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  1. Article ; Online: Subcutaneous Versus Transvenous Implantable Defibrillators: A Systematic Review and Meta-Analysis.

    Saleem, Maryam / Arshad, Verda / Nabavizadeh, Pooneh / Rajsheker, Srinivas / Costea, Alexandru

    The American journal of cardiology

    2024  Volume 218, Page(s) 32–33

    MeSH term(s) Humans ; Defibrillators, Implantable ; Death, Sudden, Cardiac ; Treatment Outcome
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Editorial
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.01.026
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  2. Article ; Online: Irregular Tachycardia in a Patient With Cardiomyopathy: It Takes Two to Tango.

    Nabavizadeh, Pooneh / Rajsheker, Srinivas / Attari, Mehran

    Circulation

    2020  Volume 141, Issue 9, Page(s) 775–780

    MeSH term(s) Action Potentials ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/physiopathology ; Cardiomyopathies/therapy ; Cardiovascular Agents/therapeutic use ; Defibrillators, Implantable ; Electric Countershock/instrumentation ; Electrocardiography ; Female ; Heart Rate ; Humans ; Immunosuppressive Agents/therapeutic use ; Middle Aged ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/physiopathology ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left
    Chemical Substances Cardiovascular Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.044164
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  3. Article: Hybrid subcutaneous and transvenous approach for cardiac resynchronization defibrillator implant in a patient with congenital heart disease and tricuspid bioprosthetic.

    Nabavizadeh, Pooneh / Rajsheker, Srinivas / Attari, Mehran

    HeartRhythm case reports

    2019  Volume 6, Issue 1, Page(s) 27–28

    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2019.10.008
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  4. Article: Porous tip radiofrequency ablation catheter reduced heart failure-related complications and healthcare resource utilization in paroxysmal atrial fibrillation patients.

    Costea, Alexandru / Haile, Bereket / Barone, Adam / Schenthal, Maddie / Romanowicz, Kathrine / Rajsheker, Srinivas / Boo, Lee Ming / Hunter, Tina D

    Journal of arrhythmia

    2023  Volume 39, Issue 3, Page(s) 352–358

    Abstract: Introduction: A 56-hole porous tip radiofrequency catheter was developed to provide more uniform cooling with less fluid delivery than a prior 6-hole irrigated design. This study aimed to evaluate the impact of contact force (CF) ablation with the ... ...

    Abstract Introduction: A 56-hole porous tip radiofrequency catheter was developed to provide more uniform cooling with less fluid delivery than a prior 6-hole irrigated design. This study aimed to evaluate the impact of contact force (CF) ablation with the porous tip on complications (congestive heart failure [CHF] and non-CHF related), healthcare resource utilization, and procedural efficiency in patients undergoing de novo paroxysmal atrial fibrillation (PAF) ablations in a real-world setting.
    Methods: Consecutive de novo PAF ablations were performed between February 2014 and March 2019 by six operators at a single US academic center. The 6-hole design was used through December 2016 with the 56-hole porous tip adopted in October 2016. The outcomes of interest included symptomatic CHF presentation and CHF-related complications.
    Results: Of 174 patients who were included, mean age was 61.1 ± 10.8 years, 67.8% were male, and 25.3% had a history of CHF. Ablation with the porous tip catheter significantly decreased fluid delivery (1177 vs. 1912 mL with the 6-hole design;
    Conclusion: The 56-hole porous tip led to significantly reduced CHF-related complications and healthcare utilization in PAF patients undergoing CF catheter ablation when compared to the prior 6-hole design. This reduction likely results from the significant decrease in fluid delivery during the procedure.
    Language English
    Publishing date 2023-03-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12830
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  5. Article: Right Bundle Branch Block and Electromechanical Coupling of the Right Ventricle: An Echocardiographic Study.

    Miller, Brian Edward / Rajsheker, Srinivas / López-Candales, Angel

    Heart views : the official journal of the Gulf Heart Association

    2015  Volume 16, Issue 4, Page(s) 137–143

    Abstract: Background: A growing body of evidence suggests that the presence of a right bundle branch block (RBBB) is a negative prognostic indicator in patients with and without preexisting heart disease. Even though electromechanical activation of the right ... ...

