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Article ; Online: ASO Author Reflections: Oncological Outcomes of Adding Induction Chemotherapy Before Chemoradiotherapy with Total Mesorectal Excision and Selective Lateral Lymph Node Dissection in Patients with Poor-Risk, Locally Advanced Rectal Cancer.

Yamaguchi, Tomohiro / Akiyoshi, Takashi / Konishi, Tsuyoshi

2023 Volume 30, Issue 8, Page(s) 4725–4726

MeSH term(s)	Humans ; Induction Chemotherapy ; Lymph Node Excision ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Chemoradiotherapy ; Treatment Outcome ; Neoplasm Staging ; Neoadjuvant Therapy ; Retrospective Studies
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13462-y
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Article ; Online: Stabilization of sp-Hybridized Nitrogen Cation by Lewis Acid-Base Complex Formation with Intramolecular Iodine.

Fujino, Tomohiro / Hyodo, Tadashi / Otani, Yuko / Yamaguchi, Kentaro / Ohwada, Tomohiko

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 30, Issue 5, Page(s) e202303393

Abstract: Here we show that the sp-hybridized nitrogen cation is strongly stabilized by a peri-iodine substituent in the tetralone system. The cation is captured by anionic species such as ... ...

Abstract	Here we show that the sp-hybridized nitrogen cation is strongly stabilized by a peri-iodine substituent in the tetralone system. The cation is captured by anionic species such as CF
Language	English
Publishing date	2023-11-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303393
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Article ; Online: Tetrodotoxin/Saxitoxin Accumulation Profile in the Euryhaline Marine Pufferfish

Zhu, Hongchen / Sakai, Takashi / Doi, Hiroyuki / Yamaguchi, Kenichi / Yamada, Akinori / Takatani, Tomohiro / Arakawa, Osamu

Toxins

2023 Volume 16, Issue 1

Abstract: ... ...

Abstract	Marine
MeSH term(s)	Animals ; Saxitoxin ; Tetrodotoxin ; Takifugu ; Fresh Water ; Liver
Chemical Substances	Saxitoxin (35523-89-8) ; Tetrodotoxin (4368-28-9)
Language	English
Publishing date	2023-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins16010018
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Article ; Online: Incidence and risk factors of bowel dysfunction after minimally invasive rectal cancer surgery and discrepancies between the Wexner score and the low anterior resection syndrome (LARS) score.

Ota, Emi / Nagasaki, Toshiya / Akiyoshi, Takashi / Mukai, Toshiki / Hiyoshi, Yukiharu / Yamaguchi, Tomohiro / Fukunaga, Yosuke

Surgery today

2024

Abstract: Purpose: Bowel dysfunction after sphincter-preserving-surgery (SPS) impacts quality of life. The Wexner score (WS) and the low anterior resection syndrome (LARS) score (LS) are instruments for assessing postoperative bowel dysfunction. We analyzed the ... ...

Abstract	Purpose: Bowel dysfunction after sphincter-preserving-surgery (SPS) impacts quality of life. The Wexner score (WS) and the low anterior resection syndrome (LARS) score (LS) are instruments for assessing postoperative bowel dysfunction. We analyzed the incidence of and risk factors for each symptom and examined the discrepancies between the two scores. Methods: A total of 142 patients with rectal cancer, who underwent minimally invasive SPS between May, 2018 and July, 2019, were included. A questionnaire survey using the two scores was given to the patients 2 years after SPS. Results: Tumor location and preoperative radiotherapy were independent risk factors for major LARS. Intersphincteric resection with a hand-sewn anastomosis (HSA) was an independent risk factor for high WS. Among the patients who underwent HSA, 82% experienced incontinence for liquid stools, needed to wear pads, and suffered lifestyle alterations. Of the 35 patients with minor LARS, only 1 had a high WS, and 80.0% reported no lifestyle alterations. Among the 75 patients with major LARS, 58.7% had a low WS and 21.3% reported no lifestyle alterations. Conclusion: The results of this study provide practical data to help patients understand potential bowel dysfunction after SPS. The discrepancies between the WS and LS were clarified, and further efforts are required to utilize these scores in clinical practice.
Language	English
Publishing date	2024-01-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-023-02789-4
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Article ; Online: An analysis of the contents of the young-onset dementia helpline: profiles of clients who consulted the helpline themselves.

