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  1. Article ; Online: Crushing the curve, the role of national and international institutions and policy makers in COVID-19 pandemic

    Koçak Tufan, Zeliha / Kayaaslan, Bircan

    Turkish journal of medical sciences

    2020  Volume 50, Issue SI-1, Page(s) 495–508

    Abstract: Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not ... ...

    Abstract Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not considered by the authorities on time. The first patients may be lost without a proper diagnosis. When everybody realizes that there may be a big problem in the horizon, sometimes it is too late. That is why it is very important to monitor contagious diseases and follow the warnings and releases of national and international disease control centers and other related organizations. China celebrated Lunar New Year with more than 40 thousand families on the 18 of January 2020. Nobody seem to be expecting this emerging new viral pneumonia outbreak appeared in Wuhan, in the last days of 2019, will break the chains and turn out to be a pandemic! But maybe this time it was not too late. There were four important pandemics within the last century: Spanish Flu, Hong Kong Flu, Asian Flu and Swine Flu. Each left different story behind. Millions of people had infected, hundreds, thousands of people died. This time, the Modern World had different tools to limit the SARS CoV2 outbreak. The national and international institutions of our globe were all communicating and taking precautions in a very fast manner than ever. However, this time, unexpectedly, the SARS-CoV-2 contagion was also faster. Besides the international organizations like WHO, UNESCO and UNICEF, the roles of local authorities, health ministries, disease control centers, health protection agencies, research centers and universities are all very important in different operational levels to control and survive from the pandemic. This paper will review the immediate response of different national and international institutions and authorities to COVID-19 pandemic.
    MeSH term(s) Administrative Personnel ; Betacoronavirus ; COVID-19 ; Centers for Disease Control and Prevention, U.S. ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Education, Distance/methods ; Humans ; International Cooperation ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Turkey ; UNESCO ; United States ; Universities ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2004-167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19 diaries of higher education during the shocking pandemic/ COVID-19 Pandemisinde Yüksekögretim Günceleri

    Tufan, Zeliha Kocak

    Gazi Med. J.

    Abstract: The ongoing pandemic due to SARS CoV2 is really a big one, which would never welcomed from any countries anytime, but knocked the door all of a sudden! The SARS CoV-2 first appeared in China in late December 2019. The virus isolated on January 7, 2020; ... ...

    Abstract The ongoing pandemic due to SARS CoV2 is really a big one, which would never welcomed from any countries anytime, but knocked the door all of a sudden! The SARS CoV-2 first appeared in China in late December 2019. The virus isolated on January 7, 2020; the disease named as COVID-19 afterwars. Since this was a SARS virus not an influenza, nobody seem to expect it as a pandemic agent, spread so fast and so globally. But actually it did spread to many countries and declared as a pandemic by the World Health Organization on March 11, 2020. The pandemic hit the universities hard. The most important topic for universities during the pandemic was of course distance and remote learning, which become widespread already. The pandemic will cause profound impacts and changes on the higher education system around the world in terms of education-teaching methods, research, internationalization and mobility. The response of Council of Higher Education of Turkey to pandemic could be evaluated in four phases: 1) Close monitoring, 2) Preparing, 3) Action, 4) New normalization. In this paper we will review the response of Turkish higher education institutions and Council of Higher Education to the COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #678103
    Database COVID19

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  3. Article ; Online: COVID-19 and Sepsis

    Koçak Tufan, Zeliha / Kayaaslan, Bircan / Mer, Mervyn

    Turkish journal of medical sciences

    2021  Volume 51, Issue SI-1, Page(s) 3301–3311

    Abstract: The COVID-19 pandemic has created a major alteration in the medical literature including the sepsis discussion. From the outset of the pandemic, various reports have indicated that although there are some unique features pertinent to COVID-19, many of ... ...

