or IVIG resistance across any comparison formats.
    Conclusions: Our study suggests that breastfeeding correlated with a reduced risk of KD but not with a reduced risk of CAL or IVIG resistance. These findings advocate for the implementation of breastfeeding policies in clinical practice.
    Language English
    Publishing date 2024-04-15
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Multiple hepatocellular carcinomas: liver resection or transcatheter arterial chemoembolization?

    Lei, Yin / Yee, Lau Wan / Zhou, Wei-Ping

    Hepatobiliary surgery and nutrition

    2019  Volume 8, Issue 5, Page(s) 519–521

    Language English
    Publishing date 2019-09-30
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2019.05.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-Throughput Microfluidic Extraction of Platelet-free Plasma for MicroRNA and Extracellular Vesicle Analysis.

    Leong, Sheng Yuan / Lok, Wan Wei / Goh, Kah Yee / Ong, Hong Boon / Tay, Hui Min / Su, Chengxun / Kong, Fang / Upadya, Megha / Wang, Wei / Radnaa, Enkhtuya / Menon, Ramkumar / Dao, Ming / Dalan, Rinkoo / Suresh, Subra / Lim, Darren Wan-Teck / Hou, Han Wei

    ACS nano

    2024  Volume 18, Issue 8, Page(s) 6623–6637

    Abstract: Cell-free RNAs and extracellular vesicles (EVs) are valuable biomarkers in liquid biopsies, but they are prone to preanalytical variabilities such as nonstandardized centrifugation ... ...

    Abstract Cell-free RNAs and extracellular vesicles (EVs) are valuable biomarkers in liquid biopsies, but they are prone to preanalytical variabilities such as nonstandardized centrifugation or
    MeSH term(s) Humans ; MicroRNAs/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Microfluidics ; Lung Neoplasms/metabolism ; Extracellular Vesicles/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c12862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: On-treatment isolated superior ophthalmic vein thrombosis complicated with carotid cavernous fistula: a case report.

    Lo, Yee Lin / Ong, Kah Wei / Cheng, Teck Chee / Wan Abdul Halim, Wan Haslina / Yong, Meng Hsien

    International journal of ophthalmology

    2022  Volume 15, Issue 10, Page(s) 1726–1728

    Language English
    Publishing date 2022-10-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2022.10.26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cross-reaction of Sera from COVID-19 Patients with SARS-CoV Assays.

    Wan, Wei Yee / Lim, Siew Hoon / Seng, Eng Hong

    Annals of the Academy of Medicine, Singapore

    2020  Volume 49, Issue 7, Page(s) 523–526

    MeSH term(s) Antibodies, Viral/physiology ; Betacoronavirus/physiology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Cross Reactions/physiology ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique, Indirect ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS Virus/physiology ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country Singapore
    Document type Letter
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lipschütz ulcers in Asian children and adolescents.

    Quek, Chrystie Wan Ning / Wee, Lynette Wei Yi / Lie, Cheryl Jia Ling / Foong, Yee Wah / Koh, Mark Jean Aan

    International journal of dermatology

    2022  Volume 62, Issue 1, Page(s) e36–e37

    MeSH term(s) Female ; Child ; Adolescent ; Humans ; Ulcer ; Vulvar Diseases ; Skin Ulcer
    Language English
    Publishing date 2022-10-02
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Improved [

    Li, Lianghua / Chen, Ruohua / Wen, Jun / Yang, Xuefei / Hu, Debin / Sun, Hongyan / Ge, Qi / Ng, Yee Ling / Zhou, Yun / Wan, Liangrong / Chen, Yumei / Wei, Weijun / Liu, Jianjun

    Quantitative imaging in medicine and surgery

    2023  Volume 13, Issue 8, Page(s) 5230–5241

    Abstract: Background: Total variation regularized expectation maximization (TVREM) reconstruction algorithm on the image quality of gallium (: Methods: Images of a phantom with small hot sphere inserts and the total-body PET/CT scans of 51 prostate cancer ... ...