Kogata, Tomohiro / Saito, Chiaki / Kato, Fukiko / Kudo, Jumpei / Yamaguchi, Yusuke / Lee, Sangyoon / Washimi, Yukihiko

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

2024 Volume 24, Issue 3, Page(s) 617–626

Abstract: Background: Young-onset dementia (YOD) community care requires personalised approaches. Yet, the specific details of YOD consultations are unclear. This study explored how initial consultations correlate with client profiles.: Methods: Data from ... ...

Abstract	Background: Young-onset dementia (YOD) community care requires personalised approaches. Yet, the specific details of YOD consultations are unclear. This study explored how initial consultations correlate with client profiles. Methods: Data from regional YOD helplines were used to analyze the main characteristics of people living with YOD or who had concerns about the possibility of YOD (n = 132). Among several categorical variables, the following were used for analysis: age group, sex, type of living arrangement, employment status, presence of dementia, and content of the consultation. To identify groups of items that frequently occur together, strongly connected rules were identified using association rule analysis with the a priori algorithm. To focus on the characteristics of clients, rules related to client characteristics were extracted based on the type of consultation. Results: A total of 51 rules were identified for the consultations. These rules fell into two categories: (1) consultations for medical matters, which mainly involved employed individuals with undiagnosed dementia, and (2) other consultations on daily life or work, which mainly involved individuals diagnosed with dementia and were characterised by the influence of sex. These rules indicate the importance of medical involvement in confirming the diagnosis and specific individualised care following diagnosis for people living with YOD. Conclusion: Clients with or without a dementia diagnosis were consulted differently in the YOD helplines. Before receiving a diagnosis, medical matters were the main theme of consultations, whereas after receiving a diagnosis, adjustments to daily life or work were the main themes. The results of this study suggest that the needs of people living with YOD and the services they require may vary depending on their backgrounds.
MeSH term(s)	Humans ; Male ; Female ; Dementia/diagnosis ; Middle Aged ; Aged ; Age of Onset ; Hotlines/statistics & numerical data ; Referral and Consultation/statistics & numerical data ; Adult ; Japan
Language	English
Publishing date	2024-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2213105-X
ISSN	1479-8301 ; 1346-3500
ISSN (online)	1479-8301
ISSN	1346-3500
DOI	10.1111/psyg.13105
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Article: Complex phenotypic heterogeneity of combined hepatocellular-cholangiocarcinoma with a homogenous

Ohni, Sumie / Yamaguchi, Hiromi / Hirotani, Yukari / Nakanishi, Yoko / Midorikawa, Yutaka / Sugitani, Masahiko / Nakayama, Tomohiro / Makishima, Makoto / Esumi, Mariko

American journal of translational research

2024 Volume 16, Issue 2, Page(s) 690–699

Abstract: To clarify the mechanism underlying the development and poor prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), we characterized liver cancer driver mutations and poor prognostic markers in both the HCC and intrahepatic CCA (iCCA) ... ...

Abstract	To clarify the mechanism underlying the development and poor prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), we characterized liver cancer driver mutations and poor prognostic markers in both the HCC and intrahepatic CCA (iCCA) components of a cHCC-CCA tumor. The telomerase reverse transcriptase (
Language	English
Publishing date	2024-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Blood flow pattern in eye before development of type 3 macular neovascularization.

Yamaguchi, Saya / Maruko, Ichiro / Maruko, Ruka / Hasegawa, Taiji / Iida, Tomohiro

PloS one

2023 Volume 18, Issue 3, Page(s) e0283202

Abstract: Purpose: To determine the blood flow pattern of eyes before the development of type 3 macular neovascularization (MNV) by optical coherence tomography angiography (OCTA).: Study design: Retrospective study.: Subjects: Ten eyes of 10 patients (4 ... ...

