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  1. Article ; Online: Bridging patient-physician language barrier starts in medical school.

    Gupta, Sneha

    Postgraduate medical journal

    2021  Volume 98, Issue e3, Page(s) e189

    MeSH term(s) Communication Barriers ; Curriculum ; Education, Medical ; Ethics, Medical ; Humans ; Physician-Patient Relations ; Physicians ; Schools, Medical
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2021-140799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of Tele-Guided Imagery on Stress among Caregivers of Chronic Neurological Patients: A Randomized Controlled Trial.

    Gupta, Minakshi / Chakraverty, Sneha

    Journal of neurosciences in rural practice

    2022  Volume 13, Issue 2, Page(s) 333–335

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.1055/s-0042-1744119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exosome-Functionalized, Drug-Laden Bone Substitute along with an Antioxidant Herbal Membrane for Bone and Periosteum Regeneration in Bone Sarcoma.

    Gupta, Sneha / Qayoom, Irfan / Gupta, Purva / Gupta, Archita / Singh, Prerna / Singh, Sneha / Kumar, Ashok

    ACS applied materials & interfaces

    2023  

    Abstract: Developing advanced methods for effective bone reconstructive strategies in case of critical bone defects caused by tumor resection, trauma, and other implant-related complications remains a challenging problem in orthopedics. In the clinical management ... ...

    Abstract Developing advanced methods for effective bone reconstructive strategies in case of critical bone defects caused by tumor resection, trauma, and other implant-related complications remains a challenging problem in orthopedics. In the clinical management of bone diseases, there is a paradigm shift in using local drugs at the injury site; however, the dead space created during the surgical debridement of necrotic bone and soft tissues (periosteum and underlying muscle) leads to ineffective bone formation, thereby leading to secondary complications, and thus calls for better regenerative approaches. In this study, we have utilized an exosome-functionalized doxorubicin-loaded biodegradable nanocement (NC)-based carrier along with a
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c18308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surface-Modified Diopside-Reinforced PCL Biopolymer Composites with Enhanced Interfacial Strength and Mechanical Properties for Orthopedic Applications.

    Ghosh, Rupita / Gupta, Sneha / Mehrotra, Shreya / Kumar, Ashok

    ACS applied materials & interfaces

    2024  Volume 16, Issue 6, Page(s) 7670–7685

    Abstract: The phase separation of ceramics in a biopolymer matrix makes it challenging to achieve satisfactory mechanical properties required for orthopedic applications. It has been found that silane coupling agents can modify the surface of the bioceramic phase ... ...

    Abstract The phase separation of ceramics in a biopolymer matrix makes it challenging to achieve satisfactory mechanical properties required for orthopedic applications. It has been found that silane coupling agents can modify the surface of the bioceramic phase by forming a molecular bridge between the polymer and the ceramic, resulting in improved interfacial strength and adhesion. Therefore, in the present study, silane-modified diopside (DI) ceramic and ε-polycaprolactone (PCL) biopolymer composites were fabricated by injection molding method. The silane modification of DI resulted in their uniform dispersion in the PCL matrix, whereas agglomeration was found in composites containing unmodified DI. The thermal stability of the silane-modified DI-containing composites also increased. The Young's modulus of the composite containing 50% w/w DI modified by 3% w/w silane increased by 103% compared to composites containing 50% w/w unmodified DI. The biodegradation of the unmodified composites was significantly high, indicating their weak interfacial strength with the PCL matrix (
    MeSH term(s) Silanes ; Polymers ; Silicic Acid ; Biopolymers
    Chemical Substances diopside (14483-19-3) ; Silanes ; Polymers ; Silicic Acid (1343-98-2) ; Biopolymers
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Nymphomania with intellectual disability.

    Sharma, Mini / Kumar, Manoj / Gupta, Sneha

    Industrial psychiatry journal

    2022  Volume 31, Issue 2, Page(s) 380–381

    Language English
    Publishing date 2022-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2580355-4
    ISSN 0976-2795 ; 0972-6748
    ISSN (online) 0976-2795
    ISSN 0972-6748
    DOI 10.4103/ipj.ipj_151_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biofunctionalization with Cissus quadrangularis phytobioactives accentuates Nano-Hydroxyapatite based ceramic Nano-Cement for Neo-Bone formation in critical sized bone defect.

    Gupta, Archita / Kumar Mehta, Sanjay / Qayoom, Irfan / Gupta, Sneha / Singh, Sneha / Kumar, Ashok

    International journal of pharmaceutics

    2023  Volume 642, Page(s) 123110

    Abstract: Developing biofunctionalized ceramic bone substitutes with phytobioactives for their sustained delivery is highly desired to enhance the osteo-active potential of ceramic bone substitutes, reduce the systemic toxicity of synthetic drugs, and increase the ...