    Abstract Background: A growing body of evidence suggests that the presence of a right bundle branch block (RBBB) is a negative prognostic indicator in patients with and without preexisting heart disease. Even though electromechanical activation of the right ventricle (RV) in patients with RBBB and pulmonary hypertension (PH) has been investigated; a direct comparison of the presence of RBBB, on the duration of RV mechanical systole using echocardiography has not been studied.
    Materials and methods: In this retrospective study, we analyzed the echocardiograms of 40 patients by measuring the magnitude and timing of tricuspid annulus plane systolic excursion (TAPSE) and tricuspid annulus systolic velocity (TA S'). Patients were selected to form four groups of ten patients based on the presence or absence of RBBB and PH to determine if RBBB has any effect on the time-to-peak of TAPSE or TA S', which for our purposes serves as a measure of duration of RV mechanical systole.
    Results: Our results demonstrate that RBBB leads to a measurable prolongation of TAPSE and TA S' in patients without PH. Time-to-peak of TAPSE or TA S' was not significantly prolonged in patients with PH.
    Conclusions: The results of this pilot study show that RV mechanical systole is prolonged in patients with RBBB, and the addition of PH attenuates this change. Additional prospective studies are now required to elucidate further the electrical and mechanical dyssynchrony that occurs as a result of RBBB, and how these new echocardiographic measurements can be applied clinically to risk stratify patients with RBBB and PH.
    Language English
    Publishing date 2015-11-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2575257-1
    ISSN 0976-5123 ; 1995-705X
    ISSN (online) 0976-5123
    ISSN 1995-705X
    DOI 10.4103/1995-705X.172197
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  6. Article ; Online: Right bundle branch block and electromechanical coupling of the right ventricle

    Brian Edward Miller / Srinivas Rajsheker / Angel López-Candales

    Heart Views, Vol 16, Iss 4, Pp 137-

    An echocardiographic study

    2015  Volume 143

    Abstract: Background: A growing body of evidence suggests that the presence of a right bundle branch block (RBBB) is a negative prognostic indicator in patients with and without preexisting heart disease. Even though electromechanical activation of the right ... ...

    Abstract Background: A growing body of evidence suggests that the presence of a right bundle branch block (RBBB) is a negative prognostic indicator in patients with and without preexisting heart disease. Even though electromechanical activation of the right ventricle (RV) in patients with RBBB and pulmonary hypertension (PH) has been investigated; a direct comparison of the presence of RBBB, on the duration of RV mechanical systole using echocardiography has not been studied. Materials and Methods: In this retrospective study, we analyzed the echocardiograms of 40 patients by measuring the magnitude and timing of tricuspid annulus plane systolic excursion (TAPSE) and tricuspid annulus systolic velocity (TA S′). Patients were selected to form four groups of ten patients based on the presence or absence of RBBB and PH to determine if RBBB has any effect on the time-to-peak of TAPSE or TA S′, which for our purposes serves as a measure of duration of RV mechanical systole. Results: Our results demonstrate that RBBB leads to a measurable prolongation of TAPSE and TA S′ in patients without PH. Time-to-peak of TAPSE or TA S′ was not significantly prolonged in patients with PH. Conclusions: The results of this pilot study show that RV mechanical systole is prolonged in patients with RBBB, and the addition of PH attenuates this change. Additional prospective studies are now required to elucidate further the electrical and mechanical dyssynchrony that occurs as a result of RBBB, and how these new echocardiographic measurements can be applied clinically to risk stratify patients with RBBB and PH.
    Keywords Echocardiography ; pulmonary hypertension ; right bundle branch bloc ; right ventricular function ; tissue Doppler imaging ; tricuspid annular plane systolic excursion ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Crosstalk between perivascular adipose tissue and blood vessels.