Abstract	Purpose: To determine the blood flow pattern of eyes before the development of type 3 macular neovascularization (MNV) by optical coherence tomography angiography (OCTA). Study design: Retrospective study. Subjects: Ten eyes of 10 patients (4 men and 6 women, mean age 80.4 years) diagnosed with unilateral Type 3 MNV who developed type 3 MNV in the fellow normal eye during the follow-up period were studied. Methods: The time of onset of type 3 MNV was defined as the time when retinal exudation was detected by OCT. The blood flow of a 3 x 3 mm or 6 x 6 mm area in the deep capillary plexus (DCP) and the outer retina (OR) including the central fovea were assessed at the onset and at 6 months prior to the onset of the type 3 MNV. Results: All MNVs that developed in the fellow eye were type 3 MNVs. Abnormal blood flow signals in the MNVs were detected in the DCP and/or the OR by OCTA at the onset in all cases. Eight of the 10 eyes had OCTA recordings prior to the development of the MNV: 3 eyes had non-exudative MNVs only in the DCP and 5 eyes had non-exudative MNVs in the DCP and OR. The exudation appeared on the average 3.5 months after the non-exudative MNV was observed in the fellow eyes. Conclusions: A non-exudative MNV in the fellow eyes can already be observed by OCTA in eyes before the onset of the exudation. Knowing this will help clinicians not only how to treat these eyes appropriately but will also help in determining the origin of the MNV.
MeSH term(s)	Male ; Humans ; Female ; Aged, 80 and over ; Retrospective Studies ; Fluorescein Angiography/methods ; Choroidal Neovascularization/diagnosis ; Fovea Centralis ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283202
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Article ; Online: Commissural alignment in the Evolut TAVR procedure: conventional versus hat marker-guided shaft rotation methods.

Konami, Yutaka / Sakamoto, Tomohiro / Suzuyama, Hiroto / Horio, Eiji / Yamaguchi, Junichi

AsiaIntervention

2023 Volume 9, Issue 2, Page(s) 156–165

Abstract: Background: Coronary cannulation after TAVR is sometimes difficult due to an overlap between native and neo-commissures, especially in Evolut devices with a supra-annular position. The Evolut C-tab corresponds to a neo-commissure, and the hat marker is ... ...

Abstract	Background: Coronary cannulation after TAVR is sometimes difficult due to an overlap between native and neo-commissures, especially in Evolut devices with a supra-annular position. The Evolut C-tab corresponds to a neo-commissure, and the hat marker is in a fixed position. Therefore, the orientation of the hat marker can be adjusted to minimise overlaps. Aims: We investigated whether the HAt marker-guided SHaft rotation method (HASH, stylised as the #rotation method) is effective in facilitating coronary artery access after transcatheter aortic valve replacement (TAVR) with an Evolut system. Methods: We retrospectively analysed 95 patients who underwent electrocardiogram-gated cardiac computed tomography after TAVR. In the #rotation method, the hat marker of the delivery catheter was adjusted to face the greater curvature of the descending thoracic aorta in the left anterior oblique view. Its orientation was maintained while the system passed through the aortic arch. Results: In total, 60 and 35 patients underwent TAVR with the #rotation and non-#rotation methods, respectively. A ±15° angle between the native and neo-commissures was more frequent in the #rotation group (p=0.001). Favourable angles and appropriate frame orientation for access to the left coronary artery were significantly more frequent in the #rotation group than in the non-#rotation group (p<0.001 and p=0.001). Although the #rotation method showed a higher rate of favourable angles and frames in the right coronary artery, statistically significant differences were not found. Conclusions: The #rotation method is useful for improving commissural post alignment in TAVR with Evolut devices, especially in the ostium of the left coronary artery.
Language	English
Publishing date	2023-09-21
Publishing country	France
Document type	Journal Article
ISSN	2491-0929
ISSN (online)	2491-0929
DOI	10.4244/AIJ-D-23-00017
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Article ; Online: Knockdown of Chronophage in the nervous system mimics features of neurodevelopmental disorders caused by BCL11A/B variants.

