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Article: Data Analysis of Impaired Renal and Cardiac Function Using a Combination of Standard Classifiers.

Tasic, Danijela / Furundzic, Drasko / Djordjevic, Katarina / Galovic, Slobodanka / Dimitrijevic, Zorica / Radenkovic, Sonja

Journal of personalized medicine

2023 Volume 13, Issue 3

Abstract: We examine the significance of the predictive potential of EPI cystatin C (EPI CysC) in combination with NTproBNP, sodium, and potassium in the evaluation of renal function in patients with cardiorenal syndrome using standard mathematical classification ... ...

Abstract	We examine the significance of the predictive potential of EPI cystatin C (EPI CysC) in combination with NTproBNP, sodium, and potassium in the evaluation of renal function in patients with cardiorenal syndrome using standard mathematical classification models from the domain of artificial intelligence. The criterion for the inclusion of subjects with combined impairment of heart and kidney function in the study was the presence of newly discovered or previously diagnosed clinically manifest cardiovascular disease and acute or chronic kidney disease in different stages of evolution. In this paper, five standard classifiers from the field of machine learning were used for the analysis of the obtained data: ensemble of neural networks (MLP), ensemble of
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13030437
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Data Analysis of Impaired Renal and Cardiac Function Using a Combination of Standard Classifiers

Danijela Tasic / Drasko Furundzic / Katarina Djordjevic / Slobodanka Galovic / Zorica Dimitrijevic / Sonja Radenkovic

Journal of Personalized Medicine, Vol 13, Iss 437, p

2023 Volume 437

Abstract	We examine the significance of the predictive potential of EPI cystatin C (EPI CysC) in combination with NTproBNP, sodium, and potassium in the evaluation of renal function in patients with cardiorenal syndrome using standard mathematical classification models from the domain of artificial intelligence. The criterion for the inclusion of subjects with combined impairment of heart and kidney function in the study was the presence of newly discovered or previously diagnosed clinically manifest cardiovascular disease and acute or chronic kidney disease in different stages of evolution. In this paper, five standard classifiers from the field of machine learning were used for the analysis of the obtained data: ensemble of neural networks (MLP), ensemble of k -nearest neighbors ( k -NN) and naive Bayes classifier, decision tree, and a classifier based on logistic regression. The results showed that in MLP, k -NN, and naive Bayes, EPI CysC had the highest predictive potential. Thus, our approach with utility classifiers recognizes the essence of the disorder in patients with cardiorenal syndrome and facilitates the planning of further treatment.
Keywords	kidney ; heart ; markers ; machine learning ; neural networks ; forecasting ensembles ; Medicine ; R
Subject code	006
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Case report the sudden cardiac death of a food delivery service worker due to unrecognized myocarditis

Stefanović Ivana / Sinđelić Vladimir / Anđelić Slađana / Tasić-Uroš Danijela / Milivojčević-Bevc Ivana / Čolaković Goran

Halo 194, Vol 29, Iss 2-3, Pp 63-

2023 Volume 67

Abstract: Introduction/Objective The COVID-19 pandemic enabled an increase in the use of food delivery apps and provided more work for delivery services, especially while the lockdown measures were in place. Many scientific papers have been written about ... ...

