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  1. Article ; Online: Targeting the m

    Jung, Hae Rim / Lee, Jeonghwan / Hong, Seung-Pyo / Shin, Nayeon / Cho, Ara / Shin, Dong-Jin / Choi, Jin Woo / Kim, Jong-Il / Lee, Jung Pyo / Cho, Sung-Yup

    Experimental & molecular medicine

    2024  Volume 56, Issue 2, Page(s) 355–369

    Abstract: Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). ... ...

    Abstract Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). N
    MeSH term(s) Animals ; Humans ; Mice ; Kidney/pathology ; Methyltransferases/genetics ; Renal Insufficiency, Chronic/genetics ; RNA, Small Interfering ; Transforming Growth Factor beta ; Fibrosis
    Chemical Substances Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; RNA, Small Interfering ; Transforming Growth Factor beta
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-024-01159-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4775: Show issues Location:
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  2. Article: Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia: A case report.

    Yoo, Seung Soo / Lee, Shin Yup / Choi, Sun Ha

    World journal of clinical cases

    2022  Volume 10, Issue 25, Page(s) 8974–8979

    Abstract: Background: Life-threatening hypoxia can occur in patients with lung cancer due to bronchial obstruction. Extracorporeal membrane oxygenation (ECMO) can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ...

    Abstract Background: Life-threatening hypoxia can occur in patients with lung cancer due to bronchial obstruction. Extracorporeal membrane oxygenation (ECMO) can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical treatment. However, the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well known.
    Case summary: A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo. A series of imaging and diagnostic tests were performed, and stage IIIB (cT4N2M0) lung cancer was eventually diagnosed. On hospital day 3, he experienced dyspnea and hypoxia that was not relieved with oxygen support
    Conclusion: ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i25.8974
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  3. Article: Preschool Exposure to Online Games and Internet Gaming Disorder in Adolescents: A Cohort Study.

    Jeong, Hyunsuk / Yim, Hyeon Woo / Lee, Seung-Yup / Lee, Hae Kook / Potenza, Marc N / Shin, Yunmi

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 760348

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.760348
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  4. Article ; Online: Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway.

    Jang, Hyeonha / Ojha, Uttam / Jeong, Ji-Hak / Park, Keun-Gyu / Lee, Shin Yup / Lee, You Mie

    Archives of pharmacal research

    2023  Volume 46, Issue 7, Page(s) 629–645

    Abstract: Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor progression including initiation, angiogenesis, metastasis, immunosuppression, and resistance to therapy. ... ...

    Abstract Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor progression including initiation, angiogenesis, metastasis, immunosuppression, and resistance to therapy. Myriocin, a natural compound isolated from Mycelia sterilia, is an immunosuppressant that inhibits tumor growth and angiogenesis. However, the mechanisms underlying the effects of myriocin on TAMs and TAM-mediated tumor growth have not yet been elucidated. In this study, we determined the effects of myriocin on TAMs and the underlying mechanism in vitro and in vivo. Myriocin significantly suppressed monocyte-macrophage differentiation and M2 polarization of macrophages but not M1 polarization. In addition, myriocin inhibited the expression of anti-inflammatory cytokines and secretion of proangiogenic factors, such as vascular endothelial growth factor, in M2 macrophages as well as M2-induced endothelial cell permeability. Myriocin also inhibited the PI3K/Akt/mTOR signaling pathway in M2 macrophages. Myriocin reduced the population of M2-like TAMs within the tumor tissue of a mouse allograft tumor model but not that of M1-like TAMs. Moreover, combined treatment with myriocin and cisplatin synergistically suppressed tumor growth and enhanced survival rate in mice by reducing the population of M2-like TAMs. Overall, these results suggest that myriocin inhibits tumor growth by remodeling the TME through suppression of differentiation and polarization of M2-like TAMs via the PI3K/Akt/mTOR signaling pathway.
    MeSH term(s) Animals ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Cell Line, Tumor ; TOR Serine-Threonine Kinases/metabolism ; Macrophages ; Tumor Microenvironment
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; thermozymocidin (YRM4E8R9ST) ; Vascular Endothelial Growth Factor A ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-07-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-023-01454-1
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    Zs.B 3229: Show issues Location:
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  5. Article ; Online: GLUT1 Variants for Predicting Prognosis After Surgery in Non-small Cell Lung Cancer.

