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  1. Article ; Online: Apixaban for the treatment of acute splanchnic vein thrombosis: A pilot study.

    Kim, Sang-A / Choi, Gwang Hyeon / Lee, Ji Yun / Jang, Eun Sun / Lee, Jeong-Ok / Kim, Jin-Wook / Jeong, Sook-Hyang / Bang, Soo-Mee

    Thrombosis research

    2024  Volume 237, Page(s) 181–183

    MeSH term(s) Humans ; Pilot Projects ; Pyrazoles/therapeutic use ; Venous Thrombosis/drug therapy ; Male ; Female ; Middle Aged ; Pyridones/therapeutic use ; Factor Xa Inhibitors/therapeutic use ; Aged ; Adult ; Splanchnic Circulation/drug effects ; Acute Disease
    Chemical Substances apixaban (3Z9Y7UWC1J) ; Pyrazoles ; Pyridones ; Factor Xa Inhibitors
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proteolytic Activity of Silkworm Thorn (

    Yang, Na-Eun / Lee, Da-Hoon / Hwang, Jun / Son, Woo-Young / Kim, Kyeong-Soo / Kim, Gwang-Yeon / Kim, Hyun-Wook

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: This study aimed to isolate the proteolytic fraction from the silkworm thorn fruit ( ...

    Abstract This study aimed to isolate the proteolytic fraction from the silkworm thorn fruit (
    MeSH term(s) Animals ; Humans ; Hydrolysis ; Bombyx/metabolism ; Papain/metabolism ; Fruit/metabolism ; Powders ; Peptide Hydrolases/metabolism ; Whey Proteins ; Maclura ; Soybean Proteins ; Subtilisins/metabolism ; Ethanol
    Chemical Substances Papain (EC 3.4.22.2) ; Powders ; Peptide Hydrolases (EC 3.4.-) ; Whey Proteins ; Soybean Proteins ; Subtilisins (EC 3.4.21.-) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hemiballism, a rare complication of coil embilization.

    Kim, Sung Ho / Yeo, Dong Kyu / Lee, Gwang Soo

    Journal of cerebrovascular and endovascular neurosurgery

    2022  Volume 24, Issue 4, Page(s) 366–371

    Abstract: Thromboembolism is one of the major complications during coil embolization of an aneurysm, which usually causes familiar neurological deficits, such as, weakness, aphasia, etc. We report a rare complication by thromboembolism after coil embolization ... ...

    Abstract Thromboembolism is one of the major complications during coil embolization of an aneurysm, which usually causes familiar neurological deficits, such as, weakness, aphasia, etc. We report a rare complication by thromboembolism after coil embolization causing hemiballism. A 69-year-old female presented with unruptured posterior communicating artery aneurysm and was treated by coil embolization. After the procedure, the patient showed global aphasia and right hemiparesis, and there were small multiple, scattered infarctions on the left middle cerebral artery territory. The neurologic deficit subsided after five days, but hemballism occurred thereafter. There was no other medical history to explain the hemiballism. The patient was treated with clonazepam and antiepileptics and the hemiballism subsided at postoperative day 20. We report a case of rare complication, hemiballism, during coil embolization.
    Language English
    Publishing date 2022-07-07
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2234-8565
    ISSN 2234-8565
    DOI 10.7461/jcen.2022.E2021.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ancistrocladus tectorius

    Kim, Minju / Paik, Jin Hyub / Lee, Hwa / Kim, Min Ji / Eum, Sang Mi / Kim, Soo Yong / Choi, Sangho / Park, Ho-Yong / Jeong, Hye Gwang / Jeong, Tae-Sook

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Root extracts ... ...

    Abstract Root extracts of
    MeSH term(s) Animals ; Mice ; Mice, Inbred C57BL ; Diet, High-Fat/adverse effects ; Mitochondrial Dynamics ; Insulin ; Caryophyllales ; Plant Extracts/pharmacology
    Chemical Substances Insulin ; Plant Extracts
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs

    Gwang-Hoon Lee / Woori Jo / Joon-Suk Park / Tae-Ku Kang / Soo-Eun Sung / Taeho Oh / KilSoo Kim

    Laboratory Animal Research, Vol 39, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: Abstract Background The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes. This study aims to ... ...

    Abstract Abstract Background The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes. This study aims to describe the process and findings of veterinary medical check-ups and its influence on laboratory dogs and pigs welfare. Regular medical checkups were conducted by the attending veterinarian twice a year to ensure the health and welfare of dogs and pigs in our animal research institute. Based on the findings from the medical checkup, we assessed the current health of dogs and pigs,providing reasonable treatments to prevent the risk of complications. Results Blood tests and physical examinations revealed clinically relevant findings. Some of these findings were due to insufficient postoperative care after invasive surgical experiments and the remaining were predictable side effects after surgical experiments. However, one finding involved severe gum bleeding due to retained deciduous teeth. This animal was euthanized because it was judged to reach the humane endpoint. Majority of the dogs and pigs at our animal research institute were considered to be healthy, based on the comprehensive results of the medical checkups. Conclusions Regular medical checkups by the attending veterinarian established enhanced animal welfare, ensuring the accuracy and reproducibility of animal studies. This pioneering veterinary animal care program can serve as a potential advanced guideline for animal research institutes to improve dogs and pigs welfare.
    Keywords Attending Veterinarian ; Laboratory animal ; Dog ; Pig ; Animal welfare ; Medical checks ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 630
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs.