    Abstract Developing biofunctionalized ceramic bone substitutes with phytobioactives for their sustained delivery is highly desired to enhance the osteo-active potential of ceramic bone substitutes, reduce the systemic toxicity of synthetic drugs, and increase the bioavailability of phytobioactives. The present work highlights the local delivery of phytobioactives of Cissus quadrangularis (CQ) through nano-hydroxyapatite (nHAP) based ceramic nano-cement. The phytoconstituent profiling represented the optimized CQ fraction to be rich in osteogenic polyphenols and flavonoids like quercetin, resveratrol, and their glucosides. Further, CQ phytobioactives-based formulation was biocompatible, increased bone formation, calcium deposition, proliferation, and migration of cells with simultaneous alleviation of cellular oxidative stress. In the in vivo critical-sized bone defect model, enhanced formation of highly mineralized tissue (BV mm
    MeSH term(s) Osteogenesis ; Durapatite ; Bone Substitutes ; Cissus ; Ceramics
    Chemical Substances Durapatite (91D9GV0Z28) ; Bone Substitutes ; N-hydroxy-2-aminopyrene (85964-28-9) ; hydroxyapatite cement
    Language English
    Publishing date 2023-06-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.123110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Exosome-Functionalized, Drug-Laden Bone Substitute along with an Antioxidant Herbal Membrane for Bone and Periosteum Regeneration in Bone Sarcoma

    Gupta, Sneha / Qayoom, Irfan / Gupta, Purva / Gupta, Archita / Singh, Prerna / Singh, Sneha / Kumar, Ashok

    ACS Applied Materials & Interfaces. 2023 Feb. 07, v. 15, no. 7 p.8824-8839

    2023  

    Abstract: Developing advanced methods for effective bone reconstructive strategies in case of critical bone defects caused by tumor resection, trauma, and other implant-related complications remains a challenging problem in orthopedics. In the clinical management ... ...

    Abstract Developing advanced methods for effective bone reconstructive strategies in case of critical bone defects caused by tumor resection, trauma, and other implant-related complications remains a challenging problem in orthopedics. In the clinical management of bone diseases, there is a paradigm shift in using local drugs at the injury site; however, the dead space created during the surgical debridement of necrotic bone and soft tissues (periosteum and underlying muscle) leads to ineffective bone formation, thereby leading to secondary complications, and thus calls for better regenerative approaches. In this study, we have utilized an exosome-functionalized doxorubicin-loaded biodegradable nanocement (NC)-based carrier along with a Cissus quadrangularis (CQ) extract-laden antioxidant herbal membrane for simultaneously managing the periosteum as well as bone formation in the tumor resection model of osteosarcoma. We initially evaluated the efficacy of scaffolds for in vitro mineralization and bone formation. To examine the in vivo effectiveness, we developed a human osteosarcoma cell line (Saos-2)-induced tumor xenograft model with a critical-sized bone defect. The findings revealed that doxorubicin released from NC was successful in killing the tumor cells and was present even after 30 days of implantation. Additionally, the incorporation of exosomes aided the bone formation, resulting in around a 2.6-fold increase in the bone volume compared to the empty group as evaluated by micro-CT. The herbal membrane assisted in the development of periosteum and mineralizing bone callous as validated through histological and immunofluorescence analysis. Thus, our findings describe a one-step biomaterial-based cell-free approach to regenerate bone in osteosarcoma and prevent further fracture due to the complete development of periosteum and lost bone.
    Keywords Cissus quadrangularis ; antioxidants ; biodegradability ; bone formation ; bone substitutes ; cell lines ; debridement ; doxorubicin ; exosomes ; fluorescent antibody technique ; histology ; humans ; micro-computed tomography ; mineralization ; models ; muscles ; orthopedics ; osteosarcoma ; periosteum ; resection ; xenotransplantation ; dead space management ; periosteum formation ; bone reconstructive surgery ; herbal membrane ; local delivery
    Language English
    Dates of publication 2023-0207
    Size p. 8824-8839.
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c18308
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Multimodal Potentials of Gold Nanoparticles for Bone Tissue Engineering and Regenerative Medicine: Avenues and Prospects.

    Gupta, Archita / Singh, Sneha

    Small (Weinheim an der Bergstrasse, Germany)

    2022  Volume 18, Issue 29, Page(s) e2201462

    Abstract: Osseous tissue repair has advanced due to the introduction of tissue engineering. The key elements required while engineering new tissues involve scaffolds, cells, and bioactive cues. The macrostructural to the nanostructural framework of such complex ... ...