    Rajsheker, Srinivas / Manka, David / Blomkalns, Andra L / Chatterjee, Tapan K / Stoll, Lynn L / Weintraub, Neal L

    Current opinion in pharmacology

    2010  Volume 10, Issue 2, Page(s) 191–196

    Abstract: Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were ...

    Abstract Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined. Emerging evidence suggests that PVAT regulates vascular function through numerous mechanisms, but evidence to date suggests modulation of three key aspects that are the focus of this review: inflammation, vasoreactivity, and smooth muscle cell proliferation.
    MeSH term(s) Adipocytes/metabolism ; Adipose Tissue/metabolism ; Adipose Tissue/physiology ; Animals ; Blood Vessels/metabolism ; Blood Vessels/physiology ; Cell Proliferation ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Models, Biological ; Muscle, Smooth, Vascular/physiology ; Signal Transduction/physiology ; Vasoconstriction/physiology ; Vasodilation/physiology
    Language English
    Publishing date 2010-01-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2009.11.005
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  8. Article ; Online: Histone deacetylase 9 is a negative regulator of adipogenic differentiation.

    Chatterjee, Tapan K / Idelman, Gila / Blanco, Victor / Blomkalns, Andra L / Piegore, Mark G / Weintraub, Daniel S / Kumar, Santosh / Rajsheker, Srinivas / Manka, David / Rudich, Steven M / Tang, Yaoliang / Hui, David Y / Bassel-Duby, Rhonda / Olson, Eric N / Lingrel, Jerry B / Ho, Shuk-Mei / Weintraub, Neal L

    The Journal of biological chemistry

    2011  Volume 286, Issue 31, Page(s) 27836–27847

    Abstract: Differentiation of preadipocytes into mature adipocytes capable of efficiently storing lipids is an important regulatory mechanism in obesity. Here, we examined the involvement of histone deacetylases (HDACs) and histone acetyltransferases (HATs) in the ... ...

    Abstract Differentiation of preadipocytes into mature adipocytes capable of efficiently storing lipids is an important regulatory mechanism in obesity. Here, we examined the involvement of histone deacetylases (HDACs) and histone acetyltransferases (HATs) in the regulation of adipogenesis. We find that among the various members of the HDAC and HAT families, only HDAC9 exhibited dramatic down-regulation preceding adipogenic differentiation. Preadipocytes from HDAC9 gene knock-out mice exhibited accelerated adipogenic differentiation, whereas HDAC9 overexpression in 3T3-L1 preadipocytes suppressed adipogenic differentiation, demonstrating its direct role as a negative regulator of adipogenesis. HDAC9 expression was higher in visceral as compared with subcutaneous preadipocytes, negatively correlating with their potential to undergo adipogenic differentiation in vitro. HDAC9 localized in the nucleus, and its negative regulation of adipogenesis segregates with the N-terminal nuclear targeting domain, whereas the C-terminal deacetylase domain is dispensable for this function. HDAC9 co-precipitates with USF1 and is recruited with USF1 at the E-box region of the C/EBPα gene promoter in preadipocytes. Upon induction of adipogenic differentiation, HDAC9 is down-regulated, leading to its dissociation from the USF1 complex, whereas p300 HAT is up-regulated to allow its association with USF1 and accumulation at the E-box site of the C/EBPα promoter in differentiated adipocytes. This reciprocal regulation of HDAC9 and p300 HAT in the USF1 complex is associated with increased C/EBPα expression, a master regulator of adipogenic differentiation. These findings provide new insights into mechanisms of adipogenic differentiation and document a critical regulatory role for HDAC9 in adipogenic differentiation through a deacetylase-independent mechanism.
    MeSH term(s) 3T3-L1 Cells ; Adipose Tissue/cytology ; Animals ; Cell Differentiation/physiology ; Down-Regulation ; Histone Deacetylases/genetics ; Histone Deacetylases/physiology ; Immunoprecipitation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Polymerase Chain Reaction ; RNA, Messenger/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/physiology
    Chemical Substances RNA, Messenger ; Repressor Proteins ; Hdac9 protein, mouse (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2011-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M111.262964
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