    Lee, Shin Yup / Park, Jae Yong

    Annals of surgical oncology

    2018  Volume 25, Issue Suppl 3, Page(s) 948–949

    MeSH term(s) Carcinoma, Non-Small-Cell Lung ; Glucose Transporter Type 1 ; Humans ; Lung Neoplasms ; Prognosis
    Chemical Substances Glucose Transporter Type 1
    Language English
    Publishing date 2018-10-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-018-6847-1
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    Zs.A 4042: Show issues Location:
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  6. Article: Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer.

    Choi, Sun Ha / Yoo, Seung Soo / Lee, Shin Yup / Park, Jae Yong

    Archives of pharmacal research

    2022  Volume 45, Issue 4, Page(s) 263–279

    Abstract: Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the use of angiogenesis inhibition have emerged in the era of targeted therapy and immune checkpoint ... ...

    Abstract Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the use of angiogenesis inhibition have emerged in the era of targeted therapy and immune checkpoint blockade. Given the shared common downstream signals of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) with their complementary roles in tumorigenesis and tumor angiogenesis, the dual inhibition of EGFR and VEGF pathways represents a rational strategy to maximize clinical efficacy and overcome resistance in the treatment of EGFR-mutant NSCLC. VEGF-driven angiogenesis is a potent driver of immunosuppressive tumor microenvironment (TME), with the recruited immunosuppressive cells driving angiogenesis, highlighting the interplay between the tumor vasculature and the anticancer immunity. Anti-angiogenic therapy can normalize the tumor vasculature and reprogram the TME from immunosuppressive into immunosupportive. Intensive research is under way to utilize the anti-angiogenic combination therapy to its full potential in diverse clinical settings in urgent unmet needs for the treatment of NSCLC. In this review, we present an overview of tumor angiogenesis and summarize the scientific background and preclinical and clinical evidence of anti-angiogenic therapy in combination with target therapy and immunotherapy for the treatment of NSCLC.
    MeSH term(s) Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; ErbB Receptors ; Humans ; Immunotherapy ; Lung Neoplasms/metabolism ; Neovascularization, Pathologic/metabolism ; Tumor Microenvironment ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-04-21
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-022-01382-6
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  7. Article ; Online: Incidental versus symptomatic pulmonary embolism in patients without cancer.

    Lee, Yong Hoon / Cha, Seung-Ick / Park, Jongmin / Lim, Jae Kwang / Lee, Won Kee / Park, Ji-Eun / Choi, Sun Ha / Seo, Hyewon / Yoo, Seung-Soo / Lee, Shin-Yup / Lee, Jaehee / Kim, Chang-Ho / Park, Jae-Yong

    Vascular medicine (London, England)

    2023  Volume 28, Issue 5, Page(s) 461–462

    MeSH term(s) Humans ; Pulmonary Embolism/diagnosis ; Neoplasms/complications ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Incidental Findings
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Letter
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X231171614
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    Zs.A 4409: Show issues Location:
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  8. Article: A Case of Paraneoplastic Neurological Syndrome Expressing Dual Antineuronal Antibodies: Anti-Hu and Recoverin.

    Ryu, Ho-Sung / Lee, Shin Yup / Park, Dong Ho / Lee, Jong-Mok

    Annals of Indian Academy of Neurology

    2020  Volume 23, Issue 1, Page(s) 133–135

    Language English
    Publishing date 2020-01-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_185_19
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  9. Article ; Online: [Brain-Gut-Microbiota Axis].