    Abstract Osseous tissue repair has advanced due to the introduction of tissue engineering. The key elements required while engineering new tissues involve scaffolds, cells, and bioactive cues. The macrostructural to the nanostructural framework of such complex tissue has engrossed the intervention of nanotechnology for efficient neo-bone formation. Gold nanoparticles (GNPs) have recently gained interest in bone tissue regeneration due to their multimodal functionality. They are proven to modulate the properties of scaffolds and the osteogenic cells significantly. GNPs also influence different metabolic functions within the body, which directly or indirectly govern the mechanism of bone regeneration. Therefore, this review highlights nanoparticle-mediated osteogenic development, focusing on different aspects of GNPs ranging from scaffold modulation to cellular stimulation. The toxic aspects of gold nanoparticles studied so far are critically explicated, while further insight into the advancements and prospects of these nanoparticles in bone regeneration is also highlighted.
    MeSH term(s) Bone Regeneration ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Osteogenesis ; Regenerative Medicine ; Tissue Engineering ; Tissue Scaffolds/chemistry
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2022-06-27
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202201462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Patient Perspectives on Contraceptive use in North India: A Case for Increased Contraceptive Counseling by Providers.

    Mittal, Sneha / Gupta, Vineeta / Saxena, Namrata / Lata, Kirti

    Journal of obstetrics and gynaecology of India

    2023  Volume 73, Issue 6, Page(s) 512–521

    Abstract: Background: Given the underutilization of contraception in India, this study was undertaken to gauge cisgender female clients' knowledge of, attitudes toward, and barriers to contraceptive usage in North India.: Methodology: The present study was ... ...

    Abstract Background: Given the underutilization of contraception in India, this study was undertaken to gauge cisgender female clients' knowledge of, attitudes toward, and barriers to contraceptive usage in North India.
    Methodology: The present study was done at a tertiary care Institute in North India, where 209 structured interviews were conducted with cisgender female patients attending the outpatient department. One-way chi-square tests for independence, Kruskal-Wallis test, and Wilcoxon test were applied to quantitative data. Themes from qualitative questions were coded and analyzed.
    Results: Differences in awareness among contraceptives were found to be highly statistically significant (H (9) = 1022.3,
    Conclusion: Our study shows differential levels of awareness, usage, and barriers on contraceptive methods among participants. Results also suggest the importance of spouses and friends in clients' contraceptive decision-making process and their limited counseling experience with health care providers.
    Language English
    Publishing date 2023-06-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 410688-x
    ISSN 0971-9202 ; 0022-3190
    ISSN 0971-9202 ; 0022-3190
    DOI 10.1007/s13224-023-01781-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Assessing mortality registration in Kerala: the MARANAM study.

    Gupta, Aashish / Mani, Sneha Sarah

    Genus

    2022  Volume 78, Issue 1, Page(s) 1

    Abstract: Complete or improving civil registration systems in sub-national areas in low- and middle-income countries provide several opportunities to better understand population health and its determinants. In this article, we provide an assessment of vital ... ...

    Abstract Complete or improving civil registration systems in sub-national areas in low- and middle-income countries provide several opportunities to better understand population health and its determinants. In this article, we provide an assessment of vital statistics in Kerala, India. Kerala is home to more than 33 million people and is a comparatively low-mortality context. We use individual-level vital registration data on more than 2.8 million deaths between 2006 and 2017 from the Kerala MARANAM (Mortality and Registration Assessment and Monitoring) Study. Comparing age-specific mortality rates from the Civil Registration System (CRS) to those from the Sample Registration System (SRS), we do not find evidence that the CRS underestimates mortality. Instead, CRS rates are smoother across ages and less variable across periods. In particular, the CRS records higher death rates than the SRS for ages, where mortality is usually low and for women. Using these data, we provide the first set of annual sex-specific life tables for any state in India. We find that life expectancy at birth was 77.9 years for women in 2017 and 71.4 years for men. Although Kerala is unique in many ways, our findings strengthen the case for more careful attention to mortality records within low- and middle-income countries, and for their better dissemination by government agencies.
    Supplementary information: The online version contains supplementary material available at 10.1186/s41118-021-00149-z.
    Language English
    Publishing date 2022-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2658579-0
    ISSN 2035-5556 ; 0016-6987
    ISSN (online) 2035-5556
    ISSN 0016-6987
    DOI 10.1186/s41118-021-00149-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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