Yamaguchi, Mizuki / Huynh, Man Anh / Chiyonobu, Tomohiro / Yoshida, Hideki

Experimental cell research

2023 Volume 433, Issue 2, Page(s) 113827

Abstract: Neurodevelopmental disorders (NDD) are a group of disorders that include intellectual disability. Although several genes have been implicated in NDD, the molecular mechanisms underlying its pathogenesis remain unclear. Therefore, it is important to ... ...

Abstract	Neurodevelopmental disorders (NDD) are a group of disorders that include intellectual disability. Although several genes have been implicated in NDD, the molecular mechanisms underlying its pathogenesis remain unclear. Therefore, it is important to develop novel models to analyze the functions of NDD-causing genes in vivo. Recently, rare pathogenic variants of the B-cell lymphoma/leukemia11A/B (BCL11A/B) gene have been identified in several patients with NDD. Drosophila carries the Chronophage (Cph) gene, which has been predicted to be a homolog of BCL11A/B based on the conservation of the amino acid sequence. In the present study, we investigated whether nervous system-specific knockdown of Cph mimics NDD phenotypes in Drosophila. Nervous system-specific knockdown of Cph induced learning and locomotor defects in larvae and epilepsy-like behaviors in adults. The number of synaptic branches was also elevated in the larval neuromuscular junction without a corresponding increase in the number of boutons. Furthermore, the expression levels of putative target genes that are Drosophila homologs of the mammalian BCL11 target genes were decreased in Cph knockdown flies. These results suggest that Cph knockdown flies are a promising model for investigating the pathology of NDD-induced BCL11A/B dysfunction.
MeSH term(s)	Drosophila/genetics ; Intellectual Disability/genetics ; Mammals ; Neurodevelopmental Disorders/genetics ; Repressor Proteins ; Transcription Factors/genetics ; Drosophila Proteins/genetics
Chemical Substances	BCL11A protein, human ; Repressor Proteins ; Transcription Factors ; Drosophila Proteins
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2023.113827
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Article ; Online: [Structural and Pharmacological Studies of an ABC Multidrug Transporter].

Yamaguchi, Tomohiro

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2016 Volume 136, Issue 2, Page(s) 197–202

Abstract: A drug's effectiveness against a disease depends not only on its interaction with receptors but also its pharmacokinetics (absorption, distribution, metabolism, and extrusion; ADME). ATP binding cassette (ABC) multidrug transporters are important ... ...

Abstract	A drug's effectiveness against a disease depends not only on its interaction with receptors but also its pharmacokinetics (absorption, distribution, metabolism, and extrusion; ADME). ATP binding cassette (ABC) multidrug transporters are important proteins that influence the ADME properties of a drug, especially the ABC transporter subfamily B member 1 (ABCB1). Elucidation of the molecular mechanisms of ABCB1 will contribute to our understanding of the molecular basis of ADME. Human ABCB1 is expressed in many organelles, and exports various substrates from cells using energy generated by its ATP hydrolase (ATPase) activity. The ATPase activity depends on the concentration of the transport substrates, and the characteristic behavior of the substrate-dependent ATPase activity can be related to the molecular mechanism of ABCB1. Recently, we have revealed the molecular mechanisms of a eukaryotic ABCB1 homolog, CmABCB1, based on structural and functional studies. In this review, I discuss the relationship between key structural features and the behavior of transport substrate-dependent ATPase activity of CmABCB1, including its role in determining the molecular basis of ADME.
MeSH term(s)	ATP Binding Cassette Transporter, Sub-Family B/chemistry ; ATP Binding Cassette Transporter, Sub-Family B/physiology ; ATP-Binding Cassette Transporters/chemistry ; ATP-Binding Cassette Transporters/physiology ; Adenosine Triphosphatases/metabolism ; Energy Metabolism ; Humans ; Pharmacokinetics
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Sub-Family B ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.15-00229-5
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