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Article ; Online: Genetics in Ischemic Stroke: Current Perspectives and Future Directions.

Zhang, Ka / Loong, Shaun S E / Yuen, Linus Z H / Venketasubramanian, Narayanaswamy / Chin, Hui-Lin / Lai, Poh San / Tan, Benjamin Y Q

Journal of cardiovascular development and disease

2023 Volume 10, Issue 12

Abstract: Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke ... ...

Abstract	Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke occurrence risk, modulation of treatment response, and effectiveness of post-stroke functional recovery. This article aims to review the recent findings from genetic studies related to various clinical and molecular aspects of ischemic stroke. The potential clinical applications of these genetic insights in stratifying stroke risk, guiding personalized therapy, and identifying new therapeutic targets are discussed herein.
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10120495
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Article ; Online: Falsely elevated serum vitamin B12 levels in a case of pernicious anemia.

Thong, Edwin W S / Tan, Shaun S / Sethi, Sunil K / Chee, Yen-Lin / Jen, Wei-Ying

Annals of hematology

2021 Volume 101, Issue 4, Page(s) 889–892

MeSH term(s)	Anemia, Pernicious/complications ; Anemia, Pernicious/diagnosis ; Humans ; Vitamin B 12 ; Vitamin B 12 Deficiency/complications
Chemical Substances	Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2021-09-10
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-021-04612-x
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Article ; Online: In pursuit of academic plastic surgery training: The O'Brien experience.

Tan, Shaun S / Morrison, Wayne A

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2016 Volume 69, Issue 7, Page(s) e157–8

MeSH term(s)	Australia ; Education ; Humans ; Reconstructive Surgical Procedures/education ; Reconstructive Surgical Procedures/methods ; Surgery, Plastic/education
Language	English
Publishing date	2016-07
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2016.04.006
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Article ; Online: Mental Health and the COVID-19 Pandemic: Observational Evidence from Malaysia.

Tan, Eugenie Sin Sing / Chin, Shaun Ashley Fung Xian / Sathapan, Manimeyapan S Palaniappan / Dewi, Astrid Disimond / Amini, Farahnaz / Bustami, Normina Ahmad / Tan, Pui Yee / Ho, Yu Bin / Tan, Chung Keat

International journal of environmental research and public health

2023 Volume 20, Issue 5

Abstract: The interplay of physical, social, and economic factors during the pandemic adversely affected the mental health of healthy people and exacerbated pre-existing mental disorders. This study aimed to determine the impact of the COVID-19 pandemic on the ... ...

Abstract	The interplay of physical, social, and economic factors during the pandemic adversely affected the mental health of healthy people and exacerbated pre-existing mental disorders. This study aimed to determine the impact of the COVID-19 pandemic on the mental health of the general population in Malaysia. A cross-sectional study involving 1246 participants was conducted. A validated questionnaire consisting of the level of knowledge and practice of precautionary behaviors, the Depression, Anxiety, and Stress Scales (DASS), and the World Health Organization Quality of Life-Brief Version (WHOQOL-BREF) was used as an instrument to assess the impacts of the COVID-19 pandemic. Results revealed that most participants possessed a high level of knowledge about COVID-19 and practiced wearing face masks daily as a precautionary measure. The average DASS scores were beyond the mild to moderate cut-off point for all three domains. The present study found that prolonged lockdowns had significantly impacted (
MeSH term(s)	Humans ; COVID-19/epidemiology ; Mental Health ; Pandemics ; Quality of Life ; Malaysia ; Cross-Sectional Studies ; SARS-CoV-2 ; Depression/epidemiology ; Communicable Disease Control ; Anxiety/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20054046
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Article: The utility of adipose-derived stem cells and stromal vascular fraction for oncologic soft tissue reconstruction: Is it safe? A matter for debate.

Tan, Shaun S / Loh, Weiliang

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

2017 Volume 15, Issue 4, Page(s) 186–189

Abstract: Autologous free-fat grafting (AFG) has emerged as an attractive proposition for soft-tissue reconstruction of various contour defects because it obviates more complex reconstructive options and reduces operative times and donor-site morbidity. ... ...

Abstract	Autologous free-fat grafting (AFG) has emerged as an attractive proposition for soft-tissue reconstruction of various contour defects because it obviates more complex reconstructive options and reduces operative times and donor-site morbidity. Nonetheless, a common complication of this procedure is the resorption of the engrafted fat. Cell-assisted lipotransfer (CAL) is now a well-regarded technique where adipose-derived stem cell (ASC)-rich stromal vascular fraction is admixed with lipoaspirate, increasing the volumetric outcome of fat grafts in light of its potent angiogenic and adipogenic properties. Criticisms, however, remain regarding this modality especially for the treatment of post-oncologic defects. Laboratory data has attested to its propensity to perpetuate tumor cells as a result of its paracrine effects on the host microenvironment. This review article aims to present the underlying facts behind ASC therapy and provide meaningful discourse as to its utility in post-oncologic soft tissue reconstruction.
Language	English
Publishing date	2017-08
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2102927-1
ISSN	1479-666X
ISSN	1479-666X
DOI	10.1016/j.surge.2016.09.010
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Article ; Online: Cross-reactivity of SARS-CoV-2 with HIV chemiluminescent assay leading to false-positive results.

