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  1. Article ; Online: HSP70: From Signaling Mechanisms to Therapeutics.

    Nunes, Kenia Pedrosa / de Oliveira, Amanda Almeida

    Biomolecules

    2023  Volume 13, Issue 7

    Abstract: Heat-shock proteins (HSPs) are primary stress responders that are vital to maintaining homeostasis [ ... ]. ...

    Abstract Heat-shock proteins (HSPs) are primary stress responders that are vital to maintaining homeostasis [...].
    MeSH term(s) HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Proteins/metabolism ; Signal Transduction ; HSP90 Heat-Shock Proteins/metabolism
    Chemical Substances HSP70 Heat-Shock Proteins ; Heat-Shock Proteins ; HSP90 Heat-Shock Proteins
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13071141
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  2. Article ; Online: Cochlear implant for profound hearing loss post COVID-19 complications.

    Almeida, Amanda Sampaio / Yonamine, Fernando Kaoru / Soares, Alexandra Dezani / Penido, Norma de Oliveira / Cruz, Oswaldo Laercio Mendonça

    Brazilian journal of otorhinolaryngology

    2023  Volume 89, Issue 6, Page(s) 101320

    Language English
    Publishing date 2023-09-04
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2023.101320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6641: Show issues Location:
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  3. Article ; Online: Seasonal and circadian variation of non-volatile metabolites in Lippia alba leaves.

    Gomes, Angélica Ferraz / Rocha, Girlane Oliveira / Scabini, Caroline / da Silva Oliveira, Jayne Ferreira / Oliveira, Déborah Neres / Mota, Luise Carvalho / Almeida Neves, Brenda Novais / Dos Santos, Amanda Menezes / Araújo, Urias Santos / Moreira, Bruno Oliveira / de Souza, Flávio Mendes / de Almeida, Maiara Prates / Amaral, Juliano Geraldo / David, Jorge Maurício

    Chemistry & biodiversity

    2024  , Page(s) e202400594

    Abstract: The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of ... ...

    Abstract The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of the leaves hydroethanolic extracts of six selected L. alba specimens. For the circadian study, the samples were collected at four different daily hours in each year's season. For the seasonal study, the samples were collected monthly from the same individuals for two consecutive years (2018 and 2019). These samples were analyzed and quantified using a validated HPLC method for flavonoids, iridoids, and phenyl ethanoid glycoside. Mussaenoside, acteoside, and tricin-7-O-diglucuronide showed a moderate positive correlation between their biosynthesis and the precipitation index, while epi-loganin had a moderate negative correlation. Acteoside showed a moderate positive correlation between the minimum registered temperature and its production. Compared with previous studies, a drastic reduction (about 95%) in the production of tricin-7-O-diglucuronide compared with previous study and this difference could be attributed to the plant's aging. Thus, the data demonstrated that lower temperatures and high rainfall could favor the production of the major L. alba active compounds (acteoside and tricin-7-O-diglucuronide) and that older plants harm their production.
    Language English
    Publishing date 2024-04-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400594
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  4. Article ; Online: Crosstalk of Inflammation and Coagulation in

    Cavalcante, Joeliton S / de Almeida, Denis Emanuel Garcia / Santos-Filho, Norival A / Sartim, Marco Aurélio / de Almeida Baldo, Amanda / Brasileiro, Lisele / Albuquerque, Polianna L / Oliveira, Sâmella S / Sachett, Jacqueline Almeida Gonçalves / Monteiro, Wuelton Marcelo / Ferreira, Rui Seabra

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Snakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of ... ...

    Abstract Snakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America,
    MeSH term(s) Humans ; Animals ; Snake Bites/complications ; Bothrops ; Blood Coagulation ; Inflammation/complications ; Signal Transduction
    Language English
    Publishing date 2023-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411508
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  5. Article: Corrigendum: Random cellulose acetate nanofibers: a breakthrough for cultivated meat production.

    Dos Santos, Ana Elisa Antunes / Guadalupe, Jorge Luís / Albergaria, Juliano Douglas Silva / Almeida, Itallo Augusto / Moreira, Amanda Maria Siqueira / Copola, Aline Gonçalves Lio / de Araújo, Isabella Paula / de Paula, Ana Maria / Neves, Bernardo Ruegger Almeida / Santos, João Paulo Ferreira / da Silva, Aline Bruna / Jorge, Erika Cristina / Andrade, Luciana de Oliveira

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1374847

    Abstract: This corrects the article DOI: 10.3389/fnut.2023.1297926.]. ...

    Abstract [This corrects the article DOI: 10.3389/fnut.2023.1297926.].
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1374847
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  6. Article: New Functional Foods with Cactus Components: Sustainable Perspectives and Future Trends.

    Monteiro, Shênia Santos / Almeida, Raphael Lucas / Santos, Newton Carlos / Pereira, Emmanuel Moreira / Silva, Amanda Priscila / Oliveira, Hugo Miguel Lisboa / Pasquali, Matheus Augusto de Bittencourt

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 13

    Abstract: The growing interest in a healthy lifestyle has contributed to disseminating perspectives on more sustainable natural resource management. This review describes promising aspects of using cacti in the food industry, addressing sustainable, nutritional, ... ...