    Abstract Background: Total variation regularized expectation maximization (TVREM) reconstruction algorithm on the image quality of gallium (
    Methods: Images of a phantom with small hot sphere inserts and the total-body PET/CT scans of 51 prostate cancer patients undergoing [
    Results: The TVREM reconstructions groups fwith 120 second acquisition and the penalization of 0.27 to 0.45 showed the best performance in terms of CR, TBR, image noise, and the gain of SUV
    Conclusions: Our study has shown the potential of the TVREM reconstruction algorithm with optimized penalization factors to achieve comparable [
    Language English
    Publishing date 2023-07-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-22-1341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Salvage Surgery for Initially Unresectable HCC With PVTT Converted by Locoregional Treatment Plus Tyrosine Kinase Inhibitor and Anti-PD-1 Antibody.

    Wang, Lei / Feng, Jin-Kai / Lu, Chong-De / Wu, Jia-Yi / Zhou, Bin / Wang, Kang / Wei, Xu-Biao / Liang, Chao / Zhou, Hong-Kun / Shi, Jie / Guo, Wei-Xing / Lau, Wan Yee / Yan, Mao-Lin / Cheng, Shu-Qun

    The oncologist

    2024  

    Abstract: Background: This study aimed to compare the survival outcomes of patients with initially unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) who underwent or did not undergo salvage surgery followed by a triple combination ... ...

    Abstract Background: This study aimed to compare the survival outcomes of patients with initially unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) who underwent or did not undergo salvage surgery followed by a triple combination conversion treatment consisted of locoregional treatment (LRT), tyrosine kinase inhibitors (TKIs), and anti-PD-1 antibodies.
    Methods: The data from 93 consecutive patients with initially unresectable HCC and PVTT across 4 medical centers were retrospectively reviewed. They were converted successfully by the triple combination treatment and underwent or did not undergo salvage resection. The baseline characteristics, conversion schemes, conversion treatment-related adverse events (CTRAEs), overall survival (OS), and progression-free survival (PFS) of the salvage surgery and non-surgery groups were compared. Multivariate Cox regression analysis was performed to identify independent risk factors for OS and PFS. Additionally, subgroup survival analysis was conducted by stratification of degree of tumor response and type of PVTT.
    Results: Of the 93 patients, 44 underwent salvage surgery, and 49 did not undergo salvage surgery. The OS and PFS of the salvage surgery and non-surgery groups were not significantly different (P = .370 and .334, respectively). The incidence and severity of CTRAEs of the 2 groups were also comparable. Subgroup analyses revealed that for patients with complete response (CR) or types III-IV PVTT, there was a trend toward better survival in patients who did not undergo salvage surgery. Multivariate analysis showed that baseline α-fetoprotein and best tumor response per mRECIST criteria were independent prognostic factors for OS and PFS.
    Conclusions: For patients with initially unresectable HCC and PVTT who were successfully converted by the triple combination therapy, salvage liver resection may not be necessary, especially for the patients with CR or types III-IV PVTT.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyae032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Adjuvant Sorafenib Following Radiofrequency Ablation for Early-Stage Recurrent Hepatocellular Carcinoma With Microvascular Invasion at the Initial Hepatectomy.

    Wei, Meng-Chao / Zhang, Yao-Jun / Chen, Min-Shan / Chen, Yong / Lau, Wan-Yee / Peng, Zhen-Wei

    Frontiers in oncology

    2022  Volume 12, Page(s) 868429

    Abstract: Background: The efficacy of radiofrequency ablation (RFA) for patients with early-stage recurrent hepatocellular carcinoma (HCC) with microvascular invasion (MVI) at the initial hepatectomy is limited. Our study aimed to explore whether adjuvant ... ...