Tan, Shaun S / Chew, Ka Lip / Saw, Sharon / Jureen, Roland / Sethi, Sunil

Journal of clinical pathology

2020 Volume 74, Issue 9, Page(s) 614

MeSH term(s)	COVID-19 ; Cross Reactions ; HIV Infections ; Humans ; Luminescent Measurements ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-09
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jclinpath-2020-206942
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Article ; Online: Optimizing post-acute coronary syndrome (ACS) dyslipidemia management: Insights from the North American Acute Coronary Syndrome ACS Reflective III.

Alanezi, Meshal / Yan, Andrew T / Tan, Mary K / Bourgeois, Ronald / Malek-Marzban, Peiman / Beharry, Rani / Alkurtass, Suhaib / Gyenes, Gabor T / Nadeau, Pierre-Louis / Nwadiaro, Nduka / Jedrzkiewicz, Sean / Gao, Dongsheng / Chandna, Harish / Nelson, William B / Goodman, Shaun G

Cardiology

2024

Abstract: ... post-event from 27 Canadian and United States (U.S.) sites from September 2018 to October 2020 and ... who did not achieve Canadian/U.S. guideline-recommended LDL-C thresholds, the number of patients who would ...

Abstract	Background: Despite contemporary practice guidelines, a substantial number of post-acute coronary syndrome (ACS) patients fail to achieve guideline-recommended LDL-C thresholds. Our study aims to objectively investigate this evidence-to-practice care gap. Specifically, we aim to identify opportunities where additional lipid-lowering therapies are indicated and explore reasons for the non-prescription of guideline-recommended therapies. Methods: ACS patients with LDL-C ≥1.81 mmol/L (70 mg/dL) despite maximally tolerated statin ± ezetimibe therapy (including those intolerant of ≥2 statins) were enrolled 1-12 months post-event from 27 Canadian and United States (U.S.) sites from September 2018 to October 2020 and followed up for three visits during the 12 months post-event. We determined the proportion of patients who did not achieve Canadian/U.S. guideline-recommended LDL-C thresholds, the number of patients who would have been eligible for additional lipid-lowering therapies, and reasons behind lack of escalation in lipid-lowering therapies when indicated. Individual patient and aggregate practice feedback, including guideline-recommended intensification suggestions were provided to each physician. Results: Of the 248 patients enrolled in the pilot study (median age 64 [57, 73] years, 31.5% -female and STEMI 27.4%), 75.4% were on high-intensity statins on the first visit. 18.5% of those who attended all 3 visits had an LDL-C measured only at the first visit which was above the threshold. After one year of follow-up, 51.9% of patients achieved LDL-C thresholds at either visit 2 or 3. In the context of feedback reminding physicians about guideline-directed LDL-C-modifying therapy in their individual participating patients, we observed an increase in the use of ezetimibe and PCSK9 inhibitor therapy at 3-12 months. This was associated with a significant lowering of the mean LDL-C (from 2.93 mmol/L [baseline] to 2.09 mmol/L [3-6 months] to 1.87 mmol/L [6-12 months]) and a significantly greater proportion of patients (from 0% [baseline] to 38.6% [3-6 months] to 53.4% [6-12 months]) achieving guideline-recommended LDL-C thresholds. The most prevalent reasons behind the non-intensification of LDL-C lowering therapy with ezetimibe and/or PCSK9i were LDL-C levels being close to target, the pre-existing use of other lipid-lowering therapies, patient refusal, and cost. Conclusion: Although most patients post-ACS are on high-intensity statin therapy, almost 50% failed to achieve guideline-recommended LDL-C thresholds by 1-year follow-up. Furthermore, additional lipid-lowering therapies in this high-risk group were underprescribed, and this may be linked to several factors including potential gaps in physician knowledge, treatment inertia, patient refusal, and cost.
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000536392
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Article ; Online: Limitations of rapid diagnostic testing in the work-up of dengue infection - a case report.