    Lee, Gwang-Hoon / Jo, Woori / Park, Joon-Suk / Kang, Tae-Ku / Sung, Soo-Eun / Oh, Taeho / Kim, KilSoo

    Laboratory animal research

    2023  Volume 39, Issue 1, Page(s) 24

    Abstract: Background: The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes. This study aims to describe ... ...

    Abstract Background: The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes. This study aims to describe the process and findings of veterinary medical check-ups and its influence on laboratory dogs and pigs welfare. Regular medical checkups were conducted by the attending veterinarian twice a year to ensure the health and welfare of dogs and pigs in our animal research institute. Based on the findings from the medical checkup, we assessed the current health of dogs and pigs,providing reasonable treatments to prevent the risk of complications.
    Results: Blood tests and physical examinations revealed clinically relevant findings. Some of these findings were due to insufficient postoperative care after invasive surgical experiments and the remaining were predictable side effects after surgical experiments. However, one finding involved severe gum bleeding due to retained deciduous teeth. This animal was euthanized because it was judged to reach the humane endpoint. Majority of the dogs and pigs at our animal research institute were considered to be healthy, based on the comprehensive results of the medical checkups.
    Conclusions: Regular medical checkups by the attending veterinarian established enhanced animal welfare, ensuring the accuracy and reproducibility of animal studies. This pioneering veterinary animal care program can serve as a potential advanced guideline for animal research institutes to improve dogs and pigs welfare.
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2623220-0
    ISSN 2233-7660 ; 1738-6055
    ISSN (online) 2233-7660
    ISSN 1738-6055
    DOI 10.1186/s42826-023-00170-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Impact of Fine Particulate Matter 2.5 on the Cardiovascular System: A Review of the Invisible Killer.

    Basith, Shaherin / Manavalan, Balachandran / Shin, Tae Hwan / Park, Chan Bae / Lee, Wang-Soo / Kim, Jaetaek / Lee, Gwang

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 15

    Abstract: Air pollution exerts several deleterious effects on the cardiovascular system, with cardiovascular disease (CVD) accounting for 80% of all premature deaths caused by air pollution. Short-term exposure to particulate matter 2.5 ( ... ...

    Abstract Air pollution exerts several deleterious effects on the cardiovascular system, with cardiovascular disease (CVD) accounting for 80% of all premature deaths caused by air pollution. Short-term exposure to particulate matter 2.5 (PM
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12152656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cera-Glow, ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, improves skin barrier function in clinical study.

    Lee, Minjee / Kim, Myun Soo / Jang, Sung Hee / Kim, Hayoung / Kim, Gwang Seob / Lee, Hyerin / Park, Hyun Min / Yang, Jungwoo

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 6, Page(s) 1879–1886

    Abstract: Background: Ceramides are essential lipids in stratum corneum for skin permeability barrier function in that they retain the skin moisture and protect from the invasion of foreign pathogens. Previously, we demonstrated that ferment lysates of ... ...

    Abstract Background: Ceramides are essential lipids in stratum corneum for skin permeability barrier function in that they retain the skin moisture and protect from the invasion of foreign pathogens. Previously, we demonstrated that ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201 enhanced ceramide production in human epidermal keratinocytes. Furthermore, for comprehensive knowledge of this effect, in vitro experiments and multi-omics analysis were conducted to explore the underlying mechanisms.
    Aims: This study was designed to identify whether a cosmetic sample (i.e., Cera-Glow) containing the lysates improves the skin barrier function in clinical trials.
    Patients/methods: Twenty-four female participants (45.46 ± 9.78 years) had been enrolled in the transepidermal water loss (TEWL) measurement for 5 days and 21 female participants (50.33 ± 5.74 years) had undergone a skin hydration evaluation for 4 weeks. TEWL and skin hydration were evaluated using a Tewameter and the Epsilon Permittivity Imaging System, respectively. After applying the Cera-Glow sample, all participants recorded a satisfaction survey questionnaire (e.g., satisfaction, efficacy, and adverse reactions).
    Results: Application of Cera-Glow significantly improved transepidermal water loss induced by 1% (w/v) sodium lauryl sulfate (p < 0.05-0.01) and increased skin hydration (p < 0.01). Metabolic analysis suggested that Cera-Glow should contain beneficial gradients for skin barrier function. According to the questionnaire, most of participants were satisfied with the skin hydration improvement and efficacy of Cera-Glow.
    Conclusions: Cera-Glow, ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, can significantly improve skin barrier function.
    MeSH term(s) Humans ; Female ; Lacticaseibacillus ; Lacticaseibacillus rhamnosus ; Skin ; Epidermis ; Dermatologic Agents/pharmacology ; Water/metabolism
    Chemical Substances Dermatologic Agents ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Human Bone Marrow-Derived Mesenchymal Stem Cell Applications in Neurodegenerative Disease Treatment and Integrated Omics Analysis for Successful Stem Cell Therapy.