    Abstract Background: The efficacy of radiofrequency ablation (RFA) for patients with early-stage recurrent hepatocellular carcinoma (HCC) with microvascular invasion (MVI) at the initial hepatectomy is limited. Our study aimed to explore whether adjuvant sorafenib following RFA could improve the situation.
    Methods: We retrospectively included 211 patients with early-stage (tumor number of ≤3 and tumor size of 2-5 cm) recurrent HCC with MVI at the initial hepatectomy who underwent adjuvant sorafenib following RFA or RFA alone in 13 centers from June 2013 to June 2020. In the combination group, sorafenib of 400 mg twice daily was administered within 7 days after RFA. Overall survival (OS) and recurrence-free survival (RFS) were compared. Subgroup analysis based on MVI grade was performed. MVI grade was based on the practice guidelines for the pathological diagnosis of HCC and included M1 (≤5 MVI sites, all located within adjacent peritumoral liver tissues 0-1 cm away from the tumor margin) and M2 (>5 MVI sites, or any MVI site located within adjacent peritumoral liver tissues > 1 cm away from the tumor margin).
    Results: A total of 103 patients received the combination therapy and 108 patients received RFA alone. The combination therapy provided better survival than RFA alone (median RFS: 17.7 vs. 13.1 months,
    Conclusions: Adjuvant sorafenib following RFA was associated with better survival than RFA alone in patients with early-stage recurrent HCC with MVI at the initial hepatectomy. Moreover, MVI grade could guide the application of adjuvant sorafenib.
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.868429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Watch-and-Wait strategy vs. resection in patients with radiologic complete response after conversion therapy for initially unresectable hepatocellular carcinoma:a propensity score-matching comparative study.

    Li, Binkui / Wang, Chenwei / He, Wei / Qiu, Jiliang / Zheng, Yun / Zou, Ruhai / Lin, Zhu / Shi, Yunxing / Yuan, Yichuan / Zhang, Rong / Zhang, Chao / Chen, Minshan / Lau, Wan Yee / Yuan, Yunfei

    International journal of surgery (London, England)

    2024  

    Abstract: Background: The optimal subsequent management for patients with initially unresectable hepatocellular carcinoma (uHCC) who have achieved complete response (CR) following conversion therapy remains unclear. This study aims to evaluate the feasibility and ...

    Abstract Background: The optimal subsequent management for patients with initially unresectable hepatocellular carcinoma (uHCC) who have achieved complete response (CR) following conversion therapy remains unclear. This study aims to evaluate the feasibility and outcomes of the watch-and-wait (W-W) strategy versus surgical resection (SR) for these patients.
    Materials and methods: This retrospective study reviewed patients with initially uHCC who underwent conversion therapy employing transarterial therapies combined with or without systemic therapies. Radiologic CR (rCR), clinical CR (cCR), and pathologic CR (pCR) were evaluated. Overall survival (OS) and progression-free survival (PFS) were compared between the W-W and SR groups.
    Results: Among 1880 patients with uHCC who underwent conversion therapy, 207 (11.0%) achieved rCR. Finally, we enrolled 149 patients meeting the inclusion criteria, including 74 receiving W-W strategy and 75 undergoing SR. Among the 149 patients with rCR, the W-W group demonstrated comparable 3-year OS rates to the SR group (80.9% vs 83.1%, P=0.77), but demonstrated inferior PFS rates (14.4% vs 46.5%, P=0.002). These results remained consistent after propensity score matching. For the 57 patients who achieved cCR, the W-W group exhibited comparable 3-year OS (88.1% vs 87.9%, P=0.89) and PFS rates (27.8% vs 40.8%, P=0.34) compared to SR group. Among the 75 patients in the SR group, 31 (41.3%) achieved pCR and 44 (58.7%) reached non-pCR. When compared with patients with pCR, those who achieved rCR in the W-W group showed comparable OS but inferior PFS rates. Moreover, patients who achieved rCR in the W-W group displayed both comparable OS and PFS rates to those with non-pCR.
    Conclusion: The W-W strategy offered comparable survival outcomes to surgical resection in patients with initially uHCC who achieved rCR or cCR after conversion therapy. For these patients, the W-W strategy could be offered as an alternative treatment option.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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