Tan, Shaun S / Saw, Sharon / Yan, Gabriel / Chong, Ai Teng / Yang, Zhixin / Tan, Ai Ping / Vathsala, Anantharaman / Sethi, Sunil K

Clinical chemistry and laboratory medicine

2020 Volume 58, Issue 10, Page(s) e245–e246

MeSH term(s)	Adult ; Antibodies, Viral/blood ; Dengue/blood ; Dengue/diagnosis ; Dengue Virus/immunology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Kidney Failure, Chronic ; Male ; Sensitivity and Specificity
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2020-05-25
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-0288
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Article ; Online: Initial experiences of switching to faricimab for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in an Asian population

Farah N. I. Ibrahim / Kelvin Y. C. Teo / Tien-En Tan / Hiok Hong Chan / Priya R. Chandrasekaran / Shu-Yen Lee / Anna C. S. Tan / Ranjana Mathur / Choi Mun Chan / Shaun S. Sim / Gavin Siew Wei Tan / Ian Y. S. Yeo / Chui Ming Gemmy Cheung

Frontiers in Ophthalmology, Vol

2024 Volume 3

Abstract: PurposeTo describe the early experiences of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) whose treatment was switched to faricimab from other anti-vascular endothelial growth factor (VEGF) ... ...

Abstract	PurposeTo describe the early experiences of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) whose treatment was switched to faricimab from other anti-vascular endothelial growth factor (VEGF) agents.MethodsThis is a prospective cohort of eyes with nAMD and PCV that were previously treated with anti-VEGF agents other than faricimab. We evaluated visual acuity (VA), central subfield thickness (CST), macular volume (MV), pigment epithelial detachment (PED) height, and choroidal thickness (CT) after one administration of faricimab. Where present, fluid was further evaluated according to intraretinal fluid (IRF), subretinal fluid (SRF), or within PED.ResultsSeventy-one eyes from 71 patients were included (45.07% PCV and 54.93% typical nAMD). The mean [standard deviation (± SD)] VA, CST, and MV improved from 0.50 logMAR (± 0.27 logMAR) to 0.46 logMAR (± 0.27 logMAR) (p = 0.20), 383.35 µm (± 111.24 µm) to 322.46 µm (± 103.89 µm (p < 0.01), and 9.40 mm3 (± 1.52 mm3) to 8.75 mm3 (± 1.17 mm3) (p < 0.01) from switch to post switch visit, respectively. The CT reduced from 167 µm (± 151 µm) to 149 µm (± 113 µm) (p < 0.01). There was also a significant reduction in the maximum PED height between visits [302.66 µm (± 217.97 µm)] and the post switch visit [236.66 µm (± 189.05 µm); p < 0.01]. This difference was greater in PEDs that were predominantly serous in nature. In the eyes with typical nAMD (n = 39), improvements were significant for CST, MV, CT, and PED. In the eyes with PCV (n = 32), only reductions in CT were statistically significant, while VA, CST, MV, and PED only showed numerically smaller improvements. One patient developed mild vitritis without vasculitis, which resolved with topical steroids with no sequelae.ConclusionsIn our case series of Asian nAMD patients, switching to faricimab was associated with a stable VA and meaningful anatomical improvements, particularly with typical nAMD subtypes.
Keywords	ANG-2 ; anti-vegf ; faricimab ; neovascular age-related macular degeneration ; polypoidal choroidal vasculopathy ; switch therapy ; Medicine ; R
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Peripheral Blood CD34 Donor Chimerism has Greater Clinical Utility Than CD3 for Detecting Relapse after Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia or Myelodysplastic Syndrome.

Das, Tongted P / North, Daniel / Fleming, Shaun A / Tan, Joanne L C / Ivey, Adam / Cummings, Nicholas J / Spencer, Andrew / Patil, Sushrut S / Widjaja, Jacqueline M L / Swain, Michael I / Bourke, Catherine / O'Brien, Maureen E / Kliman, David S / Curtis, David J

Transplantation and cellular therapy

2023 Volume 29, Issue 7, Page(s) 454.e1–454.e8

Abstract: Monitoring of donor chimerism (DC) may detect early relapse following allogeneic hematopoietic stem cell transplantation (allo-SCT) for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Most centers use unfractionated peripheral blood or T- ... ...

Abstract	Monitoring of donor chimerism (DC) may detect early relapse following allogeneic hematopoietic stem cell transplantation (allo-SCT) for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Most centers use unfractionated peripheral blood or T-cells to monitor DC, although CD34
MeSH term(s)	Humans ; Antigens, CD34/immunology ; Azacitidine/therapeutic use ; Chimerism ; Chronic Disease ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/therapy ; Leukemia, Myeloid, Acute/drug therapy ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Nuclear Proteins/genetics ; Recurrence
Chemical Substances	Antigens, CD34 ; Azacitidine (M801H13NRU) ; Nuclear Proteins
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2023.03.025
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