Abstract	Introduction/Objective The COVID-19 pandemic enabled an increase in the use of food delivery apps and provided more work for delivery services, especially while the lockdown measures were in place. Many scientific papers have been written about epidemiological measures and the safety of delivered food in the prevention of COVID-19, but there is little research dedicated to the pressures suffered by delivery service workers and the health consequences that may have arisen due to their unregulated work status. We present the rare combination of difficult work conditions and myocarditis, which led to the sudden cardiac death of a food delivery worker. Case report The Emergency Medical Team (EMT) was dispatched to help a person lying in a corridor of a building showing no signs of life. Upon arrival at the scene, they found an approximately 30-40-year-old man lying on the ground near the entrance of the building next to his bicycle with a delivery bag still on his back. He was unconscious, with no breathing or pulse, and with no visible signs of injury. Information was obtained from bystanders about a delivery to the fifth floor of the building with no elevator, but there was no reliable information about the time of cardiac arrest. The initial rhythm was asystole, so the non-shockable rhythm cardiopulmonary resuscitation (CPR) protocol was immediately initiated. During CPR, two IV lines were opened, seven adrenaline injections were administered intravenously (IV), a 0.9% NaCl solution was initiated, and the airway was secured by placing an endotracheal tube. Despite all the efforts, the resuscitation measures were unsuccessful, and the patient was pronounced dead. Because the patient had died in a public place of an unknown cause, the police was notified, and the body was transferred to forensic pathology. The autopsy revealed no macroscopic changes in the myocardium, but pathohistology did reveal myocarditis. Since all this occurred during the COVID-19 pandemic, a PCR test was performed, which was negative. ...
Keywords	myocarditis ; sudden cardiac arrest ; delivery workers ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	City Medical emergency department, Belgrade
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Non-Uniform Bioaccumulation of Lead and Arsenic in Two Remote Regions of the Human Heart's Left Ventricle: A Post-Mortem Study.

Cirovic, Ana / Orisakwe, Orish E / Cirovic, Aleksandar / Jevtic, Jovan / Tasic, Danijela / Tasic, Nebojsa

Biomolecules

2023 Volume 13, Issue 8

Abstract: The extent of heavy-metal-induced cardiotoxicity is proportional to the levels of metal bioaccumulation, and it was previously assumed that heavy metals accumulate uniformly in the myocardium. Therefore, the aim of this study was to investigate ... ...

Abstract	The extent of heavy-metal-induced cardiotoxicity is proportional to the levels of metal bioaccumulation, and it was previously assumed that heavy metals accumulate uniformly in the myocardium. Therefore, the aim of this study was to investigate concentrations of metals and metalloids in two distant regions of the left ventricle (LV), the base of the LV, and apex of the LV using inductively coupled plasma mass spectrometry (ICP-MS). We also examined the potential correlation between metal levels and the thickness of the interventricular septum in twenty LV specimens (ten from the base of LV and ten from the apex of LV) from 10 individuals (mean age 75 ± 6 years). We found significantly higher concentrations of arsenic and lead in the LV apex compared to the base of the LV. We also found a positive correlation between the concentrations of arsenic in the myocardium of LV and the thickness of the interventricular septum. Our results indicate that arsenic and lead accumulate to a higher extent in the apex of the LV compared to the base of the LV. Therefore, future studies designed to measure levels of metals in heart muscle should consider non-uniform accumulation of metals in the myocardium.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Arsenic/metabolism ; Arsenic/pharmacokinetics ; Arsenic/toxicity ; Autopsy ; Bioaccumulation ; Cardiotoxicity/metabolism ; Heart Ventricles/cytology ; Heart Ventricles/drug effects ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Lead/metabolism ; Lead/pharmacokinetics ; Lead/toxicity ; Ventricular Septum/cytology ; Ventricular Septum/drug effects ; Ventricular Septum/metabolism ; Ventricular Septum/pathology ; Aging/metabolism
Chemical Substances	Arsenic (N712M78A8G) ; Lead (2P299V784P)
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13081232
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Article ; Online: The application of the Kampala trauma Score for prehospital assessment of severity of injuries and prediction of outcome after severe trauma

Milivojčević-Bevc Ivana / Tasić-Uroš Danijela / Anđelić Slađana / Čolaković Goran / Petrović Snežana / Stefanović Ivana / Vukićević Verica

Halo 194, Vol 29, Iss 2-3, Pp 68-

2023 Volume 73

Abstract: Severe trauma is the main cause of mortality and disability in modern society. Emergency medical doctors are usually the first to establish contact with the injured person, and the extent of definitive care largely depends on their correct assessment of ... ...