    Abstract The growing interest in a healthy lifestyle has contributed to disseminating perspectives on more sustainable natural resource management. This review describes promising aspects of using cacti in the food industry, addressing sustainable, nutritional, and functional aspects of the plant's production. Our study provides an overview of the potential of cacti for the food industry to encourage the sustainable cultivation of underutilized cactus species and their commercial exploitation. The commercial production of cacti has advantages over other agricultural practices by mitigating damage to ecosystems and encouraging migration to sustainable agriculture. The application of cactus ingredients in food development has been broad, whether in producing breads, jellies, gums, dyes, probiotics, and postbiotic and paraprobiotic foods. However, in the field of probiotic foods, future research should focus on technologies applied in processing and researching interactions between probiotics and raw materials to determine the functionality and bioactivity of products.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12132494
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  7. Article ; Online: 3-phenacylideneoxindoles as a new class of antifungal compounds against

    Silva, Lívia C / Dos Santos Filho, Raimundo F / de Oliveira, Amanda A / Martins, Felipe T / Cunha, Silvio / de Almeida Soares, Célia M / Pereira, Maristela

    Future microbiology

    2023  Volume 18, Page(s) 93–105

    Abstract: Aims: ...

    Abstract Aims:
    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Itraconazole/pharmacology ; Microbial Sensitivity Tests ; Oxindoles/chemistry ; Oxindoles/pharmacology ; Paracoccidioides/metabolism ; Paracoccidioidomycosis/drug therapy
    Chemical Substances Antifungal Agents ; Itraconazole (304NUG5GF4) ; Oxindoles ; 3-phenacylideneoxindole
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2022-0133
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  8. Article ; Online: Obesity Is a Major Determinant of Impaired Cardiac Energy Metabolism in Heart Failure with Preserved Ejection Fraction.

    Güven, Berna / Sun, Qiuyu / Wagg, Cory S / Almeida de Oliveira, Amanda / Silver, Heidi / Persad, Kaya L / Onay-Besikci, Arzu / Vu, Jennie / Oudit, Gavin Y / Lopaschuk, Gary D

    The Journal of pharmacology and experimental therapeutics

    2024  Volume 388, Issue 1, Page(s) 145–155

    Abstract: Heart failure with preserved ejection fraction (HFpEF) is a major health problem with limited treatment options. Although optimizing cardiac energy metabolism is a potential approach to treating heart failure, it is poorly understood what alterations in ... ...

    Abstract Heart failure with preserved ejection fraction (HFpEF) is a major health problem with limited treatment options. Although optimizing cardiac energy metabolism is a potential approach to treating heart failure, it is poorly understood what alterations in cardiac energy metabolism actually occur in HFpEF. To determine this, we used mice in which HFpEF was induced using an obesity and hypertension HFpEF protocol for 10 weeks. Next, carvedilol, a third-generation
    MeSH term(s) Mice ; Animals ; Heart Failure ; Stroke Volume ; Myocardium/metabolism ; Carvedilol/pharmacology ; Carvedilol/metabolism ; Energy Metabolism ; Obesity/complications ; Obesity/metabolism ; Hypertension/metabolism ; Glucose/metabolism
    Chemical Substances Carvedilol (0K47UL67F2) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.001791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.40: Show issues Location:
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  9. Article ; Online: Energy-lowering and constant-energy spin flips: Emergence of the percolating cluster in the kinetic Ising model.

    de Azevedo-Lopes, Amanda / Almeida, Renan A L / de Oliveira, Paulo Murilo C / Arenzon, Jeferson J

    Physical review. E

    2022  Volume 106, Issue 4-1, Page(s) 44105

    Abstract: After a sudden quench from the disordered high-temperature T_{0}→∞ phase to a final temperature well below the critical point T_{F}≪T_{c}, the nonconserved order parameter dynamics of the two-dimensional ferromagnetic Ising model on a square lattice ... ...

    Abstract After a sudden quench from the disordered high-temperature T_{0}→∞ phase to a final temperature well below the critical point T_{F}≪T_{c}, the nonconserved order parameter dynamics of the two-dimensional ferromagnetic Ising model on a square lattice initially approaches the critical percolation state before entering the coarsening regime. This approach involves two timescales associated with the first appearance (at time t_{p_{1}}>0) and stabilization (at time t_{p}>t_{p_{1}}) of a giant percolation cluster, as previously reported. However, the microscopic mechanisms that control such timescales are not yet fully understood. In this paper, to study their role on each time regime after the quench (T_{F}=0), we distinguish between spin flips that decrease the total energy of the system from those that keep it constant, the latter being parametrized by the probability p. We show that observables such as the cluster size heterogeneity H(t,p) and the typical domain size ℓ(t,p) have no dependence on p in the first time regime up to t_{p_{1}}. Furthermore, when energy-decreasing flips are forbidden while allowing constant-energy flips, the kinetics is essentially frozen after the quench and there is no percolation event whatsoever. Taken together, these results indicate that the emergence of the first percolating cluster at t_{p_{1}} is completely driven by energy decreasing flips. However, the time for stabilizing a percolating cluster is controlled by the acceptance probability of constant-energy flips: t_{p}(p)∼p^{-1} for p≪1 (at p=0, the dynamics gets stuck in a metastable state). These flips are also the relevant ones in the later coarsening regime where dynamical scaling takes place. Because the phenomenology on the approach to the percolation point seems to be shared by many 2D systems with a nonconserved order parameter dynamics (and certain cases of conserved ones as well), our results may suggest a simple and effective way to set, through the dynamics itself, t_{p_{1}} and t_{p} in such systems.
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.106.044105
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  10. Article ; Online: Cheminformatics-driven discovery of hit compounds against

    de Oliveira, Amanda Alves / Carmo Silva, Lívia do / Neves, Bruno Junior / Fiaia Costa, Vinícius Alexandre / Muratov, Eugene N / Andrade, Carolina Horta / de Almeida Soares, Célia Maria / Alves, Vinicius M / Pereira, Maristela

    Future medicinal chemistry

    2023  Volume 15, Issue 17, Page(s) 1553–1567

    Abstract: Aims: ...

    Abstract Aims:
    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Paracoccidioides ; Cheminformatics ; Paracoccidioidomycosis/drug therapy ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2022-0288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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