    Kim, Seok Gi / George, Nimisha Pradeep / Hwang, Ji Su / Park, Seokho / Kim, Myeong Ok / Lee, Soo Hwan / Lee, Gwang

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 5

    Abstract: Neurodegenerative diseases (NDDs), which are chronic and progressive diseases, are a growing health concern. Among the therapeutic methods, stem-cell-based therapy is an attractive approach to NDD treatment owing to stem cells' characteristics such as ... ...

    Abstract Neurodegenerative diseases (NDDs), which are chronic and progressive diseases, are a growing health concern. Among the therapeutic methods, stem-cell-based therapy is an attractive approach to NDD treatment owing to stem cells' characteristics such as their angiogenic ability, anti-inflammatory, paracrine, and anti-apoptotic effects, and homing ability to the damaged brain region. Human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) are attractive NDD therapeutic agents owing to their widespread availability, easy attainability and in vitro manipulation and the lack of ethical issues. Ex vivo hBM-MSC expansion before transplantation is essential because of the low cell numbers in bone marrow aspirates. However, hBM-MSC quality decreases over time after detachment from culture dishes, and the ability of hBM-MSCs to differentiate after detachment from culture dishes remains poorly understood. Conventional analysis of hBM-MSCs characteristics before transplantation into the brain has several limitations. However, omics analyses provide more comprehensive molecular profiling of multifactorial biological systems. Omics and machine learning approaches can handle big data and provide more detailed characterization of hBM-MSCs. Here, we provide a brief review on the application of hBM-MSCs in the treatment of NDDs and an overview of integrated omics analysis of the quality and differentiation ability of hBM-MSCs detached from culture dishes for successful stem cell therapy.
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10050621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical application of bone turnover markers in treating osteoporotic vertebral compression fractures and their role in predicting fracture progression.

    Han, Moon-Soo / Lee, Gwang-Jun / Lee, Seul-Kee / Lee, Jung-Kil / Moon, Bong Ju

    Medicine

    2022  Volume 101, Issue 32, Page(s) e29983

    Abstract: This study aimed to investigate whether changes in the bone turnover markers (BTMs) during teriparatide therapy for osteoporotic vertebral compression fractures could reflect therapeutic effects by analyzing the relationship between clinical and ... ...

    Abstract This study aimed to investigate whether changes in the bone turnover markers (BTMs) during teriparatide therapy for osteoporotic vertebral compression fractures could reflect therapeutic effects by analyzing the relationship between clinical and radiological features and BTMs. A total of 33 patients with 51 osteoporotic vertebral compression fracture segments were included. Plain radiographs and BTM levels were evaluated at the pretreatment and at 3 months after teriparatide treatment. Based on serial vertebral compression ratio analysis, the progression of fracture was defined as a vertebral compression ratio decrease of ≥10%, relative to the pretreatment values. All segments were divided into 2 groups: the "maintain" group with 32 (62.7%) segments and the "progression" group with 19 (37.3%) segments. After the teriparatide treatment, serum osteocalcin and serum C-terminal telopeptide of type I collagen levels (P = .028 and .008, respectively), and change amounts of them were significantly larger, increasing (P = .001) in the progression group. The vitamin D (25OH-D) levels were significantly lower (P = .038) in the progression group; however, the relative changes in the 25OH-D levels between the 2 groups, before and after the treatment, were not significantly different (P = .077). The parathyroid hormone (PTH) levels were reduced by the teriparatide treatment in both groups, while the decrease in PTH concentration after the treatment was significantly more pronounced in the progression group (P = .006). Significant increase in the osteocalcin and serum C-terminal telopeptide of type I collagen levels and a simultaneous decrease in the PTH levels during the teriparatide treatment suggest that clinicians should assume the progression of fracture.
    MeSH term(s) Bone Density ; Bone Density Conservation Agents/therapeutic use ; Bone Remodeling ; Collagen Type I ; Fractures, Compression/drug therapy ; Humans ; Osteocalcin ; Osteoporotic Fractures/drug therapy ; Parathyroid Hormone ; Spinal Fractures/drug therapy ; Teriparatide/therapeutic use
    Chemical Substances Bone Density Conservation Agents ; Collagen Type I ; Parathyroid Hormone ; Osteocalcin (104982-03-8) ; Teriparatide (10T9CSU89I)
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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