Abstract	Severe trauma is the main cause of mortality and disability in modern society. Emergency medical doctors are usually the first to establish contact with the injured person, and the extent of definitive care largely depends on their correct assessment of the severity of the injury, using an adequate pre-hospital trauma score. Injury severity scores are used to numerically categorize the type and extent of the injury. They represent an important additional instrument, which is used to enable faster triage, the categorization of injury severity, adequate care, treatment, and transport of patients with multiple injuries to the appropriate hospital. They are also important in research. This paper aims to suggest, using several case reports, the possibility of pre-hospital use of the Kampala Trauma Score (KTS) as an easily applicable and very suitable system for monitoring the condition and predicting the outcome of seriously injured patients. The patients were primarily assessed at the pre-hospital level and assigned a certain injury severity score according to the KTS, which later proved to reflect their definitive outcome. It can be concluded that the KTS is an effective scoring system that can be used during initial triage of the seriously injured for categorization of the severity of the injury, prediction of mortality and necessity of hospitalization. The possibility of its potential application during emergency care of the seriously injured, both for differentiating the severity of injuries and for predicting the definitive outcome, is indicated. However, due to the limited number of patients, original research should be conducted on a larger sample.
Keywords	kampala trauma score ; trauma ; outcome ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	City Medical emergency department, Belgrade
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Activity of

Fonseca, Maísa Santos / Rodrigues, Daniela Méria / Sokolonski, Ana Rita / Stanisic, Danijela / Tomé, Luiz Marcelo / Góes-Neto, Aristóteles / Azevedo, Vasco / Meyer, Roberto / Araújo, Danilo Barral / Tasic, Ljubica / Portela, Ricardo Dias

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: ... ...

Abstract	Candida
Language	English
Publishing date	2022-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12030501
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Article ; Online: Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections

Zorica Dimitrijevic / Goran Paunovic / Danijela Tasic / Branka Mitic / Dragoslav Basic

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study ... ...

Abstract	Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study was undertaken to evaluate the incidence and possible risk factors for urosepsis among patients hospitalized with UTI in a cohort of CKD patients. Patients were divided into the urosepsis group and the non-urosepsis group. Of 489 hospitalized patients with UTI, 70 (14.3%) acquired urosepsis. Stepwise multivariate logistic regression demonstrated that diabetes, urinary catheter and length of hospital stay (p < 0.001 for all) were significant independent predictive risk factors for urosepsis in CKD patients with UTI in addition to age, glomerular filtration rate, hydronephrosis, acute kidney injury and E. coli infection (p < 0.05 for all). Finally, Klebsiella spp. cases were associated with significantly higher odds for urosepsis than E. coli cases (OR: 3.5, 95% CI: 2.86–7.23, p < 0.001 vs. OR: 1.38, 95% CI: 1.19–3.69, p = 0.038). Diabetes, presence of an indwelling urinary catheter, length of hospitalization, and infection with Klebsiella spp were independent risk factors for urosepsis in CKD patients with UTI.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Is It Possible to Analyze Kidney Functions, Electrolytes and Volemia Using Artificial Intelligence?

Tasić, Danijela / Đorđević, Katarina / Galović, Slobodanka / Furundžić, Draško / Dimitrijević, Zorica / Radenković, Sonja

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: Markers used in everyday clinical practice cannot distinguish between the permanent impairment of renal function. Sodium and potassium values and their interdependence are key parameters in addition to volemia for the assessment of cardiorenal balance. ... ...

Abstract	Markers used in everyday clinical practice cannot distinguish between the permanent impairment of renal function. Sodium and potassium values and their interdependence are key parameters in addition to volemia for the assessment of cardiorenal balance. The aim of this study was to investigate volemia and electrolyte status from a clinical cardiorenal viewpoint under consideration of renal function utilizing artificial intelligence. In this paper, an analysis of five variables: B-type natriuretic peptide, sodium, potassium, ejection fraction, EPI creatinine-cystatin C, was performed using an algorithm based on the adaptive neuro fuzzy inference system. B-type natriuretic peptide had the greatest influence on the ejection fraction. It has been shown that values of both Na+ and K+ lead to deterioration of the condition and vital endangerment of patients. To identify the risk of occurrence, the model identifies a prognostic biomarker by random regression from the total data set. The predictions obtained from this model can help optimize preventative strategies and intensive monitoring for patients identified as at risk for electrolyte disturbance and hypervolemia. This approach may be superior to the traditional diagnostic approach due to its contribution to more accurate and rapid diagnostic interpretation and better planning of further patient treatment.
Language	English
Publishing date	2022-12-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12123131
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Article ; Online: Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections.

