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  1. Article ; Online: Editorial: Systems Biology Approach to the Immunology of Asthma and Allergy.

    Karaaslan, Cagatay / Mayorga, Cristobalina / Baerenfaller, Katja / Escribese, María M

    Frontiers in immunology

    2022  Volume 13, Page(s) 857403

    MeSH term(s) Asthma ; Humans ; Hypersensitivity ; Systems Biology
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.857403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The TGF-β-Th2 axis: A new target for cancer therapy?

    García de Durango, Cira Rosario / Escribese, Maria M / Rosace, Domenico

    Allergy

    2021  Volume 76, Issue 11, Page(s) 3563–3565

    MeSH term(s) Humans ; Interleukin-4 ; Neoplasms/drug therapy ; Th2 Cells ; Transforming Growth Factor beta
    Chemical Substances Transforming Growth Factor beta ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2021-06-25
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 125: Show issues

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  3. Article: Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes.

    Barber, Domingo / Villaseñor, Alma / Escribese, Maria M

    Asia Pacific allergy

    2019  Volume 9, Issue 4, Page(s) e37

    Abstract: In the last decades have emerged new technological platforms that allow evaluation of genes, transcripts, proteins, or metabolites of a living being, so-called omics sciences. More importantly, new technics for their integration have provided access to a ...

    Abstract In the last decades have emerged new technological platforms that allow evaluation of genes, transcripts, proteins, or metabolites of a living being, so-called omics sciences. More importantly, new technics for their integration have provided access to a complete set of information of the current conditions and features of a specific biological sample in a precise moment. Thus, omic sciences are now considered an essential tool for patient stratification in base to their severity, to understand disease progression and to identify new biomarkers. Severe patients, that are out of control, provide an excellent model to understand disease evolution and to identify new intervention and biomarkers strategies. Here we discuss the use of metabolomics to understand severity in allergic diseases in a strategy that opens new insights as well as identify new biological systems relevant for allergy progression. Metabolomics strategies are based in parallel evaluation of different allergy severity models by mean of untargeted analysis that allows the identification of potential biomarkers. Overlapping of different biomarkers in multiple models, provides information of general as well as specific biological systems involved in each model. Later a selected panel of biomarkers will be used in a target method to explore the diagnosis potential to stratify allergic patients.
    Language English
    Publishing date 2019-10-28
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.2019.9.e37
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial

    Cagatay Karaaslan / Cristobalina Mayorga / Katja Baerenfaller / María M. Escribese

    Frontiers in Immunology, Vol

    Systems Biology Approach to the Immunology of Asthma and Allergy

    2022  Volume 13

    Keywords allergy ; system biology ; asthma ; immunology ; biomarker ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Allergen-specific immunotherapy: Power of adjuvants and novel predictive biomarkers.

    Sokolowska, Milena / Boonpiyathad, Tadech / Escribese, Maria M / Barber, Domingo

    Allergy

    2019  Volume 74, Issue 11, Page(s) 2061–2063

    MeSH term(s) Adjuvants, Immunologic ; Allergens ; Animals ; Arachis ; Biomarkers ; Desensitization, Immunologic ; Interleukin-10 ; Mice ; Th2 Cells
    Chemical Substances Adjuvants, Immunologic ; Allergens ; Biomarkers ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2019-07-02
    Publishing country Denmark
    Document type Editorial ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 125: Show issues

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  6. Article ; Online: The Role of Sphingolipids in Allergic Disorders.

    Díaz-Perales, Araceli / Escribese, Maria M / Garrido-Arandia, María / Obeso, David / Izquierdo-Alvarez, Elena / Tome-Amat, Jaime / Barber, Domingo

    Frontiers in allergy

    2021  Volume 2, Page(s) 675557

    Abstract: Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, ...

    Abstract Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders.
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2021.675557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation.

    Sahiner, Umit M / Giovannini, Mattia / Escribese, Maria M / Paoletti, Giovanni / Heffler, Enrico / Alvaro Lozano, Montserrat / Barber, Domingo / Canonica, Giorgio Walter / Pfaar, Oliver

    Journal of personalized medicine

    2023  Volume 13, Issue 5

    Abstract: Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise ...

    Abstract Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT's future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy.
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13050845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Metabolomics in the Identification of Biomarkers of Asthma.

    Villaseñor, Alma / Eguiluz-Gracia, Ibon / Moreira, André / Wheelock, Craig E / Escribese, María M

    Metabolites

    2021  Volume 11, Issue 6

    Abstract: Asthma is a major non-communicable disease characterized by recurrent attacks of breathlessness and wheezing [ ... ]. ...

    Abstract Asthma is a major non-communicable disease characterized by recurrent attacks of breathlessness and wheezing [...].
    Language English
    Publishing date 2021-05-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11060346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Platelet-Derived Extracellular Vesicles as Lipid Carriers in Severe Allergic Inflammation.

    Couto-Rodriguez, Alba / Villaseñor, Alma / Pablo-Torres, Carmela / Obeso, David / Rey-Stolle, María Fernanda / Peinado, Héctor / Bueno, José Luis / Reaño-Martos, Mar / Iglesias Cadarso, Alfredo / Gomez-Casado, Cristina / Barbas, Coral / Barber, Domingo / Escribese, María M / Izquierdo, Elena

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: The resolution of inflammation is a complex process that is critical for removing inflammatory cells and restoring tissue function. The dysregulation of these mechanisms leads to chronic inflammatory disorders. Platelets, essential cells for preserving ... ...

    Abstract The resolution of inflammation is a complex process that is critical for removing inflammatory cells and restoring tissue function. The dysregulation of these mechanisms leads to chronic inflammatory disorders. Platelets, essential cells for preserving homeostasis, are thought to play a role in inflammation as they are a source of immunomodulatory factors. Our aim was to identify key metabolites carried by platelet-derived extracellular vesicles (PL-EVs) in a model of allergic inflammation. PL-EVs were isolated by serial ultracentrifugation using platelet-rich plasma samples obtained from platelet apheresis from severely (
    MeSH term(s) Humans ; Blood Platelets ; Gas Chromatography-Mass Spectrometry ; Extracellular Vesicles ; Arachidonic Acid ; Inflammation
    Chemical Substances Arachidonic Acid (27YG812J1I)
    Language English
    Publishing date 2023-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biomarkers of AIT: Models of prediction of efficacy.

    Tan, Tiak Ju / Delgado-Dolset, María I / Escribese, María M / Barber, Domingo / Layhadi, Janice A / Shamji, Mohamed H

    Allergologie select

    2022  Volume 6, Page(s) 267–275

    Abstract: Allergic rhinitis is an IgE-mediated inflammation that remains a clinical challenge, affecting 40% of the UK population with a wide range of severity from nasal discomfort to life-threatening anaphylaxis. It can be managed by pharmacotherapeutics and in ... ...

    Abstract Allergic rhinitis is an IgE-mediated inflammation that remains a clinical challenge, affecting 40% of the UK population with a wide range of severity from nasal discomfort to life-threatening anaphylaxis. It can be managed by pharmacotherapeutics and in selected patients by allergen immunotherapy (AIT), which provides long-term clinical efficacy, especially during peak allergy season. However, there are no definitive biomarkers for AIT efficacy. Here, we aim to summarize the key adaptive, innate, humoral, and metabolic advances in biomarker identification in response to AIT. Mechanisms of efficacy consist of an immune deviation towards T
    Language English
    Publishing date 2022-11-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02333E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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