    Abstract The COVID-19 pandemic has created a major alteration in the medical literature including the sepsis discussion. From the outset of the pandemic, various reports have indicated that although there are some unique features pertinent to COVID-19, many of its acute manifestations are similar to sepsis caused by other pathogens. As a consequence, the old definitions now require consideration of this new etiologic agent, namely SARS-CoV-2. Although the pathogenesis of COVID-19 has not been fully explained, the data obtained so far in hospitalized patients has revealed that serum cytokine and chemokine levels are high in severe COVID-19 patients, similar to those found with sepsis. COVID-19 may involve multiple organ systems. In addition to the lungs, the virus has been isolated from blood, urine, faeces, liver, and gallbladder. Results from autopsy series in COVID-19 patients have demonstrated a wide range of findings, including vascular involvement, congestion, consolidation, and hemorrhage as well as diffuse alveolar damage in lung tissue consistent with acute respiratory distress syndrome (ARDS). The presence of viral cytopathic-like changes, infiltration of inflammatory cells (mononuclear cells and macrophages), and viral particles in histopathological samples are considered a consequence of both direct viral infection and immune hyperactivation. Thromboembolism and hyper-coagulopathy are other components in the pathogenesis of severe COVID-19. Although the pathogenesis of hypercoagulability is not fully understood, it has been pointed out that all three components of Virchow’s triad (endothelial injury, stasis, and hypercoagulable state) play a major role in contributing to clot formation in severe COVID-19 infection. In severe COVID-19 cases, laboratory parameters such as hematological findings, coagulation tests, liver function tests, D-dimer, ferritin, and acute phase reactants such as CRP show marked alterations, which are suggestive of a cytokine storm. Another key element of COVID-19 pathogenesis in severe cases is its similarity or association with hemophagocytic lymphohistiocytosis (HLH). SARS-CoV-2 induced cytokine storm has significant clinical and laboratory findings overlapping with HLH. Viral sepsis has some similarities but also some differences when compared to bacterial sepsis. In bacterial sepsis, systemic inflammation affecting multiple organs is more dominant than in COVID-19 sepsis. While bacterial sepsis causes an early and sudden onset clinical deterioration, viral diseases may exhibit a relatively late onset and chronic course. Consideration of severe COVID-19 disease as a sepsis syndrome has relevance and may assist in terms of determining treatments that will modulate the immune response, limit intrinsic damage to tissue and organs, and potentially improve outcome.
    MeSH term(s) COVID-19/immunology ; Chemokines/blood ; Cytokine Release Syndrome ; Cytokines/blood ; Humans ; Inflammation ; Lymphohistiocytosis, Hemophagocytic/immunology ; Pandemics ; SARS-CoV-2 ; Sepsis/blood ; Sepsis/complications
    Chemical Substances Chemokines ; Cytokines
    Language English
    Publishing date 2021-12-17
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2108-239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Crushing the curve, the role of national and international institutions and policy makers in COVID-19 pandemic

    Koçak Tufan, Zeliha / Kayaaslan, Bircan

    Turk J Med Sci

    Abstract: Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not ... ...

    Abstract Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not considered by the authorities on time. The first patients may be lost without a proper diagnosis. When everybody realizes that there may be a big problem in the horizon, sometimes it is too late. That is why it is very important to monitor contagious diseases and follow the warnings and releases of national and international disease control centers and other related organizations. China celebrated Lunar New Year with more than 40 thousand families on the 18 of January 2020. Nobody seem to be expecting this emerging new viral pneumonia outbreak appeared in Wuhan, in the last days of 2019, will break the chains and turn out to be a pandemic! But maybe this time it was not too late. There were four important pandemics within the last century: Spanish Flu, Hong Kong Flu, Asian Flu and Swine Flu. Each left different story behind. Millions of people had infected, hundreds, thousands of people died. This time, the Modern World had different tools to limit the SARS CoV2 outbreak. The national and international institutions of our globe were all communicating and taking precautions in a very fast manner than ever. However, this time, unexpectedly, the SARS-CoV-2 contagion was also faster. Besides the international organizations like WHO, UNESCO and UNICEF, the roles of local authorities, health ministries, disease control centers, health protection agencies, research centers and universities are all very important in different operational levels to control and survive from the pandemic. This paper will review the immediate response of different national and international institutions and authorities to COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #71826
    Database COVID19

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  5. Article ; Online: Crushing the curve, the role of national and international institutions and policy makers in COVID-19 pandemic

    KOÇAK TUFAN, Zeliha / KAYAASLAN, Bircan

    Volume: 50, Issue: 495-508 ; 1300-0144 ; 1303-6165 ; Turkish Journal of Medical Sciences

    2020  

    Abstract: Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not ... ...

    Abstract Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not considered by the authorities on time. The first patients may be lost without a proper diagnosis. When everybody realizes that there may be a big problem in the horizon, sometimes it is too late. That is why it is very important to monitor contagious diseases and follow the warnings and releases of national and international disease control centers and other related organizations. China celebrated Lunar New Year with more than 40 thousand families on the 18 of January 2020. Nobody seem to be expecting this emerging new viral pneumonia outbreak appeared in Wuhan, in the last days of 2019, will break the chains and turn out to be a pandemic! But maybe this time it was not too late. There were four important pandemics within the last century: Spanish Flu, Hong Kong Flu, Asian Flu and Swine Flu. Each left different story behind. Millions of people had infected, hundreds, thousands of people died. This time, the Modern World had different tools to limit the SARS CoV2 outbreak. The national and international institutions of our globe were all communicating and taking precautions in a very fast manner than ever. However, this time, unexpectedly, the SARS-CoV-2 contagion was also faster. Besides the international organizations like WHO, UNESCO and UNICEF, the roles of local authorities, health ministries, disease control centers, health protection agencies, research centers and universities are all very important in different operational levels to control and survive from the pandemic. This paper will review the immediate response of different national and international institutions and authorities to COVID-19 pandemic.
    Keywords coronavirus,SARS-CoV-2,World Health Organization,CDC,Ministry of Health,Pandemic ; covid19
    Language English
    Publishing date 2020-04-21T00:00:00Z
    Publisher TÜBİTAK
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Tenofovir disoproxil fumarate may not cause renal and bone toxicity in chronic hepatitis B patients: a retrospective cross-sectional study