Dimitrijevic, Zorica / Paunovic, Goran / Tasic, Danijela / Mitic, Branka / Basic, Dragoslav

Scientific reports

2021 Volume 11, Issue 1, Page(s) 14414

Abstract: Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study was ... ...

Abstract	Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study was undertaken to evaluate the incidence and possible risk factors for urosepsis among patients hospitalized with UTI in a cohort of CKD patients. Patients were divided into the urosepsis group and the non-urosepsis group. Of 489 hospitalized patients with UTI, 70 (14.3%) acquired urosepsis. Stepwise multivariate logistic regression demonstrated that diabetes, urinary catheter and length of hospital stay (p < 0.001 for all) were significant independent predictive risk factors for urosepsis in CKD patients with UTI in addition to age, glomerular filtration rate, hydronephrosis, acute kidney injury and E. coli infection (p < 0.05 for all). Finally, Klebsiella spp. cases were associated with significantly higher odds for urosepsis than E. coli cases (OR: 3.5, 95% CI: 2.86-7.23, p < 0.001 vs. OR: 1.38, 95% CI: 1.19-3.69, p = 0.038). Diabetes, presence of an indwelling urinary catheter, length of hospitalization, and infection with Klebsiella spp were independent risk factors for urosepsis in CKD patients with UTI.
MeSH term(s)	Aged ; Escherichia coli ; Humans ; Length of Stay ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Urinary Tract Infections
Language	English
Publishing date	2021-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-93912-3
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Article ; Online: Accuracy of the COMBEI BP118A Device for Self-Blood Pressure Measurements in General Population - Validation According to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization Universal Standard.

Tasić, Nebojsa / Topouchian, Jirar / Tasic, Danijela / Kovacevic, Zorana / Filipovic, Marko / Asmar, Roland

Vascular health and risk management

2022 Volume 18, Page(s) 123–129

Abstract: Background: Electronic devices for blood pressure (BP) measurements must undergo independent clinical validation as recommended by various authorities and scientific societies.: Objective: To assess the accuracy of the Combei BP118A device in the ... ...

Abstract	Background: Electronic devices for blood pressure (BP) measurements must undergo independent clinical validation as recommended by various authorities and scientific societies. Objective: To assess the accuracy of the Combei BP118A device in the general population according to the Universal Standard Validation Protocol. Methods: The new-developed Combei BP118A device measures BP at the brachial level using the oscillometric method. The study was performed according to the "AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) protocol". Subjects (n = 88) were recruited to fulfill the age, gender, BP and cuff distribution criteria according to the protocol requirements using the same arm sequential BP measurement method. Differences between observers' mercury sphygmomanometer reference measurements and device BP values (test versus reference) and their standard deviation (SD) were calculated. Results: Ninety-one subjects were selected, 88 of whom were included. The mean BP differences between the simultaneous observers' reference measurements were -0.2 ± 1.7 mmHg for systolic BP (SBP) and -0.2 ± 1.7 mmHg for diastolic BP (DBP). For validation criterion 1, the mean difference ± SD between the reference and device BP values were 3.6 ± 5.5 mmHg for SBP and 1.4 ± 4.5 mmHg for DBP. For criterion 2, the SD of the mean BP differences between the test device and reference BP per subject was 5/4.1 mmHg for SBP/DBP (≤5.9/6.8). These results fulfilled the protocol requirements. Conclusion: The Combei BP118A oscillometric device for home BP measurement fulfilled all of the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) in general population and consequently can be recommended for home BP measurements.
MeSH term(s)	Blood Pressure ; Blood Pressure Determination ; Humans ; Hypertension/diagnosis ; Reference Standards ; Sphygmomanometers
Language	English
Publishing date	2022-03-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/VHRM.S353715
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