    Lee, Ayoung / Lee, Ju Yup / Jung, Sung Won / Shin, Seung Yong / Ryu, Han Seung / Jang, Seung-Ho / Kwon, Joong Goo / Kim, Yong Sung

    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

    2023  Volume 81, Issue 4, Page(s) 145–153

    Abstract: Patients frequently report that stress causes or exacerbates gastrointestinal (GI) symptoms, indicating a functional relationship between the brain and the GI tract. The brain and GI tract are closely related embryologically and functionally, interacting ...

    Abstract Patients frequently report that stress causes or exacerbates gastrointestinal (GI) symptoms, indicating a functional relationship between the brain and the GI tract. The brain and GI tract are closely related embryologically and functionally, interacting in various ways. The concept of the brain-gut axis was originally established in the 19th and early 20th centuries based on physiological observations and experiments conducted in animals and humans. In recent years, with the growing recognition that gut microbiota plays a vital role in human health and disease, this concept has been expanded to the brain-gut-microbiota axis. The brain influences the motility, secretion, and immunity of the GI tract, with consequent effects on the composition and function of the gut microbiota. On the other hand, gut microbiota plays an essential role in the development and function of the brain and enteric nervous system. Although knowledge of the mechanisms through which the gut microbiota influences distant brain function is incomplete, studies have demonstrated communication between these organs through the neuronal, immune, and endocrine systems. The brain-gut-microbiota axis is an essential aspect of the pathophysiology of functional GI disorders such as irritable bowel syndrome, and is also involved in other GI diseases, including inflammatory bowel disease. This review summarizes the evolving concept of the brain-gut-microbiota axis and its implications for GI diseases, providing clinicians with new knowledge to apply in clinical practice.
    MeSH term(s) Animals ; Humans ; Brain-Gut Axis ; Microbiota ; Gastrointestinal Diseases ; Brain
    Language Korean
    Publishing date 2023-04-25
    Publishing country Korea (South)
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2611091-X
    ISSN 2233-6869 ; 1598-9992
    ISSN (online) 2233-6869
    ISSN 1598-9992
    DOI 10.4166/kjg.2023.028
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    Zs.A 6910: Show issues Location:
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  10. Article: A Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study.

    Lee, Ju Yup / Kim, Nayoung / Yoon, Hyuk / Shin, Cheol Min / Park, Young Soo / Lee, Dong Ho

    Journal of neurogastroenterology and motility

    2022  Volume 28, Issue 2, Page(s) 265–275

    Abstract: Background/aims: To assess the effects and safety of DA-9701 (Motilitone) in patients with constipation-type irritable bowel syndrome (IBS-C) which frequently accompany functional dyspepsia (FD).: Methods: FD and IBS-C were diagnosed based on the ... ...

    Abstract Background/aims: To assess the effects and safety of DA-9701 (Motilitone) in patients with constipation-type irritable bowel syndrome (IBS-C) which frequently accompany functional dyspepsia (FD).
    Methods: FD and IBS-C were diagnosed based on the Rome III criteria. Randomized subjects were administered 30 mg of DA-9701 or placebo 3 times a day for 4 weeks. The study endpoints were evaluated the percentage of responders in the overall symptom evaluation of IBS-C and FD.
    Results: Thirty IBS-C patients and 30 placebos were prospectively enrolled. The proportion of responders with improvement in overall symptoms of IBS-C was 53.33% in the DA-9701 group and 40.00% in the placebo group (
    Conclusions: DA-9701 showed trend of treatment efficacy in patients with IBS-C and FD overlap including overall improvement, and safety, compared to placebo but without significance probably due to small numbers. It is suggested the need for a large-scale clinical trial to confirm this preliminary effect of DA-9701.
    Language English
    Publishing date 2022-03-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2573719-3
    ISSN 2093-0887 ; 2093-0879
    ISSN (online) 2093-0887
    ISSN 2093-0879
    DOI 10.5056/jnm20236
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