    Güner, Rahmet / Koçak Tufan, Zeliha / Yılmaz, Gül Ruhsar / Mehmet A, Taşyaran

    Turkish journal of medical sciences

    2019  Volume 49, Issue 1, Page(s) 451–452

    MeSH term(s) Antiviral Agents/adverse effects ; Bone Density/drug effects ; Calcium/blood ; Cross-Sectional Studies ; Glomerular Filtration Rate/drug effects ; Hepatitis B, Chronic/drug therapy ; Humans ; Hypocalcemia/blood ; Hypocalcemia/chemically induced ; Hypophosphatemia/blood ; Hypophosphatemia/chemically induced ; Phosphates/blood ; Retrospective Studies ; Tenofovir/adverse effects
    Chemical Substances Antiviral Agents ; Phosphates ; Tenofovir (99YXE507IL) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-02-11
    Publishing country Turkey
    Document type Letter
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1805-233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Telaprevir use in a chronic hepatitis C patient with hemophilia.

    Guner, Rahmet / Tufan, Zeliha Kocak

    European journal of gastroenterology & hepatology

    2014  Volume 26, Issue 2, Page(s) 248

    MeSH term(s) Antiviral Agents/therapeutic use ; Drug Therapy, Combination ; Hemophilia A/complications ; Hemophilia A/diagnosis ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferons/therapeutic use ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Oligopeptides/therapeutic use ; Ribavirin/therapeutic use ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Oligopeptides ; Ribavirin (49717AWG6K) ; telaprevir (655M5O3W0U) ; Interferons (9008-11-1)
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/01.meg.0000435549.89036.a9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Empirical therapy and teicoplanin use in periprosthetic joint infections

    Koçak Tufan, Zeliha / Güner, Hatice Rahmet / Yılmaz, Gülruhsar / Özşahin, Aybegüm / Bozkurt, Murat / Taşyaran, Mehmet Akın

    Turkish journal of medical sciences

    2017  Volume 47, Issue 6, Page(s) 1947–1949

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Empirical Research ; Female ; Humans ; Male ; Middle Aged ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/microbiology ; Teicoplanin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Teicoplanin (61036-62-2)
    Language English
    Publishing date 2017-12-19
    Publishing country Turkey
    Document type Letter
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1604-39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Growing OXA-23 type strains among carbapenem-resistant

    Altun, Şerife / Koçak Tufan, Zeliha / Altun, Belgin / Önde, Ufuk / Kınıklı, Sami / Demiröz, Ali Pekcan

    Turkish journal of medical sciences

    2016  Volume 46, Issue 6, Page(s) 1894–1899

    Abstract: Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of ... ...

    Abstract Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains.
    Materials and methods: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA-58, and NDM-1 was investigated by PCR.
    Results: In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% (1/43) to tigecycline. All of the strains were susceptible to colistin. blaOXA-58 was found only in one (2%) strain while blaOXA-23 was found in 14 (32%) strains. All strains were negative for blaOXA-48 and NDM-1.
    Conclusion: blaOXA-23 was the main resistance pattern in carbapenem-resistant A. baumannii strains. blaOXA-58 was present only in one strain and no blaOXA-48 was found. Tigecycline susceptibility is high and it can be a treatment option for a possible combination therapy of carbapenem-resistant A. baumannii, especially for those for whom colistin is contraindicated because of its toxicity.
    MeSH term(s) Acinetobacter Infections ; Acinetobacter baumannii ; Anti-Bacterial Agents ; Carbapenems ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Minocycline/analogs & derivatives ; Tigecycline ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; Tigecycline (70JE2N95KR) ; beta-Lactamases (EC 3.5.2.6) ; Minocycline (FYY3R43WGO)
    Language English
    Publishing date 2016-12-20
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1508-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dynamics of Anidulafungin use in a Tertiary Care Hospital.

    Tufan, Zeliha Kocak / Guner, Rahmet / Guven, Tumer / Yilmaz, Gul Ruhsar / Tasyaran, Mehmet A

    Journal of clinical and diagnostic research : JCDR

    2014  Volume 8, Issue 12, Page(s) ML02

    Language English
    Publishing date 2014-12-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2014/10612.5317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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